Synthetic Route of 116986-08-4, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 116986-08-4, name is Methyl 2-(bromomethyl)nicotinate. A new synthetic method of this compound is introduced below.
To a solution of methyl 2-(bromomethyl)nicotinate (6.0 g, 26.0 mmol) in CH3CN (200 mL) was added TBAF (10.2 g, 39.0 mmol) and TMSCN (5.2 g, 52.0 mmol) at 0C. The mixture was then stuffed at 30C for 16h under N2. The solution of the reaction was washed with water (30 mL) and extracted with EtOAc (15 mLx3). The organic layer was concentrated, and the residue was purified by column chromatography (PE:EA=5: 1–2: 1) to give the desired product (2.3 g, 50.3%). LCMS (mlz): 177.0 [M+H]
At the same time, in my other blogs, there are other synthetic methods of this type of compound,116986-08-4, Methyl 2-(bromomethyl)nicotinate, and friends who are interested can also refer to it.
Reference:
Patent; EPIZYME, INC.; DUNCAN, Kenneth, W.; CHESWORTH, Richard; MUNCHHOF, Michael, John; SHAPIRO, Gideon; (393 pag.)WO2015/200677; (2015); A2;,
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