Electric Literature of 17282-04-1, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 17282-04-1, name is 2-Chloro-3-fluoropyridine, molecular formula is C5H3ClFN, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.
To a flask was charged with 2-chloro-3-fluoropyridine (1.163 g, 8.84 mmol) and THF (15 mL). The mixture was cooled to -78 C and then a solution of n-butyl lithium BuLi (2.83 ml, 7.07 mmol) in tolune solution was added dropwise. The mixture was aged at -78 C for 30 min, and a solution of (6R,8aS)-N-methoxy-N-methyl-3- oxooctahydroindolizine-6-carboxamide (1.0 g, 4.42 mmol) in THF ( 2.5 mL) was added dropwise by syringe. The resulting reaction mixture was stirred at -78 C for 2 hrs. The mixture was quenched with water at low temperature, extracted with EtOAc 3x, dried over MgS04, filtered and concentrated in vacuo to give crude. Crude was loaded and purified on 24 gr Redi Sep Rf filter column on CombiFlash with 10% MeOH/DCM 0- 3% to afford product (6R,8aS)-6-(2-chloro-3-fluoroisonicotinoyl)hexahydroindolizin- 3(2H)-one LC-MS (ES, m/z) Ci4H14ClF 202: 296; Found 297[M+H]+.
According to the analysis of related databases, 17282-04-1, the application of this compound in the production field has become more and more popular.
Reference:
Patent; MERCK SHARP & DOHME CORP.; LIU, Jian; KIM, Ronald, M.; KOZLOWSKI, Joseph; KRIKORIAN, Arto, D.; ANAND, Rajan; WO2015/95099; (2015); A1;,
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