With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.1334411-79-8, name is 4-Bromo-2-(2,6-dichlorophenyl)-1H-imidazo[4,5-c]pyridine, molecular formula is C12H6BrCl2N3, molecular weight is 343.01, as common compound, the synthetic route is as follows.HPLC of Formula: C12H6BrCl2N3
To a solution of 4-bromo-2-(2,6-dichlorophenyl)-lH-imidazo[4,5-c]pyridine (1.0 g,2.9 mmol) in DMF (5 mL) at 23 C was added sodium hydride (0.1 1 g, 4.4 mmol). The mixture was allowed to stir at 23 C for 30 min before iodomethane (0.46 g, 3.2 mmol) was added in one portion and the mixture was stirred at 23 C overnight. The reaction mixture was quenched with water (50 mL), extracted with ethyl acetate (3 x 50 ml). The combined organic phase was washed with brine, dried over Na2S04, and then concentrated. The residue was purified by column chromatography on silica gel with dichloromethane/rnethanol ( 10:1) to give the desired products as a mixture (0.65 g, 62% yield). LCMS(ESI) m/z: 358.1 [M+H+].
At the same time, in my other blogs, there are other synthetic methods of this type of compound,1334411-79-8, 4-Bromo-2-(2,6-dichlorophenyl)-1H-imidazo[4,5-c]pyridine, and friends who are interested can also refer to it.
Reference:
Patent; F. HOFFMANN-LA ROCHE AG; LAI, Yingjie; LIANG, Jun; MAGNUSON, Steven R.; TSUI, Vickie H.; ZHANG, Birong; ROBARGE, Kirk; WO2011/113802; (2011); A2;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem