Application of 929022-76-4, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 929022-76-4, name is 2-Chloro-4-fluoronicotinic acid, molecular formula is C6H3ClFNO2, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.
To a solution of Example 75a (2.74 g, 15.6 mmol) in THF (50 mL), tBuOCOCl ( 3.2 g, 23.4 mmol) at 0C was added TEA (3.16 g, 31.2 mmol), the mixture was stirred at r.t. for 0.5 min, and then NaBD4 ( 1.31 g, 31.2 mmol) in EtOH (10 mL) was added at 0C, which was turned to r.t for another 30 min. The reaction was then quenched by adding water (10 mL), then concentrated, the residue was purified by flash column chromatography (eluted with EtOAc) to give the desired product (Example 75b, 1.05 g, yield 41 %) as yellow oil. LCMS [M+1]+= 164
While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 929022-76-4, 2-Chloro-4-fluoronicotinic acid.
Reference:
Patent; FRONTHERA U.S. PHARMACEUTICALS LLC; JIN, Bohan; DONG, Qing; HUNG, Gene; (212 pag.)WO2017/218960; (2017); A1;,
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