14 Sep 2021 News A new synthetic route of 5912-34-5

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,5912-34-5, its application will become more common.

Adding a certain compound to certain chemical reactions, such as: 5912-34-5, 3-(Cyanomethyl)picolinonitrile, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 5912-34-5, blongs to pyridine-derivatives compound. category: pyridine-derivatives

(3) 8-bromo-l,7-naphthyridin-6-amine.; To a 50 mL round-bottomed flask was added hydrobromic acid, 30% in acetic acid (317 mul, 5868 mumol). 3-(cyanomethyl)picolinonitrile (280 mg, 1956 mumol) in AcOH (0.5 mL) was then added at 0 0C. The reaction mixture was stirred at 0 0C for 30 min. The solid was filtered out and washed with 50% EtOAc/hexanes. The solid was treated with sat. NaHCO3 (5 mL) and the mixture was extracted with EtOAc (2 x 50 mL). The organic extract was washed with satd NaCl (5 mL), dried over Na2SO4, filtered and concentrated in vacuo and the residue was purified by silica gel chromatography, eluting with 40% EtOAc/hexanes to give 8-bromo-l,7-naphthyridin-6-amine (312 mg, 71% yield). MS (ESI pos. ion) m/z calc’d for C8H6BrN3: 223.0, 225.0; found 224.0, 226.0. 1H NMR (300 MHz, CHLOROFORM-^) delta ppm 4.63 (s, 2 H) 6.61 (s, 1 H) 7.42 (dd, J=8.48, 4.09 Hz, 1 H) 7.85 (dd, J=8.48, 1.61 Hz, 1 H) 8.78 (dd, J=3.95, 1.61 Hz, 1 H)

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,5912-34-5, its application will become more common.

Reference:
Patent; AMGEN INC.; WO2009/155121; (2009); A2;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem