Day: September 14, 2021

With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.1796-83-4, name is Dimethyl pyridine-3,4-dicarboxylate, molecular formula is C9H9NO4, molecular weight is 195.1721, as common compound, the synthetic route is as follows.name: Dimethyl pyridine-3,4-dicarboxylate

10267] Compound WXO1S-2 (26.00 g, 133.22 mmol, 1.00 eq) was dissolved in anhydrous dichioromethane (400.00 mE), then 3-chloroperoxybenzoic acid (40.57 g, 199.83 mmol, 85% purity, 1.50 eq) was added to reaction liquid at 0 C., and the mixture was stirred at 00 C. for 14 h under nitrogen condition. After reaction, water (500 mE) and sodium thiosulfate (about 20 g) were added in reaction liquid to quench the reaction. The resulting mixture was stirred for 1 h, and neutralized with sodium bicarbonate powder (about 20 g), then extracted with dichioromethane (400 mEx3). The organic phase was washed with saturated sodium chloride solution (400 mEx3), dried with anhydrous sodium sulfate and filtered. The filtrate was dried by rotary evaporation to obtain the crude. The crude was purified by colunm chromatography (petroleum ether:ethyl acetate=50:1-1:1) to obtain WXO18-3. ?H NMR (400 MHz, CDC13) oe ppm: 8.35 (d, J=1.64 Hz, 1H), 8.25 (dd, J=6.78, 1.76 Hz, 1H), 7.70 (d, J=6.78 Hz, 1H), 3.96 (s, 3H), 3.93 (s, 3H).

At the same time, in my other blogs, there are other synthetic methods of this type of compound,1796-83-4, Dimethyl pyridine-3,4-dicarboxylate, and friends who are interested can also refer to it.

Reference:
Patent; SHENZHEN SALUBRIS PHARM CO LTD.; Wu, Chengde; Yan, Jie; Xu, Wenjie; Yu, Tao; Li, Ning; Chen, Shuhui; US2018/305346; (2018); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Synthetic Route of 55676-21-6, Adding some certain compound to certain chemical reactions, such as: 55676-21-6, name is 1-(2-Chloropyridin-3-yl)ethanone,molecular formula is C7H6ClNO, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 55676-21-6.

General procedure: 2-chloride pyridine derivatives (5mmol, 1.0eq), K2CO3 (7.5mmol, 1.5eq), 3-amino-1H-pyrazole-4-carbonitrile (5mmol, 1.0eq), CuI (0.5mmol, 0.1eq), ethylenediamine (1.0mmol, 0.2eq) were suspended in DMF. After three cycles of evacuating and backfilling with argon, the reaction tube was sealed and heated to 110°C for 20 hours. After cooling to room temperature, the mixture was diluted with water (100mL), and extracted with ethyl acetate (100mL×3). The organic phase was washed with water, brine, dried over anhydrous sodium sulfate, and concentrated under vacuum. The residue was purified using silica gel chromatography to give the title compounds, yield 37-45percent.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 55676-21-6, 1-(2-Chloropyridin-3-yl)ethanone, other downstream synthetic routes, hurry up and to see.

Reference:
Article; Fang, Zhen; Wang, Tian-qi; Li, Hui; Zhang, Guo; Wu, Xiao-ai; Yang, Li; Peng, Yu-lan; Zou, Jun; Li, Lin-li; Xiang, Rong; Yang, Sheng-yong; Bioorganic and Medicinal Chemistry Letters; vol. 27; 14; (2017); p. 3201 – 3204;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Adding a certain compound to certain chemical reactions, such as: 83004-10-8, 2-Bromo-6-(bromomethyl)pyridine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Formula: C6H5Br2N, blongs to pyridine-derivatives compound. Formula: C6H5Br2N

To a stirred solution of N-hydroxy-1-(4-methyl-4H-1 ,2,4-triazol-3-yl)-1- phenylmethanimine (0.45 g, 2.22 mmol, 1.0 eq.) in 20 ml of MeCN was added C82CO3 (0.795 g, 2.44 mmol, 1.1 eq.) followed by Kl (0.0365 g, 0.22 mmol, 0.1 eq.) in one portion. The resulting suspension was stirred for 5 mins before addition of 2-bromo-6-(bromomethyl)pyridine (0.586 g, 2.33 mmol, 1.05 eq.) in one portion. The reaction was stirred for 4 h at room temperature. The solid was removed by filtration and washed with 250 ml of fresh MeCN. The filtrate was evaporated, and 500 ml of EtOAc were added. The organic layer was washed with H2O and dried over MgSO4 then concentrated. Chromatography of the crude on silica gel gave N-[(6- bromopyridin-2-yl)methoxy]-1-(4-methyl-4H-1 ,2,4-triazol-3-yl)-1-phenylmethanimine (0.748 g, 90 % yield) as a yellow oil. HPLC/MS : m/z = 373 (M+H)

The synthetic route of 83004-10-8 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; BAYER CROPSCIENCE SA; WO2009/130193; (2009); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 13600-47-0, name is 5-Aminonicotinonitrile, molecular formula is C6H5N3, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below. Application In Synthesis of 5-Aminonicotinonitrile

(S)-4-Bromo-2,2-difluoro-7-((trifluoromethyl)sulfonyl)-2,3-dihydro-1H-inden-1-ol (23 mg, 0.060 mmol) was dissolved in 1,4-dioxane (0.20 mL) and treated with 3-pyridinecarbonitrile, 5-amino- (8.6 mg, 0.070 mmol), cesium carbonate (27.5 mg, 0.080 mmol), palladium (II) acetate (0.68 mg, 0.003 mmol), and Xantphos (3.5 mg, 0.010 mmol). After cooling, the mixture was diluted with water and ethyl acetate then separated. This mixture didn’t separate well and there was insoluble yellow solid present, which was removed by filtration. The aqueous was washed with ethyl acetate and the combined organics were washed with saturated NaHCO3, saturated NaCl, dried over Na2S04, and concentrated in vacuo to a dark residue. The crude material was chromatographed on Si02 eluting with a gradient of ethyl acetate / hexane. The product was recovered as light tan solid, (12 mg, 47%). LCMS ESI (+) m/z (M+H) 420; 1H MR (400 MHz, CDCl3 plus CD3OD): delta 8.66 (s, 1H), 8.60 (s, 1H), 7.79-7.75 (m, 2H), 7.22-7.20 (m, 1H), 5.30 (d, 1H), 3.92-3.90 (m, 1H), 3.46-3.32 (m, 1H), 3.31-3.21 (m, 1H).

With the rapid development of chemical substances, we look forward to future research findings about 13600-47-0.

Reference:
Patent; PELOTON THERAPEUTICS, INC.; JOSEY, John, A.; (281 pag.)WO2016/145045; (2016); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 98400-69-2, name is 4-(Boc-Amino)pyridine. This compound has unique chemical properties. The synthetic route is as follows. Formula: C10H14N2O2

A 500 rnL two-necked round bottom flask equipped with nitrogen inlet adaptor and magnetic stirring bar was charged with tert-butyi pyridin-4-ylcarbamate (3.88 g, 20.0 mmol, prepared as described in Spivey, A. C. et al. J. Org. Chem. 64, pp. 9430-9443 (1999)), lambdaWlambda^-tetramethylethylenediamine (TMEDA) (8.15 mL, 54.0 mmol), and anhydrous tetrahydrofuran (THF) (10 mL). The resultant clear, colorless solution was degassed with several cycles of evacuation under reduced pressure followed by a nitrogen purge, then cooled to -78 0C with a dry ice/acetone bath. A solution of n-butyllithium in hexanes (20.0 mL of a 2.5 M solution, 50.0 mmol) was added via syringe under nitrogen atmosphere over 15 minutes (min), resulting in the formation of a thick tan slurry. After 10 min, the cooling bath was replaced with a 5 0C ice bath, and the slurry was allowed to stir for 2 hours. The slurry was then cooled again to -78 0C, and triisopropylborate (17.5 mL, 76.0 mmol) was added dropwise via syringe over 10 min. The reaction mixture was then warmed to ambient temperature and allowed to stir for 20 min. The reaction mixture initially became clear, and then a white precipitate formed. The resultant slurry was then poured into saturated aqueous ammonium choride (100 mL) and allowed to stir vigorously for an additional 20 min. The white precipitate was isolated by filtration, washed sequentially with water (100 mL) and diethyl ether (100 mL), and then dried overnight under reduced pressure, providing 3.10 g of 4-[(tert-butoxycarbonyl)amino]pyridin-3- ylboronic acid as a white solid.

With the rapid development of chemical substances, we look forward to future research findings about 98400-69-2.

Reference:
Patent; COLEY PHARMACEUTICAL GROUP, INC.; WO2007/143526; (2007); A2;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Related Products of 586-95-8, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.586-95-8, name is 4-Pyridinemethanol, molecular formula is C6H7NO, molecular weight is 109.13, as common compound, the synthetic route is as follows.

(l-Benzyl-l,2,3,6-tetrahydropyridin-4-yl)methanol. 4-Hydroxymethyl- pyridine (20 g, 183 mmol, 1.0 eq) was dissolved in DMF (80 mL) andbenzylbromide (24.2 mL; 202 mmol) was added and the solution was stirred at 100 C for 2 hours. The solution was allowed to cool to RT and diluted with EtOH (300 mL) and treated portionwise with NaBH4 (8.7 g; 230 mmol) and stirred at reflux for 3 hours. The solution was allowed to cool to RT and concentrated largely. The residue was taken up in EtOAc and water and the organic phase was dried (Na2S04), filtered and concentrated to give 35 g crude oil. The material was purified with a short plug (10 cm) of silica eluting with EtOAc to give the product (23.9 g; 64%) which was isolated as an oil. NMR (300 MHz, CDC13) delta ppm 7.39-7.2 (m, 5H), 5.69-5.63 (m, 1H), 4.03 (s, 2H), 3.58 (s, 2H), 3.0 (m, 2H), 2.6 (t, J= 6 Hz, 2H), 2.21-2.11 (m, 2H).

Statistics shows that 586-95-8 is playing an increasingly important role. we look forward to future research findings about 4-Pyridinemethanol.

Reference:
Patent; ABBOTT HEALTHCARE PRODUCTS B.V.; STOIT, Axel; IWEMA BAKKER, Wouter, I.; COOLEN, Hein K.A.C.; VAN DONGEN, Maria J.P.; LEFLEMME, Nicolas J.-L.D.; WO2012/4378; (2012); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 153034-90-3, name is 2-Chloro-4-iodonicotinaldehyde. This compound has unique chemical properties. The synthetic route is as follows. Safety of 2-Chloro-4-iodonicotinaldehyde

Step 1. 2-chloro-4-iodonicotinonitrileTo 2-chloro-4-iodonicotinaldehyde (1.0 g, 3.7 mmol) dissolved in THF (11 mL) was added ammonium hydroxide (11 mL, 280 mmol) followed by iodine (1040 mg, 4.11 mmol), the reaction was held at ambient temperature 3.5 h, color visibly lightens as reaction progresses until the end when it is nearly colorless. LCMS indicates reaction to be complete. Reaction was quenched by addition of saturated NaHSO3, extracted into EtOAc. The organic phase was washed with brine, dried over MgSO4, filtered and concentrated in vacuo to provide the crude product, 926 mg. Dissolved in CHCl3/MeOH and applied to 120 g silica gel column, the product fractions were concentrated in vacuo to give 728 mg product. The purified material was taken directly to next step.

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 153034-90-3, 2-Chloro-4-iodonicotinaldehyde.

Reference:
Patent; Rodgers, James D.; Shepard, Stacey; Arvanitis, Argyrios G.; Wang, Haisheng; Storace, Louis; Folmer, Beverly; Shao, Lixin; Zhu, Wenyu; Glenn, Joseph; US2010/298334; (2010); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Reference of 947249-14-1, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.947249-14-1, name is 3-(Difluoromethoxy)pyridin-2-amine, molecular formula is C6H6F2N2O, molecular weight is 160.1215, as common compound, the synthetic route is as follows.

To a solution of 3-(difluoromethoxy)pyridin-2-amine (2.3 g, 14.36 mmol) in acetonitrile (15 was added N-bromosuccinimide (2.61 g, 14.65 mmol) over 3 min at 0 C. The reaction mixture was stirred at the same temperature for another 20 min and subsequently concentrated to dryness in vacuo. The resulting viscous mass was diluted with water and extracted with ethyl acetate (3 x 60 mL). The combined organic layers were dried over sodium sulfate and concentrated to dryness in vacuo. The resulting residue was purified by column chromatography (silica gel, 100-200 mesh, 20% ethyl acetate in hexane) affording 5-bromo-3-(difluoromethoxy)pyridin-2-amine (3.2 g, 93%): NMR (400 MHz, DMSO-d6) delta 7.89 (s, 1H), 7.51 (s, 1H), 7.16 (t, / = 73.6 Hz, 1H), 6.34 (s, 2H).

The chemical industry reduces the impact on the environment during synthesis 947249-14-1, I believe this compound will play a more active role in future production and life.

Reference:
Patent; F. HOFFMANN-LA ROCHE AG; GENENTECH, INC.; ESTRADA, Anthony; LIU, Wen; PATEL, Snahel; SIU, Michael; WO2014/111496; (2014); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 6969-71-7, name is [1,2,4]Triazolo[4,3-a]pyridin-3(2H)-one, the common compound, a new synthetic route is introduced below. name: [1,2,4]Triazolo[4,3-a]pyridin-3(2H)-one

Firstly, 1.35 g (10 mmol) of 1,2,4-triazolo[4,3-a]pyridin-3-(2H)-one (1), 2.5 cm3 (26 mmol) of1-bromo-3-chloropropane (2a), 322 mg (1 mmol) of TBAB, 8.28 g (60 mmol) of K2CO3, and 5 cm3 ofacetonitrile were placed in a conical flask. The reactions were carried out under microwave radiation(Samsung M182DN; 300 W) for 50 s. After this time, 2.3 g (10 mmol) of 1-(3-chlorophenyl)piperazine hydrochloride (4) and 5 cm3 of acetonitrile were added to the reaction mixture. Reactions were carriedout in the presence of microwave radiation for another 90 s. The progress of the reaction was monitoredby TLC (eluent chloroform-methanol 9:1). After the reaction, 50 cm3 of water was added and theresulting product was filtered o on a Buechner funnel. Yield (Samsung M182DN; 300 W) 31%, yield(CEM Discover SP reactor; 100 W) 71%.

The synthetic route of 6969-71-7 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Jaskowska, Jolanta; Zar eba, Przemys?aw; Sliwa, Pawe?; Pindelska, Edyta; Sata?a, Grzegorz; Majka, Zbigniew; Molecules; vol. 24; 8; (2019);,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Adding a certain compound to certain chemical reactions, such as: 65515-28-8, Methyl 2,6-dichloronicotinate, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Application In Synthesis of Methyl 2,6-dichloronicotinate, blongs to pyridine-derivatives compound. Application In Synthesis of Methyl 2,6-dichloronicotinate

A 250 mL eggplant flask was sequentially charged with methyl 2,6-dichloronicotinate (3.09 g, 15 mmol), 4-methoxyphenol (1.86 g, 15mmol), and 18 mL of N, N-dimethylformamide for dissolving them. Triethylamine (2.7 ml, 19.5mmol) was added dropwise under stirring at room temperature, and after completion of the dropwise addition, triethylenediamine (252 mg, 2.25 mmol) was added. The mixture was stirred at room temperature for 4-5 hours and the solutionchanged from clear to turbid. Thin layer chromatography [V (petroleum ether) / V (ethyl acetate) = 6/1] detected thatmost of the raw material disappeared. Then, 1.30 mL of HOAc, 25 mL of isopropanol and 15 mL of ice water weresequentially added while the solution changed from turbid to clear, and stirred at room temperature for 0.5 hour. 40 mLof water was slowly dropwise added, and after completion of the dropwise addition, stirred at room temperature for 2hours. A large number of white solid precipitated and was filtered. The filter cake was washed with a mixed solution ofisopropyl alcohol / water = 1: 1 and dried under vacuum at 50 C for 8 hours to obtain 4.05 g of methyl 2-chloro-6-(4-methoxyphenoxy) nicotinate as a solid, 91.84%

At the same time, in my other blogs, there are other synthetic methods of this type of compound,65515-28-8, Methyl 2,6-dichloronicotinate, and friends who are interested can also refer to it.

Reference:
Patent; Shenyang Sunshine Pharmaceutical Co., Ltd.; ZHOU, Yunlong; CAI, Suixiong; WANG, Guangfeng; JIAO, Lingling; MIN, Ping; JING, Yu; GUO, Ming; (44 pag.)EP3275881; (2018); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem