Day: September 17, 2021

Adding a certain compound to certain chemical reactions, such as: 6000-50-6, 2,3-Dihydro-1H-pyrrolo[3,4-c]pyridine dihydrochloride, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Safety of 2,3-Dihydro-1H-pyrrolo[3,4-c]pyridine dihydrochloride, blongs to pyridine-derivatives compound. Safety of 2,3-Dihydro-1H-pyrrolo[3,4-c]pyridine dihydrochloride

To a solution of 6-(4-aminophenyl)-4-(quinolin-7-yl)pyridazin-3(2H)-one, (800 mg, 2.54 mmol), in tetrahydrofuran, 160 mL, was added 4-nitrophenyl carbonochloridate (615 mg, 3.05 mmol). The reaction mixture was heated at 60 C for 5 hours and concentrated under vacuum. The residue was dissolved in N,N-dimethylformamide, 20 mL and added to 2,3- dihydro-1H-pyrrolo[3,4-c]pyridine dihydrochloride (588 mg, 2.54 mmol) and N,N- diisopropylethylamine, (2.21 mL, 12.7 mmol) in dichloromethane (60 mL) and stirred at r.t. for 16 hours. The precipitate was collected by filtration, washed with water and dried to give the desired product, 850 mg (98% purity, 65% yield over two steps).PRODUCTS: (1029) LC-MS (Method 3): Rt = 0.32 min; MS (ESIpos): m/z = 461 [M+H]+ 1H-NMR (400 MHz, DMSO-D6) delta [ppm]: 4.79-4.81 (m, 4H), 7.41 (d, 1H), 7.54-7.57 (m, 1H), 7.68-7.71 (m, 2H), 7.91-7.93 (m, 2H), 8.03-8.05 (m, 1H), 8.15-8.17 (m, 1H), 8.31 (s, 1H), 8.38-8.40 (m, 1H), 8.46-8.48 (m, 1H), 8.58-8.60 (m, 2H), 8.74 (s, 1H), 8.93-8.94 (m, 1H).

The synthetic route of 6000-50-6 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; BAYER AKTIENGESELLSCHAFT; BAYER PHARMA AKTIENGESELLSCHAFT; BOeHNKE, Niels; BERGER, Markus; SOMMER, Anette; HAMMER, Stefanie; FERNANDEZ-MONTALVAN, Ernesto, Amaury; STELTEN-LUDWIG, Beatrix; GUeNTHER, Judith; MAHLERT, Christoph; GREVEN, Simone; SARKER, Abul, Basher; TAIT, Michael; (451 pag.)WO2019/149637; (2019); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Adding a certain compound to certain chemical reactions, such as: 78607-36-0, 2-Chloro-3-iodopyridine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Computed Properties of C5H3ClIN, blongs to pyridine-derivatives compound. Computed Properties of C5H3ClIN

To a flame-dried flask were added Pd(PPh3)4 (10 mol %), Xantphos (10 mol %), Cs2CO3 (3 eq) and 2-chloro-3-iodopyridine (1.2 eq). Then, 6SB (1 eq) and DMF (0.15 M) were added to the reaction mixture under an N2 atmosphere. The reaction mixture was stirred for 10 min at room temperature, and then heated at 140 C. in a pre-heated oil bath for 24 h. After that, the reaction mixture was cooled to room temperature, diluted with CH2Cl2, filtered through a short pad of Celite, and washed with CH2Cl2. The combined organic extracts were concentrated under reduced pressure and the resulting residue was purified by column chromatography on silica gel to provide the product DFE-6SB-2 in 39% yield.

The synthetic route of 78607-36-0 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Arizona Board of Regents on behalf of Arizona State University; Li, Jian; Zhu, Zhi-Qiang; (232 pag.)US2018/337345; (2018); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 89-00-9, name is Pyridine-2,3-dicarboxylic acid, the common compound, a new synthetic route is introduced below. category: pyridine-derivatives

A solution of pyridine-2,3-dicarboxylic acid (0.5 g, 3 mmol) and NaOH (0.24 g, 6 mmol) in water (25 mL) was added dropwise with stirring at 60 C to a solution of CdSO4·8/3H2O (0.77 g, 3 mmol) in water (25 mL). A precipitate immediately formed and stirring was continued for 4 h at 50 C. The addition of the 2-meim ligand (0.49 g, 6 mmol) in water (10 mL) to the precipitate mixture resulted in a clear solution. The mixture was stirred for 2 h at 60 C and then cooled to room temperature. The crystals that formed were filtered, washed with 10 mL of water, and dried in air. The crystals were collected for 1 in 69.3% yield. Anal. Calc. for C11H9CdN3O4: C, 36.74; H, 2.52; N, 11.68. Found: C, 36.67; H, 2.71; N, 11.52%.

The synthetic route of 89-00-9 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Semerci, Fatih; Ye?ilel, Okan Zafer; Soylu, Mustafa Serkan; Keskin, Seda; Bueyuekguengoer, Orhan; Polyhedron; vol. 50; 1; (2013); p. 314 – 320;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.105596-61-0, name is Ethyl 2-methoxyisonicotinate, molecular formula is C9H11NO3, molecular weight is 181.19, as common compound, the synthetic route is as follows.Recommanded Product: Ethyl 2-methoxyisonicotinate

A solution of ethyl 2-methoxy-pyridine-4-carboxylate (0.93 g, 5 mmol) in ether (5 ml) was added to lithium aluminium hydride (0.3 g, 8 mmol) in ether (10 ml) cooled to 5 C. and the mixture stirred for 2 hours. Water was added, the mixture was filtered through diatomaceous earth and the pad was washed through with ethyl acetate. The filtrate was extracted with ethyl acetate and the combined extracts were washed with brine, dried (MgSO4) and the solvent removed by evaporation to give 4-hydroxymethyl-2-methoxypyridine (0.64 g, 89%) as a yellow oil. 1 H NMR Spectrum: (CDCl3) 3.86(s, 3H); 4.62(s, 2H); 6.65(s, 1H); 6.76(d, 1H); 8.05(d, 1H) MS – ESI: 140 [MH]+

At the same time, in my other blogs, there are other synthetic methods of this type of compound,105596-61-0, Ethyl 2-methoxyisonicotinate, and friends who are interested can also refer to it.

Reference:
Patent; Zeneca Limited; Zeneca Pharma S.A.,; US5962458; (1999); A;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 73027-79-9, name is 4,6-Dichloronicotinic acid. This compound has unique chemical properties. The synthetic route is as follows. Safety of 4,6-Dichloronicotinic acid

The solution of Example 146a (3.0 g, 19.2 mmol, 1.0 eq) in POCl3(30 mL) was stirred for 4 h at 100oC. After the reaction completed, it was concentrated under vacuo to give crude product (3.0 g, crude) which was used to next step without further purification.

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 73027-79-9, 4,6-Dichloronicotinic acid.

Reference:
Patent; FRONTHERA U.S. PHARMACEUTICALS LLC; JIN, Bohan; DONG, Qing; HUNG, Gene; KALDOR, Stephen W.; (0 pag.)WO2020/86616; (2020); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 61889-48-3, name is 2-Chloro-1-(pyridin-3-yl)ethanone hydrochloride, the common compound, a new synthetic route is introduced below. Computed Properties of C7H7Cl2NO

Recombinant E. coli HB101 (pNTFPG) accession number FERM BP-7117 (April 11, 2000, International Patent Organism Depositary, National Institute of Advanced Industrial Science and Technology, address: AIST Tsukuba Central 6, 1-1, Higashi 1-Chome, Tsukuba-shi, Ibaraki-ken 305-8566 Japan) was inoculated in 50 ml of 2xYT medium, which was sterilized in a 500 ml Sakaguchi flask, and cultured by shaking at 37C for 18 hours. After 2 mg of NAD+ and 2.8 g of glucose were added to 40 ml of the obtained culture solution, 2 g of 3-(2-chloro-acetyl)pyridine hydrochloride was added over 5 hours while adjusting the pH to 6.5 at 30C and then agitation was conducted for 2 hours. After the reaction was finished, the reaction solution was extracted by ethyl acetate and concentrated under reduced pressure to obtain 1.6 g of yellow oily matter, which is the title compound. The chemical purity and optical purity were analyzed in the same manner as in Example 1. The chemical purity was 96.5 % and the optical purity was 99.0 %ee

The synthetic route of 61889-48-3 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; KANEKA CORPORATION; EP1454899; (2004); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 62774-90-7, name is 2,6-Dichloro-4-methylnicotinic acid, the common compound, a new synthetic route is introduced below. COA of Formula: C7H5Cl2NO2

To a solution of 2,6-dichloro-4-methylnicotinic acid (10 g, 48.5 mmol) in DMF (162 mL) was added potassium carbonate (10.06 g, 72.8 mmol) and MeI (12 mL, 192 mmol) at 0 C. The reaction mixture was stirred at RT for 3 h and was subsequently poured into water. This mixture was extracted with EtOAc and the organic layer was washed with water and brine, dried over anhydrous sodium sulfate and concentrated in vacuo. The crude material was used without further purification.

The synthetic route of 62774-90-7 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; BAO, JIANMING; GAO, XIAOLEI; KNOWLES, SANDRA L.; LI, I, CHUNSING; LO, MICHAEL MAN-CHU; MAZZOLA, Jr., ROBERT D.; ONDEYKA, DEBRA L.; STAMFORD, ANDREW W.; ZHANG, FENGQI; (214 pag.)US2017/183342; (2017); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Related Products of 74784-70-6, Adding some certain compound to certain chemical reactions, such as: 74784-70-6, name is 5-(Trifluoromethyl)pyridin-2-amine,molecular formula is C6H5F3N2, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 74784-70-6.

Example 100 [6-TRIFLUOROMETHYL-2- [4- (3-TRIFLUOROMETHYL-PYRIDIN-2-YL)-PIPERAZIN-1-YL]-3H-] [IMIDAZO [4, 5-B] PYRIDINE,] trifluoroacetic acid salt. (a) [3-NITRO-5-TRIFLUOROMETHYL-PYRIDIN-2-YLAMINE.] To a 250-mL, round-bottomed flask was added [5-TRIFLUOROMETHYL-PYRIDIN-] 2-ylamine (8.3 g, 51.2 mmol, Matrix Scientific) and H2SO4 (49 mL). The resulting mixture was cooled to [0 C,] and [HN03] (8.2 mL) was added dropwise. The mixture was heated to [80 C] for [48] h, cooled to room temperature and added dropwise into a vigorously stirred ice-water (500 mL). After the addition, the mixture was basified to pH 9 with [1 ON NAOH] and extracted with EtOAc (2 x [500] mL). The combined organic extracts were dried over [MGS04] and filtered. The solvent was removed in vacuo and the residue was purified by silica gel column chromatography, eluting with [ETOAC/HEXANE] (1: 2) to give the title compound as a yellow solid. MS (ESI, positive ion) m/z: 208 (M+1).

According to the analysis of related databases, 74784-70-6, the application of this compound in the production field has become more and more popular.

Reference:
Patent; AMGEN INC.; WO2004/35549; (2004); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Adding a certain compound to certain chemical reactions, such as: 106877-33-2, 5-Amino-2-(trifluoromethyl)pyridine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Recommanded Product: 5-Amino-2-(trifluoromethyl)pyridine, blongs to pyridine-derivatives compound. Recommanded Product: 5-Amino-2-(trifluoromethyl)pyridine

Example 4; 5-amino-l-(3-(pyrrolidin-l-ylmethyl)benzyl)-7-(trifluoromethyl)pyrMdionePreparation of 2-chloro-6-(trifluoromethyl)pyridin-3-amine (19)[000396] To a solution of 6-(trifluoromethyl)pyridin-3-amine (18) (1 equiv) (commercially available) in CH3CN (0.25M) was added N-cholorosuccinimide (1 equiv) and stirred at 80 C for 2 hours. The mixture was then cooled down to room temperature and concentrated en vaccuo. The residue was purified by Combi-Flash using 0-20% EtOAc in hexane to afford 2-chloro-6- (trifluoromethyl)pyridin- 3 – amine (19).

At the same time, in my other blogs, there are other synthetic methods of this type of compound,106877-33-2, 5-Amino-2-(trifluoromethyl)pyridine, and friends who are interested can also refer to it.

Reference:
Patent; IRM LLC; CORTEZ, Alex; LI, Yongkai; LIAO, Xuebin; WU, Tom Yao-Hsiang; ZHANG, Xiaoyue; WO2011/57148; (2011); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 10128-71-9, name is 3-Hydroxyisonicotinic acid, the common compound, a new synthetic route is introduced below. Computed Properties of C6H5NO3

A solution of 3-hydroxyisonicotinic acid (495 g, 3.56 mol) in EtOH (7 L) and concentrated H2SO4 (250 mL) was heated under reflux for 72 h and then cooled to rt and concentrated under reduced pressure to remove the solvent. The residue was dissolved in water (3 L) and the pH was adjusted to 4 by addition of saturated aqueous NaHCO3 solution. The resulting precipitate was removed by filtration and the filtrate was extracted with DCM (2 Lx3 ). The combined organic phase was washed with brine, dried over anhydrous Na2SO4 and then concentrated under reduced pressure to give ethyl 3-hydroxyisonicotinate (414 g, 70%) as yellow oil.

The synthetic route of 10128-71-9 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; GENENTECH, INC.; FORMA TM, LLC; BAIR, Kenneth W.; BAUMEISTER, Timm R.; BUCKMELTER, Alexandre J.; CLODFELTER, Karl H.; DRAGOVICH, Peter; GOSSELIN, Francis; GUNZNER-TOSTE, Janet; HAN, Bingsong; LIN, Jian; LIU, Xiongcai; REYNOLDS, Dominic J.; SMITH, Chase C.; WANG, Zhongguo; ZAK, Mark; ZHANG, Yamin; ZHAO, Guiling; ZHENG, Xiaozhang; YUEN, Po-Wai; WO2013/127266; (2013); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem