Day: September 29, 2021

Related Products of 1000342-71-1, Adding some certain compound to certain chemical reactions, such as: 1000342-71-1, name is 6-Bromo-1H-pyrrolo[3,2-c]pyridine,molecular formula is C7H5BrN2, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 1000342-71-1.

a) Preparation of intermediate 79A stirred solution of 6-bromo-5-azaindole (3.00 g, 15.2 mmol) in DMF (30 ml) at ambient temperature was treated with powdered potassium hydroxide (3.42 g, 60.9 mmol). After stirring for 15 minutes, iodine (4.25 g, 16.74 mmol) was added and the resulting mixture was stirred for 18 hours. The mixture was concentrated in vacuo and the residue triturated with water to afford the desired product as a cream solid (5.06 g, 100%).LCMS (Method C): Rt= 2.92 min, m/z [M+H]+= 322/324

According to the analysis of related databases, 1000342-71-1, the application of this compound in the production field has become more and more popular.

Reference:
Patent; JANSSEN PHARMACEUTICA NV; HYND, George; TISSELLI, Patrizia; CLARK, David, Edward; KULAGOWSKI, Janusz, Jozef; MACLEOD, Calum; MANN, Samuel, Edward; PANCHAL, Terry, Aaron; PRICE, Stephen, Colin; MONTANA, John, Gary; WO2015/44267; (2015); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 92914-74-4, name is Isoxazolo[5,4-b]pyridin-3-amine. This compound has unique chemical properties. The synthetic route is as follows. Recommanded Product: 92914-74-4

General procedure: To a solution of 3-aminoisoxazolo[5,4-b]pyridine(1) (1.35 g, 0.01 mol) in tetrahydrofurane (100mL) a few drops of pyridine and benzoyl chloride or4-bromobenzoyl chloride or 4-chlorobenzoyl chloridewas added. The reaction mixture was heatedunder reflux while being stirred in the microwavereactor in an aluminum bath at 60-65OC for 15 min.(3 5 min. with 5 min. breaks) at microwave powerP = 240 W. The solvent was removed under reducedpressure. The residue obtained was triturated withwater, filtered, dried and crystallized from ethanol.

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 92914-74-4, Isoxazolo[5,4-b]pyridin-3-amine.

Reference:
Article; Por?ba, Krystyna; Pawlik, Krzysztof; Rembacz, Krzysztof P.; Kurowska, Ewa; Matuszyk, Janusz; D?ugosz, Anna; Acta poloniae pharmaceutica; vol. 72; 4; (2015); p. 727 – 735;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Electric Literature of 1215387-58-8, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 1215387-58-8, name is 5-Bromo-1H-pyrrolo[2,3-c]pyridine, molecular formula is C7H5BrN2, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

A stirred solution of 5-bromo-lH-pyrrolo[2,3-c]pyridine (2.22 g, 11.3 mmol) in DMF (30 ml) at ambient temperature was treated with potassium hydroxide (2.53 g, 45.1 mmol). After 10 minutes, iodine (3.15 g, 12.4 mmol) was added and the resulting mixture was stirred for 2 hours. The mixture was diluted with water and extracted with EtOAc. The organic phase was washed with brine, dried over Na2S04 and concentrated in vacuo. The residue was triturated with water, filtered and dried in vacuo to afford the desired product as an orange solid (3.39 g, 93%). LCMS (Method C): Rt= 3.14 min, m/z [M+H]+ = 323/325.

According to the analysis of related databases, 1215387-58-8, the application of this compound in the production field has become more and more popular.

Reference:
Patent; JANSSEN PHARMACEUTICA NV; HYND, George; TISSELLI, Patrizia; MACLEOD, Calum; MANN, Samuel, Edward; MONTANA, John, Gary; PRICE, Stephen, Colin; (91 pag.)WO2016/62789; (2016); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 571189-16-7, name is tert-Butyl 4-(6-nitropyridin-3-yl)piperazine-1-carboxylate. This compound has unique chemical properties. The synthetic route is as follows. category: pyridine-derivatives

A 500-mL bottle was purged with nitrogen and charged with 115a (3.1 g, 10 mmol), 10% palladium on carbon (50% wet, 1.0 g) and ethanol (100 mL). It was evacuated, charged with hydrogen gas, and stirred for 16 h at room temperature. The hydrogen was then evacuated and nitrogen was charged into the bottle. The catalyst was removed by filtration through a pad of Celite and the filtrate concentrated under reduced pressure to afford 115b (2.7 g, 97%). MS: [M+H]+279

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 571189-16-7, tert-Butyl 4-(6-nitropyridin-3-yl)piperazine-1-carboxylate.

Reference:
Patent; GENENTECH, INC.; Crawford, James John; Ortwine, Daniel Fred; Young, Wendy B.; US2013/116262; (2013); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Reference of 13466-38-1 ,Some common heterocyclic compound, 13466-38-1, molecular formula is C5H4BrNO, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

To a stirred solution of 5-bromopyridin-2-ol (10 g, 57.5 mmol) in anhydrous THF (200 ml) at RT was added hydroxypivalic acid methyl ester (9.16 ml, 71.8 mmol).Triphenylphosphine (18.8 g, 71.8 mmol) was then added followed by dropwise addition ofdiisopropyl azodicarboxylate (14.1 ml, 71.8 mmol) at OoC. The reaction was then heated to 55C and allowed to stir at this temperature over night. The reaction mixture was concentrated. The residue was treated with EtOAc (70 ml) and then Hexane (70 ml), the solid was filtered off. The filtrate was concentrated, separated by MPLC (10-100% EtoAC in hexane) to give methyl 3-(5-bromopyridin-2-yloxy)-2,2-dimethylpropanoate (9.94 g). LC-MS (ES, mlz) C11H14BrNO3: 287; Found: 288 [M+H]+.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 13466-38-1, 5-Bromopyridin-2-ol, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; MERCK SHARP & DOHME CORP.; DEVITA, Robert, J.; YU, Yang; LIU, Jian; HE, Shuwen; KRIKORIAN, Arto, D.; MILLER, Daniel, J.; WU, Zhicai; YANG, Ginger Xu-Qiang; HONG, Quingmei; LAI, Zhong; ZORN, Nicolas; TING, Pauline, C.; WO2013/130370; (2013); A2;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Application of 609-71-2, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 609-71-2, name is 2-Oxo-1,2-dihydropyridine-3-carboxylic acid, molecular formula is C6H5NO3, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

To 2-hydroxynicotinic acid (3.6 mmol) in sulfuric acid (30% free S03, 2 ml) was added sodium nitrate (7.2 mmol) portionwise over 20 min. The solution was allowed to stir for 20 h at room temperature. The solution was then poured onto ice-water and the precipitate that formed was filtered off, washed with water and dried in a vacuum oven to afford a pale yellow solid (45%). (0176) ESIMS: M-l: 183 (0177) 1H NMR (300 MHz, DMSO) d 8.94 (1H, d, H-4), 8.67 (1H, d, H-6).

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 609-71-2, 2-Oxo-1,2-dihydropyridine-3-carboxylic acid.

Reference:
Patent; BIONOMICS LIMITED; O’CONNOR, Sue; RATHJEN, Deborah; (55 pag.)WO2019/109150; (2019); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 823-56-3, name is 2-Fluoro-3,5-dichloropyridine, the common compound, a new synthetic route is introduced below. Quality Control of 2-Fluoro-3,5-dichloropyridine

5.00g (0.030 mol) of 3,5-dichloro-2-fluoropyridine and 5.01g of 1-(1- cyclohexen-l-yl)pyrrolidine (0.033 mol) are stirred neat together at room temperature for Ih and are left at room temperature overnight. The reaction mixture is quenched with 40ml of sulfuric acid 2M. Water is added to the reaction mixture (100 ml) which is extracted thrice with ethyl acetate (50 ml). The combined organic phases are washed with water (150 ml) and brine (100 ml). After separation, the organic phase is dried over magnesium sulfate filtered, concentrated to dryness and purified on silica gel to yield to 0.22 g of 2-[3,5-dichloro-2-pyridinyl]cyclohexanoneMass spectrum : [M+l] = 244.

The synthetic route of 823-56-3 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; BAYER CROPSCIENCE SA; WO2006/122955; (2006); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Adding a certain compound to certain chemical reactions, such as: 944401-77-8, 2-Amino-4-fluoropyridine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, SDS of cas: 944401-77-8, blongs to pyridine-derivatives compound. SDS of cas: 944401-77-8

To a solution of 2-amino-4-fluoropyridine (75.0 g, 0.67 mol) in dry MeCN (700 mL), N-bromosuccinimide (122.8 g, 0.69 mol) was added portionwise upon stirring and cooling in an ice-water bath. The reaction mixture was stirred at r.t. for 1 h. After evaporation under reduced pressure, the residue was thoroughly washed with water (3 x 300 mL), taken up by MeCN and concentrated in vacuo yielding the title compound as an off white solid (124 g, 97 %). LCMS (ES+) RT 0.79 min, 19.0/193.0 (M+H)+.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,944401-77-8, 2-Amino-4-fluoropyridine, and friends who are interested can also refer to it.

Reference:
Patent; UCB BIOPHARMA SPRL; ALEXANDER, Rikki, Peter; BRACE, Gareth, Neil; BROWN, Julien, Alistair; CALMIANO, Mark, Daniel; CHOVATIA, Praful, Tulshi; DELIGNY, Michael; GALLIMORE, Ellen, Olivia; HEER, Jag, Paul; JACKSON, Victoria, Elizabeth; KROEPLIEN, Boris; MAC COSS, Malcolm; QUINCEY, Joanna, Rachel; SABNIS, Yogesh, Anil; SWINNEN, Dominique, Louis, Leon; ZHU, Zhaoning; WO2015/86526; (2015); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Adding a certain compound to certain chemical reactions, such as: 73583-37-6, 4-Bromo-2-chloropyridine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Product Details of 73583-37-6, blongs to pyridine-derivatives compound. Product Details of 73583-37-6

A mixture of 4-bromo-2-chloropyridine (1 .92 g, 10 mmol), (4-fluoro-2- methoxyphenyl)boronic acid (1 .70 g, 10 mmol) and K3P04 (4.24 g, 20 mmol) in dioxane/water 10: 1 (20 mL) was degassed with a stream of nitrogen for 10 min. After addition of Pd(dppf)Cl2 (816 mg, 1 mmol) the reaction mixture was heated at 145C for 90 minutes in a microwave oven. It was diluted with EtOAc and washed twice with sat. aq. NaHC03 solution and once with brine. The organic layer was dried over MgS04 and concentrated under reduced pressure. The residue was purified by flash chromatography on silica gel (cHex/EtOAc 100:0 to 60:40) to yield the desired product A2 as a white solid (1 .07 g, 45%). 1 H NMR (400MHz, d6-DMSO, 300K) delta 3.81 (s, 3H), 6.87 (dt, J = 8.5 Hz, J = 3.5 Hz, 1 H), 7.05 (dd, J = 1 1 .4 Hz, J = 2.5 Hz, 1 H), 7.44 (dd, J = 8.5 Hz, J = 6.8 Hz, 1 H), 7.48 (dd, J = 5.3 Hz, J = 1 .5 Hz, 1 H), 7.55 (m, 1 H), 8.38 (d, J = 5.3 Hz, 1 H). MS (ES) C12H9CIFNO requires: 237, found: 238 (M+H)+.

The synthetic route of 73583-37-6 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; LEAD DISCOVERY CENTER GMBH; BAYER INTELLECTUAL PROPERTY GMBH; RUeHTER, Gerd; NUSSBAUMER, Peter; CHOIDAS, Axel; SCHULTZ-FADEMRECHT, Carsten; KLEBL, Bert; EICKHOFF, Jan; WO2012/117059; (2012); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Adding a certain compound to certain chemical reactions, such as: 55279-29-3, 3-Aminoisonicotinaldehyde, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, category: pyridine-derivatives, blongs to pyridine-derivatives compound. category: pyridine-derivatives

Example 3 [0159] 3-aminonicotinaldehyde (50 mg, 0.41 mmol) and 1 -(2-chloro-5- nitrophenyl)ethanone (82 mg, 0.41 mmol) were put into ethanol (1 ml_), and then added NaOH (0.3 mg, 0.01 mmol) at room temperature. The solution was heated to 70 C and stirred at this temperature for overnight. The reaction mixture was concentrated under reduced pressure. The residue was purified by flash column chromatography on silica gel to yield the desired product (38 mg, 33 % yield) as a white solid. 1H NMR (400 MHz, DMSO-d6): delta 9.50 (s, 1 H), 8.71 (d, J = 5.2 Hz, 1 H), 8.63 (d, J = 8.4 Hz, 1 H), 8.53 (d, J = 2.8 Hz, 1 H), 8.40-8.37 (m, 1 H), 8.16 (d, J = 8.8 Hz, 1 H), 8.04-8.02 (m, 1 H), 7.99-7.97 (m, 1 H). MS (ESI): Calcd. for Ci4H8CIN3O2: 285, found 286 (M+H)+.

The synthetic route of 55279-29-3 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; NANT HOLDINGS IP, LLC; TAO, Chunlin; YU, Chengzhi; ARP, Forrest; WEINGARTEN, Paul; SOON-SHIONG, Patrick; WO2014/71298; (2014); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem