Month: September 2021

Application of 193902-78-2, Adding some certain compound to certain chemical reactions, such as: 193902-78-2, name is tert-Butyl 4-(5-nitropyridin-2-yl)piperazine-1-carboxylate,molecular formula is C14H20N4O4, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 193902-78-2.

Place 4-(5-nitro-pyridin-2-yl)-piperazine-l-carboxylic acid tert-butyl ester (1.14 g, 3.70 mmol) in 1:1 EtOAc:MeOH (20 mL). Add 10% Pd on carbon using EtOAc (5 mL). Purge the reaction and then add hydrogen. Repeat the purge/fill cycle twice, and place the reaction under a balloon of hydrogen and stir at room temperature for 20 hours. Filter the reaction through a pad of Celite and wash the filter cake with EtOAc. Collect the filtrate and concentrate under reduced pressure to yield 1.01 g (98%) of the title compound. MS(ES): m/z = 279 [M+H].

According to the analysis of related databases, 193902-78-2, the application of this compound in the production field has become more and more popular.

Reference:
Patent; ELI LILLY AND COMPANY; WO2007/53394; (2007); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 1335210-23-5, name is 1-(2,2-Dimethoxyethyl)-5-methoxy-6-(methoxycarbonyl)-4-oxo-1,4-dihydropyridine-3-carboxylic acid. This compound has unique chemical properties. The synthetic route is as follows. category: pyridine-derivatives

100 g of compound (2) was charged along with acetonitrile 800 ml followed by acetic acid 100 ml and methane sulphonic acid 5 ml. The contents were heated at 70-80C and maintained for 6-8 hours. The reaction mass was cooled to room temperature and 52 g of compound (4) was added to it followed by addition of potassium carbonate 52.5 g. The reaction mass was stirred for 16-18 hours and 1000 ml of water was added to the reaction mass and then extracted with dichloromethane 1000 ml. The reaction mass was re-extracted two more times with dichloromethane. The combined organic layer was washed with water 500 ml and concentrated to get residue. 300 ml of methanol was charged to the residue and stirred for 30 minutes and then filtered. The residue was washed with methanol 50 ml and then dried and then recrystallized from dichloromethane / methyl tert-butyl ether to get pure compound (5).Yield-70gHPLC Purity: > 99.5 %

With the rapid development of chemical substances, we look forward to future research findings about 1335210-23-5.

Reference:
Patent; CIPLA LIMITED; PHULL, Manjinder Singh; RAO, Dharmaraj Ramachandra; BIRARI, Dilip Ramdas; (28 pag.)WO2018/229798; (2018); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Adding a certain compound to certain chemical reactions, such as: 55934-01-5, 2,4,5-Trichloropyridine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Application In Synthesis of 2,4,5-Trichloropyridine, blongs to pyridine-derivatives compound. Application In Synthesis of 2,4,5-Trichloropyridine

To a solution of 2,4,5-trichloropyridine (5 g, 27.4 mmol) in 150 ml of THF was added LDA (2 M in heptane, 20.56 ml, 41.1 mmol) at -78 C. The mixture was stirred at -78 C. for 1 hour. Then methyl formate (8.23 g, 137 mmol) in THF (20 mL) was added quickly into the reaction mixture followed by stirring at -78 C. for 1 hour. The reaction mixture was quenched with aqueous saturated NH4Cl solution and extracted with EtOAc three times. The combined organic layers were dried over anhydrous Na2SO4 and, volatiles were removed under reduced pressure. The residue was purified with silica-gel chromatography (10-100% EtOAc in heptane) to afford the desired compound as a solid (4.2 g, 73%). ESI-MS m/z: 211.8 [M+H]+ (Rt=0.86 min, LC-method 1), 1H NMR (400 MHz, DCM-d2) delta ppm=10.43 (s, 1H), 8.61 (s, 1H).

At the same time, in my other blogs, there are other synthetic methods of this type of compound,55934-01-5, 2,4,5-Trichloropyridine, and friends who are interested can also refer to it.

Reference:
Patent; NOVARTIS AG; BARBE, Guillaume; BEBERNITZ, Gregory Raymond; GENG, Sicong; GULGEZE EFTHYMIOU, Hatice Belgin; LIAO, Lv; MA, Fupeng; MO, Ruowei; PARKER, David Thomas; PENG, Yunshan; PEUKERT, Stefan; YAMADA, Ken; YASOSHIMA, Kayo; (78 pag.)US2018/111932; (2018); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Application of 719268-89-0, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 719268-89-0, name is 4-Chloro-1-methyl-3-nitropyridin-2(1H)-one, molecular formula is C6H5ClN2O3, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

4-Chloro-1-methyl-3-nitro-1H-pyridin-2-one (0.71 g, 3.8 mmol) and 3′-aminobiphenyl-2-carbonitrile (0.73 g, 3.8 mmol) were dissolved in triethylamine (5.25 ml, 37.8 mmol) and DMSO (5 ml) and heated at 90 C. for 18 h.The mixture was allowed to cool to ambient temperature then poured onto water (150 ml).The aqueous phase was extracted with ethyl acetate (2*150 ml), the combined organics were washed with water (3*75 ml) and brine (50 ml), dried over anhydrous sodium sulfate, filtered and evaporated to give a brown solid.The solid was triturated with diethyl ether (20 ml), filtered and left to air dry, to give 3′-(1-methyl-3-nitro-2-oxo-1,2-dihydropyridin-4-ylamino)biphenyl-2-carbonitrile (1.28 g, 98%) as a brown solid: delta (400 MHz, CDCl3) 3.50 (3H, s), 6.24 (1H, d, J 8), 7.26 (1H, d, J 8), 7.34 (1H, d, J 8), 7.48 (2H, dd, J 4 and 2), 7.51-7.59 (2H, m), 7.60 (1H, t, J 8), 7.68-7.72 (1H, m), 7.81 (1H, dd, J 8 and 1), 10.47 (1H, s).

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 719268-89-0, 4-Chloro-1-methyl-3-nitropyridin-2(1H)-one.

Reference:
Patent; Goodacre, Simon Charles; US2004/132767; (2004); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Related Products of 62733-99-7, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.62733-99-7, name is Methyl 3-hydroxypicolinate, molecular formula is C7H7NO3, molecular weight is 153.1354, as common compound, the synthetic route is as follows.

The 3-(2,2,2-trifluoro-ethoxy)-pyridine-2-carboxylic acid was prepared as follows:a) To a solution of 3-hydroxy-pyridine-2-carboxylic acid methyl ester (200 mg, 1.3 mmol) in N,N-dimethylformamide (2.0 ml) was added at 22 C. sodium hydride (55% in oil, 64 mg) and stirring was continued until gas evolution ceased. The suspension was cooled to 0 C. and treated with trifluoroethyl trifluormethanesulfonate (728 mg) and stirring was continued at 22 C. for 2 hours. The mixture was partitioned between saturated sodium hydrogen-carbonate solution and ethyl acetate, and the organic layer was dried and evaporated. The residue was purified by chromatography on silica using n-heptane and ethyl acetate (3:1) as the eluent to give 3-(2,2,2-trifluoro-ethoxy)-pyridine-2-carboxylic acid methyl ester as a pale green oil. MS (ISP): m/z=236 [M+H]+.

Statistics shows that 62733-99-7 is playing an increasingly important role. we look forward to future research findings about Methyl 3-hydroxypicolinate.

Reference:
Patent; Hilpert, Hans; Wostl, Wolfgang; US2012/258962; (2012); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Reference of 1659-31-0, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 1659-31-0, name is Dipyridin-2-yl carbonate, molecular formula is C11H8N2O3, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

Example 754-[(3-Bromo-4-fluorophenvD(isothiocyanato’)methyl1pyridine; 0,0-Dipyridin-2-yl thiocarbonate (0.285 g, 1.23 mmol) was added to a solution of l-(3- bromo-4-fluorophenyl)-l-pyridin-4-ylmethanamine (0.230 g, 0.818 mmol) in o dichloromethane (18 mL). The mixture was stirred at room temperature for 1 h and then diluted with dichloromethane (20 mL). The organic layer was washed with brine, dried over sodium sulfate and concentrated in vacuo to give 0.252 g (95% yield) of the title compound. MS (ESI) m/z 324 [M+l]+.

According to the analysis of related databases, 1659-31-0, the application of this compound in the production field has become more and more popular.

Reference:
Patent; ASTRAZENECA AB; ASTEX THERAPEUTICS LTD; WO2007/145571; (2007); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 109-09-1, name is 2-Chloropyridine. This compound has unique chemical properties. The synthetic route is as follows. Formula: C5H4ClN

General procedure: To a stirred suspension of appropriate aryl halide(2.0 mmol) and phenol (2.0 mmol) in 6 ml water, Ni-alumina (0.125g, 6 mol % ofnickel metal) was added followed by K2CO3 (0.28 g, 2mmol) and SDS (0.04 g, 8 mol%). The reaction mixture was stirred for therequired period of time at 80C till the reaction was complete (monitored withTLC). Then the reaction mixture was cooled to room temperature, ethyl acetate(20 mL) was added to dissolve the product and the catalyst was separated simplyby filtration. The residue (recovered catalyst) was thoroughly washed withEtOAc (4×5 mL) followed by water (2×10 mL). The aqueous reaction mixture was repeatedly extracted with ethyl acetate (3×5 mL). The combined organic extractswere washed with water (3× 10 mL) and dried over anhydrous Na2SO4.The crude product was obtained by removal of the solvent under reduced pressure which was furtherpurified by filtration chromatography on a short column of silica gel using1-4% ethyl acetate-hexane as eluent.

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 109-09-1, 2-Chloropyridine.

Reference:
Article; Ghatak, Avishek; Khan, Sagar; Roy, Rimi; Bhar, Sanjay; Tetrahedron Letters; vol. 55; 51; (2014); p. 7082 – 7088;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Adding a certain compound to certain chemical reactions, such as: 791644-48-9, 2-Chloro-5-fluoronicotinonitrile, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 791644-48-9, blongs to pyridine-derivatives compound. Computed Properties of C6H2ClFN2

2-Chloro-5-fluoronicotinonitrile (1.95 g, 12.50 mmol) was dissolved in n-butanol (30 mL).Then hydrazine hydrate (80percent, 8 mL, 125 mmol) was added thereto.The resulting mixture was warmed to 120 ° C and stirred for 6 hours.After cooling to room temperature, a small amount of solid was precipitated, and the mixture was allowed to stand in an ice water bath for 1 hour.A large amount of solid was precipitated, suction filtered, and the filter cake was washed with water (20 mL) at 0 ° C.Then vacuum dry,The title compound was obtained as a pale yellow solid (1. 36 g, 73percent).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,791644-48-9, its application will become more common.

Reference:
Patent; Guangdong Dongyangguang Pharmaceutical Co., Ltd.; Ren Qingyun; Tang Changhua; Yin Junjun; Yi Kai; Lei Yibo; Wang Yejun; Zhang Yingjun; (138 pag.)CN108276401; (2018); A;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 26156-51-4, name is Methyl 2-methoxyisonicotinate. This compound has unique chemical properties. The synthetic route is as follows. Formula: C8H9NO3

To a 100-mL round-bottomed flask was added methyl 2- methoxyisonicotinate (2.04 mL, 14.12 mmol, Aldrich, St. Louis, MO) and borane methyl sulfide complex (4.02 mL, 42.4 mmol, Aldrich, St. Louis, MO) in THF (30 mL). The reaction mixture was stirred at 70 C for 18 h, cooled to 0 C and quenched by the addition of MeOH (5 mL), followed by IN NaOH (20 mL). The reaction mixture was extracted with EtOAc (2 x 50 mL), the organic extract was washed with saturated NaCl (20 mL) and dried over Na2S04. The solution was filtered and concentrated in vacuo to give the crude material as a light-yellow oil. The crude product was purified by silica gel chromatography, eluting with 60% EtOAc/hexanes to give (2-methoxy-4-pyridinyl)methanol (1.56 g) as colorless oil.

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 26156-51-4, Methyl 2-methoxyisonicotinate.

Reference:
Patent; AMGEN INC.; ASHTON, Kate; BARTBERGER, Michael David; BO, Yunxin; BRYAN, Marian C.; CROGHAN, Michael; FOTSCH, Christopher Harold; HALE, Clarence Henderson; KUNZ, Roxanne Kay; LIU, Longbin; NISHIMURA, Nobuko; NORMAN, Mark H.; PENNINGTON, Lewis Dale; POON, Steve Fong; STEC, Markian Myroslaw; ST. JEAN, David, Joseph, Jr.; TAMAYO, Nuria A.; TEGLEY, Christopher Michael; YANG, Kevin Chao; WO2012/27261; (2012); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 889865-45-6, name is 2,3-Dichloro-4-iodopyridine. A new synthetic method of this compound is introduced below., SDS of cas: 889865-45-6

[0196] To a solution of 2,3-dichloro-4-iodopyridine (1.2 g, 4.4 mmol) and 3,4-dihydro- 2H-pyrimido[1,2-cjquinazolin-1O-ol (0.8 g, 4.0 mmol) in DMF (30 mL) was added Cs2CO3 (14.7 g, 5.0 mmol). The reaction mixture was degassed with N2 and stirred at 60 C for 3 hours. The resulting mixture was evaporated and the residue was purified by column chromatography on silica gel (DCM/MeOH from 100:1 to 30:1, v/v) to afford 10-((2,3- dichloropyridin-4-yl)oxy)-3 ,4-dihydro-2H-pyrimido [1 ,2-cj quinazoline (0.6 g, 44% yield) as a white solid.

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 889865-45-6, 2,3-Dichloro-4-iodopyridine.

Reference:
Patent; ABM THERAPEUTICS, INC.; CHEN, Chen; (154 pag.)WO2019/60611; (2019); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem