Day: April 6, 2022

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 128071-77-2, name is 4-Bromo-2-fluoronicotinaldehyde, the common compound, a new synthetic route is introduced below. Computed Properties of C6H3BrFNO

Intermediate 25A4-bromo- I -(2-fluorophenyl)- I H-pyrazolo[3,4-b]pyridine 3.70 g (18.14 mmo[) 4-Bromo-2-f[uoronicotina[dehyde and 2.29 g (18.14 mmo[) (2- f[uoropheny[)hydrazine were disso[ved in 82.6 mL 2-methy[propanenitri[e. After addition of 17.74 g (54.44 mmo[) cesium carbonate the reaction mixture was stirred for 4 hours at room temperature to a[[ow comp[ete reaction to the intermediatehydrazone (safety reasons). Stirring was now continued over night at 120 C. Due to an incomp[ete reaction stirring was continued for 65 hours at 120 C. The reaction mixture was di[uted with water and extracted twice with dich[oromethane. The combined organic extracts were washed with brine and dried (sodium carbonate). After evaporation of the so[vent the residue was purified by chromatography(si[icage[, e[uents: ethy[ acetate hexane) yie[ding 1.80 g (33.3%) of the tit[e compound.UPLC-MS: RT = 1.23 mm; mz = 292 4 (ES+, M+1)

The synthetic route of 128071-77-2 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; BAYER PHARMA AKTIENGESELLSCHAFT; HEISLER, Iring; MUeLLER, Thomas; GOLZ, Stefan; TELSER, Joachim; REHWINKEL, Hartmut; SIEBENEICHER, Holger; BUCHMANN, Bernd; ZORN, Ludwig; EIS, Knut; KOPPITZ, Marcus; LINDNER, Niels; HEROULT, Melanie; NEUHAUS, Roland; WO2013/182612; (2013); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.39998-25-9, name is Methyl 2-(pyridin-3-yl)acetate, molecular formula is C8H9NO2, molecular weight is 151.16, as common compound, the synthetic route is as follows.Application In Synthesis of Methyl 2-(pyridin-3-yl)acetate

To a solution of methyl 2-(pyridin-3-yl)acetate (15.1 g, 100 mmol, 1 equiv) in anhydrous THF (180 mL) was added LiAlH4 (4.l8 g, 110 mmol, 1.1 equiv) in portions at 0C. The reaction mixture was stirred at 0C for 1 hour. Then the reaction was quenched carefully with 10% NaOH (aq.), filtered, and extracted with DCM (3 * 150 mL). The combined organic phase were washed with brine (30 mL), dried over anhydrous Na2S04, filtered and concentrated in vacuo to afford the title compound 2-(pyri din-3 -yl)ethanol as a yellow oil (6.1 g, 51% yield). LC-MS: m/z 124.1 (M+H)+

At the same time, in my other blogs, there are other synthetic methods of this type of compound,39998-25-9, Methyl 2-(pyridin-3-yl)acetate, and friends who are interested can also refer to it.

Reference:
Patent; ANNAPURNA BIO INC.; TANG, Haifeng; BOYCE, Sarah; HANSON, Michael; NIE, Zhe; (213 pag.)WO2019/169193; (2019); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Reference of 54453-93-9 , The common heterocyclic compound, 54453-93-9, name is Ethyl 2-Chloropyridine-4-carboxylate, molecular formula is C8H8ClNO2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

General procedure: For the synthesis of substituted benzoylhydrazines, a mixture of corresponding esters (20 mmol), 85% hydrazine hydrate (20 mmol) in ethanol (35 ml) was heated to reflux for 5 h. After that, the solution was poured into ice-water. The precipitate was filtered and crystallized from ethanol.

The synthetic route of 54453-93-9 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Liu, Kai; Lu, Xiang; Zhang, Hong-Jia; Sun, Juan; Zhu, Hai-Liang; European Journal of Medicinal Chemistry; vol. 47; 1; (2012); p. 473 – 478;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Electric Literature of 94220-38-9, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 94220-38-9, name is 7-Chloro-5-methyl-1H-pyrazolo[4,3-b]-pyridine. This compound has unique chemical properties. The synthetic route is as follows.

EXAMPLE 1 7-(4-Cyanoanilino)-5-methyl-1H-pyrazolo[4,3-b]pyridine (E1) STR14 7-Chloro-5-methyl-1H-pyrazolo[4,3-b]pyridine (4 g, 0.024 mole) was heated at reflux under nitrogen with 4-aminobenzonitrile (9.44 g, 0.08 mole) in dry xylene (25 ml) for 8 h. The resulting yellow crystalline solid was collected and washed repeatedly with ethyl acetate. This solid was recrystallized from methanol/ethyl acetate to give yellow needles (2.96 g, 43%) of the required product as its hydrochloride salt. A sample of this material (500 mg) was neutralised by dissolving with warming in the minimum volume of water/methanol and adding sufficient 10% sodium hydroxide to give a pH of 8. The resulting flocculant precipitate was collected, washed with water and dried to give a pale yellow solid (408 mg, 94%) which was recrystallized from ethyl acetate/methanol to give the title compound as the free base, m.p. 280-282 C. (decomposition). (Found: C, 66.13; H, 4.28; N, 27.81. C14 H11 N5.0.25H2 O requires C, 66.26; H, 4.57; N, 27.59%).

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 94220-38-9, 7-Chloro-5-methyl-1H-pyrazolo[4,3-b]-pyridine.

Reference:
Patent; Beecham Group p.l.c.; US4576952; (1986); A;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Reference of 709652-82-4, Adding some certain compound to certain chemical reactions, such as: 709652-82-4, name is 2-Amino-5-bromonicotinonitrile,molecular formula is C6H4BrN3, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 709652-82-4.

1.2 e-Amino-S-cyano-S’.e’-dihydro^’H-tS^’jbipyridinyM ‘-carboxylic acid tert- butyl ester To a solution of 2-amino-5-bromo-nicotinonitrile (0.60 g; 3.02 mmol) in dioxane (24 mL) and water (6 mL) 4-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan- 2-yl)-3,6-dihydro-2H-pyridine-1-carboxylic acid tert-butyl ester (1.04 g; 3.32 mmol) and Na2CO3 (0.98 g; 9.05 mmol) were added and the mixture was degassed for 30 min. 1 ,1’-Bis(diphenylphosphino)ferrocene]dichloro- palladium(ll) complex with dichloromethane (0.13 g; 0.15 mmol) was added and the reaction mixture was heated to 90 C for 10 h. The reaction mixture was cooled to ambient temperature, filtered through celite and the solvent was concentrated under reduced pressure. The residue was purified by flash column chromatography using petrol ether and ethyl acetate (5:5) to afford the title compound (450.0 mg; 50%) as a pale-yellow solid; 1H NMR (400 MHz, DMSO-d6) delta 8.32 (d, J = 2.5 Hz, 1H), 7.92 (d, J = 2.5 Hz, 1H), 6.92 (s, 2H), 6.08 (s, 1H), 3.94 (s, 2H), 3.49 (t, J = 5.6 Hz, 2H), 2.37 (d, J = 1.5 Hz, 2H), 1.40 (s, 9H); LC/MS (B), Rt: 3.50 min; (M+H) 301.2.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 709652-82-4, 2-Amino-5-bromonicotinonitrile, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; MERCK PATENT GMBH; DORSCH, Dieter; BUCHSTALLER, Hans-Peter; WO2015/14442; (2015); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Related Products of 944317-27-5, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 944317-27-5, name is 6-Bromo-3-chloro-2-methylpyridine. A new synthetic method of this compound is introduced below.

6-Bromo-3-chloro-2-methylpyridine (1.07 g), Pd(dppf)Cl2 DCM (423 mg) and triethylamine (524 mg) were stirred in a mixed solution of methanol (7.5 mL) and DMF (7.5 mL) in the presence of carbon monoxide (3 atm) at 90C for 3 hr. The solvent of the reaction mixture was evaporated under reduced pressure, and the obtained residue was purified by silica gel column chromatography (ethyl acetate/hexane) to give the title compound (724 mg). MS (ESI+) : [M+H]+185.9.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,944317-27-5, 6-Bromo-3-chloro-2-methylpyridine, and friends who are interested can also refer to it.

Reference:
Patent; Takeda Pharmaceutical Company Limited; OGINO, Masaki; KIMURA, Eiji; SUZUKI, Shinkichi; ASHIZAWA, Tomoko; IMAEDA, Toshihiro; FUJIMORI, Ikuo; ARAI, Ryosuke; (82 pag.)EP3156397; (2017); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Related Products of 112006-57-2, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 112006-57-2, name is 2-(Benzylthio)-N,N-dimethylnicotinamide. A new synthetic method of this compound is introduced below.

EXAMPLE 2 N,N-Dimethyl-2-aminosulfonyl-3-pyridinecarboxamide A mixture of 4.4 ml of concentrated hydrochloric acid, 66 ml of methylene chloride, 34 ml of water and 4.0 g (14.7 mmol) of the N,N-dimethyl-2-(phenylmethylthio)-3-pyridinecarboxamide was cooled to 0 C. Maintaining a temperature of -5 to 3 C., 60 ml (40.5 mmol) of 5% sodium hypochlorite was added dropwise over 15 minutes. The resulting yellow emulsion was stirred at 0 C. an additional 20 minutes. The reaction mixture was then poured into water and extracted with methylene chloride. The combined organic extracts were kept at 0 C. and washed with a saturated sodium bisulfite solution and dried over sodium sulfate. After 30 minutes, the yellow solution was filtered into a reaction flask and cooled to -78 C. and 5 ml (431 mmol) of dry ammonia added. The reaction mixture was allowed to warm to room temperature and the solvent removed under reduced pressure. The resulting solid was slurried with 5 ml of water and the insoluble white solid collected by filtration to provide 2.0 g of the subject compound, m.p. 198-209 C.(d). NMR (DMSO): delta 2.70 (s, 3H, NCH3); 2.93 (s, 3H, NCH3); 7.60-7.75 (m, 1H); 7.90 (m, 1H); and 8.75 (m, 1H).

At the same time, in my other blogs, there are other synthetic methods of this type of compound,112006-57-2, 2-(Benzylthio)-N,N-dimethylnicotinamide, and friends who are interested can also refer to it.

Reference:
Patent; E. I. Du Pont de Nemours and Company; US4789393; (1988); A;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Reference of 18677-43-5, Adding some certain compound to certain chemical reactions, such as: 18677-43-5, name is 2,4-Dimethoxypyridine,molecular formula is C7H9NO2, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 18677-43-5.

[1036] To a solution of compound 2 (28.7 g. 0.2 mol) in DMF (50 mL) was added NBS (35.5 g, 0.2 mol). The mixture was heated at 90 C. for 8 hours. The crude compound 3 was collected by filtration. (22 g, 50% yield).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 18677-43-5, 2,4-Dimethoxypyridine, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; Buckman, Brad Owen; Nicholas, John Beamond; Ramphal, Johnnie Y.; Emayan, Kumaraswamy; Seiwert, Scott D.; US2014/94456; (2014); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Adding a certain compound to certain chemical reactions, such as: 1796-84-5, 4-Ethoxy-3-nitropyridine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, SDS of cas: 1796-84-5, blongs to pyridine-derivatives compound. SDS of cas: 1796-84-5

Step 7: 3-[(4-(N-3-Nitropyrid-4-yl)aminomethyl)phenylsulfonyl]indole. A solution of 1-phenylsulfonyl-3-[(4-aminomethyl)phenylsulfonyl]indole (2.10 g, 4.79 mmol), prepared in step 6, and 4-ethoxy-3-nitropyridine (0.894 g, 5.31 mmol) in ethanol (20 mL) and triethylamine (1 mL) was heated at reflux for 70 hours. The reaction mixture was cooled to ambient temperature and diluted with ethyl acetate (250 mL). The organic phase was washed twice with H2 O and once with brine. The combined aqueous washings were extracted with ethyl acetate. The combined organic as layers were dried over Na2 SO4, filtered, and concentrated in vacuo. Chromatography on silica gel (ethyl acetate, then 0.2% ethanol/ethyl acetate) followed by recrystallization from ethyl acetate/ether gave 3-[(4-(N-3-nitropyrid-4-yl)aminomethyl)phenylsulfonyl]indole (350 mg, 23% yield). mp 97-102 C.

The synthetic route of 1796-84-5 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Abbott Laboratories; US5486525; (1996); A;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Application of 850663-54-6, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 850663-54-6, name is 4-Chloro-5-nitropyridin-2(1H)-one. This compound has unique chemical properties. The synthetic route is as follows.

Intermediate 34: 5-isopropoxy-lH-pyrrolo[2,3-c]pyridin-2(3H)-oneStep a: 4-chloro-2-isopropoxy-5-nitropyridine[0558] To a solution of 4-chloro-5-nitropyridin-2-ol (4.0 g, 23.0 mmol) in DMSO (25.0 mL)[0559] was added K2CO3 (6.35 g, 46.0 mmol) and the mixture was stirred at room temperature for 30 min. 2-iodopropane (5.87 g, 34.5 mmol) was added dropwise and the reaction mixture was stirred at 50C for 2 h. The mixture was poured into water and the resulting mixture was extracted with ethyl acetate. The combined extracts were washed with brine, dried over anhydrous Na2S04 and concentrated. The residue was purified by flash column chromatography to give 0.9 g of the title compound as an oil (18% yield).

According to the analysis of related databases, 850663-54-6, the application of this compound in the production field has become more and more popular.

Reference:
Patent; ZENOBIA THERAPEUTICS, INC.; BOUNAUD, Pierre-Yves; NIENABER, Vicki; STEENSMA, Ruo, W.; LOWE, John, A., III; WO2012/178015; (2012); A2;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem