Day: April 7, 2022

Reference of 6515-09-9, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 6515-09-9, name is 2,3,6-Trichloropyridine. This compound has unique chemical properties. The synthetic route is as follows.

To fuming HNO3 (136 rn) were added H2S04 (111 rn) and 23,6-trichoropyridine (24.2g, 133 mmo) at 0C. The reaction mixture was sHowed to warm to RT, then stirred at100C overnight. After cooing to 0C, the mixture was poured onto ice-water. Theunsoube materia was coHected by fitration to afford 2,3,6-trichoro-5-nitropyridine. Rt =1.07 mm (UPLC Method B2), 1H NMR (400 MHz, DMSO-d6) 6 ppm: 9.06 (s, IH).

According to the analysis of related databases, 6515-09-9, the application of this compound in the production field has become more and more popular.

Reference:
Patent; NOVARTIS AG; PISSOT SOLDERMANN, Carole; QUANCARD, Jean; SCHLAPBACH, Achim; SIMIC, Oliver; TINTELNOT-BLOMLEY, Marina; ZOLLER, Thomas; (161 pag.)WO2015/181747; (2015); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Synthetic Route of 131747-53-0, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 131747-53-0, name is (6-(Trifluoromethyl)pyridin-2-yl)methanol. A new synthetic method of this compound is introduced below.

Methanesulfonyl chloride (0.15 mL, 1.96 mmol) was added to a 0 C cooled solution of [6-(trifluoromethyl)pyridin-2-yl]methanol (0.32, 1.78 mmol) and Et3N (0.30 mL, 2.13 mmol) in CH2Cl2 (15 mL). The reaction mixture was stirred at room temperature for 22 h and concentrated to dryness, rendering the title compound as a white sticky solid, which was used in the next step without further purification. HPLC-MS (Method H): Ret, 9.06 min; ESI+-MS m/z: 256 (M+1).

At the same time, in my other blogs, there are other synthetic methods of this type of compound,131747-53-0, (6-(Trifluoromethyl)pyridin-2-yl)methanol, and friends who are interested can also refer to it.

Reference:
Patent; LABORATORIOS DEL DR. ESTEVE, S.A.; GOYA, Pilar; TORRENS-JOVER, Antoni; ALMANSA-ROSALES, Carmen; DIAZ-FERNANDEZ, Jose-Luis; CAAMANO MOURE, Ana; (347 pag.)WO2017/178510; (2017); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Related Products of 175204-82-7, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 175204-82-7, name is Methyl 4-(trifluoromethyl)nicotinate. A new synthetic method of this compound is introduced below.

Step 2; In a 100 mL flask was placed 1.84 g (9.7 mmol, 1 eq) of methyl 4- trifluoromethylnicotinate in 25 mL of 1 M HCI in CHsCOOH. To this was then added 1.3 g of NCS (9.7 mmol, 1 eq) and the reaction allowed to. stir overnight. (18h). The mixture was then transferred to a 500 mL Erlenmeyer flask and to this was added 300 mL of 2 M HCI in Et20 with stirring. This resutted in a. white precipitate which was then filtered to provide 1.2 g (49%) of the desired 2-chloro-1-[4-(trifluoromethyl)-3- pyridinyl] ethanone hydrochloride as a white solid. 1H-NMR (DMSO-d6) No. 9. 21 (s, 1H), 9.02 (d, 1H), 7.94 (d, 1H), 5.19 (s, 2H).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,175204-82-7, its application will become more common.

Reference:
Patent; BAYER PHARMACEUTICALS CORPORATION; WO2003/72561; (2003); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Related Products of 116355-18-1, In the chemical reaction process,reaction time,type of solvent,can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product.An updated downstream synthesis route of 116355-18-1 as follows.

The compound of example 146 (10 g, 47.4 mmol) was treated with pyridin-3-ylboronic acid (6.41 g, 52.1 mmol) in the presence of [1 ,1 ‘-bis(diphenylphosphino)- ferrocene]dichloropalladium(ll) complex with dichloromethane (0.77 g, 0.948 mmol) and sodium carbonate (7.53 g, 71 .1 mmol) according to the procedure for the preparation of the compound of example 2 to afford the title compound. Yield: 8.2 g (83 %); 1H NMR (DMSO-de, 300 MHz): delta 2.2 (s, 3H, CH3), 7.49-7.57 (m, 3H, Ar), 7.70-7.84 (d, 1 H, J=8.1 Hz Ar), 7.90-7.92 (d, 1 H, J=7.5 Hz, Ar), 8.5 (s, 1 H, Ar), 8.6 (s, 1 H, Ar), 8.9 (s, 1 H, Ar); MS (ES+): m/e 210.1 (M+1 ).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,116355-18-1, its application will become more common.

Reference:
Patent; PIRAMAL ENTERPRISES LIMITED; SHARMA, Rajiv; GHOSH, Usha; MORE, Tulsidas; KULKARNI, Mahesh; BAJAJ, Komal; BURUDKAR, Sandeep; RIZVI, Zejah; WO2014/80241; (2014); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 195044-14-5, name is 2-Bromo-6-tert-butylpyridine, the common compound, a new synthetic route is introduced below. COA of Formula: C9H12BrN

Preparative Example P1Step 1 : Methyl 6-(tert-butvhpicolinate (P1a)To the solution of 2-bromo-6-(tert-butyl)pyridine (20.0 g, 93.9 mmol) in MeOH (100 mL) was added dppp (3.86 g, 9.39 mmol), Pd(OAc)2 (6.32 g, 9.39 mmol) and TauEpsilonXiAlpha (28.5 g, 281 mmol) and then the mixture was stirred under CO (4 MPa) at 70C for 12 h. The reaction mixture was filtered, concentrated and purified by CC (RhoEpsilonXi/EpsilonAlpha = 40/1) to give compound P1a (12.0 g, 66%) as a colorless oil.

The synthetic route of 195044-14-5 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; PHENEX PHARMACEUTICALS AG; STEENECK, Christoph; KINZEL, Olaf; GEGE, Christian; KLEYMANN, Gerald; HOFFMANN, Thomas; WO2012/139775; (2012); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Reference of 884494-82-0, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 884494-82-0, name is 5-Fluoro-2-methoxynicotinic acid, molecular formula is C7H6FNO3, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

In a round bottom flask, 5-fluoro-2-methoxy-nicotinic acid (150, 250 mg, 1.46 mmol) was combined with thionyl chloride (3.00 mL, 41.1 mmol) and the suspension was stirred at room temperature for 3 hours. The reaction was concentrated to dryness under vacuum to provide the desired compound, used in the next step without further purification.

According to the analysis of related databases, 884494-82-0, the application of this compound in the production field has become more and more popular.

Reference:
Patent; Plexxikon Inc.; Zhang, Jiazhong; Ibrahim, Prabha N.; Bremer, Ryan; Spevak, Wayne; Cho, Hanna; US9096593; (2015); B2;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Adding a certain compound to certain chemical reactions, such as: 22353-40-8, 2,3-Dichloro-5-nitropyridine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, name: 2,3-Dichloro-5-nitropyridine, blongs to pyridine-derivatives compound. name: 2,3-Dichloro-5-nitropyridine

2,3-Dichloro-5-nitropyridine (3.9 g) and iron powder (3.0 g) were added to isopropyl alcohol (40 ml) and water (8 ml) and the mixture refluxed for 4 hours. The mixture was then cooled to room temperature and filtered (celite). The filtrate was evaporated under reduced pressure and chromatographed ?SiO2; hexane:ethyl acetate (80:20) to[(50:50)] to give 5-amino-2,3-dichloropyridine (1.71 g).

At the same time, in my other blogs, there are other synthetic methods of this type of compound,22353-40-8, 2,3-Dichloro-5-nitropyridine, and friends who are interested can also refer to it.

Reference:
Patent; Zeneca Limited; US5922732; (1999); A;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Application of 886365-47-5 ,Some common heterocyclic compound, 886365-47-5, molecular formula is C7H5BrClNO, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

Starting material l-(5- bromo-2-chloropyridin-3-yl)ethanone (5.8 g, 24.7 mmol) and 100 ml anhydrous hydrazine was charged into 500 ml round bottom flask and the resulting mixture was allowed to stir at room temperature for overnight. After removing the excess hydrazine via rotatory evaporation under reduced pressure, the remaining residue was diluted with distilled water and solid was appeared. After filtering the water, the resulting solid was taken up in ethylacetate and saturated aqueous sodium bicarbonate and was extracted by ethylacetate twice. The combined organic layer was washed with water and brine and dried over sodium sulfate. The crude product was eluted through a short silica gel column (3 inch in length) with ethylacetate as a white solid (4.0 g, y=77%).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,886365-47-5, its application will become more common.

Reference:
Patent; AMGEN, INC.; WO2006/44860; (2006); A2;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 1079179-12-6, name is 2-Chloro-3-fluoro-5-nitropyridine, the common compound, a new synthetic route is introduced below. Safety of 2-Chloro-3-fluoro-5-nitropyridine

Step 2 To a stirred solution of 2-chloro-3-fluoro-5-nitropyridine (1.6 g, 9.0 mmol) in tetrahydrofuran (16 mL) under nitrogen atmosphere were added tributylvinyl tin (3.42 g, 10.8 mmol), Pd2(dba)3 (0.42 g, 0.45 mmol) and trifuryl phosphene (0.2 g, 0.9 mmol). The reaction mixture was deoxygenated thoroughly and was heated to 60 C. for 6 h. The reaction mixture was diluted with water (20 mL) and extracted with ethyl acetate (3*25 mL). The combined organic layer was washed with brine (25 mL) and dried over anhydrous magnesium sulfate and concentrated under reduced pressure to afford the crude compound. The crude compound was purified by column chromatography (silica gel: 100-200 mesh; eluent: 5% ethyl acetate in n-hexane) to afford 3-fluoro-5-nitro-2-vinylpyridine (1.5 g, 96%).

The synthetic route of 1079179-12-6 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Gruenenthal GmbH; FRANK, Robert; BAHRENBERG, Gregor; CHRISTOPH, Thomas; LESCH, Bernhard; LEE, Jeewoo; US2013/29962; (2013); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 60186-15-4, name is 2,4-Difluoro-5-nitropyridine. This compound has unique chemical properties. The synthetic route is as follows. COA of Formula: C5H2F2N2O2

2-Fluoro-5-nitro-4-(2,2,2-trifluoroethoxy)pyridine.A solution of 2,4-difluoro-5- nitropyridine (0.1523 g, 0.951 mmol) intetrahydrofuran (2 mL) was cooled to 0 C. 2,2,2-Trifluoroethanol (0.082mL, 1.142 mmol) was added to the mixture. After 5 min, triethylamine (0.265 mL,1.903 mmol) was added. The reaction was stirred at 0 C for 1 h, and thenallowed to warm to rt. The reaction was stirred at rt for 4.5 h. The solventwas removed in vacuo and the crude product carried on without furtherpurification.

With the rapid development of chemical substances, we look forward to future research findings about 60186-15-4.

Reference:
Patent; BRISTOL-MYERS SQUIBB COMPANY; LUO, Guanglin; CHEN, Ling; DUBOWCHIK, Gene M.; JACUTIN-PORTE, Swanee E.; VRUDHULA, Vivekananda M.; PAN, Senliang; SIVAPRAKASAM, Prasanna; MACOR, John E.; WO2015/69594; (2015); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem