Day: April 8, 2022

Adding a certain compound to certain chemical reactions, such as: 823-39-2, 3,4-Dimethylpyridin-2-amine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 823-39-2, blongs to pyridine-derivatives compound. COA of Formula: C7H10N2

Preparation M (3beta,5alpha,25R)3-trimethylsilyloxy-spirostan-11-one Silylation of Spirostanes Trimethylsilylchloride (3.27 mL, 25.8 mmol) was added to a solution of (3beta,5alpha,25R)3-hydroxy-spirostan-11-one (4.0 g, 9.3 mmol) and triethylamine (6.5 mL, 46 mmol) in dichloromethane (60 mL) at room temperature. One gram of dimethyl aminopyridine was added and the reaction was stirred at room temperature for 12 hours. The reaction was quenched with methanol (1 mL) and diluted with ethyl acetate, washed with water (5*) and brine (1*), dried (Na2 SO4), filtered and concentrated in vacuo. The product was triturated with methanol, filtered and dried to afford 3.94 g (85percent) product as a white solid. 1 H NMR (250 MHz, CDCl3) 6 4.5 (q, 1H, J=6Hz); 3.45 (m, 2H); 2.35 (t, 1H, J=10 Hz); 2.4 (dt, 1H, J=12.2 Hz); 2.2 (s, 2H); 2.1-1.1 (m, 12H); 1.02 (s, 3H); 0.9 (d, 3H, J=7.0 Hz); 0.78 (d, 3H, J=7 Hz); 0.69 (s, 3H); 0.1 (s, 9H).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,823-39-2, its application will become more common.

Reference:
Patent; Pfizer Inc.; US5939398; (1999); A;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 866775-18-0, name is Methyl 3-amino-6-bromo-5-(trifluoromethyl)picolinate. This compound has unique chemical properties. The synthetic route is as follows. Safety of Methyl 3-amino-6-bromo-5-(trifluoromethyl)picolinate

3-Amino-6-bromo-5-trifluoromethyl-pyridine-2-carboxylic acid methyl ester (Intermediate A4) (2 g, 6.69 mmol) was suspended in toluene (8 ml), then p-toluenesulfonic acid (TsOH) (0.1 15 g, 0.669 mmol) and acetonylacetone (0.941 ml, 8.03 mmol) was added. The reaction mixture was heated at reflux for 2hrs and allowed to cool to RT overnight. The resulting dark red/ black solution was concentrated in vacuo to remove toluene and the crude residue diluted with 200ml EtOAc, washed with NaHC03 (50 ml), dried (MgS04) and concentrated in vacuo to give a brown solid; LC-MS Rt = 5.58 min [M+H]+ 377/379 (Method 10minl_C_v002). 1 H NMR (400 MHz, DMSO-d6) ? 8.50 (1 H, s), 7.77 (2H, s), 5.83 (3H, s), 1.90 (6H, s); 19F NMR (400 MHz, DMSO-d6) ? -62.26 (CF3, s)

With the rapid development of chemical substances, we look forward to future research findings about 866775-18-0.

Reference:
Patent; NOVARTIS AG; BALA, Kamlesh, Jagdis; BUTLER, Rebecca; COLLINGWOOD, Stephen, Paul; HALL, Edward, Charles; EDWARDS, Lee; LEGRAND, Darren, Mark; SPIEGEL, Katrin; WO2013/38386; (2013); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Application of 21717-95-3, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 21717-95-3, name is 2-Amino-3-fluoropyridine. This compound has unique chemical properties. The synthetic route is as follows.

A 25 -mL round-bottomed flask was charged with 3-fluoro-2- pyridinamine (1.0 g 8.9 mmol, Matrix Scientific, USA) and AcOH (10 mL). The reaction mixture was cooled to 0 C and NIS (2.0 g, 8.9 mmol, Sigma-Aldrich, India) was added in portions under a nitrogen atmosphere. The reaction mixture was warmed to room temperature and stirred for 5 h. The reaction mixture was diluted with cold water (30 mL), followed by a mixture of 5% Na2S203 (50 mL) and NaHC03 (100 mL) at room temperature. The solid that formed was collected via filtration, washed thoroughly with water and dried under reduced pressure at 40 C to give 3-f uoro-5-iodo-2-pyridinamine (2.0 g) as a white solid.

According to the analysis of related databases, 21717-95-3, the application of this compound in the production field has become more and more popular.

Reference:
Patent; AMGEN INC.; ASHTON, Kate; BOURBEAU, Matthew, Paul; HONG, Fang-Tsao; LIU, Longbin; NISHIMURA, Nobuko; NORMAN, Mark, H.; POON, Steve, F.; STEC, Markian, M.; ST. JEAN, David, J., JR; TAMAYO, Nuria, A.; YANG, Kevin, C.; WO2013/123444; (2013); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Adding a certain compound to certain chemical reactions, such as: 63237-88-7, Pyrazolo[1,5-a]pyridine-2-carboxylic acid, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 63237-88-7, blongs to pyridine-derivatives compound. Formula: C8H6N2O2

[00274] A mixture of 0.1 g [1 ,3]thiazolo[5,4-e][1 ,3]benzothiazol-2-amine, 0.094 g pyrazolo[1 ,5-a]pyridine-2-carboxylic acid, 0.275 g HATU, and 0.156 g DIEA were stirred at 50C in 9 mL of dry THF for 8 hours. The mixture was diluted with water and the precipitate was recrystallized from methanol/DMF to yield 0.07 g of N-([1 ,3]thiazolo[5,4-e][1 ,3]benzothiazol-2- yl)pyrazolo[1 ,5-a]pyridine-2-carboxamide.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,63237-88-7, its application will become more common.

Reference:
Patent; KINEATA INC; Ladonato, Shawn P.; Bedard, Kristin M.; Munoz, Ernesto J.; Imanaka, Myra W.; Fowler, Kerry W.; (122 pag.)WO2014/113492; (2014); A2;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 59290-81-2, name is 2-Methyl-5-nitro-3-pyridinecarboxylic acid. A new synthetic method of this compound is introduced below., Product Details of 59290-81-2

ED-14a (1.01 g, 5.52 mmol) is placed in tBuOU (50 mL), combined with DPPA (1.8 mL, 8.35 mmol) and NMM (724 muL, 6.59 mmol) and refluxed for 15 h. After cooling, saturated sodium chloride solution is added and the mixture is extracted several times with EE. The combined organic phases are washed with saturated sodium chloride solution, dried on MgSO4, filtered and evaporated down using the rotary evaporator. The residue is taken up in some water and freeze-dried. The Z-4a thus obtained (HPLC-MS: tRet. = 1.73 min; MS (M+H)+ = 254) is used without further purification.

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 59290-81-2, 2-Methyl-5-nitro-3-pyridinecarboxylic acid.

Reference:
Patent; BOEHRINGER INGELHEIM INTERNATIONAL GMBH; STEURER, Steffen; ETTMAYER, Peter; MANTOULIDIS, Andreas; WO2010/34838; (2010); A2;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Reference of 824-52-2, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 824-52-2, name is 5-Methyl-1H-pyrrolo[2,3-b]pyridine, molecular formula is C8H8N2, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

Example 36: Synthesis of 5-chloro-2-[5-fluoro-2-methoxy-4-(5-methyl-lH-pyrrolo[2,3- b]pyridin-3-ylmethyl)-phenoxymethyl]-lH-benzoimidazole P-2184[0272] 5-Chloro-2-[5-fluoro-2-methoxy-4-(5-methyl-lH-pyrrolo[2,3-b]pyridin-3-ylmethyl)- phenoxymethyl]-lH-benzoimidazole P-2184 was synthesized in 2 steps from 4-(l H-Benzoimidazol- 2-ylmethoxy)-2-fluoro-5-methoxy-benzaldehyde 227 as shown in Scheme 60.Scheme 60Step 1 – Preparation of[4-(5-chloro-lH-benzoimidazol-2-ylmethoxy)-2-fluoro-5-methupsilonxy-phenyl]-(5- methyl-lH~pyrrolo[2,3-b]pyridin~3-yl)-meiotahanol (228a) and 5-chloro-2-{5-betauoro-2-methoxy-4- [methoxy-(5-methyl-lH-pyrrupsilonlupsilon[2,3-b]pyridin-3-yl)-methyl]-phenoxymethyl}-lH-benzoimidazole (228b):[0273] 5-Methyl-lH-pyrrolo[2,3-b]pyridine (13) was combined with methanol and potassium hydroxide. After the mixture was stirred for 45 minutes 4-(5-chloro-lH-benzoimidazol-2-ylmethoxy)- 2-fluoro-5-methoxy-benzaldehyde (227, per step 1 of Example 33 substituting 2-chloromethyl-lH- benzoimidazole-5-sulfonic acid dimethylamide 217 with 5-chloro-2-chloromethyl-lH- benzoimidazole) was added and the reaction was stirred at room temperature overnight. The solvent was removed under reduced pressure. Ethyl acetate was added and washed with sodium bicarbonate saturated solution and brine, dried over anhydrous sodium sulfate and concentrated. Purification with silica gel chromatography, eluting with a gradient of ethyl acetate (10-100%) in hexanes, gave the desired compounds 228a and 228b as a mixture.

According to the analysis of related databases, 824-52-2, the application of this compound in the production field has become more and more popular.

Reference:
Patent; PLEXXIKON, INC.; WO2008/80001; (2008); A2;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 1142197-14-5, name is 2-Bromo-5-cyclopropylpyridine. This compound has unique chemical properties. The synthetic route is as follows. Application In Synthesis of 2-Bromo-5-cyclopropylpyridine

39.1 5-cyclopropyl-2-iodopyridine 2-bromo-5-cyclopropylpyridine (purchased from Combi-Phos) (500 mg, 2.52 mmol) is dissolved in 5 mL of dioxane. Copper (I) iodide (96.2 mg, 0.50 mmol), sodium iodide (946 mg, 6.31 mmol) and N,N’-dimethylethylenediamine (105 mg, 1.01 mmol) are added and the mixture is stirred at 130 C. for 2 hours. Ethyl acetate is added and the mixture is washed with half concentrated aqueous sodium bicarbonate solution. The organic phase is dried and concentrated under reduced pressure. Yield: 541 mg (87% of theory) Mass spectrometry (ESI+): m/z=245 [M+H]+

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 1142197-14-5, 2-Bromo-5-cyclopropylpyridine.

Reference:
Patent; Boehringer Ingelheim International GmbH; GODBOUT, Cedrickx; TRIESELMANN, Thomas; VINTONYAK, Viktor; (84 pag.)US2018/37594; (2018); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Application of 52092-47-4, Adding some certain compound to certain chemical reactions, such as: 52092-47-4, name is 5-Chloro-2-nitropyridine,molecular formula is C5H3ClN2O2, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 52092-47-4.

To a solution of 5-chloro-2-nitropyridine (3 g, 19 mmol) in EtOH (30 mL) was added saturated NH3.H2O (20 mL) ‘ the mixture was stirred under 50 psi at 150 C overnight. TLC showed that the reaction was complete. After the reaction mixture was cooled to r.t, the resulting solid was collected by filtration. The solid was washed with PE (100 mL) to give 0.7 g (yield: 26%) of 6-nitro-pyridin-3-ylamine as a yellow solid. MS: m/z 140.1 (M+H+).

According to the analysis of related databases, 52092-47-4, the application of this compound in the production field has become more and more popular.

Reference:
Patent; SANFORD-BURNHAM MEDICAL RESEARCH INSTITUTE; PINKERTON, Anthony, B.; DAHL, Russell; COSFORD, Nicholas, D.P.; MILLAN, Jose, Luis; WO2013/126608; (2013); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 184416-83-9, name is 2,3-Dichloropyridin-4-amine. This compound has unique chemical properties. The synthetic route is as follows. category: pyridine-derivatives

A solution of 2,3-dichloropyridin-4-amine (900 mg, 5.521 mmol), (Boc)2O (3012.52 mg, 13.803 mmol), Et3N (2230.61 mg, 22.085 mmol), DMAP (67.36 mg. 0.552 mmol) in CH2Cl2 was stirred at rt for 12 h. The mixture was diluted with water (100 mL) and extracted with CHI-2Cl2 (100 mL*3). The organic layers were dried (MgSO4), filtered, and the filtrate concentrated under reduced pressure. The residue was purified by column chromatography over silica gel (eluent: petrol ether/EtOAc=100:0 to 70:30). The desired fractions were collected and the solvent was concentrated under reduced pressure to afford 4,4-tert-butyl carbamate-2,3-dichloropyridin-4-amine, cpd 119a (1600 mg, 77.7% yield) as a white solid. LCMS (ESI) m/z M+1: 362.8.

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 184416-83-9, 2,3-Dichloropyridin-4-amine.

Reference:
Patent; Janssen Pharmaceutica NV; Lu, Tianbao; Connolly, Peter J.; Cummings, Maxwell David; Barbay, Joseph Kent; Kreutter, Kevin D.; Wu, Tongfei; Diels, Gaston Stanislas Marcella; Thuring, Jan Willem; Philippar, Ulrike; Edwards, James Patrick; Shen, Fang; (202 pag.)US2019/381019; (2019); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Electric Literature of 145255-19-2, In the chemical reaction process,reaction time,type of solvent,can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product.An updated downstream synthesis route of 145255-19-2 as follows.

[1144] 40 mg (0.098 mmol) of 2-[4-(5-chioro-2-cyano- phenyl)-5-methoxy-2-oxopyridin-i (2H)-yl] -3-(i ,3-oxazol- 2-yl)propanoic acid (racemate) and 20mg (0.147 mmol, 1.5 eq.) of 5-aminopyridine-2-carboxamide were initially charged in 0.8 ml of pyridine, 93 j±1 (0.392 mmol, 50% in ethyl acetate, 4.0 eq.) of T3P were added and the mixture was stirred at 50 C. for 2 h. The reaction mixture was cooled, 6 ml of saturated aqueous sodium hydrogencarbonate solution were added and the mixture was stirred for 15 mm. The crystals formed were filtered oil with suction and washed with water, 500 j±1 of isopropanol and then pentane. The residue was dried under high vacuum. Yield: 29 mg (57% of theory).11145] LCMS [Method 1]: R=0.79 mm; MS (ESIpos):mlz=5 19 (M+H), j1146] ?H-NMR (400 MHz, DMSO-d5): oe [ppm]=i0.91(s, 1H), 8.84 (d, 1H), 8.20 (dd, 1H), 8.07-7.95 (m, 4H), 7.73 (dd, 1H), 7.68 (d, 1H), 7.52 (s, 2H), 7.12 (s, 1H), 6.51 (s, 1H), 6.00 (t, 1H), 3.78 (d, 2H), 3.64 (s, 3H)

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,145255-19-2, its application will become more common.

Reference:
Patent; BAYER PHARMA AKTIENGESELLSCHAFT; ROeHRIG, Susanne; JIMENEZ-NUNEZ, Eloisa; SCHLEMMER, Karl-Heinz; TERSTEEGEN, Adrian; TELLER, Henrik; HILLISCH, Alexander; HEITMEIER, Stefan; SCHMIDT, Martina Victoria; ACKERSTAFF, Jens; STAMPFUss, Jan; (87 pag.)US2017/291892; (2017); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem