Day: April 11, 2022

Reference of 884495-01-6, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 884495-01-6, name is 4-Bromo-5-fluoro-2-hydroxypyridine. This compound has unique chemical properties. The synthetic route is as follows.

0.20 g (1.04 mmol) 4-bromo-5-fluoro-pyridin-2-ol, 0.83 mL (10.4 mmol) ethyliodide and 0.43 g ( .56 mmol) Ag2C03 are added to 5 mL DCM and stirred at r.t. over night. The reaction is quenched by the addition of water. DCM is added, the resulting mixture is filtered and the organic layer is separted, dried over MgS04, filtered again and the solvent is removed in vacuo. C7H7BrFNO (M= 220.0 g/mol) ESI-MS: 220/222 [M+H]+ Rt (HPLC):1.27 min (method B)

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 884495-01-6, 4-Bromo-5-fluoro-2-hydroxypyridine.

Reference:
Patent; BOEHRINGER INGELHEIM INTERNATIONAL GMBH; FLECK, Martin; HEINE, Niklas; NOSSE, Bernd; ROTH, Gerald Juergen; WO2014/114578; (2014); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 65515-39-1, name is 2-Methoxy-4,6-dimethylnicotinonitrile. This compound has unique chemical properties. The synthetic route is as follows. Recommanded Product: 65515-39-1

To a solution of 2-methoxy-4,6-dimethylnicotinonitrile (1.5 g, 9.25 mmol) in tetrahydrofuran (40 mL) was added lithium bis(trimethylsilyl)amide (10.17 mL, 10.17 mmol) at -78 C, and the mixture was stirred at -78 C for 1 hour. 3-Bromoprop-1-ene (0.880 mL, 10.17 mmol) was added and the mixture was stirred at -78 C for 1 hour and warmed to 0 C over 1 hour. The mixture was then stirred at 0 C for 3 hours. The reaction was quenched with saturated aqueous NH4Cl solution and extracted with EtOAc (3x). The combined organics were dried over Na2SO4 and concentrated. The residue was purified using reverse HPLC using Trilution software, with a phenomenex Gemini 5u CI 8(2) 100 A, AXIA 30×100 mm 5 micron, 10-minute run (30 mL/min, 40%ACN/H2O, 0.1% formic acid to 80% ACN/H2O, 0.1% formic acid) with UV detection at 254 nm to afford 4-(but-3-en-1-yl)-2-methoxy-6-methylnicotinonitrile (1.01 g, 54%) as a pale yellow oil. LC-MS(ES) m/z = 203 [M+H]+.

With the rapid development of chemical substances, we look forward to future research findings about 65515-39-1.

Reference:
Patent; GLAXOSMITHKLINE INTELLECTUAL PROPERTY (NO.2) LIMITED; MILLER, William Henry; ROMERIL, Stuart Paul; VERMA, Sharad Kumar; TIAN, Xinrong; WO2015/132765; (2015); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 847729-27-5, name is Methyl 2-chloro-5-fluoronicotinate, molecular formula is C7H5ClFNO2, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below. Safety of Methyl 2-chloro-5-fluoronicotinate

[0583] A solution of methyl 2-chloro-5-fluoronicotinate (100 mg, 0.53 mmol) in anhydrous THF (4 mL) was cooled to 0 C and treated with sodium borohydride (120 mg, 3.17 mmol) in a portion-wise manner over a period of 5 min, and the resulting mixture was heated at 70 C for 15 min. Methanol (0.8 mL) was then added in a dropwise manner over 15 min, resulting in considerable effervescence, and the resulting mixture was heated at 70 C for 30 min. The mixture was cooled to ambient temperature and treated with a saturated solution of aqueous ammonium chloride (5 mL). Ethyl acetate (5 mL) was added, resulting in a biphasic mixture, which stirred for 30 min. The organic phase was collected and the aqueous layer was extracted with ethyl acetate (2 x 5 mL). The combined organic phases were then dried over Na2SC>4, filtered and concentrated under vacuum to give the desired product as an orange glass (84 mg, 99%). UPLC-MS (Acidic Method, 2 min): rt = 0.73 min, m/z 162.0/164.0 [M+H]+. ‘H NMR (400 MHz, CDCb) d ppm 8.1 7 (d,.7=3.0 Hz, 1H), 7.71 (ddt, =8.3, 3.0, 0.9, 0.9 Hz, 1H), 4.78 (s, 2H).

With the rapid development of chemical substances, we look forward to future research findings about 847729-27-5.

Reference:
Patent; NFLECTION THERAPEUTICS, INC.; TSAI, Kenneth, Y.; KINCAID, John; SARIN, Kavita, Yang; (319 pag.)WO2020/106303; (2020); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Application of 100848-70-2 ,Some common heterocyclic compound, 100848-70-2, molecular formula is C7H9NO, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

Sodium acetate (3.54g. 43.23mmol) was added to a solution of 2-methoxy-4-methylpyridine 54-5-1 (5.0g.3gmmol) in EtOAc (25mL). Br2 (1 .52mL, 58mmol) was added drop wise over 20 mm at 0C. The RM wasstirred at 50C for 18 h. The total reaction mass was cooled and after diluting with water, the pH was adjusted to 8 with aq. NaOH. The organic layer was separated and aq. layer extracted with EtOAc (250mL x 3). The combined extract was washed with water (300 mL), brine (200 mL), dried (Na2SO4) and concentrated under reduced pressure to get crude compound. The crude compound was purified by CC(silica gel 100-200mesh, 0-5% EtOAc in PE) to obtain 5-bromo-2-methoxy-4-methylpyridine (2.82g. 40%) as liquid.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 100848-70-2, 2-Methoxy-4-methylpyridine, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; GRUeNENTHAL GMBH; SCHUNK, Stefan; REICH, Melanie; JAKOB, Florian; DAMANN, Nils; HAURAND, Michael; KLESS, Achim; ROGERS, Marc; SUTTON, Kathy; WO2015/158427; (2015); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Application of 92992-85-3, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 92992-85-3, name is 2-Bromo-3,5-dimethylpyridine. A new synthetic method of this compound is introduced below.

To 2-bromo-3,5-dimethylpyridine (6.62 g) were added N-Boc-1,2,3,6-tetrahydropyridine-4-boronic acid pinacol ester (10 g),sodium carbonate (7.54 g),1,4-dioxane (50 mL),water (50 mL) and tetrakis(triphenylphosphine)palladium(0)(1.87 g) and the mixture was stirred under a nitrogen stream at 100c for 5 hr. Water was added to the reaction mixture and the mixture was extracted with ethyl acetate. The organic layer was washed with saturated brine,dried over sodium sulfate,and treated with activated carbon. The solvent was evaporated and the obtained residue was purified by column chromatography (hexane:ethyl acetate)to give 3,5-dimethyl-3′,6′-dihydro-2’H-[2,4′]bipyridinyl-1′-carboxylic acid tert-butyl ester (8.93 g).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,92992-85-3, its application will become more common.

Reference:
Patent; Mitsubishi Tanabe Pharma Corporation; ISHIBUCHI, Seigo; SARUTA, Kunio; HAMADA, Maiko; MATOBA, Nobuatsu; MATSUDAIRA, Tetsuji; SEKI, Maki; TARAO, Akiko; HONJO, Takashi; OGATA, Shingo; KAWATA, Atsushi; MOROKUMA, Kenji; FUJIE, Naoto; AOYAMA, Yukio; (251 pag.)EP3321256; (2018); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Electric Literature of 73455-13-7, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 73455-13-7, name is 4,5-Dichloropicolinic acid. A new synthetic method of this compound is introduced below.

A mixture of 4,5-dichloropicolinic acid (100 mg, 521 imol; CAN 73455-13-7), 1-cyclopropyl-2- (5-methyl-i ,2,4-oxadiazol-3-yl)propan-2-amine hydrochloride (136 mg, 625imol; CAN 1415900-39-8), 2-bromo-i-ethylpyridinium tetrafluoroborate (284 mg, 885imol) and N,N-diisopropyl ethyl amine (212 mg, 281 iL) in dioxane (0.8 mL) was stirredfor 14 h at 80 C, poured onto ice / brine (1 x 25mL) and extracted with EtOAc (2 x 25mL). The combined extracts were washed with ice water / brine (25 mL), dried overNa2SO4 and filtered. The filtrate was brought to dryness and the residue was purified by column chromatography (silica gel, 10 g, heptane / ethyl acetate) to obtain the title compound (120 mg, 65%) as colorless liquid, LC-MS: 355.2 [MH?i.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,73455-13-7, its application will become more common.

Reference:
Patent; F. HOFFMANN-LA ROCHE AG; HOFFMANN-LA ROCHE INC.; FREI, Beat; GOBBI, Luca; GRETHER, Uwe; RICKLIN, Fabienne; ROEVER, Stephan; ROGERS-EVANS, Mark; ROMBACH, Didier; (49 pag.)WO2018/234284; (2018); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 131747-62-1, name is 3-(Trifluoromethyl)pyridine-2-carboxaldehyde, the common compound, a new synthetic route is introduced below. Product Details of 131747-62-1

To a solution of 13 (250 mg, 1.010 mmol) in toluene 10 mL was added 3-(trifluoromethyl) picolinaldehyde (177.0 mg, 1.010 mmol). PTSA (384.5 mg, 2.021 mmol) was added to the reaction mixture and stirred at 120 C. for 6 h. The reaction mass was diluted with ethyl acetate and washed with water (3×25 mL). The organic layer was dried over sodium sulphate and concentrated to get the crude compound (E)-6-methoxy-5-morpholino-2-((3-(trifluoromethyl)pyridin-2-yl)methylene)-2,3-dihydro-1H-inden-1-one 67. The compound 67 was purified through flash chromatography by using 100-200 mesh silica gel. The compound was eluted at 34% ethyl acetate in hexane to afford yellow coloured solid.

The synthetic route of 131747-62-1 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Vankayalapati, Hariprasad; Yerramreddy, Venkatakrishnareddy; US2015/72980; (2015); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Reference of 10273-89-9, Adding some certain compound to certain chemical reactions, such as: 10273-89-9, name is 2-(o-tolyl)pyridine,molecular formula is C12H11N, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 10273-89-9.

EXAMPLE 1 Production of 2-[2-methyl-6-(2-methyl-propenyl)-phenyl]-pyridine A teflon (registered trade mark)-coated magnetic stirring rod was placed in a 4 mL pressure proof screw vial, dried with heating, then, N2 gas was allowed to flow through the reaction apparatus for several minutes to purge the whole reaction apparatus with nitrogen. The reaction vessel was left to cool to room temperature, then, under a nitrogen flow, into the reaction vessel was added Ru(cod)(cot) complex (0.1 mmol, 31.6 mg), trisfurylphosphine (0.1 mmol, 23.2 mg), 2-o-tolylpyridine (1 mmol, 169 mg), 2-methylpropenyl acetate (3 mmol, 342.4 mg) and toluene (1 mL), and the reaction vessel was sealed. The mixture was heated at 100 C. by an oil bath, and reacted for 24 hours. 50 hours after, the reaction solution was left to cool to room temperature, then, an internal standard was added, and the product was quantified by gas chromatography. Isolation of the product was carried out by silica gel column chromatography (i.d.=30 mm; length=170-250 mm; hexane:EtOAc:Et3N=8:1:0.1; 25 mL each). A subject substance 2-[2-methyl-6-(2-methyl-propenyl)-phenyl]-pyridine was obtained with a yield of 86%. IR (neat) 3058 m, 2969 m, 2856 m, 1654 w, 1587 s, 1563 m, 1459 s, 1421 m, 1376 m, 1280 w, 1182 w, 1147 w, 1091 w, 1064 w, 1025 w, 987 w, 892 m, 840 m, 775 m, 752 s, 649 m, 622 m, 472 s, 441 s, cm-1 1H NMR (CDCl3) d 1.658 (d, J=1.4 Hz, 3H, CH3), 1.719 (dt, J=1.4 Hz, 3H, CH3), 2.083 (s, 3H, CH3), 5.802 (s, 1H, CH), 7.11-7.28 (m, 5H, ArH), 7.700 (td, J=7.6 Hz, 1.9 Hz, 1H, ArH), 8.692 (dd, J=4.9 Hz, 1.9 Hz, 1H, ArH); 13C NMR (CDCl3) d 19.41, 20.21, 26.09, 121.42, 124.33, 125.18, 127.23, 127.37, 128.12, 134.93, 135.76, 135.91, 137.15, 139.81, 149.19, 159.64; MS m/z (% relative intensity) 223 (M+, 5), 209 (17), 208 (100), 90 (10), 51 (10) Elemental Analysis Anal. Calcd for C16H17N: C, 86.05; H, 7.67; N, 6.27%. Found: C, 85.93; H, 7.38; N, 6.38%

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 10273-89-9, 2-(o-tolyl)pyridine, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; SUMITOMO CHEMICAL COMPANY, LIMITED; OSAKA UNIVERSITY; US2009/43096; (2009); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Synthetic Route of 60186-13-2, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 60186-13-2, name is 2,4,6-Trichloro-3-nitropyridine. This compound has unique chemical properties. The synthetic route is as follows.

To a solution of 1 (1.00 mmol) in DMF (3 mL) was added (PPh3)2PdCl2 (21 mg, 0.030 mmol) under an N2 atm and the reaction mixture was stirred for 5 min, before 2-furyl(tributyl)tin (0.32 mL, 1.0 mmol) was added. The resulting mixture was stirred for the time and at the temperature given in Table 1. H2O (40 mL) was added and the aqueous mixture extracted with EtOAc (2 × 30 mL). The combined organic phases were washed with brine (30 mL), dried (MgSO4) and evaporated in vacuo. The 1H NMR spectrum of the crude reaction mixture was recorded. The residue was dissolved in THF (8 mL), KF (ca. 200 mg) was added and the resulting suspension was stirred at ambient temperature for 18-20 h, evaporated with a small amount of silica gel and purified by flash chromatography on silica gel.

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 60186-13-2, 2,4,6-Trichloro-3-nitropyridine.

Reference:
Article; Khoje, Abhijit Datta; Gundersen, Lise-Lotte; Tetrahedron Letters; vol. 52; 4; (2011); p. 523 – 525;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 67367-24-2, name is Methyl 4-hydroxynicotinate. This compound has unique chemical properties. The synthetic route is as follows. Computed Properties of C7H7NO3

Reference example 30: methyl 5-bromo-4-hydroxypyridine-3-carboxylate To a suspension of methyl 4-hydroxypyridine-3-carboxylate (CASNo.67367-24-2) (1.96 g) in acetonitrile (20 mL)/acetic acid (4 mL) was added N-bromosuccinimide (CASNo.128-08-5) (2.39 g) at room temperature, and the mixture was stirred at 60 degrees C for 4 hours followed by concentration. To the obtained residue was added acetone, and the mixture was stirred for 5 min. The insoluble matter was collected by filtration to obtain the title compound having the following physical property values. Description: white powder; TLC: Rf 0.53 (ethyl acetate : methanol = 4 : 1);

With the rapid development of chemical substances, we look forward to future research findings about 67367-24-2.

Reference:
Patent; ONO Pharmaceutical Co., Ltd.; ISHIDA, Akiharu; MATSUSHITA, Takeshi; SEKIGUCHI, Tetsuya; KOMAGATA, Tatsuya; NISHIO, Takuya; EP2871179; (2015); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem