Day: April 11, 2022

Related Products of 4684-94-0 ,Some common heterocyclic compound, 4684-94-0, molecular formula is C6H4ClNO2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

General procedure: An oven dried resealable screw cap standard reaction tube containinga magnetic stir bar was charged with potassium persulfate(1.75 mmol, 472.5 mg), bismuth nitrate (1.0 mmol, 486 mg). Thenaryl carboxylic (0.5 mmol) was introduced in this mixture followedby acetonitrile (3 mL) was added in it. The tube was placed in apreheated oil bath at 130 C and the reaction mixture was stirredvigorously for 24 h in air atmosphere. The reaction mixture wascooled to room temperature, diluted with 2 mL ethyl acetate andfiltered through celite, eluting with additional 10 mL of ethyl acetate.The filtrate was concentrated and the resulting residue waspurified by column chromatography.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,4684-94-0, its application will become more common.

Reference:
Article; Agasti, Soumitra; Maiti, Siddhartha; Maity, Soham; Anniyappan; Talawar; Maiti, Debabrata; Polyhedron; vol. 172; (2019); p. 120 – 124;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 790692-90-9, name is 6-Chloro-5-iodo-3-nitropyridin-2-amine, the common compound, a new synthetic route is introduced below. Product Details of 790692-90-9

A solution of palladium acetate (187 mg, 0.83 mmol) and triphenyl arsine (509 mg, 1.66 mmol) in chloroform (30 mL) was stirred for 30 min at room temperature. This solution was added to the mixture of glycal (3.25 g, 9.2 mmol), 2 (2.49 g, 8.3 mmol) and silver carbonate (4.59 g, 16.6 mmol) in chloroform (60 mL) at room temperature. The reaction mixture was refluxed overnight, cooled to room temperature and filtered through a celite pad, the filtrate was concentrated and the residue was purified by silica gel column chromatography (Hex/EtOAc=4/1 to 7/3) to give compound 3 (2.75 g, 5.23 mmol, 63%) as an orange foam. 1H NMR (CDCl3, 300 MHz) delta8.42 (s, 1H), 7.73-7.82 (m, 4H), 7.41-7.48 (m, 6H), 5.83 (nm, 1H), 7.77 (m, 1H), 4.23 (s, 1H), 3.90 (m, 2H), 1.78 (t, 1H, J=6.0), 1.23 (t, 1H, J=6.9), 1.08 (s, 9H).

The synthetic route of 790692-90-9 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Benner, Steven A; Hoshika, Shuichi; (37 pag.)US10059737; (2018); B1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Adding a certain compound to certain chemical reactions, such as: 94220-38-9, 7-Chloro-5-methyl-1H-pyrazolo[4,3-b]-pyridine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Formula: C7H6ClN3, blongs to pyridine-derivatives compound. Formula: C7H6ClN3

EXAMPLE 8 7-(2-Methylallylamino)-5-methyl-1H-pyrazolo[4,3-b]pyridine (E8) STR22 The title compound was prepared from 7-chloro-5-methyl-1H-pyrazolo[4,3-b]pyridine (D4) and 2-methylallylamine as a pale yellow solid, m.p. 161-164, by the method given in Example 1. delta(DMSO-d6) 1.78 (3H,br s); 2.42 (3H,s); 3.87 (2H,br d, J-5 Hz); 4.8-5.1 (2H,m); 6.19 (1H,s); 6.57 (1H, br t); 7.93 (1H,s); 12.58 (1H,br s).

At the same time, in my other blogs, there are other synthetic methods of this type of compound,94220-38-9, 7-Chloro-5-methyl-1H-pyrazolo[4,3-b]-pyridine, and friends who are interested can also refer to it.

Reference:
Patent; Beecham Group p.l.c.; US4670432; (1987); A;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Adding a certain compound to certain chemical reactions, such as: 887266-57-1, 3-Fluoro-2-hydrazinylpyridine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, name: 3-Fluoro-2-hydrazinylpyridine, blongs to pyridine-derivatives compound. name: 3-Fluoro-2-hydrazinylpyridine

Under argon, a solution of methyl 2-{3-(4-chlorophenyl)-5-oxo-4-[(2S)-3,3,3-trifluoro-2- hydroxypropyl]-4,5-dihydro-1H-l,2,4-triazol-1-yl}ethanimidate (Example 2A, 200 mg, 528 muiotaetaomicron) in THF (2.0 ml) was treated at 0C with N,N-diisopropylethylamine (280 mu, 1.6 mmol) and (2R)- l-chloro-1-oxopropan-2-yl acetate (73 mu, 580 muiotaetaomicron) and stirred at 0C for 30 min. 3-Fluoro-2- hydrazinylpyridine (73.8 mg, 581 muiotaetaomicron) was then added and the resulting mixture was stirred overnight at room temperature and evaporated. The residue was purified by preparative HPLC (Method 4) affording 195 mg (65% of th.) of the title compound.LC-MS (Method 1): Rt = 1.01 min; MS (ESIpos): m/z = 570 [M+H]+-NMR (400 MHz, DMSO-d6) delta [ppm]: 8.46 (br. d, 1H), 8.14 (m, 1H), 7.86-7.53 (m, 5H), 6.89 (d, 1H), 5.93 (q, 1H), 5.12 (m, 2H), 4.30 (m, 1H), 4.11-3.74 (m, 2H), 1.79 (s, 3H), 1.59 (d, 3H).

At the same time, in my other blogs, there are other synthetic methods of this type of compound,887266-57-1, 3-Fluoro-2-hydrazinylpyridine, and friends who are interested can also refer to it.

Reference:
Patent; BAYER PHARMA AKTIENGESELLSCHAFT; COLLIN-KROePELIN, Marie-Pierre; KOLKHOF, Peter; NEUBAUER, Thomas; FUeRSTNER, Chantal; POOK, Elisabeth; TINEL, Hanna; SCHMECK, Carsten; WASNAIRE, Pierre; SCHIRMER, Heiko; LUSTIG, Klemens; GRIEBENOW, Nils; (195 pag.)WO2019/81302; (2019); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 1026796-81-5, name is N-(4-Bromopyridin-2-yl)acetamide. This compound has unique chemical properties. The synthetic route is as follows. Quality Control of N-(4-Bromopyridin-2-yl)acetamide

To the solution of tert-butyl (4-(trimethylstannyl)phenyl)carbamate (750 mg,2.106 mmol) in DMF (7.5 mL) was added N-(4-bromopyridin-2-yl)acetamide (453mg, 2.106 mmol), K2C03 (873 mg, 6.32 mmol) and tetrabutylammonium bromide (1 .019 g, 3.16 mmol). The reaction mixture was purged with nitrogen and bis(triphenylphosphine)palladium(II) chloride (148 mg, 0.211 mmol) was added. The reaction mixture was heated at 110 C for 16 h. The reaction mixture wasdiluted with water (50 mL). The aq. layer was extracted with ethyl acetate (3 x 25 mL). The combined organic layers were dried over Na2SO4 and concentrated under reduced pressure to afford tert-butyl (4-(2-acetamidopyridin-4-yl)phenyl)carbamate (900 mg, 63% yield) as a brown sticky solid, which was used as is in the next step. LCMS (ESI) rn/c 328.2 [(M+H), calcd for C,8H22N303, 328.2]; LC/MS retentiontime (method B): tR = 1.49 min.

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 1026796-81-5, N-(4-Bromopyridin-2-yl)acetamide.

Reference:
Patent; BRISTOL-MYERS SQUIBB COMPANY; HARTZ, Richard A.; AHUJA, Vijay T.; BRONSON, Joanne J.; DZIERBA, Carolyn Diane; MACOR, John E.; NARA, Susheel Jethanand; RAJAMANI, Ramkumar; WO2015/6100; (2015); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Application of 107867-51-6, In the chemical reaction process,reaction time,type of solvent,can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product.An updated downstream synthesis route of 107867-51-6 as follows.

Unpurified 5-(trifluoromethyl)pyridin-2,3-diamine was added to diethyl oxalate (10.0 mL). The mixture was stirred at 120 C. for 12 hours and then cooled to room temperature. Et2O was added thereto to form a solid, and the formed solid was filtered under reduced pressure to obtain brown solid compound of 7-(trifluoromethyl)pyrido[2,3-b]pyrazin-2,3-diol. The mixture of unpurified 7-(trifluoromethyl)pyrido[2,3-b]pyrazin-2,3-diol and POCl3 (10.0 mL) was stirred at 130 C. for 12 hours and then cooled to room temperature. The reaction mixture was poured into ice water to form a solid. The formed solid was filtered and then dried under reduced pressure to obtain brown solid compound of 2,3-dichloro-7-(trifluoromethyl)pyrido[2,3-b]pyrazine (370.0 mg, 53% in 3 steps).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,107867-51-6, its application will become more common.

Reference:
Patent; C&C RESEARCH LABORATORIES; Ho, Pil Su; Yoon, Dong Oh; Han, Sun Young; Lee, Won Il; Kim, Jung Sook; Park, Woul Seong; Ahn, Sung Oh; Kim, Hye Jung; US2014/315888; (2014); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Electric Literature of 79491-46-6 ,Some common heterocyclic compound, 79491-46-6, molecular formula is C6H4Br2N2O3, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

E4. 2-Bromo-5,6-dimethoxy-3-nitropyridine 20 g of 2,6-dibromo-3-methoxy-5-nitropyridine (example E3) are dissolved in 550 ml of anhydrous methanol at 30-40 C. 4.6 g sodium methoxide dissolved in 30 ml anhydrous methanol is added to this solution. The reaction mixture is stirred for one hour at room temperature, poured into 700 ml of water and stored in the refrigerator overnight. The precipitate is filtered, washed with ice cold water and dried under vacuum to yield the title compound. 1H NMR (400 MHz, CDCl3): delta = 3.95 (s, 3H), 4.12 (s, 3H), 7.69 (s, 1 H). 13C NMR (100 MHz, CDCl3): delta = 55.68, 56.73, 115.33, 121.89, 143.18, 155.10.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 79491-46-6, 2,6-Dibromo-3-methoxy-5-nitropyridine, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; 4SC AG; EP2017277; (2009); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 1211518-35-2, name is Methyl 6-chloro-5-(trifluoromethyl)picolinate. A new synthetic method of this compound is introduced below., Quality Control of Methyl 6-chloro-5-(trifluoromethyl)picolinate

d) 6-Cyclopropylmethoxy-5-trifluoromethyl-pyridine-2-carboxylic acid Sodium hydride (1.1 g, 31.4 mmol) was added in portions to cyclopropylmethanol (20 mL) and the mixture was stirred at room temperature for 0.5 hours. 6-Chloro-5-(trifluoromethyl)-pyridine-2-carboxylic acid methyl ester (1.5 g, 6.3 mmol) was added and the resulting solution was stirred at 80 C for 1 h. Water (20 mL) was added; the solution was acidified with 6 N hydrochloric acid and then concentrated to give a residue which was partitioned between water (30 mL) and ethyl acetate (20 mL). The aqueous solution was extracted with ethyl acetate (2 x 20 mL) and the combined organic phase was washedwith brine (20 mL), dried over anhydrous sodium sulfate, filtered and concentrated to give the crude target compound. The crude target compound was purified by column chromatography (silica gel, 10 g, 15% ethyl acetate in petroleum ether) to give the title compound (1.4 g, 85%) as white solid; MS (El): mle = 262.0 [MH?i.

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 1211518-35-2, Methyl 6-chloro-5-(trifluoromethyl)picolinate.

Reference:
Patent; F. HOFFMANN-LA ROCHE AG; HOFFMANN-LA ROCHE INC.; FREI, Beat; GOBBI, Luca; GRETHER, Uwe; KIMBARA, Atsushi; NETTEKOVEN, Matthias; ROEVER, Stephan; ROGERS-EVANS, Mark; SCHULZ-GASCH, Tanja; WO2014/86705; (2014); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Electric Literature of 73583-41-2 ,Some common heterocyclic compound, 73583-41-2, molecular formula is C5H3BrClN, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

General procedure: Toluene/tert-butanol(6 mL, v/v, 5:1) was added to the mixture of 4-piperidone ketal(1.0 mmol, 1.0 equiv), aryl bromide 15af. (1.1 mmol, 1.1 equiv),sodium tert-butoxide (1.0 mmol, 1.0 equiv), palladium diacetate(0.05 mmol, 0.05 equiv), and X-Phos (0.05 mmol, 0.05 equiv), andthe mixture was stirred in a microwave reactor under argon for15 min at 160 C. After the reaction vials were cooled to roomtemperature and filtered over celite, they were rinsed well withethyl acetate. The filtrate was subsequently evaporated underreduced pressure to obtain the compounds 16a-f.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,73583-41-2, its application will become more common.

Reference:
Article; Wang, Zhengyu; Shi, Xiaofan; Zhang, Huan; Yu, Liang; Cheng, Yanhua; Zhang, Hefeng; Zhang, Huibin; Zhou, Jinpei; Chen, Jing; Shen, Xu; Duan, Wenhu; European Journal of Medicinal Chemistry; vol. 139; (2017); p. 128 – 152;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Electric Literature of 358780-14-0, Adding some certain compound to certain chemical reactions, such as: 358780-14-0, name is 1-(6-(Trifluoromethyl)pyridin-3-yl)ethanone,molecular formula is C8H6F3NO, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 358780-14-0.

In methanol (30.0 mL), 10.3 mmol l-[6-(Trifluoromethyl)-3- pyridinyl]ethanone is dissolved. Sodium borohydride (584 mg, 15.4 mmol) is added and the mixture is stirred at 0C for 30 minutes. The solvent is evaporated under reduced pressure and water is added. Extraction with ethyl acetate, washing with saturated brine and drying over anhydrous sodium sulfate is performed. After filtration, the solvent in the filtrate is evaporated under reduced pressure.

According to the analysis of related databases, 358780-14-0, the application of this compound in the production field has become more and more popular.

Reference:
Patent; SOLVAY SA; BRAUN, Max Josef; (21 pag.)WO2017/198812; (2017); A2;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem