Day: April 11, 2022

Related Products of 56673-34-8, In the chemical reaction process,reaction time,type of solvent,can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product.An updated downstream synthesis route of 56673-34-8 as follows.

2.0 g of 5-Bromo-pyridine-2-thiol (compound C1 ) are dissolved in 40 ml of carbon tetrachloride and 8 ml of water. Subsequently, the suspension is cooled in an ice bath and chlorine gas is passed into the reaction mixture for 20 min (flow: 35 ml/min). Thereafter, nitrogen is passed into the yellow solution to remove excess chlorine. Subsequently, the mixture is diluted with 150 ml of dichloromethane and extracted with 50 ml of brine. The organic layer is separated, dried using Na2SO4, filtered with suction, and evaporated to dryness to afford 2.70 g of the title compound as light yellow needles. M. p. 8O0C. GC-MS: 254.8/256.8/258.8 (77:100:25; M+). TLC: Rf = 0.84 (dichloromethane/ethanol 20:1 parts by volume).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,56673-34-8, its application will become more common.

Reference:
Patent; ALTANA PHARMA AG; WO2007/39580; (2007); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Related Products of 16744-81-3 ,Some common heterocyclic compound, 16744-81-3, molecular formula is C7H7NO2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

To a solution of 4-methoxypicolinaldehyde (1.01 g, 7.36 mmol) in DCM (40 mL) was added trimethylsilanecarbonitrile (1.106 mL, 8.84 mmol). The mixture was stirred at room temperature overnight. The mixture was concentrated down to afford a light brown oil, which was treated with conc. sulfuric acid (5 mL, 94 mmol) for 4 hours, then poured the reaction mixture into ice, and adjusted the PH to 9 using NH4OH. The mixture was concentrated down with Celite®, purified by silica column( CombiFlash®, 40g column) using 0-10percent MeOH/DCM to afford 2-hydroxy-2-(4-methoxypyridin-2-yl)acetamide (748 mg, 4.11 mmol, 55.7percent yield) as a yellow solid. LCMS m/z = 183.0 [M+H]+.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,16744-81-3, its application will become more common.

Reference:
Patent; GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED; ADAMS, Nicholas David; BENOWITZ, Andrew B.; RUEDA BENEDE, Maria Lourdes; EVANS, Karen Anderson; FOSBENNER, David T.; KING, Bryan Wayne; LI, Mei; MILLER, William Henry; REIF, Alexander Joseph; ROMERIL, Stuart Paul; SCHMIDT, Stanley J.; WIGGALL, Kenneth; (1283 pag.)WO2017/216726; (2017); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Related Products of 54957-86-7, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.54957-86-7, name is 2,3-Dichloro-6-methylpyridine, molecular formula is C6H5Cl2N, molecular weight is 162.0166, as common compound, the synthetic route is as follows.

A mixture of 8,1 (1 .70 g, 10,51 mmol), Zn(CN)2 (0.74 g, 6.30 mmol) and Zn (0.031 g, 0,47 mmol) in DMF (10.5 mL) is degassed (B. Van Wagenen, US2003/55085). PdC^dppfj-CHzCIs adduct (0.189 g, 0.231 mmol) is added and the solution is again degassed then is heated at 125C for 5 h. The crude mixture is diluted with EtOAc (150 mL) and the mixture is filtered through diatomaceous earth (washing the cake with EtOAc (25 mL)). The filtrate is washed twice with a mixture of water and saturated NaHC03 solution (3/1 ) and with brine, then dried (Na2S04), filtered and concentrated under reduced pressure. The residue is purified by flash chromatography (10-10Q%EtQAc:Hex) to give 8.2; MS: m/z = 153.1/155.1 (MH+); 1 H NMR (400 MHz, CDCI3) delta ppm 2.60 (s, 3 H), 7.34 (d, J=8.22 Hz, 1 H), 7.73 (d, J=8.61 Hz, 1 H).

Statistics shows that 54957-86-7 is playing an increasingly important role. we look forward to future research findings about 2,3-Dichloro-6-methylpyridine.

Reference:
Patent; UNIVERSITE DE MONTREAL; SIMONEAU, Bruno; CHANTIGNY, Yves; YEH, Jonathan; SAUVAGEAU, Guy; MARINIER, Anne; (94 pag.)WO2019/87129; (2019); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 73112-16-0, name is 2,6-Dibromo-4-methylpyridine. A new synthetic method of this compound is introduced below., Application In Synthesis of 2,6-Dibromo-4-methylpyridine

A suspension of 2,6-dibromo-4-methylpyridine (2.91 g, 11.6 mmol), pivalic acid (0.25 mL, 2.11 mmol), potassium carbonate (2.92 g, 21.1 mmol), thiazole (0.75 mL, 10.6 mmol) and tetrakis(triphenylphosphine)palladium(0) (0.49 g, 0.42 mmol) in N,N- dimethylacetamide (23 mL) was heated at 130 C for 18 hours. The reaction mixture was diluted with ethyl acetate, filtered through a pad of CELITE, and washed with water (2x). The organic layer was dried over magnesium sulfate, filtered, and concentrated under reduced pressure. The residue was purified by chromatography on silica gel (ethyl acetate/hexanes) to afford 2-bromo- 4-methyl-6-(l,3-thiazol-5-yl)pyridine. 1H NMR (600 MHz, CDC13) delta 8.80 (s, 1H), 8.29 (s, 1H), 7.38 (s, 1H), 7.19 (s, 1H), 2.34 (s, 3H).

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 73112-16-0, 2,6-Dibromo-4-methylpyridine.

Reference:
Patent; MERCK SHARP & DOHME CORP.; MERCK CANADA INC.; ANTHONY, Neville, J.; ANDRESEN, Brian, M.; NORTHRUP, Alan, B.; CHILDERS, Kaleen, K.; DONOFRIO, Anthony; MILLER, Thomas, A.; LIU, Yuan; MACHACEK, Michelle, R.; WOO, Hyun Chong; SPENCER, Kerrie, B.; ELLIS, John Michael; ALTMAN, Michael, D.; ROMEO, Eric, T.; GUAY, Daniel; GRIMM, Jonathan; LEBRUN, Marie-Eve; ROBICHAUD, Joel, S.; WANG, Liping; DUBOIS, Byron; DENG, Qiaolin; WO2014/176210; (2014); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Related Products of 824-51-1, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 824-51-1, name is 6-Methyl-1H-pyrrolo[2,3-b]pyridine. A new synthetic method of this compound is introduced below.

(d) Step 4 6-Methyl-1H-pyrrolo[2,3-b]pyridine (0.066 g, 0.50 mmol) was successively added with acetic acid (0.2 mL), water (0.4 mL), and hexamethylenetetramine (0.098 g, 0.70 mmol), and then the mixture was stirred overnight at 120C in a sealed tube. The reaction mixture was added with water, and then the precipitated solid was collected by filtration to obtain 6-methyl-1H-pyrrolo[2,3-b]pyridine-3-carboxaldehyde (0.054 g, 67%). 1H NMR (300 MHz, DMSO-d6) delta 2.55 (s, 3H), 7.16 (d, J = 8.1 Hz, 1H), 8.27 (d, J = 8.1 I Hz, 1H), 8.36 (s, 1H), 10.28 (s, 1H).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,824-51-1, its application will become more common.

Reference:
Patent; The University of Tokyo; Riken; NAGANO Tetsuo; OKABE Takayoshi; KOJIMA Hirotatsu; SAITO Nae; NAKANO Hirofumi; ABE Masanao; TANAKA Akiko; HONMA Teruki; YOKOYAMA Shigeyuki; TSUGANEZAWA Keiko; YUKI Hitomi; EP2565192; (2013); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Reference of 97004-04-1, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.97004-04-1, name is (6-Chloropyridin-3-yl)methanamine, molecular formula is C6H7ClN2, molecular weight is 142.59, as common compound, the synthetic route is as follows.

A mixture of 4-METHYL-3-OXO-3, 4-dihydro-quinoxaline-2-carbaldehyde (0.1 g), sodium triacetoxyborohydride (0.170 g, 1.5 eq), and 2-chloro-5-aminomethylpyridine (0.076 g, leq) in dry CH2CL2 (1.5 mL) was stirred at rt under nitrogen for 1 day. The orange reaction mixture was basified with a sat. NAHCO3 solution, extracted CH2Cl2. The combined organic extracts were dried (MgSO4), filtered and concentrated in vacuo to give a crude oil. FC (CH2C12/MEOH : 9/1) gave the title compound as an orange oil. LC-MS: Rt = 2.93 min. m/z = 315 (M + 1).

The chemical industry reduces the impact on the environment during synthesis 97004-04-1, I believe this compound will play a more active role in future production and life.

Reference:
Patent; ACTELION PHARMACEUTICALS LTD; FISCHLI, Walter; WO2004/96780; (2004); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 1032943-43-3, name is 4-Bromo-1H-pyrazolo[3,4-c]pyridine. A new synthetic method of this compound is introduced below., Recommanded Product: 4-Bromo-1H-pyrazolo[3,4-c]pyridine

To a solution of 4-bromo-lH-pyrazolo[3,4-c]pyridine (680.0 mg, 3.43 mmol, 1.0 eq) and Pd(PPh3)4 (396.0 mg, 0.343 mmol, 0.1 eq) in DMF (15.0 mL) was added Zn(CN)2 (804.0 mg, 6.87 mmol, 2.0 eq) and the mixture was stirred at 130 C under microwave irradiation for 2 h. After the reaction was complete, the reaction mixture was diluted by EA (50.0 mL), quenched by H20 (100.0 mL), filtered. The solid was washed by EA (50.0 mL). The filtrate was extracted by EA (50.0 mL X3), washed by brine, dried over Na2S04, concentrated to get a residue which was purified by column chromatography (PE: EA = 2: 1) to provide lH-pyrazolo[3,4-c]pyridine-4-carbonitrile (210 mg, 42.3 %) as a white solid. LCMS (M+H+) m/z calculated 145, found 145.

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 1032943-43-3, 4-Bromo-1H-pyrazolo[3,4-c]pyridine.

Reference:
Patent; LIFESCI PHARMACEUTICALS, INC.; MCDONALD, Andrew; QIAN, Shawn; (346 pag.)WO2018/11628; (2018); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 112110-07-3, name is 5-(Trifluoromethyl)pyridin-3-amine. A new synthetic method of this compound is introduced below., Recommanded Product: 112110-07-3

289 mg of compound (IIb-13)And 0.95eq5-trifluoromethyl-3-aminopyridine weighed in a sealed tube,0.1 eq tris (dibenzylidene indenone) dipalladium,0.2eqX-phos, 1.39eq CS2CO3,5 ml of dioxane was added,Replace N2 protection,After the reaction at 50 24h move to room temperature,cool down.The reaction solution was filtered,100 ml of ethyl acetate,100ml saturated NaCl wash,Dry and spin dry,PE: EA = 5: 1 After column separation,277.3 mg of product (IIc-17)The yield is 86.03%.

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 112110-07-3, 5-(Trifluoromethyl)pyridin-3-amine.

Reference:
Patent; Sichuan University; Zhang Tao; Wang Fangying; Chen Yuanwei; Wei Yuquan; (41 pag.)CN107382840; (2017); A;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Electric Literature of 66909-38-4, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.66909-38-4, name is 6-Chloro-4-methylpyridin-3-amine, molecular formula is C6H7ClN2, molecular weight is 142.5862, as common compound, the synthetic route is as follows.

To the suspension of 6-chloro-4-methylpyridin-3-amine (10.0 g, 70 mmol) in toluene (110 mL), KOAc (8.2 g, 84.0 mmol) was added in one portion, followed by addition of Ac2O (84 mmol). The mixture was heated at 70 C. overnight. Then, to the mixture, isoamyl nitrite (10.4 mL, 77 mmol) was added. The mixture was heated at 95 C. for 30 hr under Ar. The reaction was cooled to room temperature and filtered through a short pad of celite, and the residue was rinsed with ethyl acetate. The combined solution was concentrated and the resulting residue was purified to afford title compound.

The chemical industry reduces the impact on the environment during synthesis 66909-38-4, I believe this compound will play a more active role in future production and life.

Reference:
Patent; ACHILLION PHARMACEUTICALS, INC.; WILES, Jason, Allan; PHADKE, Avinash, S.; DESHPANDE, Milind; AGARWAK, Atul; CHEN, Dawei; GADHACHANDA, Venkat, Rao; HASHIMOTO, Akihiro; PAIS, Godwin; WANG, Qiuping; WANG, Xiangzhu; (905 pag.)WO2017/35353; (2017); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Related Products of 1796-84-5, Adding some certain compound to certain chemical reactions, such as: 1796-84-5, name is 4-Ethoxy-3-nitropyridine,molecular formula is C7H8N2O3, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 1796-84-5.

A solution consisting of 4-ethoxy-3-nitropyridine (15.0 g, 97.3 MMOL) and EtNH2 (46.5 mL, 70% aq. solution, 584 MMOL) in ETOH (30 mL) was stirred at 85 C in a pressure vessel for 2 h. Removal of all VOLATILES IN VACUO afforded the title compound (16.2 g, 99 %). MS (ES+) m/z 168 (M+H) +.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 1796-84-5, 4-Ethoxy-3-nitropyridine, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; SMITHKLINE BEECHAM CORPORATION; WO2005/11700; (2005); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem