Day: April 12, 2022

The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 71670-70-7, name is 2-(Chloromethyl)-5-methylpyridine hydrochloride. This compound has unique chemical properties. The synthetic route is as follows. Recommanded Product: 2-(Chloromethyl)-5-methylpyridine hydrochloride

EXAMPLE 7 Preparation of 2-methyl-6-[[(5-methyl-2-pyridyl)methyl]-thio]-5H-1,3-dioxolo(4,5-f)benzimidazole To 3.9 g of 2-methyl-5H-1,3-dioxolo-(4,5-f)benzimidazole-6-thiol, suspended in 60 ml of alcohol, were added dropwise while stirring 1.57 g of sodium hydroxide in 30 ml of water and, after 30 minutes, there were added 3.44 g of 5-methyl-2-chloromethylpyridine hydrochloride. The mixture was left to boil at reflux overnight, then evaporated and the residue was taken up in 500 ml of ethyl acetate. This was washed with 100 ml of sodium hydroxide, three times with 100 ml of water, dried over sodium sulfate and evaporated in vacuo. The crude product was recrystallized from ethyl acetate/petroleum ether (low boiling) and there were obtained 4.8 g (81.7% of theory) of 2-methyl-6-[[(5-methyl-2-pyridyl)methyl]-thio]-5H-1,3-dioxolo(4,5-f)benzimidazole of melting point 147-148 C.

With the rapid development of chemical substances, we look forward to future research findings about 71670-70-7.

Reference:
Patent; Hoffmann-La Roche Inc.; US4435406; (1984); A;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Electric Literature of 1241752-31-7, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 1241752-31-7, name is 5-Bromo-2-ethoxy-3-methoxypyridine. A new synthetic method of this compound is introduced below.

d. Preparation of Compound To a solution of known 2-ethoxy-3-methoxy-5-bromopyridine (100 mg, 0.34 mmol) in 1,4- dioxane ( 3.0 ml), trimethyl boroxine (80 mg, 0.69 mmol) and Pd(dppf)Cl2 (56.3 mg, 0.069 mmol) was added, followed by CsC03 (300 mg, 0.92 mmol). The mixture was degassed for 30 minutes, and then heated to 90 C for 16 hr. After cooling, the crude mixture was filtered on celite and extracted with EtOAc (3x), washed with NaCl, the organic layer was dried with Na2S04 and concentrated to give crude product . The crude product was purified by ISCO flash chromatography using 10% EtOAc in hexane, giving 50 mg compound (Yield: 84%). ‘H NMR (300 MHz, CDC13) delta: 7.52 (s, I H), 6.84 (s, IH), 4.45 (q, 2H), 3.82 (s, 3H), 2.21 (s, 3H), 1.39 (t, 3H).

At the same time, in my other blogs, there are other synthetic methods of this type of compound,1241752-31-7, 5-Bromo-2-ethoxy-3-methoxypyridine, and friends who are interested can also refer to it.

Reference:
Patent; RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY; LAVOIE, Edmond J.; BAUMAN, Joseph David; PARHI, Ajit; SAGONG, Hye Yeon; PATEL, Disha; ARNOLD, Eddy; DAS, Kalyan; VIJAYAN, Suyambu Kesava; WO2014/43252; (2014); A2;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Synthetic Route of 69045-83-6, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 69045-83-6, name is 2,3-Dichloro-5-(trichloromethyl)pyridine. A new synthetic method of this compound is introduced below.

EXAMPLE 3 Conversion of 2,3-dichloro-5-(trichloromethyl)pyridine to 2,3-dichloro-5- (trifluoromethyl)pyridine. 2,3-dichloro-5-(trichloromethyl)pyridine (5 g, 18.84 mmole), iron(III) chloride (0.153 g, 0.942 mmole) and hydrogen fluoride (2.423 g, 85 mmole) in pyridine solution (70%) was added to an autoclave and heated to 175 C over night. The autoclave was cooled to 130 C and left for stirring additional 5 hours, followed by cooling to 25 C and opened carefully leaving gas phase through a Caustic Lye scrubber. The crude was dissolved in dichloromethane, washed with 1 M NaOH (aq) and water. The organic phase was removed by distillation and the product was obtained by distillation (3.0 g, 73 % yield).

At the same time, in my other blogs, there are other synthetic methods of this type of compound,69045-83-6, 2,3-Dichloro-5-(trichloromethyl)pyridine, and friends who are interested can also refer to it.

Reference:
Patent; CHEMINOVA A/S; ANDERSEN, Casper Stoubaek; WO2014/198278; (2014); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Adding a certain compound to certain chemical reactions, such as: 170165-79-4, 1,3-Di(pyridin-4-yl)benzene, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Quality Control of 1,3-Di(pyridin-4-yl)benzene, blongs to pyridine-derivatives compound. Quality Control of 1,3-Di(pyridin-4-yl)benzene

General procedure: A mixture of Zn(NO3)2 (0.15 mmol), 1,3-dpb and glu2- (0.1 mmol) was dissolved in 8 ml of DMF-MeOH-H2O (1 : 1 : 2, v/v). The final mixture was placed in a Parr Teflon-lined stainless steel vessel (15 ml) and heated at 110 C for3 days, colourless crystals were obtained (52% yield based on 1,3-dpb). IR (KBr, gamma/cm-1): 3425 (m), 3068 (w), 2848 (w), 2359 (m), 1580 (s), 1515 (s), 1394 (s), 1226 (s), 1156 (w), 1056 (s), 964 (w), 852 (w), 757 (m), 674 (m), 536 (m). Found (%): C, 59.06; H, 4.13; N, 6.41. Calc. for C21H18N2O4Zn (%): C, 58.96; H, 4.24; N, 6.55.

The synthetic route of 170165-79-4 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Hu, Jin-Song; Lei, Zhang; Xing, Hong-Long; Zhang, Xiao-Mei; Shi, Jian-Jun; He, Jie; Mendeleev Communications; vol. 23; 4; (2013); p. 229 – 230;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Electric Literature of 866775-18-0, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 866775-18-0, name is Methyl 3-amino-6-bromo-5-(trifluoromethyl)picolinate. This compound has unique chemical properties. The synthetic route is as follows.

3-Amino-6-bromo-5-trifluoromethyl-pyridine-2-carboxylic acid methyl ester (1.40 g, 4.68 mmol) was suspended in MeOH (15 ml); Sodium hydroxide (2.0 M aqueous solution) (14.04 ml, 28.1 mmol) was added and the suspension was stirred at RT overnight. The reaction mixture was concentrated under reduced pressure and the resulting residue was dissolved in water (100 ml) and then acidifed by the addition of 5.0M HCI(aq). The product was extracted into ethyl acetate (2 x 75 ml) and the combined organic extracts were washed with water (50 ml), brine (25 ml), dried (MgS04) and concentrated under reduced pressure to afford the title product as a yellow solid. H-NMR: 9400MHz, DMSO-d6) ? 13.24 (1 H, br s, C02H), 7.74 (1 H, s, ArH), 7.17 92H, br s ArNH2). m/z 285.1 , 287.1 [M+H]+

According to the analysis of related databases, 866775-18-0, the application of this compound in the production field has become more and more popular.

Reference:
Patent; NOVARTIS AG; LEGRAND, Darren Mark; WO2013/38373; (2013); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 188637-63-0, name is (6-Bromopyridin-2-yl)methanamine, the common compound, a new synthetic route is introduced below. Formula: C6H7BrN2

To a solution of C-(6-Bromo-pyridin-2-yl)-methylamine (5440 mg, 29.08 MMOL) in dichloromethane (100 mL) at room temperature was added triethylamine (5886 mg, 58.17 MMOL) and acetyl chloride (2511 mg, 31.99 MMOL). The reaction mixture was heated at 40C for 3h and cooled down to room temperature. A solution of sodium hydroxide (1 N) was added and the reaction was stirred for 1 h at room temperature. The layers were separated and the organic phase was concentrated under reduced pressure. The crude mixture was dissolved in EtOH (50 mL) and concentrated hydrochloric acid (10 mL) was added. The mixture was stirred for 30 min and benzene was added followed by sodium hydroxide pellets until pH 10 was reached. The phases were separated and the organic layer was washed with an aqueous solution of ammonium chloride and the volatiles were removed in vacuo. The crude material was purified by column chromatography with a gradient of 0 to 5% METHANOL/DICHLOROMETHANE to give N- (6-Bromo-pyridin-2-ylmethyl)- acetamide as viscous orange oil. MS ES (MH+ 229.1/231. 0).

The synthetic route of 188637-63-0 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; BAYER PHARMACEUTICALS CORPORATION; WO2005/14566; (2005); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Adding a certain compound to certain chemical reactions, such as: 13296-04-3, 4-(Pyridin-4-yl)aniline, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Safety of 4-(Pyridin-4-yl)aniline, blongs to pyridine-derivatives compound. Safety of 4-(Pyridin-4-yl)aniline

EXAMPLE 2 N-Methyl-N’-[4-(4-pyridinyl)phenyl]urea–To 10.52 g. of 4-(4-pyridinyl)benzeneamine suspended in 400 ml. of chloroform was added with stirring 0.76 g. of N,N-dimethyl-4-pyridineamine and 5.5 ml. of methyl isocyanate. The resulting reaction mixture was stirred under reflux for sixteen hours. The reaction mixture was filtered to collect the suspended solid and the filtrate was concentrated in vacuo to yield more solid product plus an oily material. The collected solid was recrystallized from 550 ml. of acetonitrile and dried at 90 C. in vacuo to yield 6.58 g. of N-methyl-N’-[4-(4-pyridinyl)phenyl]urea, m.p. 233-234 C. Another 3.22 g. of this product, m.p. 233-234 C., was obtained by recrystallizing from methanol the above-noted material obtained by concentration of the reaction filtrate.

The synthetic route of 13296-04-3 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Sterling Drug Inc.; US4376775; (1983); A;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Related Products of 22282-99-1, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.22282-99-1, name is 4-Bromo-2-methylpyridine, molecular formula is C6H6BrN, molecular weight is 172.02, as common compound, the synthetic route is as follows.

To a solution of compound 5-5 (26 g, 151.14 mmol, 1 eq) and compound 5-6 (23.40 g, 198.09 mmol, 24 mL, 1.31 eq) in tetrahydrofuran (300 mL) was added LDA (2 M, 39 mL) at -70C under nitrogen atmosphere. The mixture was stirred at -70C for 1 hour prior to the addition of LDA (2 M, 39.00 mL). The reaction was stirred at -70C for another 1 hour. LCMS showed 25% of starting material remained and 54% of desired compound mass was detected. The reaction mixture was quenched with water (50 mL), and extracted with ethyl acetate (100 mLx3). The combined organic layers was dried over anhydrous sodium sulfate, filtered and concentrated in vacuum. The residue was purified by reverse phase flash (trifluoroacetic acid condition). Then basified with saturated sodium bicarbonate (10 mL), extracted with ethyl acetate (100 mLx3). The combined organic layers was dried over anhydrous sodium sulfate, filtered and concentrated in vacuum to give compound 5-7 (22 g, 59.63% yield) as yellow oil. 1H NMR (CDCl3, 400 MHz): d 8.45 (d, J = 5.6 Hz, 1H), 7.61 (d, J = 2.0 Hz, 1H), 7.50 (dd, J1 =5.6 Hz, J2 = 2.0 Hz, 1H), 4.20 (q, J = 7.2 Hz, 2H), 3.89 (s, 2H), 1.27 (t, J = 7.2 Hz, 3H).

The chemical industry reduces the impact on the environment during synthesis 22282-99-1, I believe this compound will play a more active role in future production and life.

Reference:
Patent; SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH; TRI-INSTITUTIONAL THERAPEUTICS DISCOVERY INSTITUTE, INC.; FUSHIMI, Makoto; SCALTRITI, Maurizio; HELLER, Daniel, Alan; MONTERRUBIO MARTINEZ, Carles; ARRUABARRENA ARISTORENA, Amaia; MEINKE, Peter, T.; FOLEY, Michael, Andrew; ASANO, Yasutomi; ASO, Kazuyoshi; TAKAHAGI, Hiroki; SHAMAY, Yosef; BASELGA TORRES, Jose, Manuel; SASAKI, Yusuke; MICHINO, Mayako; (271 pag.)WO2020/72892; (2020); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Adding a certain compound to certain chemical reactions, such as: 188637-63-0, (6-Bromopyridin-2-yl)methanamine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, HPLC of Formula: C6H7BrN2, blongs to pyridine-derivatives compound. HPLC of Formula: C6H7BrN2

General procedure: The reaction substrate (0.3 mmol) was added to the reaction vessel.Benzyl alcohol (2mL) and tert-butyl nitrite (1.5equiv),Pumping the reaction vessel – nitrogen-filled operation for 3 consecutive times, reacting at room temperature, after the reaction is over,Diluted with ethyl acetate, concentrated under reduced pressure, and the concentrate was separated by column chromatography(wherein silica gel is 300-400 mesh silica gel), the ratio of petroleum ether to ethyl acetate isThe 4:1 mixture was used as an eluent, and the eluate was collected, and the solution was spun off to obtain a product.

The synthetic route of 188637-63-0 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Wenzhou University; Liu Miaochang; Zhang Xue; An Cui; Cai Yueming; Yang Yefei; Zhou Yunbing; Wu Huayue; (18 pag.)CN109503575; (2019); A;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 69422-72-6, name is 2,4,6-Trichloronicotinic acid, molecular formula is C6H2Cl3NO2, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below. name: 2,4,6-Trichloronicotinic acid

EXAMPLE 3D /erf-butyl 2-(2,4,6-trichloronicotinamido)ethylcarbamate A solution of the product of EXAMPLE 3C (6.0 g, 26.5 mmol) in dichloromethane (150 mL) was treated at 0C with 2 drops of N-dimethy lformamide. Oxalyl chloride (6.73 g, 53 mmol) was added dropwise over 30 minutes and stirring was continued for 2 hours. The solution was concentrated and dried under vacuum to give the crude acid chloride. A solution of the acid chloride (4.5 g, 18.4 mmol) in 60 mL of dry dichloromethane was added dropwise over 1 hour to a solution of tert-butyl 2-aminoethylcarbamate (5.9 g, 36.8 mmol) and triethylamine (3.7 g, 36.8 mmol) in 40 mL of dry dichloromethane at 0C and stirring was continued for 2 hours. The mixture was concentrated under vacuum and the residue was purified by flash chromatography on silica gel (200-300 mesh) eluting with 100/1 dichloromethane/methanol to give the title compound. MS: 390 (M+Na+).

With the rapid development of chemical substances, we look forward to future research findings about 69422-72-6.

Reference:
Patent; ABBOTT LABORATORIES; ABBOTT LABORATORIES TRADING (SHANGHAI) COMPANY, LTD.; VASUDEVAN, Anil; PENNING, Thomas Dale; CHEN, Huanming; LIANG, Bo; WANG, Shaohui; ZHAO, Zhongqiang; CHAI, Dikun; YANG, Leifu; GAO, Yingxiang; WO2012/97682; (2012); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem