Day: April 15, 2022

Reference of 13602-82-9, Adding some certain compound to certain chemical reactions, such as: 13602-82-9, name is N-(2-Chloropyridin-4-yl)acetamide,molecular formula is C7H7ClN2O, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 13602-82-9.

A mixture of 10 g (59 mmol) N~(2-chloropyridin-4-yl)acetamide (commercially available), 9.8 g (17.6 mmol) pulverized KOH and 4.1 ml (6.4 mmol) methyl iodide in 60 ml acetone was stirred at room temperature for 2 h. After evaporation of all volatiles the residue was taken up in water and extracted with ethyl acetate. The combined organic layers were dried with MgSQ4 and evaporated to yield 7.1 g (66%) of the title compound as off-white solid. MS: (m/e): 345.2 (MH+).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 13602-82-9, N-(2-Chloropyridin-4-yl)acetamide, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; F.HOFFMANN-LA ROCHE AG; WO2006/63718; (2006); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Synthetic Route of 884495-00-5, In the chemical reaction process,reaction time,type of solvent,can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product.An updated downstream synthesis route of 884495-00-5 as follows.

Preparation of intermediate (40) All apparatus was flushed with N2 and dried by heating. Reaction under Ar flow.Intermediate (8) (0.00187 mol) was dissolved in degassed TFA (15 ml), then stirred for 4 hours at 85C. The mixture was cooled. The solvent was evaporated in vacuo. The residue was taken up into degassed toluene. The organic layer was separated, washed with a degassed aqueous NaHCO3 solution (2 x 50 ml), dried, filtered and the solvent was evaporated in vacuo to give a yellow foam (*). Under Ar, 4-bromo-5-fiuoro-2- methoxypyridine (1.3 equiv.; 0.50Og) was dissolved in degassed dioxane (10 ml). Cs2CO3 (0.914 g) was added to give suspension (**). A solution of the crude residual oil (*) in degassed dioxane (10 ml) was added to the suspension (**). Then, Pd2(dba)3 (0.029 g) and Xantphos (0.032 g) were added. The resultant brown reaction suspension was stirred overnight at 1000C. The reaction mixture was cooled, and the solvent was evaporated. The residue was dissolved in ethyl acetate, then washed with an aqueous NaHCO3 solution, and once with brine. The organic layer was separated, dried, filtered and the solvent was evaporated. The residue was purified by column chromatography over silica gel. The product fractions were collected and the solvent was evaporated, yielding 0.5113 g of intermediate (40).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,884495-00-5, its application will become more common.

Reference:
Patent; JANSSEN PHARMACEUTICA NV; WO2008/3665; (2008); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Application of 98353-08-3 ,Some common heterocyclic compound, 98353-08-3, molecular formula is C8H9NO3, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

To a solution of 5-ethoxypicolinic acid (14.36 mg, 0.086 mmol) in DMF (1 mL)was added HATU (33 mg, 0.086 mmol). The reaction mixture was stirred at rt for 5 mm, followed by addition of (R)- 1 -(cis-4-(6-fluoroquinolin-4-yl)cyclohexyl)ethanamine (18 mg, 0.066 mmol) Intermediate 40L and N-methylmorpholine (0.032 mL, 0.264 mmol). The resulting mixture was stirred at rt for 2 h. The reaction mixture was concentrated in vacuo and the residue was dissolved in MeOH, filtered, and purified via preparativeHPLC to give Example 163 (16 mg, 0.03 8 mmol, 57% yield). LC-MS Anal. Calc?d for C25H28FN302 421.22, found [M+H] 422.3. T = 1.63 mm (Method I). ?H NMR (500MHz, DMSO-d6) oe: 8.81 (d, J=4.4 Hz, 1H), 8.36 (d, J=9.6 Hz, 1H), 8.26 (d, J2.4 Hz, 1H), 8.07 (dd,J9.1, 5.8 Hz, 1H), 7.99-7.85 (m, 2H), 7.73-7.59 (m, 1H), 7.55-7.39 (m, 2H),4.39 (d, J6.6 Hz, 1H), 4.14 (q, J6.9 Hz, 2H), 3.71 – 3.52 (m, 1H), 1.94 – 1.52 (m, 9H),1.34 (t, J=6.9 Hz, 3H), 1.19 (d, J6.4 Hz, 3H).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 98353-08-3, 5-Ethoxypicolinic acid, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; FLEXUS BIOSCIENCES, INC.; BECK, Hilary Plake; JAEN, Juan Carlos; OSIPOV, Maksim; POWERS, Jay Patrick; REILLY, Maureen Kay; SHUNATONA, Hunter Paul; WALKER, James Ross; ZIBINSKY, Mikhail; BALOG, James Aaron; WILLIAMS, David K.; MARKWALDER, Jay A.; SEITZ, Steven P.; CHERNEY, Emily Charlotte; ZHANG, Liping; SHAN, Weifang; GUO, Weiwei; HUANG, Audris; (231 pag.)WO2016/73774; (2016); A2;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 131747-55-2, name is 2-Fluoro-3-(hydroxymethyl)pyridine. This compound has unique chemical properties. The synthetic route is as follows. Application In Synthesis of 2-Fluoro-3-(hydroxymethyl)pyridine

Step (ii)A solution of (2-fluoropyridin-3-yl)methanol (400mg, 3.1mmol), methanesulfonyl chloride (0.37mL, 4.7mmol) and triethylamine (0.88mL, 6.30mmol) in dichloromethane (lOmL) was stirred at rt for 16h. The mixture was then diluted with dichloromethane and washed with H20, then brine. The organic phase was collected, dried (MgS04) and concentrated in vacuo to give (2-fluoropyridin-3-yl)methyl methanesulfonate.

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 131747-55-2, 2-Fluoro-3-(hydroxymethyl)pyridine.

Reference:
Patent; CELLZOME LIMITED; RAMSDEN, Nigel; HARRISON, Richard John; OXENFORD, Sally; BELL, Kathryn; PITON, Nelly; DAGOSTIN, Claudio; BOUSSARD, Cyrille; RATCLIFFE, Andrew; WO2011/48082; (2011); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Application of 127446-34-8 ,Some common heterocyclic compound, 127446-34-8, molecular formula is C11H13ClN2O2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

Intermediate 7:[0122] To a solution of 4-(benzyloxy)butan-l-ol (15.42 g, 85.6 mmol) in DMF (120 mL) was added sodium hydride (4.11 g, 171 mmol) at 0C. The mixture was stirred for 20 min, then intermediate 6 (10.28 g, 42.7 mmol) was added portion-wise and the resulting mixture was stirred overnight. The mixture was quenched with saturated aq NH CI and extracted with EtOAc. The combined organic layers were washed with water, brine, dried over anhydrous Na2S04 and concentrated in vacuo. The residue was purified by flash chromatography on silica gel column (elution with PE EtOAc = 8: 1 – 4: 1) to give N-(6-(4-(benzyloxy)butoxy)-3-formylpyridin-2- yl)pivalamide (intermediate 7) (5.04 g, 31%).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 127446-34-8, N-(6-Chloro-3-formylpyridin-2-yl)pivalamide, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL; JIN, Jian; ROTH, Bryan; FRYE, Stephen; WO2012/3418; (2012); A2;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Application of 1071727-78-0 ,Some common heterocyclic compound, 1071727-78-0, molecular formula is C9H10N2O, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

6,7-Dihydro-5H-[1]pyrindin-7-ylamine: 5,6-Dihydro-[1]pyrindin-7-one O-methyl-oxime (4.1 g, 25.28 mmol) and Pd/C (150 mg) were mixed in TFA and then resulting reaction mixture was hydrogenated under 50 psi for 14 hours. Filtration via celite and concentration afforded the desired title amine. Spectroscopic data: 1H NMR (300 MHz, CDCl3) delta 1.89-2.02 (m, 1H), 2.46-2.58 (m, 1H), 2.89-3.01 (m, 2H), 4.62-4.73 (m, 1H), 7.30-7.37 (m, 1H), 7.77 (d, J=7.62 Hz, 1H), 8.35-8.50 (m, 3H).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 1071727-78-0, (Z)-5H-Cyclopenta[b]pyridin-7(6H)-one O-methyl oxime, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; Allergan, Inc.; US2008/255239; (2008); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 31181-88-1, name is 5-Fluoropicolinaldehyde. This compound has unique chemical properties. The synthetic route is as follows. Application In Synthesis of 5-Fluoropicolinaldehyde

a) 2-Ethynyl-5-fluoro-pyridineTo a mixture of 5-fluoro-2-formylpyridine (1.10 g, 9.0 mmol) in MeOH (38 mL) was added potassium carbonate (2.44 g, 0.018 mol) followed by a solution of (l-diazo-2-oxo-propyl)- phosphonic acid dimethyl ester (2.03 g, 11 mmol) in MeOH (12 mL). The mixture was stirred at room temperature for 90 min, then extracted with diethylether. The organic layers were then washed with sodium hydrogen carbonate solution (1 M) and brine, dried over sodium sulfate, filtered and evaporated at to give the title compound (1.01 g, 78%) as a light brown liquid. MS: m/e = 121.0 [M]+.

With the rapid development of chemical substances, we look forward to future research findings about 31181-88-1.

Reference:
Patent; F. HOFFMANN-LA ROCHE AG; HERNANDEZ, Maria-Clemencia; LUCAS, Matthew C.; THOMAS, Andrew; WO2012/62687; (2012); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Reference of 1133879-69-2, Adding some certain compound to certain chemical reactions, such as: 1133879-69-2, name is 3-Fluoro-5-vinylpyridine,molecular formula is C7H6FN, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 1133879-69-2.

A mixture of carboline 2 (1 mmol), vinylpyridine 3a (1 mmol), CsF (0.1 g), hydroquinone(0.02 g), and DMSO (1.5 mL) was heated with stirring for 6 h at 150-160 C and then concentrated in vacuo (3 Torr). The residue was extracted with CH2Cl2, and the solution was concentrated. The product was isolated by chromatography on silica gel(260 mesh) using MeOH-CHCl3, 1 : 10, as the eluent. Yield 2.6 g (80%). M.p. 103-104 C. 1H NMR (CDCl3), delta: 2.44 (s, 3 H,Me); 2.49-2.56 (m, 5 H, CH2 and MeN); 2.72 (t, 2 H, CH2, 3JH,H = 6.1 Hz); 3.01 (t, 2 H, CH2, 3JH,H = 6.0 Hz); 3.65 (s, 2 H, CH2); 4.20 (t, 2 H, CH2, 3JH,H = 6.0 Hz); 6.88 (dt, 1 H, CHPy, 3JH,F = 9.1 Hz, 4JH,H = 1.9 Hz); 6.98 (d, 1 H, CHInd, 3JH,H = 8.4 Hz); 7.10 (d, 1 H, CHInd, 3JH,H = 8.4 Hz); 7.20 (s, 1 H, CHInd); 8.11 (t, 1 H, CHPy, 4JH,H = 1.9 Hz); 8.32 (d, 1 H, CHPy, 4JH,H = 1.9 Hz). 13C NMR (CDCl3), delta: 21.2, 22.5, 32.8, 43.6, 45.4, 51.4, 52.1, 107.6, 108.1, 117.5, 122.1, 122.8 (d, CPy(4), 2JC,F = 18 Hz); 125.9, 128.0, 132.5, 134.0, 135.6 (d, CPy(3), 3JC,F = 3 Hz); 136.1 (d, CPy(6), 2JC,F = 23 Hz); 145.5 (d, CPy(2), 3JC,F = 4 Hz); 156.4, 161.5 (d, CPy(5), 1JC,F = 257 Hz). 19F NMR (CDCl3), delta: -47.5 (d, 3JF,H = 9.1 Hz). Rf 0.46 (CHCl3-MeOH,10 : 1). Found (%): C, 74.41; H, 6.68; N, 12.79. C20H22FN3. Calculated (%): C, 74.28; H, 6.86; N, 12.99.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 1133879-69-2, 3-Fluoro-5-vinylpyridine, other downstream synthetic routes, hurry up and to see.

Reference:
Article; Aksinenko, A. Yu.; Bachurin, S. O.; Maleev, G. V.; Nebogatikov, V. O.; Shevtsova, E. F.; Ustyugov, A. A.; Vasil?eva, N. A.; Vikharev, Yu. B.; Russian Chemical Bulletin; vol. 69; 4; (2020); p. 781 – 786; Izv. Akad. Nauk, Ser. Khim.; 4; (2020); p. 781 – 786,6;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Application of 75806-86-9, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.75806-86-9, name is 2-Bromo-5-chloro-3-nitropyridine, molecular formula is C5H2BrClN2O2, molecular weight is 237.44, as common compound, the synthetic route is as follows.

Example 192: 5-Chloro-2-(2,6-dimethyl-phenoxy)-pyridin-3-ylamine; 2-Bromo-3-nitro-5-chloropyridine (4.8g, 20mmol) and 2,6-dimethylpheno. (5.Og, 41 mmol) were magnetically stirred in dry DMF (65mL) and potassium carbonate 0 was added. The mixture was heated at 50 0C for 4 days, allowed to cool to room temperature and added to ice; the product was extracted with ethyl acetate (3 x 100 mL). The extracts were washed with saturated aqueous NaHCO3 and dried (MgSO4), filtered and concentrated to provide the desired product. [00601] The nitro compound (4.5g, 16 mmol) was dissolved in glacial acetic acid (80 mL) and this solution was added dropwise to a well-stirred suspension of iron powder (4.5 g, 80 mmol) in glacial acetic acid (40 mL) heated in an oil bath at 80 0C under nitrogen. The progress of the reaction was checked by LCMS. After 20 min, the reaction was allowed to cool and was diluted with ethyl acetate (120 mL). The resulting mixture was vacuum filtered through a pad of Celite, the filter cake was washed with ethyl acetate (100 mL) and the filtrate was concentrated. The residue was slowly treated with saturated aqueous sodium bicarbonate, followed by the addition of small portions of solid sodium EPO bicarbonate to neutralize the acetic acid. The mixture was extracted using ethyl acetate (3 x 150 m._) and the extracts were dried (MgSO4), filtered and concentrated (rotovap). The product was isolated as a crystalline solid after drying (vacuum), mass spectrum m/z 251.3 (M + H).

The chemical industry reduces the impact on the environment during synthesis 75806-86-9, I believe this compound will play a more active role in future production and life.

Reference:
Patent; CHEMOCENTRYX, INC.; WO2006/76644; (2006); A2;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Related Products of 1214328-96-7, Adding some certain compound to certain chemical reactions, such as: 1214328-96-7, name is Methyl 3-bromo-6-chloropicolinate,molecular formula is C7H5BrClNO2, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 1214328-96-7.

At 0 C., to a solution of methyl 3-bromo-6-chloropyridine-2-carboxylate (700 mg, 2.81 mmol) in methanol (15 mL) was added sodium borohydride (534 mg, 14.06 mmol) in portions. The resulting mixture was then stirred room temperature for 4 h. The reaction was quenched with water (80 mL) carefully and the mixture was extracted with ethyl acetate (80 mL*3). The combined organic phase was washed with brine, and dried over sodium sulfate. The solvent was removed under reduced pressure and the residue was purified by flash chromatography eluting with ethyl acetate in petroleum ether (25% to 60% gradient) to yield (3-bromo-6-chloropyridin-2-yl)methanol as light yellow oil (395 mg, 64%). MS: m/z=221.8 [M+H]+.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 1214328-96-7, Methyl 3-bromo-6-chloropicolinate, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; Merck Patent GmbH; SHERER, Brian A.; (167 pag.)US2016/75711; (2016); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem