Day: April 18, 2022

Electric Literature of 81565-19-7, In the chemical reaction process,reaction time,type of solvent,can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product.An updated downstream synthesis route of 81565-19-7 as follows.

(3) The title compound was obtained from 3-chloro-4- trifluoromethylpyridine by the method described in Eur . J . Org . Chem., (2004), 3793.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,81565-19-7, its application will become more common.

Reference:
Patent; TAISHO PHARMACEUTICAL CO., LTD.; WO2008/18639; (2008); A2;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 56057-19-3, name is 6-Chloro-5-nitro-2-picoline, the common compound, a new synthetic route is introduced below. Application In Synthesis of 6-Chloro-5-nitro-2-picoline

Method B applied to 2-chloro-6-methyl-3-nitropyridine (86 mg, 0.5 mmol) and 5-phenylcarbamoyl-pentanoic acid methyl ester (141 mg, 0.6 mmol) afforded the title compound as viscous oil (61 mg, 38%). 1H NMR (DMSO) delta 1.52-1.73 (m, 4 H), 2.22 (t, J = 6.8 Hz, 2 H), 2.48 (s, 3 H), 2.75 (t, J = 6.8 Hz, 2 H), 3.53 (s, 3 H), 7.13 (d, J = 8.0 Hz), 7.47-7.63 (m, 5 H), 7.93 (d, J = 8.0 Hz).

The synthetic route of 56057-19-3 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; sanofi-aventis; EP1878724; (2008); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 133081-25-1, name is 6-(2-(tert-Butoxycarbonyl)hydrazinyl)nicotinic acid, the common compound, a new synthetic route is introduced below. Recommanded Product: 6-(2-(tert-Butoxycarbonyl)hydrazinyl)nicotinic acid

4. Synthesis of ((3aR, 4R, 6R, 6aR)-6-(7-allyl-2 -amino-6, 8-dioxo-], 6,7,8-tetrahydropurin-9-yl)-2, 2-dimethyl-tetrahydrofuro[3, 4-dill, 3]dioxol-4-ylfrnethyl 6-(2- (tert-butoxycarbonyl)hydrazinyl)nicotinate To a suspension of 6-(2-(tert-butoxycarbonyl)hydrazinyl)nicotinic acid (668 mg,2.63 mmol) in toluene (10 mL, anhydrous) was added 2,4,6-trichlorobenzoyl chloride(959 mg, 3.95 mmol) and DIPEA(679 mg, 5.62 mmol). The suspension was stirred for10 mm and then a suspension of 7-allyl-2-amino-9-((3aR,4R,6R,6aR)-6-(hydroxymethyl)-2,2-dimethyl-tetrahydrofuro[3 ,4-dj [1 ,3]dioxol-4-yl)- lil-purine6,8(711,9H)-dione (500 mg,1.32 mmol) and DMAP (321 mg, 2.63 mmol) in toluene (10 mL, anhydrous) was added. The suspension was stirred for 15 hrs then quenched with brine. The aqueous phase was extracted with EtOAc (20 mL*3). The organic phase was combined, dried over Na2504, filtered and concentrated. The residue was purified byreverse phase biotage to give a white solid product (390 mg, 48%).

The synthetic route of 133081-25-1 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; ASCEND BIOPHARMACEUTICALS PTY LTD; PIETERSZ, Geoffrey, Alan; WO2013/67597; (2013); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Electric Literature of 1211517-76-8, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 1211517-76-8, name is 3-Bromo-5-fluoro-4-methylpyridine. This compound has unique chemical properties. The synthetic route is as follows.

Step 2: A mixture of the intermediate of step 1 (150 mg, 475 pmol), 3-bromo-5-fluoro-4-methylpyridine(108 mg, 570 pL), Cu(l)l (6 mg, 24 pmol), K2C03 (132 mg, 964 pmol) and N,N?-dimethyl ethylendiamine(30 mg, 81 pmol) in toluene (0.5 mL) was heated in a sealed tube to 120 C under N2 atmosphereovernight. The volatiles were removed under reduced pressure and the residue was purified bychromatography (Interchim cartridge 5OSiHP /12 g, EtOAc/Cy) to yield the title compound of example17(111 mg,55%).LC-MS (Method 2): m/z [M-?-H] = 425.1(MW calc. = 424.76); R = 0.79 mm. Step 2: A mixture of the intermediate of step 1 (150 mg, 475 pmol), 3-bromo-5-fluoro-4-methylpyridine(108 mg, 570 pL), Cu(l)l (6 mg, 24 pmol), K2C03 (132 mg, 964 pmol) and N,N?-dimethyl ethylendiamine(30 mg, 81 pmol) in toluene (0.5 mL) was heated in a sealed tube to 120 C under N2 atmosphereovernight. The volatiles were removed under reduced pressure and the residue was purified bychromatography (Interchim cartridge 5OSiHP /12 g, EtOAc/Cy) to yield the title compound of example17(111 mg,55%).LC-MS (Method 2): m/z [M-?-H] = 425.1(MW calc. = 424.76); R = 0.79 mm.

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 1211517-76-8, 3-Bromo-5-fluoro-4-methylpyridine.

Reference:
Patent; GRUeNENTHAL GMBH; NORDHOFF, Sonja; VOSS, Felix; WACHTEN, Sebastian; KLESS, Achim; RITTER, Stefanie; WO2015/90580; (2015); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 107867-51-6, name is 5-(Trifluoromethyl)pyridine-2,3-diamine, molecular formula is C6H6F3N3, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below. Formula: C6H6F3N3

Production Example 59-4 6.1 g of sodium hydrogen sulfite was added to a mixture of 8.6 g of 5-trifluoromethyl-pyridine-2,3-diamine, 11 g of 2-formyl-5-trifluoromethylphenyl ethyl sulfide, and 67 mL of DMF at room temperature. After heating and stirring the mixture for 3 hours at 100C. 1 g of copper (II) chloride dihydrate was added thereto, and the mixture was heated and stirred for 1 hour at 100C. After allowing the mixture to cool to room temperature, the reaction mixture was added to water and was subjected to extraction using ethyl acetate. A combined organic layer was dried using sodium sulfate, and then, was condensed under reduced pressure. The residue was subjected to silicagel column chromatography to obtain yellow solid powder. The powder was washed with hexane to obtain 12 g of 2-(2-ethylsulfanyl-4-trifluoromethyl-phenyl)-6-trifluoromethyl-3H-imidazo[4,5-b]pyridine (hereinafter, referred to as the present condensed heterocyclic compound 59).

With the rapid development of chemical substances, we look forward to future research findings about 107867-51-6.

Reference:
Patent; Sumitomo Chemical Company, Limited; SUZUKI, Tatsuya; IWATA, Atsushi; NOKURA, Yoshihiko; EP2865266; (2015); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Application of 3430-21-5 ,Some common heterocyclic compound, 3430-21-5, molecular formula is C6H7BrN2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

6-Amino-5-methylnicotinonitrile. A mixture of 2-Amino-5-bromo-3-methylpyridine (15.49 g, 82.8 mmol) and Cu(I)CN (9.27 g, 103.5 mmol) in DMF (160 mL) was heated at 150 C. for 24 h. The reaction mixture was poured onto water and the solid which formed was extracted by using ethylacetate (600 mL, 3 times) from aq. NH4OH. The solvent was evaporated and the precipitate purified by chromatography (SiO2, hexanes/EtOAc 4:6). Yield 70%, mp 198-200 C., (Lit. mp 203-205 C.; see Dunn A. D. and Norrie R. J. Prakt. Chem./Chem.-Ztg, 338 (7), 663-666 (1996). Lit. melting point not reported via palladium-catalyzed cyanation; see Maligres, P. et al., Tetrahedron Lett., 40, 8193-8195 (1999).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 3430-21-5, 5-Bromo-3-methylpyridin-2-amine, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; Boykin, David W.; Tidwell, Richard R.; Wilson, W. David; Ismail, Mohamed A.; US2005/282853; (2005); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Related Products of 597532-36-0, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 597532-36-0, name is Ethyl 6-(trifluoromethyl)nicotinate, molecular formula is C9H8F3NO2, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

A mixture of ethyl 6-(trifluoromethyl)nicotinate (2.2 g, 10 mmol), Pd/C (10 wt.%, 100 mg) and platinum(IV)oxide (150 mg, 0.661 mmol) in acetic acid (30 ml_) was stirred in a steel bomb under hydrogen atmosphere (200 psi) at 25 C for 24 hrs. The reaction mixture was filtered through a pad of celite and washed with MeOH (150 ml_). The filtrate was concentrated under reduced pressure providing crude ethyl 6-(trifluoromethyl)piperidine-3-carboxylate (776 mg; mixture of cis and trans isomers) as a colorless oil, which was directly used in the next step without further purification. LCMS (m/z): 226.1 [M+H]+; Rt = 0.36 min.

According to the analysis of related databases, 597532-36-0, the application of this compound in the production field has become more and more popular.

Reference:
Patent; NOVARTIS AG; BARSANTI, Paul A.; HU, Cheng; JIN, Xianming; NG, Simon C.; PFISTER, Keith B.; SENDZIK, Martin; SUTTON, James; WO2012/101063; (2012); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.113293-70-2, name is 2,6-Dichloroisonicotinaldehyde, molecular formula is C6H3Cl2NO, molecular weight is 176, as common compound, the synthetic route is as follows.Product Details of 113293-70-2

Exemplified dye D-2-9a was synthesized in the same manner as exemplified dye D-1-1a, except that compound d-1-8 for exemplified dye D-1-1a was changed to compound d-39-1.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,113293-70-2, 2,6-Dichloroisonicotinaldehyde, and friends who are interested can also refer to it.

Reference:
Patent; FUJIFILM Corporation; Tani, Yukio; Kobayashi, Katsumi; (63 pag.)US9953768; (2018); B2;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 5006-66-6, name is 6-Oxo-1,6-dihydropyridine-3-carboxylic acid. A new synthetic method of this compound is introduced below., Formula: C6H5NO3

To a stirred solution of 6-hydroxynicotinic acid (10 g, 72 mmol) in absolute ethanol (500 mL) was added sulfuric acid (4 mL) at room temperature. The mixture was heated to reflux for 48 h. After cooling down to room temperature, water (50 mL) was added and the reaction mixture was neutralised to pH= 6-7 by portionwise addition of sodiumhydrogen carbonate (caution: gas evolution). The mixture was evaporated under reduced pressure (most of ethanol was removed), and the residue was extracted with ethyl acetate (3 × 50 mL). The combined organic extracts were washed with brine, dried over Na2SO4 and evaporated under reduced pressure leading to the pure ethyl 6-hydroxynicotinate[30] (10 g, 86percent). 1H NMR (400 MHz, CDCl3): delta 13.07 (s,1H), 8.14 (s, 1H), 7.94 (d, 1H, J = 9.9 Hz), 6.51 (d, 1H, J = 9.4 Hz),4.25 (q, 2H, J =7.1 Hz), 1.29 ppm.To a stirred solution of lithium aluminium hydride (1.4 g, 37 mmol,1.2 equiv.) in anhydrous THF (20 mL) at room temperature was added dropwise over 1 h a solution of ethyl 6-hydroxynicotinate (5.1 g,31 mmol) in anhydrous THF (150 mL) at the same temperature. The mixture was stirred at room temperature for 2 h and then heated toreflux for 30 min. The reaction mixture was cooled down to 0 °C andquenched with ethyl acetate (12 mL) and water (6 mL). The solventswere removed and the residue was taken up in refluxing ethanol(200 mL). The solution was filtered through Celite® and ethanol was evaporated under reduced pressure. The crude material was purified bycolumn chromatography on silica gel with ethyl acetate/methanol(75:25) as eluent to afford the pure title compound 12 (2.3 g, 60percent).

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 5006-66-6, 6-Oxo-1,6-dihydropyridine-3-carboxylic acid.

Reference:
Article; Landelle, Gregory; Schmitt, Etienne; Panossian, Armen; Vors, Jean-Pierre; Pazenok, Sergiy; Jeschke, Peter; Gutbrod, Oliver; Leroux, Frederic R.; Journal of Fluorine Chemistry; vol. 203; (2017); p. 155 – 165;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Reference of 10273-89-9, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 10273-89-9, name is 2-(o-tolyl)pyridine. This compound has unique chemical properties. The synthetic route is as follows.

General procedure: Unless otherwise stated, in an Argon filled glove-box a crimp-cap microwave vial equipped with a magnetic stirring bar was charged with the appropriate cyclometalated Ru(ll)-catalyst (like Ru1-Ru46, from 3 mol % to 10 mol %), KOAc (5.9 mg, 0.06 mmol, 30 mol %), K2CO3 (2.0 – 4.0 equiv.), the appropriate DG-containing arene (like N1-N12, 0.20 mmol, 1.0 equiv.), the appropriate (hetero)aryl (pseudo)halide (like X1-X42, 0.2 mmol, 1.0 equiv) and /V-methyl-2- pyrrolidone (NMP) (200 pL, 1 M). The vial was capped and stirred at 35 C for 24 hours. Upon completion, the crude mixture was loaded on a silica gel column and purified by flash chromatography

According to the analysis of related databases, 10273-89-9, the application of this compound in the production field has become more and more popular.

Reference:
Patent; THE UNIVERSITY OF MANCHESTER; LARROSA, Igor; SIMONETTI, Marco; CANNAS, Diego Maria; (94 pag.)WO2019/215426; (2019); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem