Day: April 21, 2022

Application of 1026796-81-5, Adding some certain compound to certain chemical reactions, such as: 1026796-81-5, name is N-(4-Bromopyridin-2-yl)acetamide,molecular formula is C7H7BrN2O, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 1026796-81-5.

A 1 L four-necked flask equipped with a magnetic stirrer, a thermometer, a reflux condenser and a bubbler was charged55.91 g (0.26 mol) of 2-acetylamino-4-bromopyridine, 66.02 g (0.26 mol) of bis (pinacolato) diboron and 76.44 g(0.78mol), 450mL of dioxane was added and stirred. Under nitrogen atmosphere, 3.81g (0.0051mol) of ferrocenepalladium chloride was added,Temperature to 100 reaction 18 to 24 hours,TLC control to the end of the reaction, the temperature was precipitated solids, beating filtration, methanol was added 500mL dissolved, filtered and evaporated to dryness, add heptane beating, to give the product 62.08g, yield 91.1%.

According to the analysis of related databases, 1026796-81-5, the application of this compound in the production field has become more and more popular.

Reference:
Patent; Dalian Lianhua Chemical Co., Ltd.; Li Xin; Zheng Peng; (5 pag.)CN103601745; (2017); B;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Electric Literature of 102645-33-0, In the chemical reaction process,reaction time,type of solvent,can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product.An updated downstream synthesis route of 102645-33-0 as follows.

This aldehyde was dissolved in 100 ml of 2-propanol, mixed with 13.8 g of hydroxylamine hydrochloride and 20 drops of concentrated HCl and heated on a steambath for 1 hour. The mixture was then poured onto 200 g of ice, stirred well and filtered leaving a solid residue. The solid was vacuum dried to give 22.8 g (85%) of the desired 2,5-dichloro-4-pyridinecarboxaldehyde oxime STR6 m.p. 173-174 C.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,102645-33-0, its application will become more common.

Reference:
Patent; The Dow Chemical Company; US4558134; (1985); A;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Adding a certain compound to certain chemical reactions, such as: 1075-62-3, N-(6-Aminopyridin-2-yl)acetamide, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Safety of N-(6-Aminopyridin-2-yl)acetamide, blongs to pyridine-derivatives compound. Safety of N-(6-Aminopyridin-2-yl)acetamide

A. N-(2-Dimethylaminoethyl)-N-(6-amino-2-pyridyl)acetamide The title compound is obtained by following the procedure of part A of Example 13 but substituting an equivalent weight of N-(6-amino-2-pyridyl)acetamide for N-(5-methyl-2-pyridyl)acetamide. The product has b.p. 140-178/0.6 mm.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,1075-62-3, N-(6-Aminopyridin-2-yl)acetamide, and friends who are interested can also refer to it.

Reference:
Patent; Merck & Co., Inc.; US4203988; (1980); A;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Reference of 64690-19-3, Adding some certain compound to certain chemical reactions, such as: 64690-19-3, name is 4-(Octylamino)pyridine,molecular formula is C13H22N2, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 64690-19-3.

Example 8 20.6 g (0.1 mol) of 4-octylaminopyridine, 10.5 g (0.05 mol) of 1,10-dichlorodecane and 30 ml of white spirit (boiling point 155 to 200 C.) were combined and heated to 130 C. The exothermic reaction causes the temperature to increase to 155 C., and at the same time white crystal precipitate out. The reaction mixture was stirred for a further 4 hours at 140 C., and after cooling to room temperature the very fine crystal sludge was filtered over a filterpaper and washed with petroleum ether, giving a beige, solid mass. The reaction product octenidine dihydrochloride in this example is very difficult to filter off with suction since it is produced in very fine form.

According to the analysis of related databases, 64690-19-3, the application of this compound in the production field has become more and more popular.

Reference:
Patent; AIR LIQUIDE SANTE (INTERNATIONAL); US2001/16660; (2001); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Adding a certain compound to certain chemical reactions, such as: 54231-35-5, 3-Fluoro-2-nitropyridine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Recommanded Product: 54231-35-5, blongs to pyridine-derivatives compound. Recommanded Product: 54231-35-5

Step 1: A mixture of 3-fluoro-2-nitropyridine (3 g, 21.1 mmol) and K2CO3 (5.8 g, mmol) in MeOH (30 mL) was refluxed for lh and then cooled to room temperature. The mixture was filtered and the filtrate evaporated to give crude 32-2 as a yellow oil. LC-MS: m/z = 155.1 [M+H]+.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,54231-35-5, 3-Fluoro-2-nitropyridine, and friends who are interested can also refer to it.

Reference:
Patent; BIOGEN IDEC MA INC.; HUTCHINGS, Richard, H.; JONES, John, Howard; CHAO, Jianhua; ENYEDY, Istvan, J.; MARCOTTE, Douglas; WO2014/28669; (2014); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Application of 56673-34-8, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.56673-34-8, name is 3-Bromo-6-mercaptopyridine, molecular formula is C5H4BrNS, molecular weight is 190.06, as common compound, the synthetic route is as follows.

B8. 5-Bromo-pyridine-2-sulfonyl chloride; 2.0 g of 5-bromo-pyridine-2-thiol (compound C2) are dissolved in 40 ml of carbon tetrachloride and 8 ml of water. Subsequently, the suspension is cooled in an ice bath and chlorine gas is passed into the reaction mixture for 20 min (flow: 35 ml/min). Thereafter, nitrogen is passed into the yellow solution to remove excess chlorine. Subsequently, the mixture is diluted with 150 ml of dichloromethane and extracted with 50 ml of brine. The organic layer is separated, dried using Na2SO4, filtered with suction, and evaporated to dryness to afford 2.70 g of the title compound as light yellow needles. M. p. 8O0C. GC-MS: 254.8/256.8/258.8 (77:100:25; M+). TLC: Rf = 0.84 (dichloromethane/ethanol 20:1 parts by volume).

Statistics shows that 56673-34-8 is playing an increasingly important role. we look forward to future research findings about 3-Bromo-6-mercaptopyridine.

Reference:
Patent; ALTANA Pharma AG; WO2007/39578; (2007); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 62150-46-3, name is 4-Bromopicolinamide, the common compound, a new synthetic route is introduced below. SDS of cas: 62150-46-3

The flask was charged with tris(dibenzylideneacetone)dipalladium (0) chloroform adduct (53.2 mg, 51.4 mumol), cesium carbonate (402 mg, 1.23 mmol), 4-bromo- picolinamide (103.4 mg, 0.514 mmol), 8-chloro-2-(2-chlorophenyl)quinoline-3- sulfonamide (200 mg, 0.566 mmol), tBuXPhos (37.0 mg, 77.2 mumol) and filled with N2. Thentoulene (15.0 ml ) was added and N2 was bubbled through the mixture for 10 minutes. The mixture was heated at 100C for 16 hours. The mixture was cooled to room temperature, evaporation of the solvent, diluted with CH2Cl2-MeOH (1:1, 25mL), filtered through a pad of Celite. The mixture was concentrated, and the residue was diluted with MeOH. The solution was purified by HPLC, 20%-70% of B in 35min. The collected fractions were concentrated and neutralized by adding aq. NaHCO3. Filtration and rinse with water gave 4-(8- chloro-2-(2-chlorophenyl)quinoline-3-sulfonamido)picolinamide, 1H-NMR (MeOD) delta 9.33 (s, 1 H), 8.21(d, J= 8.0 Hz, IH), 8.09 (d, J= 7.8 Hz, IH), 7.74 (t, J= 7.8 Hz, IH), 7.61 (s, 1 H), 7.36-7.50 (m, 6 H), 7.08 (d, J= 8.0 Hz, IH) . Mass Spectrum (ESI) m/e = 472.9 (M + 1).

The synthetic route of 62150-46-3 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; AMGEN INC.; WO2008/118455; (2008); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Related Products of 13466-35-8, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 13466-35-8, name is 3-Chloro-2-hydroxypyridine, molecular formula is C5H4ClNO, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

Equipped with a thermometer,Mechanical agitation,Add 150 grams of 1,2-dichloroethane to a 500-mL four-necked flask with a reflux condenser,26.0 g (0.2 mol) of 3-chloro-2-hydroxypyridine (IV) prepared in Example 3,52.0 grams (0.25 moles) of phosphorus pentachloride,Stir the reaction at 60-65 for 10 hours,Then slowly pour the remainder into 200 grams of ice water,Stir well,Then 40wt% sodium hydroxide aqueous solution neutralizes the pH value to 7-8,Layered,Use 1,2-dichloroethane three times for the water layer,50 grams each time,Combine the organic phase,Wash with 30 grams of saturated saline,Then dry with 5 grams of anhydrous sodium sulfate,The solvent was removed by rotary evaporation to obtain 28.1 g of 2,3-dichloropyridine (I), Yield 94.9%, gas phase purity 99.9%.

According to the analysis of related databases, 13466-35-8, the application of this compound in the production field has become more and more popular.

Reference:
Patent; Xin Fa Pharmaceutical Co., Ltd.; Qi Yuxin; Zhang Mingfeng; Ju Lizhu; Wang Quanlong; (9 pag.)CN110818621; (2020); A;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Application of 1111637-74-1, Adding some certain compound to certain chemical reactions, such as: 1111637-74-1, name is 1-(5-Bromo-2-fluoropyridin-3-yl)ethanone,molecular formula is C7H5BrFNO, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 1111637-74-1.

Step 4:77 78To a solution of compound 77 (40 g, 0.184 mol) in ethanol (300 mL) was added NH2NH2 (27.6 g, 0.553 mol) at room temperature. After the addition, the reaction mixture was refluxed overnight. TLC (petroleum ether/EtOAc 3:1 ) indicated the complete consumption of compound 77. The reaction mixture was allowed to cool to room temperature, and concentrated in vacuo to give crude product, which was purified by column chromatography (silica gel, petroleum ether/EtOAc from 10:1 to 3:1 ) to yield 78 (30 g, 76%) as a white solid.

According to the analysis of related databases, 1111637-74-1, the application of this compound in the production field has become more and more popular.

Reference:
Patent; PFIZER INC.; WO2009/16460; (2009); A2;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Electric Literature of 39658-41-8, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 39658-41-8, name is Ethyl 6-aminonicotinate, molecular formula is C8H10N2O2, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

Step 2: To a stirred solution of lithium aluminium hydride (73 mg, 1.93 mmol) in tetrahydrofuran was slowly added solution of ethyl 6-aminonicotinate (80 mg, 0.48 mmol) in tetrahydrofuran at 0 C. under nitrogen. The reaction mixture was stirred at 0 C. for 30 minutes then at room temperature for 3 h. The mixture was quenched at 0 C. with 1N HCl until pH is 3 then basified with sodium carbonate solution until pH is 7. Then the mixture was filtered using celite to remove LAH residue and it was dissolved in ethylacetate and washed with saturated sodium carbonate solution. The organic layer was dried over MgSO4 and filtered. The filtrate was removed in vacuo. The crude condition of (6-aminopyridin-3-yl)methanol (30 mg, crude) was obtained in 50% yield.

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 39658-41-8, Ethyl 6-aminonicotinate.

Reference:
Patent; Gruenenthal GmbH; FRANK, Robert; Christoph, Thomas; Lesch, Bernhard; Lee, Jeewoo; US2013/29961; (2013); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem