Month: April 2022

Application of 56673-34-8, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.56673-34-8, name is 3-Bromo-6-mercaptopyridine, molecular formula is C5H4BrNS, molecular weight is 190.06, as common compound, the synthetic route is as follows.

A suspension of 5-bromo-pyridine-2-thiol (which may be prepared as described for Intermediate 1.05; 2 g, 10.5 mmol) in carbon tetrachloride (40 mL) and water (8 mL) was cooled to 0 C. using an ice-bath. Chlorine gas was bubbled through the reaction mixture for 20 min and then CH2Cl2 (100 mL) was added. The mixture was washed with brine. The organic layer was dried over anhydrous Na2SO4, filtered, and evaporated under reduced pressure to give 5-bromo-pyridine-2-sulfonyl chloride (1.92 g, 71%) as a light yellow solid which was used directly in the next step without further purification. NMR (400 MHz, DMSO-d6) delta: 8.63 (d, J=1.5 Hz, 3H), 8.07 (dd, J=8.3, 2.2 Hz, 3H), 7.68 (d, J=8.3 Hz, 3H).

Statistics shows that 56673-34-8 is playing an increasingly important role. we look forward to future research findings about 3-Bromo-6-mercaptopyridine.

Reference:
Patent; Firooznia, Fariborz; Gillespie, Paul; Lin, Tai-An; So, Sung-Sau; US2012/309796; (2012); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 108118-69-0, name is 2,6-Difluoropyridin-3-amine. This compound has unique chemical properties. The synthetic route is as follows. Quality Control of 2,6-Difluoropyridin-3-amine

The mixture of methyl (3R,4S)- 1 -methyl-2-oxo-4- [4-(trifluoromethyl)phenyll -3- pyrrolidinecarboxylate (i.e. the product obtained in Step D above) (5 g, 16.6 mmol), 2,6- difluoropyridin-3-amine (2.37 g, 18.2 mmol) and xylene (45 mL) was heated to the refluxtemperature (142 C) for 10 h, while the methanol generated was distilled out to maintain the pot temperature at 142 C. The progress of reaction was monitored by HPLC until the conversion was greater than 97%. The mixture was concentrated under reduced pressure and purified by silica gel colunm chromatography, eluting with 35% ethyl acetate in hexanes to provide 5.88 g of an off-white solid, which was recrystallized from a mixture of n-chlorobutane (50 mL) and hexanes 75 mL to afford the title product (2.3 g, 99.8% e.e.) as white solid.1H NMR oe 3.02 (s, 3H), 3.48 (dd, 1H), 3.64 (d, 1H), 3.81 (dd, 1H), 4.12 (q, 1H), 6.78 (dd,1H), 7.49 (d, 2H), 7.65 (d, 2H), 8.72 (m, 1H), 10.07 (s, 1H).

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 108118-69-0, 2,6-Difluoropyridin-3-amine.

Reference:
Patent; FMC CORPORATION; CHEN, Yuzhong; (56 pag.)WO2018/175226; (2018); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Related Products of 271-29-4, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.271-29-4, name is 1H-Pyrrolo[2,3-c]pyridine, molecular formula is C7H6N2, molecular weight is 118.14, as common compound, the synthetic route is as follows.

1.1 7.0 g (106 mmol) of potassium hydroxide pellets are added to a solution of 5.00 g (42.3 mmol) of 1H-pyrrolo[2,3-c]pyridine in 80 ml of DMF, and a solution of 10.9 g (42.7 mmol) of iodine in 80 ml of DMF is added dropwise thereto at room temperature and with stirring and stirred for 45 minutes. A solution of 5 ml of 32% ammonia and 1 g of sodium disulfite in 1 l of water is added to the reaction mixture. The resultant precipitate is filtered off with suction, washed with water and dried in vacuo, giving 3-iodo-1H-pyrrolo-[2,3-c]pyridine as orange-yellow solid; ESI 245.

Statistics shows that 271-29-4 is playing an increasingly important role. we look forward to future research findings about 1H-Pyrrolo[2,3-c]pyridine.

Reference:
Patent; Merck Patent Gesellschaft Mit Beschrankter Haftung; US2010/292262; (2010); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Electric Literature of 886373-28-0, Adding some certain compound to certain chemical reactions, such as: 886373-28-0, name is 5-Bromo-3-fluoropicolinonitrile,molecular formula is C6H2BrFN2, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 886373-28-0.

Cone. HCl (300 mL) were added to 5-Bromo-3-fluoro-pyridine-2-carbonitrile (21.0 g,0.11 mol) and stirred over night at 600C. After evaporation ether was added and the suspension was stirred for additional time. The solid was collected and dried. The crude product was used without any further purification. MS (m/z): 219.8 [M+H*]

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 886373-28-0, 5-Bromo-3-fluoropicolinonitrile, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; JERINI AG; WO2009/36996; (2009); A2;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.75711-01-2, name is 6-Chloro-5-methoxypyridin-3-amine, molecular formula is C6H7ClN2O, molecular weight is 158.59, as common compound, the synthetic route is as follows.SDS of cas: 75711-01-2

a 2-Chloro-3-methoxypyridin-5 -amine (500 mg, 3.15 mmol; Eastman Kodak US patent US4204870, column 38) and triethyl orthoformate (3.04 ml, 18.29 mmol) under a dry atmosphere was stirred at 145 0C for 1 hour. The solution was cooled to room temperature and concentrated. The residue was dried under high vacuum overnight, dissolved in ethanol (5 ml). Sodium borohydride (143 mg, 3.78 mmol) was added to this solution. The resulting mixture was stirred at 800C for 1 hour. The reaction mixture was concentrated and quenched with ice and water (20ml). Concentrated hydrochloric acid (0.5 ml) was added. The pH of solution was adjusted to pH 7 with sodium bicarbonate and the mixture was extracted with ethyl acetate (x3) The combined organic phases were washed with water, dried over sodium sulfate and concentrated. The crude product was purified by flash chromatography on silica gel eluting with 25 to 30% ethyl acetate in petroleum ether. The solvent was evaporated to dryness to afford 6-chloro-5 -me thoxy-N-methylpyridin-3 -amine (357 mg, 65.6%) as a beige solid. NMR Spectrum: (DMSOd) 2.71 (d, 3H), 3.82 (s, 3H), 6.07 (q, IH), 6.65 (d, IH), 7.28 (d, IH); Mass spectrum: MH+ 173.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,75711-01-2, 6-Chloro-5-methoxypyridin-3-amine, and friends who are interested can also refer to it.

Reference:
Patent; ASTRAZENECA AB; ASTRAZENECA UK LIMITED; WO2009/10794; (2009); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 88912-24-7, name is 5,6-Dichloropicolinic acid, the common compound, a new synthetic route is introduced below. Safety of 5,6-Dichloropicolinic acid

EXAMPLE 14 5,6-bis(ethylthio)-2-pyridinecarboxylic acid Potassium t-butoxide (111 g) was stirred in 200 ml of DMSO under N2. The reaction vessel was cooled with an ice bath while ethanethiol (43 g) was added, and the mixture was stirred for 30 minutes. The cold bath was removed, and 5,6-dichloro-2-pyridinecarboxylic acid (55 g) in 300 ml of DMSO was added. The mixture was stirred at 75 C. for 20 hours. After cooling, the mixture was added to 2 liters of ice water, then acidified with concentrated HCl. The white solid which formed was collected and dried to give 66.15 g of the crude product. A portion of the crude product was recrystallized from isopropanol which gave purified 5,6-bis(ethylthio)-2-pyridinecarboxylic acid, m.p. 112-113 C. Other bis(R-thio)pyridines were prepared by the decarboxylation of the appropriate bis(R-thio)-2-pyridinecarboxylic acid using the procedures described herein. These compounds are:

The synthetic route of 88912-24-7 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; The Dow Chemical Company; US4616087; (1986); A;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Synthetic Route of 77199-09-8, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 77199-09-8, name is Ethyl 5-bromopicolinate. This compound has unique chemical properties. The synthetic route is as follows.

Reference Example 256 Production of ethyl 5-ethenylpyridine-2-carboxylate A mixture of the compound of Reference Example 255 (20.0 g, 86.9 mmol), tributylvinyltin (28.1 mL, 95.6 mmol), Pd(PPh3)4 (2.01 g, 1.74 mmol) and DMF (100 mL) was stirred at 100C for 2 hr under an argon atmosphere. To the reaction mixture was added water (200 mL), and the mixture was extracted with ethyl acetate (400 mL). The extract was washed with brine (200 mL), and dried over anhydrous sodium sulfate. The insoluble material was removed by filtration, and the solution was concentrated under reduced pressure. The residue was purified by silica gel column chromatography (eluent, hexane:ethyl acetate=98:2?20:80) to give the title compound (16.5 g, 100%) as a pale-yellow oil. 1H NMR (300 MHz, DMSO-d6) delta:1.33 (3 H, t, J = 7.1 Hz), 4.34 (2 H, q, J = 7.1 Hz), 5.56 (1 H, d, J = 11.1 Hz), 6.14 (1 H, d, J = 17.8 Hz), 6.87 (1 H, dd, J = 11.1, 17.8 Hz), 8.00-8.06 (1 H, m), 8.07-8.16 (1 H, m), 8.80 (1 H, d, J = 1.9 Hz).

According to the analysis of related databases, 77199-09-8, the application of this compound in the production field has become more and more popular.

Reference:
Patent; Takeda Pharmaceutical Company Limited; EP2471789; (2012); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Adding a certain compound to certain chemical reactions, such as: 71777-70-3, Ethyl 4-ethoxypicolinate, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Recommanded Product: 71777-70-3, blongs to pyridine-derivatives compound. Recommanded Product: 71777-70-3

Step-2: 4-Ethoxypicolinohydrazide: To a 0 C cooled solution of ethyl 4-ethoxypicolinate (5.0 g, 25.6 mmol) in ethanol (20 mL) was added hydrazine hydrate (6.0 g, 120 mmol) drop-wise. After stirring for 2 h at RT, the separated out solid was filtered. The solid residue was washed with water (50 mL) and dried to yield 5.80 g (99%) of the title compound as white solid HNMR (400 MHz, DMSO) delta 9.82 (brs, 1H, D20 exchangeable), 8.40 (d, = 5.5 Hz, 1Eta), 7.46 (d, = 2.5 Hz, 1Eta), 7.09(dd, = 5.5 &2.5HZ, 1Eta), 4.54 (brs, 2Eta, D20 exchangeable), 4.11(q, = 7.0Hz, 2Eta), 1.38 (t, = 7.0Hz,3H); GC-MS (m/z) 181(M)+.

The synthetic route of 71777-70-3 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; LUPIN LIMITED; IRLAPATI, Nageswara, Rao; SHAIKH, Zubair, Abdul Wajid; KARCHE, Vijay, Pandurang; DESHMUKH, Gokul, Keruji; SINHA, Neelima; PALLE, Venkata, P.; KAMBOJ, Rajender, Kumar; WO2013/164769; (2013); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Adding a certain compound to certain chemical reactions, such as: 13269-19-7, 2-Nitropyridin-3-amine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, category: pyridine-derivatives, blongs to pyridine-derivatives compound. category: pyridine-derivatives

Oxalylchloride (132 muL, 1.5 mmol) was added dropwise to a stirred suspension ofbenzoic acid 124 (355 mg, 1.0 mmol) and DMF (1 drop) in dry THF (20 mL) and thesolution was stirred at 20 C. for 2 h, then at 66 C. for 1 h. The solutionwas cooled to 20 C., then the solvent was evaporated and the residue dissolvedin dry pyridine (10 mL). 2-Nitro-3-pyridinylamine (156 mg, 1.1 mmol) was addedand the solution stirred at 20 C. for 16 h. The solvent was evaporated and theresidue suspended in ice/water (50 mL) for 1 h. The precipitate was filtered,washed with water (5 mL) and dried. The crude solid was purified by columnchromatography, eluting with a gradient (50-100%) of EtOAc/pet. ether, to givebenzamide 134 (64 mg, 13%).

At the same time, in my other blogs, there are other synthetic methods of this type of compound,13269-19-7, 2-Nitropyridin-3-amine, and friends who are interested can also refer to it.

Reference:
Patent; THEBOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY; AUCKLANDUNISERVICES LIMITED; SUTPHIN, PATRICK; CHAN, DENISE; TURCOTTE, SANDRA; DENNY, WILLIAMALEXANDER; HAY, MICHAELPATRICK; GIDDENS, ANNACLAIRE; BONNET, MURIEL; GIACCIA, AMATO; (181 pag.)JP5789603; (2015); B2;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Related Products of 89809-63-2, Adding some certain compound to certain chemical reactions, such as: 89809-63-2, name is 5-Methoxypicolinonitrile,molecular formula is C7H6N2O, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 89809-63-2.

To a suspension of 5-(methyloxy)-2-pyridinecarbonitrile (3 g, 22.4 mmol) in dry EtOH (35 mL) was added NaOMe (0.12 g, 2.24 mmol). The resulting mixture was stirred at room temperature for 17 hr. Ammonium chloride (1 .56 g, 29.1 mmol) was added then the resulting mixture refluxed for 1 hr. The mixture was allowed to cool to room temperature then concentrated under reduced pressure to give the crude product as a brown solid. The crude product was triturated with diethyl ether and the resulting suspension filtered under vacuum then dried at 40C under vacuum to give the title compound as an orange solid (4.3g). LCMS (Method B): Rt = 0.49min, MH+ 152.0

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 89809-63-2, 5-Methoxypicolinonitrile, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; GLAXO GROUP LIMITED; ATKINSON, Stephen John; BARKER, Michael David; CAMPBELL, Matthew; HUMPHREYS, Philip; LIDDLE, John; SHEPPARD, Robert John; WILSON, David; WO2012/52390; (2012); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem