Month: April 2022

Related Products of 97944-43-9, Adding some certain compound to certain chemical reactions, such as: 97944-43-9, name is 3-Bromo-5-methylpyridin-4-amine,molecular formula is C6H7BrN2, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 97944-43-9.

2.2 5-Methyl-[3,4′]bipyridinyl-4-ylamine A mixture of 3-bromo-5-methyl-pyridin-4-ylamine (1.00 g, 5.347 mmol), pyridin-4-yl boronic acid (0.65 g, 5.347 mmol), K2CO3 (2.22 g, 16.04 mmol) and Pd(dppf)Cl2 (436 mg, 0.5347 mmol) in water (3 mL) and 1,4-dioxane (15 mL) was stirred at 105 C. overnight. The mixture was diluted with EtOAc (100 mL) and washed with brine (30 mL*4). The organic layer was dried over Na2SO4, filtered and concentrated in vacuo. The residue was purified on a silica column (EtOAc) to afford the title product as a white solid (554 mg, yield 56%). LCMS (ESI+): m/z 186 (M+H)+, Rt: 1.16 min.

According to the analysis of related databases, 97944-43-9, the application of this compound in the production field has become more and more popular.

Reference:
Patent; Abbott Laboratories; Abbott GmbH & Co. KG; US2013/5705; (2013); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 92992-85-3, name is 2-Bromo-3,5-dimethylpyridine. This compound has unique chemical properties. The synthetic route is as follows. SDS of cas: 92992-85-3

j0209] Under nitrogen condition, 2-bromine-3,5-dimethyl pyridine (500.00 mg, 2.69 mmol, 1.00 eq) and WX1313-3-1 (592.07 mg, 2.96 mmol, 1.10 eq) were dissolved in methylbenzene (25 ml). Tris(dibenzylideneacetone)dipalladium (246.10 mg, 269.00 tmol, 0.10 eq), sodium tert-butoxide (387.40 mg, 4.04 mmol, 1.50 eq) and 1,1?-binaphthyl-2,2?- bis (diphenylphosphino) (335.00 mg, 538.00 tmol, 0.20 eq) were added. The mixture was stirred at 90 C. for 18 h. After reaction, the reaction liquid was filtered through diatomite to remove the palladium catalyst, the filter cake was washed with ethyl acetate (10 ml), the solvent was dried by rotary evaporation under vacuum, and ethyl acetate (30 ml) was added. Then the resulting mixture was washed with water (10 ml), the methyl acetate phase was dry-spined under vacuum, and the crude was purified by column chromatography (ethyl acetate:petroleum ether=1.-20%) to obtain WXO12-1 (Rf=0.5). ?H NMR (400 MHz, CDC13) oeppm:7.74 (s, 1H), 6.99 (s, 1H), 4.08-4.02 (m, 1H), 3.98 (br, s, 1H), 3.60-3.57 (m, 1H), 3.30-3.38 (m, 2H), 3.29-3.24 (m, 1H), 2.07 (s, 3H), 1.97 (s, 3H), 1.84-1.82 (m, 1H), 1.71-1.60 (m, 2H), 1.49-1.43 (m, 1H), 1.33 (s, 9H).

With the rapid development of chemical substances, we look forward to future research findings about 92992-85-3.

Reference:
Patent; SHENZHEN SALUBRIS PHARM CO LTD.; Wu, Chengde; Yan, Jie; Xu, Wenjie; Yu, Tao; Li, Ning; Chen, Shuhui; US2018/305346; (2018); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 6854-07-5, name is 5-Nitro-2-oxo-3-pyridinecarboxylic Acid. This compound has unique chemical properties. The synthetic route is as follows. Formula: C6H4N2O5

4b) 2-Chloro-5-nitropyhdin-3-yl phenyl ketone; 18.4 g of the acid prepared in example 4a) is admixed at 25C with 120 ml of thionyl chloride followed by 3 ml of DMF, and subsequently heated at reflux for 3 hours. The excess thionyl chloride is removed under reduced pressure and the yellow solid that remains is dissolved in 100 ml of benzene. This solution is admixed with 4O g of AICI3 at 00C and then stirred at 25C for 16 hours. The reaction mixture is then poured cautiously into cold (partly frozen) concentrated hydrochloric acid; after one hour the mixture is filtered and the organic phase is separated off. The organic phase is washed with hydrochloric acid, dried over sodium sulfate, filtered and concentrated under reduced pressure. The resulting residue is purified by chromatography on silica gel with hexane/10% ethyl acetate. This gives 15 g of the title compound. NMR (300 MHz, DMSO-d6): delta = 7.60 (2H), 7.77 (1 H), 7.87 (2H), 8.95 (1 H), 9.4 (1 H).

With the rapid development of chemical substances, we look forward to future research findings about 6854-07-5.

Reference:
Patent; BAYER SCHERING PHARMA AKTIENGESELLSCHAFT; BAYER HEALTHCARE AKTIENGESELLSCHAFT; WO2009/30725; (2009); A2;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Related Products of 1003711-43-0, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 1003711-43-0, name is 2-Bromo-5-hydroxy-3-methylpyridine, molecular formula is C6H6BrNO, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

(A) A mixture of 6-bromo-5-methylpyridin-3-ol (1 g, 5.32 mmol), 1-bromo-2- methoxyethane (730 mg, 5.25 mmol) and K2CO3 (1.5 g, 10.87 mmol) in MeCN (20 mL) was stirred at rt overnight, after which the reaction was quenched by the addition of water (100 mL). The resulting solution was extracted with EtOAc (2 x 100 mL) and the combined organic phase was dried (Na2SO4) and concentrated under reduced pressure. The resultant residue was purified by silica gel chromatography (0-15% EtOAc/petroleum ether) to afford 2-bromo-5-(2-methoxyethoxy)-3-methylpyridine (500 mg, 38 %) as colorless oil. LC/MS: mass calcd. for C9H12BrNO2: 246.10, found: 246.0 [M]+, 248.0 [M+2]+.

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 1003711-43-0, 2-Bromo-5-hydroxy-3-methylpyridine.

Reference:
Patent; JANSSEN PHARMACEUTICA NV; KUO, Gee-Hong; PLAYER, Mark R.; YANG, Shyh-Ming; ZHANG, Yue-Mie; HUANG, Hui; (260 pag.)WO2016/57731; (2016); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Related Products of 23056-40-8, Adding some certain compound to certain chemical reactions, such as: 23056-40-8, name is 2-Chloro-5-methyl-3-nitropyridine,molecular formula is C6H5ClN2O2, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 23056-40-8.

Synthesis of the compound 16 The compound 15 (3 g, 0.017 mol) was dissolved with agitation in a concentrated sulphuric acid (80 mL) in ice bath , the sodium dichromate (7.5 g, 0.025 mol) was added slowly in batches into the system, and the reaction was run at room temperature (25C) for 12 h. The above reaction liquid was added slowly into broken ice (50 g) and extracted with 50mL of ethyl acetate for three times. The extracts were combined, washed with a saturated aqueous solution of table salt, dried over anhydrous magnesium sulfate, and then was subject to filtration. The solvent was evaporated off and 2.9 g of the crude product was obtained with a yield of 82.8%. The crude product was recrystallized in ethanol to obtain 2.4 g of the solid product with a yield of 68.6 % and a melting point of 218C (ethanol)[J.O.C., 1985, 50, 1041].

According to the analysis of related databases, 23056-40-8, the application of this compound in the production field has become more and more popular.

Reference:
Patent; Beijing Yiling Bioengineering Co., Ltd.; EP2366691; (2011); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Electric Literature of 97986-08-8, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 97986-08-8, name is N,6-dimethylpyridin-2-amine. A new synthetic method of this compound is introduced below.

Example 110 4′-Cyano-biphenyl-4-sulfonic acid methyl-(6-methyl-pyridin-2-yl)-amide To a solution of N,6-dimethylpyridin-2-amine (0.15 g, 1.24 mmol) in THF (5 ml) was added NaHMDS (1.56 mL, 1.56 mmol) at R.T. After 15 min, 4′-cyanobiphenyl-4-sulfonyl chloride (0.28 g, 1.03 mmol) was added to the reaction mixture and stirred for 1 hour. The reaction mixture was diluted with ethyl acetate (30 mL) and washed with saturated aqueous sodium bicarbonate (2*30 mL). The collected organic layer was dried over anhydrous sodium sulfate, filtered, and concentrated. The resulting residue was purified with radial chromatography (2 mm silica plate, 2:1 hexanes/ethyl acetate) to yield a clear oil. The product was converted to a HCl salt by dissolving in 5 mL diethyl ether and adding 1 N HCl in diethyl ether dropwise.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,97986-08-8, its application will become more common.

Reference:
Patent; AGOURON PHARMACEUTICALS, INC.; US2005/148631; (2005); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 823221-93-8, name is 5-Bromo-2-chloro-4-(trifluoromethyl)pyridine. A new synthetic method of this compound is introduced below., Quality Control of 5-Bromo-2-chloro-4-(trifluoromethyl)pyridine

To a solution of butyl magnesium chloride (27.8mL, 47.2mmol, 0.7eq, 1.7 M in THF) in THF was added butyl lithium (30.0mL, 74.3mmol, l. leq, 2.5M in hexane) at 0C and the reaction mixture was stirred for 10 min, then diluted with THF (80mL) and cooled to -78C. Then, 5-bromo-2-chloro-4-(trifluoromethyl)pyridine (17.5g, 67.5mmol, leqm procedure described in Example 93) in THF (30mL) was added and the reaction mixture was stirred for lh at same temperature, before being poured onto crushed dry ice then slowly allowed to warm to RT for 16h. TLC indicated polar spot and the reaction mixture was concentrated and acidified with 2N HC1 (80mL) and extracted with EtOAc (2X 500mL). The organic layer was separated, dried with sodium sulfate and concentrated under reduced pressure to give crude residue. The crude compound was recrystallized from n-pentane (30mL) and dried using high vacuum to give 6-chloro-4-(trifluoromethyl)nicotinic acid (lOg, 66.6%) as an off white solid compound. LCMS: [M+H]+ 224.05.

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 823221-93-8, 5-Bromo-2-chloro-4-(trifluoromethyl)pyridine.

Reference:
Patent; ONTARIO INSTITUTE FOR CANCER RESEARCH (OICR); AL-AWAR, Rima; ZEPEDA-VELAZQUEZ, Carlos Armando; PODA, Gennady; ISAAC, Methvin; UEHLING, David; WILSON, Brian; JOSEPH, Babu; LIU, Yong; SUBRAMANIAN, Pandiaraju; MAMAI, Ahmed; PRAKESCH, Michael; STILLE, Julia Kathleen; (1053 pag.)WO2017/147700; (2017); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 13362-30-6, name is Ethyl 2-aminoisonicotinate, the common compound, a new synthetic route is introduced below. Product Details of 13362-30-6

Example 97 Preparation of ethyl 2-valeramidoisonicotinate ([9]-(94)-467) The compound ([9]-(93)-467′) (2.0691 g) prepared in Example 96 was dissolved in anhydrous pyridine (25 ml), and valeryl chloride (1.5 ml) was added dropwise to the solution with stirring and cooling on ice. After stirring and cooling on ice for 1 hour, the reaction solution was poured into ice water. The solution was extracted with ethyl acetate, washed with water and saturated brine, dried over anhydrous sodium sulfate, and concentrated. The resulting light yellow oil (3.2548 g) was purified by silica gel column chromatography (Kieselgel 60=160 g, hexane/ethyl acetate=5/1) to obtain the above-captioned compound ([9]-(94)-467) (3.0820 g) as white crystals. Melting point: 46.0-47.0 C. 1 H-NMR (500MHz, CDCl3) delta: 0.96 (t, 3H), 1.41 (t, 3H), 1.43 (sext, 2H), 1.74 (quint, 2H), 2.42 (t, 2H), 4.41 (q, 2H), 7.60 (dd, 1H), 8.04 (bs, 1H), 8.38 (dd, 1H), 8.74 (s, 1H)

The synthetic route of 13362-30-6 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Kureha Chemical Industry Co., Ltd.; US5696118; (1997); A;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Adding a certain compound to certain chemical reactions, such as: 1214323-40-6, 5-Chloro-2-(difluoromethoxy)pyridine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Product Details of 1214323-40-6, blongs to pyridine-derivatives compound. Product Details of 1214323-40-6

A stirred mixture of 5-chloro-2-(difluoromethoxy)pyridine (0.13 g, 0.75 mmol), bis(pinacolato)diboron (0.21 g, 0.83 mmol), [l,l-bis(diphenylphosphino)- ferrocene]palladium(II) chloride, complex with DCM (62 mg, 0.076 mmol), and potassium acetate (0.23 g, 2.3 mmol) in dry 1,4-dioxane (4 mL) was purged three times with argon and placed under vacuum three times. The mixture was heated to 90 C and monitored with LC-MS and TLC. After 21 h, the reaction was cooled to rt then filtered through Celite. The organic solvent was removed under reduced pressure, and the black residue was identified as (6-(difluoro- methoxy)pyridin-3-yl)boronic acid, used without purification.

The synthetic route of 1214323-40-6 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; AMGEN INC.; DRANSFIELD, Paul, John; GONZALEZ LOPEZ DE TURISO, Felix; KOHN, Todd, J.; PATTAROPONG, Vatee; SIMARD, Jillian, L.; WO2012/3283; (2012); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Application of 62002-31-7 ,Some common heterocyclic compound, 62002-31-7, molecular formula is C6H11Cl2N3, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

To a stirred solution of 1H,4H,5H,6H,7H-imidazo[4,5-c]pyridine dihydrochloride(7 g, 35.70 mmol, 1 equiv.) and DIEA(13.8 g, 107.10 mmol, 3 equiv.) in DMA(150 mL) was added 4,5-dichloro-2-(oxan-2-yl)-2,3-dihydropyridazin-3-one (8.9 g, 35.70 mmol, 1 equiv.) at room temperature. The resulting mixture was stirred for 16 h at 100 degrees C. The product was purified by reverse phase flash with the following conditions (Column: spherical C18, 20-40 um,330g; Mobile Phase A: Water(5mmol/L NH4HCO3), Mobile Phase B: MeCN; Flow rate: 80 mL/min; Gradient: 15% B to 30% B in 20 min; 220 nm) to afford 4-chloro-5-[1H,4H,5H,6H,7H- imidazo[4,5-c]pyridin-5-yl]-2-(oxan-2-yl)-2,3-dihydropyridazin-3-one (6.86 g, 57.23%) as a yellow solid.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,62002-31-7, its application will become more common.

Reference:
Patent; GOLDFINCH BIO, INC.; YU, Maolin; DANIELS, Matthew, H.; HARMANGE, Jean-christophe, P.; TIBBITTS, Thomas, T.; LEDEBOER, Mark, W.; WALSH, Liron; MUNDEL, Peter, H.; MALOJCIC, Goran; (860 pag.)WO2019/55966; (2019); A2;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem