Month: April 2022

Application of 878197-68-3, Adding some certain compound to certain chemical reactions, such as: 878197-68-3, name is 5-Bromoimidazo[1,2-a]pyridine-2-carbaldehyde,molecular formula is C8H5BrN2O, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 878197-68-3.

A solution of (5-bromoimidazo[1 ,2-a]pyridin-2-yl)methanol (150 mg, 0.66 mmol) in morpholine (500 muL) was subjected to microwave irradiation at 200C for 20 minutes. Reaction mixture was concentrated and purified by preparative chromatography (0- 5% ammonium hydroxide-acetonitrile) to give [5-(4-morpholinyl)imidazo[1 ,2-a]pyridin- 2-yl]methanol. To this alcohol in chloroform (6.6 mL) was added manganese dioxide (574 mg, 6.6 mmol). The reaction mixture was stirred at room temperature overnight, filtered through celite, rinsed with dichloromethane, and concentratred to give 150 mg (98% yield) 5-(4-morpholinyl)imidazo[1 ,2-a]pyridine-2-carbaldehyde. 1H-NMR (CDCI3): delta 10.16 (s, 1 H), 8.16 (s, 1 H), 7.46 (d, 1 H), 7.30 (m, 1 H), 6.40 (d, 1 H), 3.94 (m, 4H), 3.13 (m, 4H); MS m/z 232 (M+1 ).

According to the analysis of related databases, 878197-68-3, the application of this compound in the production field has become more and more popular.

Reference:
Patent; SMITHKLINE BEECHAM CORPORATION; WO2006/36816; (2006); A2;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 799293-73-5, name is 3-Bromofuro[3,2-c]pyridin-4-amine. This compound has unique chemical properties. The synthetic route is as follows. Quality Control of 3-Bromofuro[3,2-c]pyridin-4-amine

The mixture of 4-amino-3-bromo-furo [3,2-c] pyridine (7) (63 mg, 0. 29MOL), 4- (4,4, 5, 5-tetramethyl-1, 3, 2-dioxaborolan-2-yl) aniline (84 mg, 0.38 MMOL), Pd (PPH3) 4 (34 mg, 0.029 MMOL) and sodium carbonate (0.74 ml, 1.5 MMOL) in 3 ml of DME was stirred for 14 hours at 80C. The solvent was removed, and the resultant residue was purified by chromatography on a silica gel column gel to afford the titled compound (55 mg) 1 H NMR (400MHZ, DMSO-d6) ppm 7.82 (d, J = 6. 1 Hz, 1H), 7.77 (s, 1H), 7.15 (d, J = 8.3 Hz, 2H), 6.89 (d, J = 5.8 Hz, 1H), 6.69 (d, J = 8. 3 Hz, 2H), 5.49 (s, 2H), 5.32 (s, 2H). MS: m/z 226 (M+H) +

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 799293-73-5, 3-Bromofuro[3,2-c]pyridin-4-amine.

Reference:
Patent; SMITHKLINE BEECHAM CORPORATION; WO2004/100947; (2004); A2;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Reference of 63572-73-6, Adding some certain compound to certain chemical reactions, such as: 63572-73-6, name is 5-Nitro-1H-pyrazolo[3,4-b]pyridine,molecular formula is C6H4N4O2, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 63572-73-6.

Compound 1 (2 g, 12.2 mmol, 1.0 eq),Soluble in DMF (20mL),NBS (2.5 g, 14.0 mmol, 1.15 eq) was added in portions at 0 C.The reaction was carried out for 16 hours at room temperature.LCMS showed the reaction of the starting material,There is product generation. Concentrate and spin dry to a crude product.Purified by column (PE/EA=100:1-10:1),Yellow solid compound 2 (1.4 g, yield: 94%).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 63572-73-6, 5-Nitro-1H-pyrazolo[3,4-b]pyridine, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; Nanjing Kefeipingshenghui Pharmaceutical Co., Ltd.; Jin Qiu; Qin Yinlin; Su Mei; Qiu Yanan; Lou Yajing; (23 pag.)CN109206401; (2019); A;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Adding a certain compound to certain chemical reactions, such as: 6515-09-9, 2,3,6-Trichloropyridine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 6515-09-9, blongs to pyridine-derivatives compound. Computed Properties of C5H2Cl3N

A solution of n-butyllithium in hexanes (2.5M, 30 mmol, 12 mL) was added drop-wise to a solution of (1321) diisopropylamine (30 mmol, 4.3 mL) in dry THF (100 mL) at -78 C. After 1 hour, a solution of 2,3,6- trichloropyridine (27.4 mmol, 5 g) in dry THF (25 mL) was added over 15 minutes. After a further 1 hour, a (1322) solution of methyl iodide (30.4 mmol, 1.9 mL) in dry THF (10 mL) was added drop-wise over 5 minutes. The orange- brown solution was stirred at -78 C for 15 minutes, then allowed to warm to room temperature and stirred at room temperature for 18 hours. The reaction was carefully quenched by the addition of saturated aqueous ammonium chloride solution and the mixture was extracted with ethyl acetate. The organic extract was washed with brine, dried (MgS04) and concentrated under reduced pressure. Partial purification of the crude product was achieved by column chromatography (silica gel, gradient of ethyl acetate in isohexane) to give the intermediate 2 , 3 , 6-trichloro-4-methylpyridine as an oily colourless solid (2.4 g) .

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,6515-09-9, its application will become more common.

Reference:
Patent; ONO PHARMACEUTICAL CO., LTD.; SAITO, Tetsuji; HIGASHINO, Masato; KAWAHARADA, Soichi; LEWIS, Arwel; CHAMBERS, Mark Stuart; RAE, Alastair; HIRST, Kim Louise; HARTLEY, Charles David; WO2015/115673; (2015); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Reference of 136888-17-0 ,Some common heterocyclic compound, 136888-17-0, molecular formula is C7H5ClN2O, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

A mixture of 5-chloro-l /-pyrrolo[2,3-c]pyridin-2(3 /)-onc (Step 3 of Intermediate B7) (750 mg, 4.44 mmol) and triethyl orthoacetate (10 mL) was heated at 130 C for 1 h. The reaction mixture was concentrated under reduced pressure and the solid was stirred with diethyl ether. The compound was filtered and dried to yield 800 mg of the desired compound. NMR (400 MHz, DMSO-de) d 1.44 (t, J= 7.2 Hz, 3H), 2.78 (s, 3H), 4.45 (q, J= 7.2 Hz, 2H), 7.41 (s, 1H), 7.82 (s, 1H), 10.58 (s, 1H).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 136888-17-0, 5-Chloro-1H-pyrrolo[2,3-c]pyridin-2(3H)-one, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; ICHNOS SCIENCES S.A.; CHAUDHARI, Sachin, Sundarlal; GHARAT, Laxmikant, Atmaram; IYER, Pravin; DHONE, Sachin, Vasantrao; ADIK, Bharat, Gangadhar; WADEKAR, Prashant, Dilip; GOWDA, Nagaraj; BAJPAI, Malini; (233 pag.)WO2020/70331; (2020); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 1032943-43-3, name is 4-Bromo-1H-pyrazolo[3,4-c]pyridine. This compound has unique chemical properties. The synthetic route is as follows. Recommanded Product: 4-Bromo-1H-pyrazolo[3,4-c]pyridine

4-Bromo- lH-pyrazolo[3 ,4-c]pyridine (2 g, 10.10 mmol) was dissolved in DCM (30 niL) and m-CPBA (2.61 g, 15.15 mmol) was added at 0 C. The reaction mixture was stirred at room temperature for 16 hours. After completion of the reaction, solid precipitate was filtered and dried to afford 4-bromo-6-oxido-lH-pyrazolo[3,4-c]pyridin-6-ium (I, 2 g, 9.34 mmol, 92 52% yield). LCMS (ES +): m/z 215 [M + l l j

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 1032943-43-3, 4-Bromo-1H-pyrazolo[3,4-c]pyridine.

Reference:
Patent; C4 THERAPEUTICS, INC.; NASVESCHUK, Christopher, G.; HENDERSON, James, A.; VORA, Harit, U.; VEITS, Gesine, Kerstin; PHILIPS, Andrew, J.; (576 pag.)WO2020/51235; (2020); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Application of 942473-59-8, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 942473-59-8, name is 2,5-Dibromoisonicotinic acid, molecular formula is C6H3Br2NO2, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

EXAMPLE 1; ethyl 2,5-dibromoisonicotinate (1-2)A solution of 2,5-dibromoisonicotinic acid (KL, 5 g, 17.80 mmol) and sulfuric acid (1.23 mL, 23.1 mmol)in ethanol (100 mL) was heated to reflux overnight. After reducing the volume of ethanol by rotary evaporation to approximately 1A of it’s original volume, the crude reaction mixture was partitioned between 2M sodium carbonate solution and EtOAc, separating layers and washing the organic layer with saturated sodium bicarbonate solution and brine. This solution was dried over anhydrous sodium sulfate, filtered and concentrated. The residue was purified by normal phase column chromatography (O to 50% EtOAc in hexanes) to afford the product (I1T) as a dark oil. ESI+ MS [M]+ C8H7Br2NO2 = 308.0.

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 942473-59-8, 2,5-Dibromoisonicotinic acid.

Reference:
Patent; MERCK SHARP & DOHME CORP.; BERGMAN, Jeffrey, M.; COLEMAN, Paul, J.; MATTERN, Mamio Christa; MERCER, Swati, P.; REGER, Thomas, S.; ROECKER, Anthony, J.; WO2010/51236; (2010); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Related Products of 1849-52-1, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 1849-52-1, name is 3-Methoxyisonicotinaldehyde. This compound has unique chemical properties. The synthetic route is as follows.

Compound VI (23.8 g, 0.1 mol) was added to a 500 mL three-necked flask. Add tetrahydrofuran (100 mL), The stirring was started, and tetramethylpiperidine lithium (LTMP) (44 mL, 0.11 mol) was added dropwise at -40 ° C under nitrogen atmosphere. After the addition is completed, continue to stir for 0.5 hours. Then, a solution of 3-methoxy-4-pyridinecarboxaldehyde (13.7 g, 0.1 mol) in tetrahydrofuran was added dropwise. After the drop, continue to react at -40 ° C for 1 hour, TLC point plate monitoring,After the material point disappears, a saturated ammonium chloride solution is added dropwise below zero, and ethyl acetate is added. Extract, separate the organic layer, add anhydrous sodium sulfate to dry, filter,The filtrate was concentrated under reduced pressure.Obtained a yellow solid compound V-1, 32.9 g,The yield was 88percent.

According to the analysis of related databases, 1849-52-1, the application of this compound in the production field has become more and more popular.

Reference:
Patent; Hunan Huateng Pharmaceutical Co., Ltd.; Jin Yanjuan; (11 pag.)CN108689998; (2018); A;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Synthetic Route of 117873-72-0, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 117873-72-0, name is 2,6-Dibromo-4-methoxypyridine, molecular formula is C6H5Br2NO, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

(1) Production of 2-bromo-4-methoxy-6-{3-(trifluoromethoxy)phenoxy} pyridine as an intermediate product 2.00 g (0.00937*1.2 mol) of 3-(trifluoromethoxy) phenol was dissolved in about 20 ml of dimethyl formamide. The solution was further mixed with 0.39 g (ca. 60% in mineral oil; 0.00937*1.04 mol) of sodium hydride and then with 2.50 g (0.00937 mol) of 2,6-dibromo-4-methoxy pyridine. After stirring at about 110 C. for about 4 hours, the mixture was allowed to stand for cooling to room temperature. After the reaction solution was distributed with hexane-saturated sodium bicarbonate water, the organic phase of the obtained solution was washed with saturated brine and dried with anhydrous sodium sulfate. The resultant solution was concentrated and then purified by silica gel column chromatography (eluding solution: ethyl acetate/hexane), and the obtained product was subjected to recrystallization using hexane, thereby obtaining an aimed product. Yield by weight: 1.40 g; yield by percentage: 41%; oily substance; 1 H-NMR (60 MHz, CDCl3, delta): 3.73 (3H, s), 6.25 (1H, d, J=2 Hz), 6.69 (1H, d, J=2 Hz), 6.7-7.5 (4H, complex).

According to the analysis of related databases, 117873-72-0, the application of this compound in the production field has become more and more popular.

Reference:
Patent; Kureha Kagaku Kogyo Kabushiki Kaisha; US6005112; (1999); A;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Application of 697739-12-1, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.697739-12-1, name is Ethyl imidazo[1,5-a]pyridine-8-carboxylate, molecular formula is C10H10N2O2, molecular weight is 190.2, as common compound, the synthetic route is as follows.

Ethyl imidazo [1, 5-a] pyridine-8-carboxylate (J. Het. CLIEIIZ., 1993,473) (0.21 g) was dissolved in 1M KOH in methanol (5 ml) and the solution heated at reflux for 5 min. The mixture was then concentrated, diluted with water (2 ml) and acidified to pH 1 with 2N HCI. The resulting precipitate was collected by filtration to give imidazo [1, 5-a] pyridine-8-carboxylic acid (80 mg) as a yellow solid.

Statistics shows that 697739-12-1 is playing an increasingly important role. we look forward to future research findings about Ethyl imidazo[1,5-a]pyridine-8-carboxylate.

Reference:
Patent; MERCK SHARP & DOHME LIMITED; WO2005/28445; (2005); A2;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem