Month: April 2022

Related Products of 83766-88-5, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 83766-88-5, name is 2-(tert-Butoxy)pyridine, molecular formula is C9H13NO, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

Carboxylic acid (0.2 g, 1.64 mmol), tert-butoxypyridine (0.33 g, 2.21 mmol) and boron trifluoride diethyl etherate (0.31 g, 2.21 mmol) in dry PhCH3 (2 mL) were added to a 20-ml vial. The reaction mixture was then allowed to stir at room temperature for 30 min before quenching with anhydrous NaHCO3. The reaction mixture was diluted with ethyl acetate (30 mL), then washed with water (20 mL), followed by brine (20 mL). The organic layer was dried over anhydrous sodium sulfate and carefully concentrated under reduced pressure. The resulting residue was then purified by flash column chromatography on silica gel with 0:4 to 1:4 dichloromethane/hexane as eluent to yield the desired product 5a as a colorless oil.

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 83766-88-5, 2-(tert-Butoxy)pyridine.

Reference:
Article; La, Minh Thanh; Kim, Hee-Kwon; Tetrahedron; vol. 74; 27; (2018); p. 3748 – 3754;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Reference of 1026201-45-5, Adding some certain compound to certain chemical reactions, such as: 1026201-45-5, name is 8-Bromoimidazo[1,2-a]pyridine-2-carboxylic acid,molecular formula is C8H5BrN2O2, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 1026201-45-5.

A suspension of intermediate 39 (322 mg, 1.34 mmol) and carbonyldiimidazole (238 mg, 1.47 mmol) in THF (11 ml) was stirred at r.t. for 2 h. DIPEA (0.233 ml, 1.34 mmol) was added and the resulting mixture was stirred for 30 min. at r.t. Then DMF (2 ml) was added to the suspension and the mixture was stirred for 60 h at r.t. The r.m. was cooled to 0 0C and O,N-dimethyl-hydroxylamine (143 mg, 1.47 mmol) was added. The mixture was stirred for 20 h at r.t. The solvents were evaporated under reduced pressure. The residue was dissolved in DCM and washed 3 times with H2O. The organic layer was dried (MgSO4), filtered and evaporated under reduced pressure. The residue was purified via flash column chromatography over silicagel (eluent: DCM/MeOH(NH3) from 100/0 to 99/1). The product fractions were collected and the solvent was evaporated in vacuo. Yield: 216 mg of intermediate 42 (57 %).

According to the analysis of related databases, 1026201-45-5, the application of this compound in the production field has become more and more popular.

Reference:
Patent; ORTHO-MCNEIL-JANSSEN PHARMACEUTICALS, INC; GIJSEN, Henricus, Jacobus, Maria; MACDONALD, Gregor, James; BISCHOFF, Francois, Paul; TRESADERN, Gary, John; TRABANCO-SUAREZ, Andres, Avelino; VAN BRANDT, Sven, Franciscus, Anna; BERTHELOT, Didier, Jean-Claude; WO2010/70008; (2010); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Related Products of 940943-37-3, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 940943-37-3, name is S-(2-(6-(4-(3-(Dimethylamino)propoxy)phenylsulfonamido)pyridin-3-yl)-2-oxoethyl) ethanethioate, molecular formula is C20H25N3O5S2, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

[0201] Into 0.3015 g of Compound 1 was added 1.0 molar equivalent of methanesulfonic acid (0.5 M in methanol) at 45 0C. The solids dissolved quickly upon stirring. The solution was allowed to cool slowly to ambient temperature. Light yellow solids were observed and obtained by vacuum filtration. The solids were left to air dry overnight (0.2959 g; yield 81%, based on unsolvated weight).

According to the analysis of related databases, 940943-37-3, the application of this compound in the production field has become more and more popular.

Reference:
Patent; KALYPSYS, INC.; WO2008/73733; (2008); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Application of 885275-59-2 , The common heterocyclic compound, 885275-59-2, name is 6-Chloro-3-iodoimidazo[1,2-a]pyridine, molecular formula is C7H4ClIN2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

A mixture of A-3 (1.00 g, 3.59 mmol), Cul (3.42 g, 17.95 mmol), TMSCF3 (1.53 g, 10.77 mmol) and KF (625.90 mg, 10.77 mmol, 252.38 mu,) in DMF (40.00 mL) was stirred at 95 C for 2 hours under N2, at which point the desired product was observed by LCMS. The mixture was then quenched with 0 (100 mL) and extracted with EtOAc (200 mL x 2). The combined organic layers were washed with 0 (100 mL x 2), brine (100 mL), dried over Na2S04, filtered and concentrated to give the crude product, which was purified by silica gel (PE : EtOAc = 15:1 to EtOAc) to afford A-4 (140.00 mg, 634.69 umol) as a solid. H NMR (CDCI3 400 MHz) delta = 8.28 (s, 1H), 7.98 (d, 1H), 7.69 (d, 1H), 7.37 (dd, lH)..Synthesis of Compound 1: A mixture of A-4 (100.0 mg, 453.35 muiotaetaomicron), [4-(trifluoromethoxy)phenyl]boronic acid (140.04 mg, 680.03 muiotaetaomicron), Pd(i-Bu3P)2 (23.17 mg, 45.34 muiotaetaomicron) and K3P04 (192.47 mg, 906.70 muiotaetaomicron) in dioxane (5.00 mL) and 0 (1.00 mL) was stirred at 80 C for 16 hours under N2. The mixture was then concentrated to give the crude product that was purified by Prep- HPLC to afford Compound 1 (87.14 mg) as a solid. H NMR (400 MHz, CDC13) deltaEta 8.35 (s, 1H), 8.01 (d, 1H), 7.82 (d, 1H), 7.65 – 7.55 (m, 3H), 7.37 (d, 2H). LCMS R, = 1.341 min in 2.0 min chromatography, MS ESI calcd. for [M+H]+ 347.1, found 346.9.

The synthetic route of 885275-59-2 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; PRAXIS PRECISION MEDICINES, INC.; REDDY, Kiran; MARTINEZ BOTELLA, Gabriel; GRIFFIN, Andrew Mark; MARRON, Brian Edward; (168 pag.)WO2018/98500; (2018); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Related Products of 56826-61-0, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 56826-61-0, name is (2-Methylpyridine-3-yl)methanol. This compound has unique chemical properties. The synthetic route is as follows.

N-((4-chloro-2-methylphenyl)(phenyl)methyl)-2-(2-((2-methylpyridin-3-yl)methyl)benzofuran-5- yl)acetamidea) 2-methylnicotinaldehydeTo a stirred solution of (2-methylpyridin-3-yl)methanol (200 mg, 1.6 mmol) in CH2CI2 (10 mL) was added M11O2 (200 mg, 2.3 mmol). The reaction mixture was refluxed overnight under N2. The solid was removed by filtration and the filtrate was concentrated. The resultant residue was purified by flash chromatography (50% EtO Ac/petroleum ether) to afford the title compound (120 mg, 60%) as a colorless liquid. LCMS-P1 : 122.0 [M+H]+; Rt: 0.344 min.

According to the analysis of related databases, 56826-61-0, the application of this compound in the production field has become more and more popular.

Reference:
Patent; TEMPERO PHARMACEUTICALS, INC.; BALOGLU, Erkan; BOHNERT, Gary, J.; GHOSH, Shomir; LOBERA, Mercedes; SCHMIDT, Darby, R.; SUNG, Leonard; WO2013/19682; (2013); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 63237-88-7, name is Pyrazolo[1,5-a]pyridine-2-carboxylic acid, the common compound, a new synthetic route is introduced below. Safety of Pyrazolo[1,5-a]pyridine-2-carboxylic acid

To a stirred solution of pyrazolo[1,5-a]pyridine-2-carboxylic acid (2.01 g, 12.4 mmol) in 65 mL of dry tetrahydrofuran (THF) cooled at 0 C, under nitrogen, were slowly added 31 mL (62.1 mmol) of a 2 M solution of borane dimethyl sulfide in toluene. After 30 min. at room temperature, the solution was heated at 65 ºC for 5 h, and then cooled to 0 ºC to add 15 mL of water. After addition of 8 mL of 6N solution of HCl, the mixture was refluxed for 2 h. Finally, the organic solvent was removed under reduced pressure, 40 mL of methanol were added and concentrated. The residue was solved in ethyl acetate, and washed with aqueous NaOH 10% solution and water. The organic layers were dried (Na2SO4) and concentrated to afford 1.42 g (77%) of pyrazolo[1,5-a]pyridin-2-ylmethanol as a colorless oil.

The synthetic route of 63237-88-7 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Laboratorios del. Dr. Esteve, S.A.; Diaz-Fernandez,Jose-Luis; Cuberes-Altisent,Mª Rosa; EP2631236; (2013); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Reference of 17117-13-4, Adding some certain compound to certain chemical reactions, such as: 17117-13-4, name is 2-Bromo-4-ethoxypyridine,molecular formula is C7H8BrNO, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 17117-13-4.

Preparation 36 To a suspension of 2-bromo-4-ethoxypyridine (879 mg), 3-nitrophenylboronic acid (944 mg) and tetrakis(triphenylphosphine)-palladium (251 mg) in 1,2-dimethoxyethane (20 ml) was added 2M aqueous solution of sodium carbonate (5.66 ml). The mixture was stirred at 90 C. for 8 hours under a nitrogen atmosphere, then cooled to room temperature and diluted with ethyl acetate. The organic layer was separated, washed with water and brine and dried over sodium sulfate. The solvent was evaporated under reduced pressure. The residue was purified by column chromatography (silica gel 40 g, 25% ethyl acetate in n-hexane) to give 3-(4-ethoxypyridin-2-yl)nitrobenzene (887 mg). 1H-NMR (CDCl3): delta1.49(3H,t,J=7.0 Hz), 4.18(2H,q,J=7.0 Hz), 6.83(1H,dd,J=5.7 Hz,2.4 Hz), 7.29(1H,d,J=2.4 Hz), 7.63(1H,t,J=8.0 Hz), 8.2-8.4(2H,m), 8.54(1H,d,J=5.7 Hz), 8.81(1H,t,J=2.0 Hz)

According to the analysis of related databases, 17117-13-4, the application of this compound in the production field has become more and more popular.

Reference:
Patent; Fujisawa Pharmaceutical Co., Ltd.; US6521643; (2003); B1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Reference of 1062368-71-1 ,Some common heterocyclic compound, 1062368-71-1, molecular formula is C9H7BrN2O2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

Methyl 4-bromopyrazolo [1,5 -a]pyridine-3 -carboxylate (100 mg, 0.39 mmol), Pd(OAc)2 (5.3 mg, 0.024 mmol), BNAP (22 mg, 0.035 mmol) and Cs2CO3 (192 mg, 0.59 mmol) were placed in a pressure vial. The reaction mixture was degassed (3x vacuum and argon), then toluene (2 mL) and morpholine (0.044 mL, 0.51 mmol) were added. Thereaction mixture was degassed again, and then was stirred at 120 C for 3 h. After cooled to rt, the reaction was filtered through a pad of CELITE, and the solvent was removed. The crude product was purified by reverse phase chromatography to provide Intermediate 109 (74 mg, 72%) as a light tan solid. ?H NMR (400MHz, CDC13) oe 8.46 (s, 1H), 8.43 (d, J=6.6 Hz, 1H), 7.31 (d, J=7.7 Hz, 1H), 7.05 (t, J7.2 Hz, 1H), 4.11 – 4.04(m, 4H), 3.94 (s, 3H), 3.40 – 3.27 (m, 4H). LC-MS(ESI) m/z: 262.0 [M+H].

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,1062368-71-1, its application will become more common.

Reference:
Patent; BRISTOL-MYERS SQUIBB COMPANY; LADZIATA, Vladimir; GLUNZ, Peter W.; HU, Zilun; WANG, Yufeng; (0 pag.)WO2016/10950; (2016); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 83766-88-5, name is 2-(tert-Butoxy)pyridine, the common compound, a new synthetic route is introduced below. name: 2-(tert-Butoxy)pyridine

Carboxylic acid (0.2 g, 1.64 mmol), tert-butoxypyridine (0.33 g, 2.21 mmol) and boron trifluoride diethyl etherate (0.31 g, 2.21 mmol) in dry PhCH3 (2 mL) were added to a 20-ml vial. The reaction mixture was then allowed to stir at room temperature for 30 min before quenching with anhydrous NaHCO3. The reaction mixture was diluted with ethyl acetate (30 mL), then washed with water (20 mL), followed by brine (20 mL). The organic layer was dried over anhydrous sodium sulfate and carefully concentrated under reduced pressure. The resulting residue was then purified by flash column chromatography on silica gel with 0:4 to 1:4 dichloromethane/hexane as eluent to yield the desired product 5a as a colorless oil.

The synthetic route of 83766-88-5 has been constantly updated, and we look forward to future research findings.

Reference:
Article; La, Minh Thanh; Kim, Hee-Kwon; Tetrahedron; vol. 74; 27; (2018); p. 3748 – 3754;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Application of 639091-75-1, Adding some certain compound to certain chemical reactions, such as: 639091-75-1, name is Methyl 2-(Boc-amino)isonicotinate,molecular formula is C12H16N2O4, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 639091-75-1.

A 500mL round bottomed flask was charged with methyl 2-((tert-butoxycarbonyl)amino)isonicotinate (5.95 g, 23.6 mmol) and suspended in methanol (1 18 ml). To this stirring solution was added 3.0M potassium hydroxide (23.6 mL, 70.8 mmol). The flask was vented and heated to 50 C for 10 minutes. LCMS analysis showed clean and complete conversion of starting material to a single product consistent with the desired product by mass (m/z=237[M-H]-). The mixture was cooled to room temperature and then 1.ON HCl was added to give a white precipitate. The solid was collected by filtration and dried overnight to give 2-((tert- butoxycarbonyl)amino)isonicotinic acid, HCl (5.2 g, 18.93 mmol, 80 % yield). 1H NMR (400 MHz, DMSO-d6) delta ppm 13.64 (1 H, br. s.), 10.06 (1 H, s), 8.39 (1 H, d, J=5.27 Hz), 8.30 (1 H, s), 7.42 (1 H, dd, J=5.02, 1.51 Hz), 1.48 (9 H, s).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 639091-75-1, Methyl 2-(Boc-amino)isonicotinate, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; BRISTOL-MYERS SQUIBB COMPANY; SCHMITZ, William D.; DEBENEDETTO, Mikkel V.; KIMURA, S. Roy; WO2013/3298; (2013); A2;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem