Month: April 2022

With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.1234616-25-1, name is 4-Bromo-1-methyl-1H-pyrrolo[2,3-b]pyridine, molecular formula is C8H7BrN2, molecular weight is 211.06, as common compound, the synthetic route is as follows.HPLC of Formula: C8H7BrN2

A mixture of 2′-amino-/V,/V-dimethyl-5′-(4,4,5,5-tetramethyl-l,3,2-dioxaborolan-2- yl)-[2,3′-bipyridine]-5-carboxamide (360 mg, crude), 4-bromo-l-methyl-pyrrolo[2,3- b]pyridine (103 mg, 0.489 mmol), Na2C03 (2 M in water, 1 mL) and Pd(dppf)Cl2 (36 mg, 0.049 mmol, 10 mol% ) in DME (5 mL) was stirred at 100 C for 16 h under N2 atmosphere. A black suspension was formed. Crude LCMS showed the purity ofproduct is 13% (Rt= 0.513 min; MS Calc?d: 372.1; MS Found: 372.8 [M+H]+). The reaction mixture was diluted with ethyl acetate (10 mL), dried over Na2S04, filtered and concentrated. The residue was purified by Combi Flash (90% EtOAc in pentane), then the impure product was purified by prep-HPLC (0.1% TFA as additive) and lyophilized to afford 2′-amino-/V/V-dimethyl-5′-( 1 -methyl- 1//- pynOlo[2,3-b]pyridin-4-yl)-[2,3′-bipyridine]-5-carboxamide (15.8 mg, yield: 9%) as a light yellow solid. LCMS (Shimadzu LCMS 2010, mobile phase: from 100% [water + 0.05% NH32O] and 0% [MeCN] to 5% [water + 0.05% NH32O] and 95% [MeCN] in 5.8 min, then under this condition for 1.1 min, finally changed to 100% [water + 0.05% NH32O] and 0% [MeCN] and under this condition for 0.09 min.) purity is 97.33%, Rt = 2.472 min; MS Calc?d.: 372.1, MS Found: 373.2 [M+H]+. NMR (400 MHz, CDCh) d 3.11 (3H, s, overlapped with H2O signal), 3.19 (3H, s, overlapped with H2O signal), 4.05 (3H, s), 6.72 (1H, d, J= 3.6 Hz), 7.29 (1H, d , J= 5.2 Hz), 7.40 (1H, d , J= 3.6 Hz), 7.98 (1H, d , J= 8.4 Hz), 8.04 (1H, dd, J= 8.0, 1.6 Hz), 8.37 (1H, s), 8.60 (1H, d , J= 6.4 Hz), 8.61 (1H, s), 8.80 (1H, d, J = 1.6 Hz). 10.27 (2H, br s).

At the same time, in my other blogs, there are other synthetic methods of this type of compound,1234616-25-1, 4-Bromo-1-methyl-1H-pyrrolo[2,3-b]pyridine, and friends who are interested can also refer to it.

Reference:
Patent; PETRA PHARMA CORPORATION; KESICKI, Edward A.; RAVI, Kannan Karukurichi; LINDSTROeM, Johan; PERSSON, Lars Boukharta; LIVENDAHL, Madeleine; VIKLUND, Jenny; GINMAN, Tobias; FORSBLOM, Rickard; RAHM, Fredrik; HICKEY, Eugene R.; DAHLGREN, Markus K.; GERASYUTO, Aleksey I.; (478 pag.)WO2019/126733; (2019); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Reference of 58553-48-3 ,Some common heterocyclic compound, 58553-48-3, molecular formula is C7H6N2O, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

1.04 g (8.2 mmol) [OXALYLCHLORIDE] are dissolved in 8 ml dichloromethane. [AT-78C,] 1.28 g (16.4 mmol) dimethylsulfoxide are added dropwise. The solution is stirred at [- 78C] for 20 minutes, then 1 g (7.46 mmol) of the compound of Example 5A, dissolved in 7 ml dichloromethane, is added, and stirring at-78C is continued for another 2 hours. 3.4 g (33.6 mmol) triethylamine are then added dropwise, and after warming up to room temperature, the mixture is purified by column chromatography (silica, eluent cyclohexane to cyclohexane/ethyl acetate 2: 1). Yield: 0.76 g (77% ofth.) Analytical data: see above

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 58553-48-3, 5-(Hydroxymethyl)picolinonitrile, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; BAYER HEALTHCARE AG; WO2004/24700; (2004); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Reference of 77837-09-3 ,Some common heterocyclic compound, 77837-09-3, molecular formula is C13H11NO3, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

A round-bottom flask was charged with methyl 6-oxo-l -phenyl- l ,6-dihydropyridine-3- carboxylate 12a (2.26 g, 9.87 mmol), THF (58.5 mL) and MeOH (14.6 mL). The resulting slurry was cooled to 0 C. A solution of LIOH (700 mg, 29.2 mmol) in water (29.2 niL) was added dropwise via cannula. After stirring for 5 minutes the ice bath was removed. The mixture was stirred at rt for 45 minutes and then at 35 C for 30 minutes. After cooling to rt, the mixture was acidified to pH 1 with 1 N HCl and extracted with EtOAc (3 times). The combined organic layers were washed with brine, dried (Na?SO4), filtered, and concentrated in vacuo to afford 1.95 g of a brown solid which was used without further purification,[128] A round-bottom flask was charged with 1.30 g of the brown solid, THF (35.8 niL) and MeOD (8.94 ml). A solution of NaOD (99,5 atom percent D, 1.86 ml, 40 wt. percent in D2O) was added. After stirring at rt for 1.5 h, the mixture was cooled to 0 C. acidified to pH 1 with DCl (35 wt. percent in D2O), and extracted with EtOAc (3times). The combined organic layers were dried (Na2SO4), filtered and concentrated in vacuo to afford 1.31 g (100 percent) of the title compound 22 as a brown solid. 1H NMR (DMSOd6): delta 8.22 (d, J= 2.4, 1H), 7.91 (dd, J- 2.7, 9.1, 1H), 7.62-7,48 (m, 5H), 6.58 (d. ,/ = 9.44, 1H). MS (M+H): 216.1.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,77837-09-3, its application will become more common.

Reference:
Patent; CONCERT PHARMACEUTICALS, INC.; HARBESON, Scott L.; WO2010/65755; (2010); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Adding a certain compound to certain chemical reactions, such as: 393-55-5, 2-Fluoronicotinic acid, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, category: pyridine-derivatives, blongs to pyridine-derivatives compound. category: pyridine-derivatives

Weigh 10 g (70.87 mmol) of 2-fluoronicotinic acid in 330 mL of anhydrous tetrahydrofuran and stir overnight in an ice bath. A small portion is slowly added with 4.3 g (113.07 mmol) of LiA1H4 to generate a large amount of bubbles. As the amount of LiAlH4 added increases, The reaction solution was yellow and turbid with white turbidity. After the addition, the reaction was continued for 2omin. TLC monitored the reaction. The reaction was completely quenched by slowly adding 10.6 mL of water to generate a large amount of bubbles and solids. The filtrate was filtered off and the solvent was evaporated under reduced pressure to give a yellow liquid. 7.78g, ready for use.

The synthetic route of 393-55-5 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; The Chinese People’s Liberation Army Military Academy Of Medical Sciences Poison Pharmaceutical Institute; Li Song; Zheng Zhibing; Lin Feng; Gong Zehui; Lu Xinqiang; Zhou Xinbo; Zhong Wu; Xiao Junhai; Xie Yunde; Li Xingzhou; Wang Xiaokui; (24 pag.)CN107964011; (2018); A;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 100397-96-4, name is 1-(4-Bromophenyl)-2-(pyridin-4-yl)ethanone, molecular formula is C13H10BrNO, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below. Recommanded Product: 1-(4-Bromophenyl)-2-(pyridin-4-yl)ethanone

Step B 1-(4-Bromophenyl)-2-(4-pyridyl)-ethan-1,2-dione A mixture of 200 mg (0.725 mmol) of l-(4-bromophenyl)-2-(4-pyridyl)-ethanone (from Step A) and 81 mg (0.725 mmol) of selenium(IV) oxide, and 5.5 mL of glacial acetic acid was heated to 135 C. for 2 h. After being cooled to room temperature, the reaction mixture was partitioned between saturated aqueous potassium carbonate and ethyl acetate. The aqueous layer was extracted twice more more with ethyl acetate. The organic layers were combined and washed with water and brine and dried over anhydrous sodium sulfate. Volatiles were removed under reduced pressure and the residue was flash chromatographed over silica gel (gradient elution 2-4% MeOH in DCM) to yield 100 mg of the titled compound, homogeous by TLC; mass spectrum (CI) m/e 290, 292 (M+1)+.

With the rapid development of chemical substances, we look forward to future research findings about 100397-96-4.

Reference:
Patent; Merck & Co., Inc.; US5955480; (1999); A;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 6318-51-0, name is (4-Chlorophenyl)(pyridin-2-yl)methanone, molecular formula is C12H8ClNO, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below. SDS of cas: 6318-51-0

To a stirred solution of N-((4-fluorophenyl)(pyridin-2-yl)methyl)piperidine-4-carboxamide (key Intermediate-TV) (0.150 g, 0.479 mmol) in DCE (3 mL) were added benzofuran-2- carbaldehyde (0.07 g, 0.479 mmol, 1 equiv), and acetic acid (0.0287 g, 0.479 mmol,at 0 C and the reaction was stirred at room temperature for ih. Then sodium triacetoxy borohydride (0.281 g, 1.43 mmol, 3 equiv) was added. After completion, the reactionwas quenched with water and pH was adjusted -7 with saturated NaHCO3 solutionextracted with CH2C12. The combined organic extract was dried over sodium sulphate, filtered and concentrated under reduced pressure. The crude compound was purifiedHPLC to afford 0.040 g of 1-(benzofuran-2-ylmethyl)-N-((4-fluorophenyl)(pyridin-2- yl)methyl)piperidine-4-carboxamide (Yield =19Title compound was prepared by reductive amination of (4-chlorophenyl)(pyridin-2-yl)methanone (1 g, 4.59 mmol) using the general methodology of Example-59 and afforded0.5 g of 1 -(4-chlorophenyl)-N-methyl- 1 -(pyridin-2-yl)methanamine (Yield = 47%).

With the rapid development of chemical substances, we look forward to future research findings about 6318-51-0.

Reference:
Patent; THE BROAD INSTITUTE, INC.; MASSACHUSETTS INSTITUTE OF TECHNOLOGY; HOLSON, Edward; WAGNER, Florence, Fevrier; WEIWER, Michel; SCOLNICK, Edward; PALMER, Michelle; LEWIS, Michael; PAN, Jennifer, Q.; ZHANG, Yan-Ling; XU, Qihong; (323 pag.)WO2016/100823; (2016); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Application of 934279-60-4, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 934279-60-4, name is 2-Chloro-5-(trifluoromethyl)nicotinaldehyde. A new synthetic method of this compound is introduced below.

To a solution of 2-chloro-5-(trifluoromethyl)pyridine-3-carbaldehyde of step 1-1 in ethanol (60 ml) was dropwise added NaBH4 (2.90g, 0.077 mol) while stimng for 30 min at room temperature. After the reaction was terminated with a saturated ammonium solution, extraction with ethylacetate was carried out. The organic layer was dried over anhydrous magnesium sulfate, filtered, and concentrated. The residue was purified by chromatography to give 2-chloro-5-(trifluoromethyl)pyr’idin-3-yl-methanol (12.3g, 76%).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,934279-60-4, its application will become more common.

Reference:
Patent; DONG-A ST CO.,LTD; PARK, Jang Hyun; SONG, Seung Hyun; CHUNG, Han Kook; KIM, Heung Jae; LEE, Ji Hye; JANG, Byeong Jun; KIM, Eun Jung; JUNG, Hae Hum; RYU, Chae Lim; HWANG, Jae-Sung; LEE, Hyung Ki; KANG, Kyung Koo; KIM, Soon Hoe; WO2014/157994; (2014); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.956010-87-0, name is 3-(Trifluoromethyl)-1H-pyrazolo[3,4-b]pyridine, molecular formula is C7H4F3N3, molecular weight is 187.12, as common compound, the synthetic route is as follows.Formula: C7H4F3N3

Step b) 1H-Pyrazolo[3,4-b]pyridine-3-carbonitrile In 33% strength aqueous ammonia solution (10 ml), 3-(trifluoromethyl)-1H-pyrazolo[3,4-b]pyridine (500 mg, 2.67 mmol) is heated in the microwave at 140 C. for 10 min. The mixture is then concentrated under reduced pressure, and the residue is triturated at 70 C. with 100 ml of ethyl acetate and 20 ml of tert-butyl methyl ether. Insoluble components are filtered off with suction in the heat, and the filtrate is concentrated. Drying gives 346 mg (90% of theory) of the title compound as light-beige crystals. 1H-NMR (400 MHz, DMSO-d6): delta=7.47 (dd, J=8.2, 4.5 Hz, 1H), 8.46 (dd, J=8.2, 1.5 Hz, 1H), 8.73 (dd, J=4.5, 1.5 Hz, 1H), 15.02 (br. s, 1H).

At the same time, in my other blogs, there are other synthetic methods of this type of compound,956010-87-0, 3-(Trifluoromethyl)-1H-pyrazolo[3,4-b]pyridine, and friends who are interested can also refer to it.

Reference:
Patent; BAYER HEALTHCARE AG; US2010/4235; (2010); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Electric Literature of 1403899-44-4, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 1403899-44-4, name is 6-Chloro-3,3-dimethyl-2,3-dihydro-1H-pyrrolo[3,2-c]pyridine, molecular formula is C9H11ClN2, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

Preparation 10: 6-Chloro-3,3-di methyl-2,3-di hydro-pyrrolo[3,2-c] pyridi ne-I -carboxyl ic acid tert-butyl esterTo a solution of 6-chloro-3,3-dimethyl-2,3-dihydro-1 H-pyrrolo[3,2-c]pyridine (1.3 g, 7.4 mmol)in THF (20 mL) were added teit-butyl dicarbonate (4.1 g, 18.6 mmol) and dimethyl-pyridin-4-yl-amine (2.22 g, 18.6 mmol) and the solution was stirred for 2 h. Water (60 mL) was addedand the product was extracted with EtOAc. The organic phase was washed with brine, dried (MgSO4), filtered and evaporated. Chromatography (Si02, eluted with petrol – EtOAc 0-40%) gave the title compound (1.04 g). 1H NMR (Me-d3-OD): 8.04 (1H, 5), 7.60 (1H, 5), 3.81 (2H,5), 1.59 (9H, 5), 1.40 (6H, 5). MS: [M+H] = 283.Alternative procedure: Potassium teit-butoxide (600 mg, 5.36 mmol) was added to a stirred solution of 6-chloro-3,3-dimethyl-2,3-dihydro-1 H-pyrrolo[3,2-c]pyridine (800 mg, 4.38 mmol) in anhydrous THF (15 mL) and the mixture was stirred at room temperature for 10 minutes. Asolution of di-teit-butyl dicarbonate (1.07 g, 4.89 mmol) in anhydrous THF (15 mL)was added and the mixture was stirred at room temperature overnight. The organic solvent was removed in vacuo, the aqueous residues were diluted with water (100 mL) and extracted with EtOAc (2 x 200 mL). The organic layers were combined and the solvent was removed in vacuo to afford the title compound (1.19g, 96%), NMR data consistent with those previouslyobtained.

According to the analysis of related databases, 1403899-44-4, the application of this compound in the production field has become more and more popular.

Reference:
Patent; ASTEX THERAPEUTICS LIMITED; CHESSARI, Gianni; JOHNSON, Christopher Norbert; PAGE, Lee William; BUCK, Ildiko Maria; DAY, James Edward Harvey; HOWARD, Steven; SAXTY, Gordon; MURRAY, Christopher William; WO2014/60770; (2014); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.156072-84-3, name is 5-Chloro-2-cyano-3-methylpyridine, molecular formula is C7H5ClN2, molecular weight is 152.58, as common compound, the synthetic route is as follows.COA of Formula: C7H5ClN2

A mixture of 2-bromo-5-chloro-3-methylpyridine (45 g, 218 mmol), zinc cyanide (8.30 mL, 131 mmol), tris(dibenzylideneacetone) dipalladium (0) (4.99 g, 5.45 mmol), and 1 ,1?-bis(diphenylphosphino)ferrocene (6.04 g, 10.90 mmol) in dimethylacetamide (40 mL) was heated to 110 C for 4 h. The reaction mixture was cooled to RT, diluted with water and extracted with EtOAc. The organic phase obtained was concentrated under reduced pressure and residue purified by chromatography on silica gel using ISCO eluting with 0-60% EtOAc/hexanes to afford 5-chloro-3-methylpicolinonitrile (25.4 g, 166 mmol, 76 % yield). LC/MS (ESI+) m/z = 153.1 (M+H) . To a solution of 5-chloro-3-methylpicolinonitrile (24.0 g, 157 mmol) in EtOH (100 mL) was added NaOH (110 mL of 5 N solution, 550 mmol). The resulting mixture was refluxed at 90 C for 18 h. After cooling to RT, the reaction mixture was concentrated. The residue was diluted with water and the pH of the solution was adjusted to 4 by addition of 5 N HCl. The solid that precipitated was filtered and set aside. The filtrate was extracted with EtOAc (2 x). The aqueous layer was again acidified with 5 N HCl to pH 4 and extracted with EtOAc (2 x). The EtOAc extracts were combined, dried, and concentrated. The solid obtained from all the workup steps were combined and dried in a vacuum oven at 40 C for 12 h to give 5-chloro-3-methylpicolinic acid (268) (24.1 g, 140 mmol, 89% yield). LC/MS (ESI+) m/z = 172.0 (M+H) +. 1H NMR (400 MHz, CHLOROFORM-d) delta ppm 11.29 (br. s., 1 H), 8.41 (d, J=1.76 Hz, 1 H), 7.73 (d, J=1.76 Hz, 1 H), 2.75 (s, 3 H).

At the same time, in my other blogs, there are other synthetic methods of this type of compound,156072-84-3, 5-Chloro-2-cyano-3-methylpyridine, and friends who are interested can also refer to it.

Reference:
Patent; AMGEN INC.; ALLEN, Jennifer R.; AMEGADZIE, Albert; BOURBEAU, Matthew P.; BROWN, James A.; CHEN, Jian J.; CHENG, Yuan; FROHN, Michael J.; GUZMAN-PEREZ, Angel; HARRINGTON, Paul E.; LIU, Longbin; LIU, Qingyian; LOW, Jonathan D.; MA, Vu Van; MANNING, James; MINATTI, Ana Elena; NGUYEN, Thomas T.; NISHMURA, Nobuko; NORMAN, Mark H.; PETTUS, Liping H.; PICKRELL, Alexander J.; QIAN, Wenyuan; RUMFELT, Shannon; RZASA, Robert M.; SIEGMUND, Aaron C.; STEC, Markian M.; WHITE, Ryan; XUE, Qiufen; (759 pag.)WO2016/22724; (2016); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem