Month: September 2022

Xu, Chanchan;Lv, Le;Zhang, Zhijuan;Liu, Wei published 《Inorganic-Organic Hybrid Molecular Clusters with Cu₂I₂ Rhomboid Dimer Core as Light-Emitting Coating Materials》. The research results were published in《Journal of Cluster Science》 in 2021.COA of Formula: C6H4N2 The article conveys some information:

In this paper, a series of light-emitting copper(I) iodide inorganic-organic hybrid clusters has been synthesized, and they are 0D-Cu₂I₂(fmp)₄ (1, fmp = 3-fluoro-5-methyl-pyridine), 0D-Cu₂I₂(iq)₄ (2, iq = isoquinoline), 0D-Cu₂I₂(ni)₄ (3, ni = nicotinonitrile). They are all mol. clusters with Cu₂I₂ rhomboid dimer core which is the result of steric hindrance of organic ligands. The emissions of these compounds range from green to red in the solid state. The band gaps and emission energies of these compounds could be tuned by selecting different organic ligands. These compounds are solution processable and could be coated onto various substrates as luminescent inorganic-organic hybrid coating materials. To complete the study, the researchers used 3-Cyanopyridine (cas: 100-54-9) .

3-Cyanopyridine(cas: 100-54-9) has been shown to have a number of pharmacological effects: it inhibits the production of prostaglandin E2 and nitric oxide in congestive heart failure patients; it prevents the formation of diazonium salt from benzene and nitrogen dioxide; it inhibits the growth of tumor cell lines; and it protects mice from radiation injury by scavenging reactive oxygen species. COA of Formula: C6H4N2

Reference:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Synthetic Route of C10H9ClN4O2SIn 2021, Ivanov, Evgeniy V. published 《A negative partial volume of methanol in aqueous solutions: How plausible is it? Some comments on “Intermolecular interactions between methanol and some sulphonamide drugs in aqueous medium using thermodynamics approach” by indra Bahadur et al. [J. Mol. Liquid 283 (2019) 451-461]》. 《Journal of Molecular Liquids》published the findings. The article contains the following contents:

The authors of the above paper came recently to the inference that the apparent (down to infinite dilution) molar volumes of methanol in water and aqueous sulfonamides are neg. in sign and unusually large in magnitude. In this regard, two main points relating to the given “phenomenon” were considered here: how plausible is it and what exptl. “features” did the authors apply to achieve such a result. Based on the recalculated authors data and reliable literature data of interest, it is concluded here on the scientific absurdity of results reported in the paper being commented. The main reasons for this could be the sloppy performing exptl. procedures as well as the incorrect using well-known thermodn. relations by the authors (Bahadur et al.). To complete the study, the researchers used 4-Amino-N-(6-chloropyridazin-3-yl)benzenesulfonamide (cas: 80-32-0) .

4-Amino-N-(6-chloropyridazin-3-yl)benzenesulfonamide(cas: 80-32-0) is a sulfonamide antibiotic that is usually used as antibacterial anti-inflammatory drug, which has been applied in the treatment of acute urinary tract infections in childhood.Synthetic Route of C10H9ClN4O2SDue to its antibiotic activity, this chemical has been selected as an ingredient to prepare antibacterial composition.

Reference:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Xu, Xu;Zhao, Wenhao;Ji, Baocheng;Han, Yu;Xu, Gaigai;Jie, Mingsha;Wu, Nan;Wu, Yongmei;Li, Junguang;Li, Ke;Zhao, Dianbo;Bai, Yanhong published 《Application of silanized melamine sponges in matrix purification for rapid multi-residue analysis of veterinary drugs in eggs by UPLC-MS/MS》. The research results were published in《Food Chemistry》 in 2022.Synthetic Route of C10H9ClN4O2S The article conveys some information:

Fast and convenient matrix purification is an important prerequisite for high-throughput anal. of drug multiresidues in food. In this study, a silanized melamine sponge was prepared and first applied in the rapid determination of multiclass veterinary drugs in eggs by ultrahigh-performance liquid chromatog.-tandem mass spectrometry. Within five seconds, fast, convenient and efficient matrix separation could be achieved through simple soaking and squeezing. Compared to other matrix adsorbents, the developed material demonstrated equivalent or better purification performance. Good validation results were obtained in terms of drug recoveries (61.5%∼97.0%, relative standard deviation (RSD) ≤ 10.8%), and linearities (R2 ≥ 0.999), as well as low limits of quantitation (0.3 ∼ 10.9μg·kg-1) and detection (0.1 ∼ 3.8μg·kg-1). By analyzing 52 egg samples, high concentrations of ofloxacin, trimethoprim, metronidazole, and dimetridazole were found at 542.9, 121.2, 66.1 and 58.0μg·kg-1, resp. The silanized melamine sponge has shown its great potential for rapid anal. of multiclass residues in food safety. The experimental procedure involved many compounds, such as 4-Amino-N-(6-chloropyridazin-3-yl)benzenesulfonamide (cas: 80-32-0) .

4-Amino-N-(6-chloropyridazin-3-yl)benzenesulfonamide(cas: 80-32-0) is a sulfonamide antibiotic that is usually used as antibacterial anti-inflammatory drug, which has been applied in the treatment of acute urinary tract infections in childhood.Synthetic Route of C10H9ClN4O2SDue to its antibiotic activity, this chemical has been selected as an ingredient to prepare antibacterial composition.

Reference:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Liu, Lin;Sim, Siong Fong;Lin, Sen;Wan, Jiang;Zhang, Wei;Li, Qiannan;Peng, Cheng published 《Integrated structural and chemical analyses for HCl-supported hydrochar and their adsorption mechanisms for aqueous sulfachloropyridazine removal》. The research results were published in《Journal of Hazardous Materials》 in 2021.Recommanded Product: 80-32-0 The article conveys some information:

In this study, various HCl-supported hydrochar made from root powder of long-root Eichhornia crassipes were applied to adsorb aqueous sulfachloropyridazine (SCP). Adsorption capacity (q_e μg g^-1) was pos. correlated with combined severity-CS. With CS increasing, carbonization degree, hydrophobicity, porosity and isoelec. point of hydrochar increased, but content of polar functional groups decreased. Hydrophobic interaction was important for SCP adsorption. A 24 x 36 peak area table was generated from 24 FT-IR absorbance spectra computed by peak detection algorithm. Afterwards, correlation anal. between qe μg g^-1 and FT-IR peak area were conducted, indicating that wavenumbers at 555.4, 1227.47, 1374.51, 1604.5, 2901.4/2919.2 and 3514.63 cm-1 were helpful for SCP adsorption. Further, multivariate linear regression analyses showed that aromatic skeleton and phenolic hydroxyl were the two biggest contributors. Electrostatic attraction did not exist during the SCP adsorption process. Under strong acid condition, protonated amino groups in cationic SCP acting as a hydrogen donator interacted with electron-rich functional groups onto hydrochar by Hydrogen interaction. Under weak acid condition, neutral SCP served as an π electron donor to bond with hydrochar by π-π electron donator-acceptor interaction. This work could guide the functional groups modification strategy of hydrochar to make better use of it in water purification field. The experimental procedure involved many compounds, such as 4-Amino-N-(6-chloropyridazin-3-yl)benzenesulfonamide (cas: 80-32-0) .

4-Amino-N-(6-chloropyridazin-3-yl)benzenesulfonamide(cas: 80-32-0) can be introduced in the drinking water to fabricate aqueous liquid formulations for combating bacterial and protozoal in animals.Recommanded Product: 80-32-0 Besides, sulfachloropyridazine associated to tripelennamine hydrocholoride has been demonstrated to function as an anti-stress agent in poultry after vaccinations.

Reference:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Luo, Lan;Liu, Hongqiang;Zeng, Wei;Hu, Wenkang;Wang, Dawei published 《BTP-Rh@g-C₃N₄ as an efficient recyclable catalyst for dehydrogenation and borrowing hydrogen reactions》 in 2022. The article was appeared in 《Applied Organometallic Chemistry》. They have made some progress in their research.SDS of cas: 100-54-9 The article mentions the following:

Highly active catalysts play an important role in modern catalysis. A novel and efficient ligand benzotriazole-pyrimidine (BTP) and the corresponding rhodium composite on C₃N₄ were successfully synthesized. The resulting rhodium composite was fully characterized by SEM (SEM), transmission electron microscopy (TEM), x-ray diffraction (XRD), thermogravimetric anal. (TGA), and XPS. The obtained composite exhibited good catalytic activity and good recovery performance in the synthesis of quinoxaline from 2-aminobenzyl alc. and benzonitrile, and more than 20 quinoxalines were obtained in good yields. Addnl., it also showed that rhodium composite could achieved good catalytic performance in the synthesis of functionalized ketone through borrowing hydrogen strategy. And 3-Cyanopyridine (cas: 100-54-9) was used in the research process.

3-Cyanopyridine(cas: 100-54-9) also shows biological activity against autoimmune diseases, such as murine hepatitis, by inhibiting the proliferation of B cells and T cells.SDS of cas: 100-54-9 This drug is not effective against cancer cells because it does not inhibit DNA synthesis or protein synthesis.

Reference:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Synthetic Route of C10H9ClN4O2S《Validation of the QuEChERSER mega-method for the analysis of pesticides, veterinary drugs, and environmental contaminants in tilapia (Oreochromis Niloticus)》 was published in 2022. The authors were Monteiro, Sergio H.;Lehotay, Steven J.;Sapozhnikova, Yelena;Ninga, Ederina;Moura Andrade, Graziela C. R.;Lightfield, Alan R., and the article was included in《Food Additives & Contaminants, Part A》. The author mentioned the following in the article:

To meet this need, the development and implementation of more efficient and effective anal. methods to monitor residues (pesticides and veterinary drugs) and contaminants in food is important. In this study, we report the validation results for a simple high-throughput mega-method for residual anal. of 213 pesticides and veterinary drugs, including 15 metabolites, plus 12 environmental contaminants (polychlorinated biphenyls) in tilapia muscle for implementation in routine laboratory analyses. The generic sample preparation method and anal. approach are known as QuEChERSER. A small portion of the initial extract (204μL) is taken for anal. by ultrahigh-performance liquid chromatog. (UHPLC) tandem mass spectrometry (MS/MS) covering 145 analytes, and the remaining extract undergoes a salting out step followed by an automated robotic instrument top sample preparation (ITSP) cleanup, also known as micro-solid-phase extraction (μSPE), plus fast low-pressure gas chromatog. LPGC-MS/MS for 134 analytes (66 pesticides are targeted in both UHPLC-MS/MS and LPGC-MS/MS). No significant matrix effects were observed for the analytes in LPGC-MS/MS, and only 5% of the analytes exceeded ±20% matrix effect in UHPLC-MS/MS. Anal. of standard reference materials (NIST SRMs 1946 and 1947) for contaminants in freeze-dried fish showed acceptable results, further demonstrating that the QuEChERSER mega-method can be implemented to expand anal. scope and increase laboratory efficiency compared to the QuEChERS method. The experimental procedure involved many compounds, such as 4-Amino-N-(6-chloropyridazin-3-yl)benzenesulfonamide (cas: 80-32-0) .

4-Amino-N-(6-chloropyridazin-3-yl)benzenesulfonamide(cas: 80-32-0) is a sulfonamide antibiotic that is usually used as antibacterial anti-inflammatory drug, which has been applied in the treatment of acute urinary tract infections in childhood.Synthetic Route of C10H9ClN4O2SDue to its antibiotic activity, this chemical has been selected as an ingredient to prepare antibacterial composition.

Reference:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Name: 4-Amino-N-(6-chloropyridazin-3-yl)benzenesulfonamideIn 2021, Wenk, Jannis;Graf, Cornelia;Aeschbacher, Michael;Sander, Michael;Canonica, Silvio published 《Effect of Solution pH on the Dual Role of Dissolved Organic Matter in Sensitized Pollutant Photooxidation》. 《Environmental Science & Technology》published the findings. The article contains the following contents:

Dissolved organic matter (DOM) has a dual role in indirect phototransformations of aquatic contaminants by acting both as a photosensitizer and an inhibitor. Herein, the pH dependence of the inhibitory effect of DOM and the underlying mechanisms were studied in more than 400 kinetic irradiation experiments over the pH range of 6-11. Experiments employed various combinations of one of three DOM isolates, one of two model photosensitizers, the model antioxidant phenol, and one of nine target compounds (TCs), comprising several aromatic amines, in particular anilines and sulfonamides, and 4-cyanophenol. Using model photosensitizers without antioxidants, the phototransformation of most TCs increased with increasing pH, even for TCs for which pH did not affect speciation. This trend was attributed to pH-dependent formation yields of TC-derived radicals and their re-formation to the parent TC. Analogous trends were observed with DOM as a photosensitizer. Comparison of model and DOM photosensitizer data sets showed increasing inhibitory effects of DOM on TC phototransformation kinetics with increasing pH. In systems with anilines as a TC and phenol as a model antioxidant, pH trends of the inhibitory effect could be rationalized based on the reduction p.d. (ΔEred) of phenoxyl/phenol and anilinyl/aniline couples. Our results indicate that the light-induced transformation of aromatic amines in the aquatic environment is governed by the pH-dependent inhibitory effects of antioxidant phenolic moieties of DOM and pH-dependent processes related to the formation of amine oxidation intermediates. And 4-Amino-N-(6-chloropyridazin-3-yl)benzenesulfonamide (cas: 80-32-0) was used in the research process.

4-Amino-N-(6-chloropyridazin-3-yl)benzenesulfonamide(cas: 80-32-0) is a sulfonamide antibiotic that is usually used as antibacterial anti-inflammatory drug, which has been applied in the treatment of acute urinary tract infections in childhood.Name: 4-Amino-N-(6-chloropyridazin-3-yl)benzenesulfonamideDue to its antibiotic activity, this chemical has been selected as an ingredient to prepare antibacterial composition.

Reference:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Application In Synthesis of 3-Cyanopyridine《Synthesis, X-ray structure, Hirshfeld, and antimicrobial studies of new Ag(I) complexes based on pyridine-type ligands》 was published in 2022. The authors were El-Naggar, Mostafa A.;Abu-Youssef, Morsy A. M.;Soliman, Saied M.;Haukka, Matti;Al-Majid, Abdullah Mohammed;Barakat, Assem;Badr, Ahmed M. A., and the article was included in《Journal of Molecular Structure》. The author mentioned the following in the article:

The two silver(I) complexes [Ag(3CNPy)₂(CF₃COO)]_n (1) and [Ag(4BzPy)₂]₂(CF₃COO)₂ (2) where 3CNPy and 4BzPy are 3-cyanopyridine and 4-benzoylpyridine, resp., were synthesized and characterized using elemental anal., FTIR spectra and single crystal x-ray diffraction. Complex 1 is a 1D coordination polymer through the bridging and the highly sym. CF₃COO group while 2 is a dinuclear complex through strong argentophilic interaction connecting the two [Ag(4BzPy)₂] cationic units. In both complexes, the pyridine ligands are acting as monodentate N-donor. Hirshfeld surface anal. revealed the importance of the polar N···H (29.9%) and H···F (10.3%) hydrogen bonds in the mol. packing of 1. For 2, the nonpolar C···H (26.2%) and the polar O···H (15.6%) interactions dominate the crystal packing. Furthermore, both complexes showed π-π stacking interactions. Antimicrobial screening revealed that 3CNPy has no activity against all tested pathogens, while 1 has good antibacterial activity. Both Ag(I) complexes and 4BzPy showed remarkable antifungal activities against A. fumigatus and C. albicans compared to Ketoconazole as control. To complete the study, the researchers used 3-Cyanopyridine (cas: 100-54-9) .

3-Cyanopyridine(cas: 100-54-9) is an antimicrobial agent that can be used in the treatment of infectious diseases.Application In Synthesis of 3-Cyanopyridine It has been shown to be effective against a variety of bacteria, including methicillin-resistant Staphylococcus aureus (MRSA) and Streptococcus pneumoniae.

Reference:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Application of 80-32-0In 2021, Jia, Wei;Zhang, Min;Du, An;Zhang, Rong;Xu, Mudan;Shi, Lin published 《Accurate Quantification of Sulfonamide Metabolites in Goat Meat: A New Strategy for Minimizing Interaction between Sheep Serum Albumin and Sulfonamide Metabolites》. 《Journal of Agricultural and Food Chemistry》published the findings. The article contains the following contents:

To date, the determination of sulfonamide metabolites in animal-derived food has universal disadvantages of low throughput and no integrated metabolites involved. In this study, a powerful and reliable strategy for high-throughput screening of sulfonamide metabolites in goat meat was proposed based on an aqueous two-phase separation procedure (ATPS) combined with ultrahigh-performance liquid chromatog. quadrupole-Orbitrap high-resolution mass spectrometry (UHPLC-Q-Orbitrap). Noncovalent interactions including van der Waals force, hydrogen bonding, and hydrophobic effect were determined to be staple interactions between the sulfonamide metabolites and sheep serum albumin by fluorescence spectroscopy and mol. docking technol., and an 80% acetonitrile-water solution/(NH₄)₂SO₄ was used as ATPS in order to release combined sulfonamide metabolites and minimize the influence of sheep serum albumin. Sulfonamide metabolites in the matrix were screened based on a mechanism of mass natural loss and core structure followed by identification combined with the pharmacokinetic. The developed strategy was validated according to EU standard 2002/657/EC with CCα ranging from 0.07 to 0.98μg kg^-1, accuracy recovery with 84-107%, and RSDs lower than 8.9%. Eighty seven goat meat samples were used for determination of 26 sulfonamides and 8 potential metabolites. On the basis of the established innovative process, this study has successfully implemented the comprehensive detection of sulfonamide metabolites, including N⁴-acetylated substitution, N⁴-hydroxylation, 4-nitroso, azo dimers, oxidized nitro, N⁴ monoglucose conjugation, β-D-glucuronide, and N-4-aminobenzenesulfonyl metabolites, which were shown to undergo oxidation, hydrogenation, sulfation, glucuronidation, glucosylation, and O-aminomethylation. And 4-Amino-N-(6-chloropyridazin-3-yl)benzenesulfonamide (cas: 80-32-0) was used in the research process.

4-Amino-N-(6-chloropyridazin-3-yl)benzenesulfonamide(cas: 80-32-0) is a sulfonamide antibiotic that is usually used as antibacterial anti-inflammatory drug, which has been applied in the treatment of acute urinary tract infections in childhood.Application of 80-32-0Due to its antibiotic activity, this chemical has been selected as an ingredient to prepare antibacterial composition.

Reference:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Gao, Lei;Wang, Peng;Chen, Zhongxiang;Tang, Shizhan;Wu, Song;Li, Gang;Qin, Dongli published 《Multi-pharmaceuticals analysis in fish by continuous series solid-phase extraction coupled with UPLC-MS/MS》. The research results were published in《Acta Chromatographica》 in 2022.Electric Literature of C10H9ClN4O2S The article conveys some information:

Pharmaceuticals which are widely used in aquatic can easily migrate into the environment and aquatic animals, and can increase the risk of drug resistance and allergic symptoms if consumed by humans. In order to achieve high-throughput anal. of pharmaceuticals with different phys. and chem. properties from complex matrixes, we developed a new method for various types pharmaceuticals in fish and shrimp tissue. Series solid-phase extraction (s-SPE) with different adsorbents was selected for extracting and purifying analytes with different paddings. s-SPE were combined with ultra performance liquid chromatog. triple quadruple tandem mass spectrometry (UPLC-MS/MS) for the detection of 30 pharmaceuticals antibiotics in fish samples. This method was stabilized and reliable to determinate the pharmaceuticals in fish and shrimp samples. As the method combined multiple Chinese national standards method, it could be easily treat the multi-pharmaceuticals from the fish and shrimp samples once time. It provided for both quant. and qual. methods and they could be applied to singleor multi-residue methods. The experimental procedure involved many compounds, such as 4-Amino-N-(6-chloropyridazin-3-yl)benzenesulfonamide (cas: 80-32-0) .

4-Amino-N-(6-chloropyridazin-3-yl)benzenesulfonamide(cas: 80-32-0) is a sulfonamide antibiotic that is usually used as antibacterial anti-inflammatory drug, which has been applied in the treatment of acute urinary tract infections in childhood.Electric Literature of C10H9ClN4O2SDue to its antibiotic activity, this chemical has been selected as an ingredient to prepare antibacterial composition.

Reference:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem