Month: September 2022

Zhang, Yue;Li, Yang;Liu, Xiaoxia;Sun, Ying published 《Determination of multiple antibiotics in agricultural soil using a quick, easy, cheap, effective, rugged, and safe method coupled with ultra-high performance liquid chromatography-tandem mass spectrometry》 in 2022. The article was appeared in 《Journal of Separation Science》. They have made some progress in their research.Application In Synthesis of 4-Amino-N-(6-chloropyridazin-3-yl)benzenesulfonamide The article mentions the following:

In this study, we combined ultra-high performance liquid chromatog. with tandem mass spectrometry to establish a quick, easy, cheap, effective, rugged, and safe method of detecting 21 target antibiotics in agricultural soil samples. Antibiotics were extracted with mixed solvents consisting of EDTA disodium salt dihydrate and phosphoric acid citric acid buffer and acetonitrile which were purified with octadecylsilyl as an adsorbent and anhydrous sodium sulfate as a desiccant. This method was able to effectively extract all of the target antibiotics from agricultural soils, with recovery efficiencies ranging from 55 to 108% and limits of detection between 0.09-0.68μg/kg. We also validated this new method for selectivity, sensitivity, and reliability of detecting multiple antibiotics in 12 samples. Considering the potential environmental and public health effects of antibiotics in agricultural soils, our new method can help analyze the degree of antibiotic contamination and provide valuable information for soil quality and risk assessment.4-Amino-N-(6-chloropyridazin-3-yl)benzenesulfonamide (cas: 80-32-0) were involved in the experimental procedure.

4-Amino-N-(6-chloropyridazin-3-yl)benzenesulfonamide(cas: 80-32-0) can be introduced in the drinking water to fabricate aqueous liquid formulations for combating bacterial and protozoal in animals.Application In Synthesis of 4-Amino-N-(6-chloropyridazin-3-yl)benzenesulfonamide Besides, sulfachloropyridazine associated to tripelennamine hydrocholoride has been demonstrated to function as an anti-stress agent in poultry after vaccinations.

Reference:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Safety of 3-Cyanopyridine《Palladium-catalyzed synthesis of nitriles from N-phthaloyl hydrazones》 was published in 2022. The authors were Ano, Yusuke;Higashino, Masaya;Yamada, Yuki;Chatani, Naoto, and the article was included in《Chemical Communications (Cambridge, United Kingdom)》. The author mentioned the following in the article:

The Pd-catalyzed transformation of N-phthaloyl hydrazones into nitriles RC≡N [R = 3-pyridyl, 4-MeC₆H₄, 2-naphthyl, etc.] and R(Me)C=CHC≡N involving the cleavage of an N-N bond was reported. The use of N-heterocyclic carbene as a ligand was essential for the success of the reaction. N-Phthaloyl hydrazones prepared from aromatic aldehydes or cyclobutanones were applicable to this transformation, which gaves aryl nitriles RC≡N or alkenyl nitriles R(Me)C=CHC≡N, resp.3-Cyanopyridine (cas: 100-54-9) were involved in the experimental procedure.

3-Cyanopyridine(cas: 100-54-9) is an antimicrobial agent that can be used in the treatment of infectious diseases.Safety of 3-Cyanopyridine It has been shown to be effective against a variety of bacteria, including methicillin-resistant Staphylococcus aureus (MRSA) and Streptococcus pneumoniae.

Reference:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Ji, Baocheng;Zhao, Wenhao;Xu, Xu;Han, Yu;Jie, Mingsha;Xu, Gaigai;Bai, Yanhong published 《Development of a modified quick, easy, cheap, effective, rugged, and safe method based on melamine sponge for multi-residue analysis of veterinary drugs in milks by ultra-performance liquid chromatography tandem mass spectrometry》. The research results were published in《Journal of Chromatography A》 in 2021.Recommanded Product: 80-32-0 The article conveys some information:

The purpose of this study was to develop a modified QuEChERS method based on melamine sponge for rapid determination of multi-class veterinary drugs in milks by UPLC-MS/MS. Through simple infiltration and extrusion, fast and convenient matrix purification could be achieved within several seconds, and there was no need of extra phase separation operations. Good linearity with correlation coefficient (R2) ≥0.999 was obtained for all drugs in the range of 2∼500μg·kg-1. The obtained matrix effects were within ±20% for all monitored drugs. The recoveries of all monitored drugs ranged from 60.7% to 116.0% at three spiked levels (50, 100, and 200μg·kg-1), with relative standard deviations less than 7.4%. Comparatively low LODs and LOQs were obtained in the ranges of 0.1∼3.8μg·kg-1 and 0.2∼6.3μg·kg-1, resp. Compared with conventional purification adsorbents, melamine sponge yielded an equal or higher purification performance with matrix removal rate as high as 52.5% and acceptable recoveries in range of 60%-120% for all monitored drugs. The satisfactory results have demonstrated the good potential of melamine sponge in matrix purification for rapid determination of multiclass residues in food safety. The experimental procedure involved many compounds, such as 4-Amino-N-(6-chloropyridazin-3-yl)benzenesulfonamide (cas: 80-32-0) .

4-Amino-N-(6-chloropyridazin-3-yl)benzenesulfonamide(cas: 80-32-0) is a sulfonamide antibiotic that is usually used as antibacterial anti-inflammatory drug, which has been applied in the treatment of acute urinary tract infections in childhood.Recommanded Product: 80-32-0Due to its antibiotic activity, this chemical has been selected as an ingredient to prepare antibacterial composition.

Reference:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Yang, Lei;Wu, Xiaona;Chen, Xiaoyu;Chen, Fei;Zheng, Xiaona;Song, Qinan;Liu, Xiang;Li, Miao published 《Synergistic Removal of Nutrient Pollutants and Pharmaceutical and Personal Care Products (PPCPs) from Contaminated Groundwater: Macro- and Microelements and Microorganisms》. The research results were published in《ACS ES&T Water》 in 2022.Related Products of 80-32-0 The article conveys some information:

The synergistic removal performance of nutrient pollutants and pharmaceutical and personal care products (PPCPs) from contaminated groundwater, and the biogeochem. interactions of macro- and microelements-contaminants-microorganisms were further studied. The electrolysis-zeolite/basalt system proved to achieve better synergistic removal performance than all other purification systems considered, reaching average removal efficiencies of 85.8% for nutrient pollutants and 74.7% for PPCPs. Electrolysis not only enhanced the abundance and distribution of MOB and DNB, but also promoted the production of microelements Fe³⁺ (0.1 ± 0.1 mg/L) and Zn²⁺ (0.3 ± 0.3 mg/L). Macroelements Ca²⁺ and Mg²⁺ increased by 27.8 ± 2.7 and 16.5 ± 9.6 mg/L, resp., which significantly stimulated the activities of function microbials. Microelements Fe3+ exchanged from zeolite, Mn²⁺ from basalt, and Cu²⁺ from groundwater itself were crucial for enzyme activity. Meanwhile, Mn²⁺ was co-regulated by oxidation-reduction processes and ion-exchange strength. Thus, the electrolysis-zeolite/basalt system is a promising technol. for synergistic nutrient pollutant and PPCP removal from contaminated groundwater, especially in dispersive water supplied in the countryside of China.4-Amino-N-(6-chloropyridazin-3-yl)benzenesulfonamide (cas: 80-32-0) were involved in the experimental procedure.

4-Amino-N-(6-chloropyridazin-3-yl)benzenesulfonamide(cas: 80-32-0) is a sulfonamide antibiotic that is usually used as antibacterial anti-inflammatory drug, which has been applied in the treatment of acute urinary tract infections in childhood.Related Products of 80-32-0Due to its antibiotic activity, this chemical has been selected as an ingredient to prepare antibacterial composition.

Reference:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Product Details of 100-54-9《A pharmaceutical-related molecules dataset for reversed-phase chromatography retention time prediction built on combining pH and gradient time conditions》 was published in 2022. The authors were Van Laethem, Thomas;Kumari, Priyanka;Hubert, Philippe;Fillet, Marianne;Sacre, Pierre-Yves;Hubert, Cedric, and the article was included in《Data in Brief》. The author mentioned the following in the article:

There is a rising interest in the modeling and predicting of chromatog. retention. The progress towards more complex and comprehensive models emphasized the need for broad reliable datasets. The present dataset comprises small pharmaceutical compounds selected to cover a wide range in terms of physicochem. properties that are known to impact the retention in reversed-phase liquid chromatog. Moreover, this dataset was analyzed at five pH with two gradient slopes. It provides a reliable dataset with a diversity of conditions and compounds to support the building of new models. To enhance the robustness of the dataset, the compounds were injected individually, and each sequence of injections included a quality control sample. This unambiguous detection of each compound as well as a systematic anal. of a quality control sample ensured the quality of the reported retention times. Moreover, three different liquid chromatog. systems were used to increase the robustness of the dataset. And 3-Cyanopyridine (cas: 100-54-9) was used in the research process.

3-Cyanopyridine(cas: 100-54-9) is an antimicrobial agent that can be used in the treatment of infectious diseases.Product Details of 100-54-9 It has been shown to be effective against a variety of bacteria, including methicillin-resistant Staphylococcus aureus (MRSA) and Streptococcus pneumoniae.

Reference:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Safety of 3-Cyanopyridine《High-throughput screening of a nicotinate dehydrogenase producing Pseudomonas putida mutant for efficient biosynthesis of 6-hydroxynicotinic acid》 was published in 2021. The authors were Shang, Yu-Ting;Qin, Jiufu;Gong, Jin-Song;Wang, Zi-Kai;Li, Heng;Li, Hui;Shi, Jin-Song;Xu, Zheng-Hong, and the article was included in《Molecular Catalysis》. The author mentioned the following in the article:

A nicotinate dehydrogenase producing strain was isolated and identified to be Pseudomonas putida, which could bio-transform nicotinic acid into 6-hydroxynicotinic acid. The activity of nicotinate dehydrogenase towards nicotinic acid could reach up to 1.11 U/mL and the yield of 6-hydroxynicotinic acid accumulated to 176 g/L within 30 h with a space time yield of 1.36 g/(g·h). In order to further improve its catalytic potential, a mutant library was constructed through atm. and room temperature plasma (ARTP) and rapidly screened by a high-throughput screening strategy, which obtained a mutant strain mut-5 with activity of 2.68 U/mL. Via developing a nitrilase-nicotinate dehydrogenase enzymic cascade system, 54.5 g/L 6-hydroxynicotinic acid could be obtained within 585 min with 3-cyanopyridine as the substrate, which would further reduce the production costs. The results indicated that the nicotinate dehydrogenase (sep. or combining with nitrilase) could serve as a superior catalyst for 6-hydroxynicotinic acid production To our knowledge, the nicotinate dehydrogenase activity reported in this study was the highest level in literature to date. The experimental procedure involved many compounds, such as 3-Cyanopyridine (cas: 100-54-9) .

3-Cyanopyridine(cas: 100-54-9) has been shown to have a number of pharmacological effects: it inhibits the production of prostaglandin E2 and nitric oxide in congestive heart failure patients; it prevents the formation of diazonium salt from benzene and nitrogen dioxide; it inhibits the growth of tumor cell lines; and it protects mice from radiation injury by scavenging reactive oxygen species. Safety of 3-Cyanopyridine

Reference:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Computed Properties of C10H9ClN4O2S《Comparison and prioritization of antibiotics in a reservoir and its inflow rivers of Beijing, China》 was published in 2022. The authors were Hu, Jingrun;Qi, Dianqing;Chen, Qian;Sun, Weiling, and the article was included in《Environmental Science and Pollution Research》. The author mentioned the following in the article:

The occurrence of antibiotics in drinking water resources, like reservoirs, is of considerable concern due to their potential risks to ecosystem, human health, and antimicrobial resistance development. Here, we quantified 83 antibiotics in water and sediments of wet and dry seasons from the Miyun reservoir and its inflow rivers in Beijing, China. Twenty-four antibiotics were detected in water with concentrations of ND-11.6 ng/L and 19 antibiotics were observed in sediments with concentrations of ND-6.50 ng/g. Sulfonamides (SAs) were the dominated antibiotics in water in two seasons. SAs and quinolones (QNs) in wet season and macrolides (MLs) and QNs in dry season predominated in sediments. The reservoir and inflow rivers showed significant differences in antibiotic concentrations and compositions in water and sediments. As an important input source of reservoir, the river water showed significantly higher total antibiotic concentrations than those in the reservoir. In contrast, the reservoir sediments are the sink of antibiotics, and had higher total antibiotic concentrations compared with rivers. A prioritization approach based on the overall risk scores and detection frequencies of antibiotics was developed, and 3 (sulfaguanidine, anhydroerythromycin, and sulfamethoxazole) and 5 (doxycycline, sulfadiazine, clarithromycin, roxithromycin, and flumequine) antibiotics with high and moderate priority, resp., were screened. The study provides a comprehensive insight of antibiotics in the Miyun Reservoir and its inflow rivers, and is significant for future monitoring and pollution mitigation of antibiotics. The experimental procedure involved many compounds, such as 4-Amino-N-(6-chloropyridazin-3-yl)benzenesulfonamide (cas: 80-32-0) .

4-Amino-N-(6-chloropyridazin-3-yl)benzenesulfonamide(cas: 80-32-0) can be introduced in the drinking water to fabricate aqueous liquid formulations for combating bacterial and protozoal in animals.Computed Properties of C10H9ClN4O2S Besides, sulfachloropyridazine associated to tripelennamine hydrocholoride has been demonstrated to function as an anti-stress agent in poultry after vaccinations.

Reference:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Feng, Xiaoxia;Li, Dong;Liang, Wenqing;Ruan, Ting;Jiang, Guibin published 《Recognition and prioritization of chemical mixtures and transformation products in Chinese estuarine waters by suspect screening analysis》 in 2021. The article was appeared in 《Environmental Science & Technology》. They have made some progress in their research.Recommanded Product: 3-Cyanopyridine The article mentions the following:

Chem. mixtures in surface waters could have significant impacts on exposure risks to human beings and pollution stress to aquatic system. By suspect screening anal. of high-resolution mass spectrometry data, occurrence, and compositions of ToxCast chems. were investigated in grab estuarine water samples from a combination of 20 rivers that represents approx. 70% of the total river flow discharge along the east coast of China. In total, 59 ToxCast chems. in seven use categories were identified, in which pesticides, intermediates, and pharmaceuticals were the abundant analogs. Significant differences in pollutant composition profiles were noticed, which possibly reflected singular release pattern and geog.-relevant usage preference (especially for herbicides and fungicides in the pesticide category). With the aid of tentative quant./semiquant. measurement, essential contributors to the cumulative pollutant mass discharges and aquatic acute toxicity potentials were focused onto few particular chems. Existence of transformation products was further explored, which indicated that the fates of the selected parent ToxCast chems. could be influenced by dominating transformation reactions (e.g., N-dealkylation and hydroxylation) and possible environmental factors (i.e., microbial activity). The results emphasize the necessity of suspect screening anal. for assessing the influence of terrestrial emissions of pollutants to the surrounding environment. And 3-Cyanopyridine (cas: 100-54-9) was used in the research process.

3-Cyanopyridine(cas: 100-54-9) has been shown to have a number of pharmacological effects: it inhibits the production of prostaglandin E2 and nitric oxide in congestive heart failure patients; it prevents the formation of diazonium salt from benzene and nitrogen dioxide; it inhibits the growth of tumor cell lines; and it protects mice from radiation injury by scavenging reactive oxygen species. Recommanded Product: 3-Cyanopyridine

Reference:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Zhou, Ruidong;Mu, Shuhe;Feng, Tengwang;Liu, Huan;Sun, Huiwu;Li, Jincheng published 《Development of a vortex oscillating clean-up column for high-throughput semi-automatic sample preparation of drug residues in fish muscle tissues》 in 2022. The article was appeared in 《Journal of Food Composition and Analysis》. They have made some progress in their research.Recommanded Product: 4-Amino-N-(6-chloropyridazin-3-yl)benzenesulfonamide The article mentions the following:

A novelty high-throughput semi-automatic sample clean-up method was developed and used for rapid anal. of 9 drug residues in fish muscle tissues combined with high-performance liquid chromatog./quadrupole-linear ion trap mass spectrometry (HPLC-QTRAP-MS/MS). The target compounds were extracted by Quick, Easy, Cheap, Effective, Rugged and Safe multiresidue (QuEChERS) method with acetonitrile. A vortex oscillating clean-up column was proposed for single step purification firstly. After centrifugation, 1 mL of acetonitrile layer was transferred into a 3 mL vortex oscillating clean-up column which packed with 150 mg C₁₈ sorbent. The column was covered with piston, placed on a column-tube rack, vigorously agitated on a multi-tube vortex mixer. After vortex oscillation, purified extract was obtained for anal. by pushing the piston of oscillating clean-up column. The performance of the developed method was validated by analyzing 9 analytes in spiked grass carp muscle tissues. The limits of quantification (LOQs) ranged from 1.0 to 5.0 μg kg^-1. The recoveries were in the range of 101-119% at the four concentration levels (2.0, 5.0, 10.0, 20.0 μg kg^-1). Inter-day and intra-day relative standard deviations (RSDs) were lower than 16% for all analytes. The experimental procedure involved many compounds, such as 4-Amino-N-(6-chloropyridazin-3-yl)benzenesulfonamide (cas: 80-32-0) .

4-Amino-N-(6-chloropyridazin-3-yl)benzenesulfonamide(cas: 80-32-0) can be introduced in the drinking water to fabricate aqueous liquid formulations for combating bacterial and protozoal in animals.Recommanded Product: 4-Amino-N-(6-chloropyridazin-3-yl)benzenesulfonamide Besides, sulfachloropyridazine associated to tripelennamine hydrocholoride has been demonstrated to function as an anti-stress agent in poultry after vaccinations.

Reference:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Ye, Chunmeng;Shi, Jiaqi;Zhang, Xuesheng;Qin, Li;Jiang, Zhongguan;Wang, Jinhua;Li, Yucheng;Liu, Bingxiang published 《Occurrence and bioaccumulation of sulfonamide antibiotics in different fish species from Hangbu-Fengle River, Southeast China》 in 2021. The article was appeared in 《Environmental Science and Pollution Research》. They have made some progress in their research.Application In Synthesis of 4-Amino-N-(6-chloropyridazin-3-yl)benzenesulfonamide The article mentions the following:

As a class of synthetic sulfur drugs, sulfonamides (SAs) have been used to treat diseases and promote organism growth. Different concentrations of SAs have been detected in the water environment, which has threatened the ecol. environment. In this study, the contamination of 9 SAs in water, sediments, and 8 fish species from the Hangbu-Fengle River, China, were analyzed using UPLC-MS/MS. The total SA concentrations in surface water, sediments, and fish were ND-5.064 ng/L, ND-5.052 ng/g dry weight (d.w.), and ND-1.42 ng/g wet weight (w.w.), resp. The major compounds were sulfadiazine (SDZ), sulfamerazine (SMZ), and sulfamethoxazole (SMX) in water and fish. The SA levels of in fish from different habitat preferences revealed a spatial difference, with the order of demersal species > pelagic species. Moreover, the SA concentrations were affected by trophic guilds, indicating their decrease in the order of piscivorous fish > omnivorous fish > planktivorous fish > herbivorous fish. The obtained bioaccumulation factors showed that SMZ and SMX have strong bioenrichments in Ophiocephalus argus Cantor and Pelteobagrus fulvidraco. The risk assessment indicated that SAs did not pose significant health threats to the organisms. This research is the first report of SA contamination in the Hangbu-Fenle River, which can provide an important scientific basis for their pollution prevention and ecol. risk assessment in the aquatic environment.4-Amino-N-(6-chloropyridazin-3-yl)benzenesulfonamide (cas: 80-32-0) were involved in the experimental procedure.

4-Amino-N-(6-chloropyridazin-3-yl)benzenesulfonamide(cas: 80-32-0) is a sulfonamide antibiotic that is usually used as antibacterial anti-inflammatory drug, which has been applied in the treatment of acute urinary tract infections in childhood.Application In Synthesis of 4-Amino-N-(6-chloropyridazin-3-yl)benzenesulfonamideDue to its antibiotic activity, this chemical has been selected as an ingredient to prepare antibacterial composition.

Reference:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem