Month: September 2022

Electric Literature of C10H9ClN4O2SIn 2021, Hu, Yaru;Jin, Lei;Zhao, Yi;Jiang, Lei;Yao, Shijie;Zhou, Wang;Lin, Kuangfei;Cui, Changzheng published 《Annual trends and health risks of antibiotics and antibiotic resistance genes in a drinking water source in East China》. 《Science of the Total Environment》published the findings. The article contains the following contents:

The extensive pollution of antibiotics and antibiotic resistance genes (ARGs) in drinking water has aroused worldwide concern. Successive monitoring of these pollutants has noteworthy significance for drinking water safety. Accordingly, this study conducted successive monitoring of antibiotics and ARGs from 2015 to 2017 in a drinking water source in East China. The total antibiotic concentration ranged from 19.68 ng/L to 497.00 ng/L, and decreased slightly from 2015 to 2017. Eighteen out of forty-one ARG subtypes showing resistance to six antibiotic classes and one class I integrase gene intI1, were detected in the drinking water source at concentrations ranging from 6.5 x 104 copies/mL to 1.6 x 106 copies/mL. Importantly, the total ARG concentration increased on an annual basis from 2015 to 2017 with an average annual increment of 0.25 orders of magnitude, which was mainly attributed to the increase in specific ARG subtypes, such as sul1, sul2, sul3, tetA, qnrB, and ermB. Most ARGs was pos. correlated with the intI1 genes (r = 0.47-0.55, P < 0.01). Furthermore, the variation of antibiotics and ARGs appeared to be related to the water indexes, particularly of the values of COD, BOD₅, NO₂-N (P < 0.05). This study provides basic data on antibiotic and ARG pollution in the studied drinking water source. Importantly, the findings expound that although the residual antibiotics in this drinking water source decreased slightly from 2015 to 2017, while its biol. effect, the antibiotic resistance, increased annually, which give a warning of the antibiotic resistance pollution in the drinking water source. The experimental procedure involved many compounds, such as 4-Amino-N-(6-chloropyridazin-3-yl)benzenesulfonamide (cas: 80-32-0) .

4-Amino-N-(6-chloropyridazin-3-yl)benzenesulfonamide(cas: 80-32-0) is a sulfonamide antibiotic that is usually used as antibacterial anti-inflammatory drug, which has been applied in the treatment of acute urinary tract infections in childhood.Electric Literature of C10H9ClN4O2SDue to its antibiotic activity, this chemical has been selected as an ingredient to prepare antibacterial composition.

Reference:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Kim, Hyeongsu;Xuan, Zi;Hyun Kim, Ju published 《Tandem Synthesis of Tetrasubstituted NH Pyrroles from Simple Nitriles》 in 2021. The article was appeared in 《Chemistry – An Asian Journal》. They have made some progress in their research.Formula: C6H4N2 The article mentions the following:

An efficient tandem route to obtain tetrasubstituted NH pyrroles I (R = Me, Et, Bn; Ar = Ph, 2-naphthyl, pyridin-3-yl, etc.) in a one-pot manner has been developed, staring from simple nitriles ArCN, Et bromoacetates BrCH₂CO₂R, and zinc. This reaction involves oxidative dimerization of the zinc bromide complex of β-enaminoesters using cerium ammonium nitrate (CAN) as an oxidant, affording 2,3,4,5-tetrasubstituted pyrroles I in yields up to 91%. To complete the study, the researchers used 3-Cyanopyridine (cas: 100-54-9) .

3-Cyanopyridine(cas: 100-54-9) has been shown to have a number of pharmacological effects: it inhibits the production of prostaglandin E2 and nitric oxide in congestive heart failure patients; it prevents the formation of diazonium salt from benzene and nitrogen dioxide; it inhibits the growth of tumor cell lines; and it protects mice from radiation injury by scavenging reactive oxygen species. Formula: C6H4N2

Reference:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Gogoi, Monsumi;Das, Birinchi Kumar published 《Tetraaquabis(pyridine-3-carbonitrile-κN¹)nickel(II) benzene-1,4-dicarboxylate tetrahydrate》. The research results were published in《Acta Crystallographica, Section E: Crystallographic Communications》 in 2021.Synthetic Route of C6H4N2 The article conveys some information:

A nickel(II) terephthalate complex, viz. [Ni(C₆H₄N₂)₂(H₂O)₄](O₂CC₆H₄CO₂)·4H₂O, has been synthesized and studied by single-crystal X-ray diffraction. It crystallizes in the triclinic space group P [inline formula omitted] . The crystal structure shows an approx. octahedral coordination environment of the complex with the [Ni(H₂O)₄(3-NCpy)₂]²⁺ (3-NCpy is pyridine-3-carbonitrile) cation associated with four free water mols. and hydrogen bonded to a terephthalate dianion [graph set R22(8)]. The supramol. structure of the compound is stabilized by a three-dimensional array of O-H···O and O-H···N hydrogen bonds, along with π-π stacked pyridine-3-carbonitrile rings and C-H···O interactions. The experimental procedure involved many compounds, such as 3-Cyanopyridine (cas: 100-54-9) .

3-Cyanopyridine(cas: 100-54-9) is an antimicrobial agent that can be used in the treatment of infectious diseases.Synthetic Route of C6H4N2 It has been shown to be effective against a variety of bacteria, including methicillin-resistant Staphylococcus aureus (MRSA) and Streptococcus pneumoniae.

Reference:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Synthetic Route of C6H4N2In 2021, Kiani, Pirouz;Dodsworth, Elaine S.;Lever, A. B. P.;Pietro, William J. published 《Modeling ligand electrochemical parameters by repulsion-corrected eigenvalues》. 《Journal of Computational Chemistry》published the findings. The article contains the following contents:

Ligand electrochem. parameters, E_L, more commonly known as Lever parameters, have played a major research role in understanding redox processes involved in inorganic electrochem., enzymic reactions, catalysis, solar cells, biochem., and materials science. Despite their broad usefulness, Lever parameters are not well understood at a 1st-principles level. Using d. functional theory, the authors demonstrate in this contribution that a ligand′s Lever parameter is fundamentally related to the ligand′s ability to alter the eigenvalue of the electroactive spin-orbital in an octahedral transition metal complex. The authors′ anal. furthers a 1st-principles understanding of the nature of Lever parameters. The experimental procedure involved many compounds, such as 3-Cyanopyridine (cas: 100-54-9) .

3-Cyanopyridine(cas: 100-54-9) also shows biological activity against autoimmune diseases, such as murine hepatitis, by inhibiting the proliferation of B cells and T cells.Synthetic Route of C6H4N2 This drug is not effective against cancer cells because it does not inhibit DNA synthesis or protein synthesis.

Reference:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Shahriman, Mohamad Shariff;Mohamad, Sharifah;Mohamad Zain, Nur Nadhirah;Alias, Yatimah;Chandrasekaram, Kumuthini;Raoov, Muggundha published 《Paper-based polymeric ionic liquid for thin film micro extraction of sulfonamides in environmental water samples prior to HPLC-DAD analysis》. The research results were published in《Microchemical Journal》 in 2021.Reference of 4-Amino-N-(6-chloropyridazin-3-yl)benzenesulfonamide The article conveys some information:

Paper-based polymeric ionic liquid (p-Poly-(MMA-IL)) was successfully developed by grafting the polymeric ionic liquid on the surface of com. filter paper by using dipping method, presenting a new cost-effective film. The newly developed p-Poly-(MMA-IL) was then applied as a paper-based thin film microextraction (p-TFME) to extract four representative sulfonamides (SAs) drugs, which were sulfadiazine, sulfachloropyridazine, sulfamethoxazole, and sulfadimethoxine in environmental water samples. Besides, p-Poly-(MMA-IL) was successfully characterised by FTIR, FESEM, and XRD techniques and underwent significant parameters optimization, which affected the extraction efficiency. Under optimal conditions, the proposed method (p-Poly-(MMA-IL)-TFME) was evaluated and applied to analyze SAs in environmental water samples by using a high-performance liquid chromatog.-diode array detector (HPLC-DAD). The validation method showed that a good linearity (0.50 μg L^-1 -500 μg L^-1) was noted (R² > 0.999, n = 3). Detection and quantification limits were within 0.14 μg L^-1 – 0.52 μg L^-1 and 0.41 – 1.57 μg L^-1, resp., the preconcentraction factors were > 14.95, and the matrix effect was less than 2.64%, an acceptable percentage for real samples anal. The extraction recoveries of environmental water samples were ranged from 90.4% to 109.9% with a relative standard deviation (RSD) of less than 9.8%. The newly developed paper-based polymeric ionic liquid p-Poly-(MMA-IL) for anal. of SAs under the p-TFME procedure was successfully achieved with limited sample volume and organic solvent, fast extraction, and practicable in the daily anal. To complete the study, the researchers used 4-Amino-N-(6-chloropyridazin-3-yl)benzenesulfonamide (cas: 80-32-0) .

4-Amino-N-(6-chloropyridazin-3-yl)benzenesulfonamide(cas: 80-32-0) is a sulfonamide antibiotic that is usually used as antibacterial anti-inflammatory drug, which has been applied in the treatment of acute urinary tract infections in childhood.Reference of 4-Amino-N-(6-chloropyridazin-3-yl)benzenesulfonamideDue to its antibiotic activity, this chemical has been selected as an ingredient to prepare antibacterial composition.

Reference:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

COA of Formula: C15H11F3N2OIn 2017, Chen, Junjie;Han, Xiuling;Lu, Xiyan published 《Atom-Economic Synthesis of Pentaleno[2,1-b]indoles via Tandem Cyclization of Alkynones Initiated by Aminopalladation》. 《Journal of Organic Chemistry》published the findings. The article contains the following contents:

An atom-economic Pd(OAc)₂-catalyzed tandem cyclization of alkynones to synthesize pentaleno[2,1-b]indoles was developed efficiently. In the formed tetracyclic indole framework, two neighboring stereocenters, one being all-carbon quaternary, are constructed in a single process with excellent diastereoselectivity. This reaction was initiated by aminopalladation of alkynes and quenched by addition to the intramol. carbonyl groups. To complete the study, the researchers used (R)-4-Phenyl-2-(5-(trifluoromethyl)pyridin-2-yl)-4,5-dihydrooxazole (cas: 1835671-08-3) .

N-Arylation of a wide range of NH substrates by reaction with boronic acid in the presence of cupric acetate and either triethylamine or pyridine at room temperature. The reaction works even for poorly nucleophilic substrates such as arylamide. So (R)-4-Phenyl-2-(5-(trifluoromethyl)pyridin-2-yl)-4,5-dihydrooxazole(cas: C15H11F3N2O) can also undergo this reaction.

Reference:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Jia, Cong-Cong;Chen, Wang;Feng, Zi-Li;Liu, Zhao-Peng published 《Recent developments of RET protein kinase inhibitors with diverse scaffolds as hinge binders》. The research results were published in《Future Medicinal Chemistry》 in 2021.COA of Formula: C6H4N2 The article conveys some information:

A review. RET is a proto-oncogene encoding a receptor tyrosine kinase. RET regulates key aspects of cellular proliferation, differentiation and survival. The activation of RET via gene fusions or point mutations is closely related to lung, thyroid and other cancers. This review summarizes the developments of a diversity of small mol. RET protein kinase inhibitors in the past 10 years. These RET inhibitors are classified according to their hinge binder chemotypes as: pyrimidines, including the pyrazolopyrimidines, pyrimidine oxazines, quinazolines, 4-aminopyrimidines and 4-aminopyridines; indolinones; 5-aminopyrazole-4-carboxamides; 3-trifluoromethylanilines; imidazopyridines, imidazopyridazines and pyrazopyridines; nicotinonitriles; pyridones and 1,2,4-triazoles. In each section, the biol. activities of the inhibitors, their structure-activity relationships and possible binding modes with the RET kinase are introduced. The experimental procedure involved many compounds, such as 3-Cyanopyridine (cas: 100-54-9) .

3-Cyanopyridine(cas: 100-54-9) has been shown to have a number of pharmacological effects: it inhibits the production of prostaglandin E2 and nitric oxide in congestive heart failure patients; it prevents the formation of diazonium salt from benzene and nitrogen dioxide; it inhibits the growth of tumor cell lines; and it protects mice from radiation injury by scavenging reactive oxygen species. COA of Formula: C6H4N2

Reference:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Xia, Yu-Yan;Lv, Qing-Yang;Yuan, Hua;Wang, Jia-Yi published 《Selective oxidation of alcohols to nitriles with high-efficient Co-[Bmim]Br/C catalyst system》. The research results were published in《Chemical Papers》 in 2021.Category: pyridine-derivatives The article conveys some information:

An efficient method for catalyzing the ammoxidation of aromatic alcs. to aromatic nitriles was developed, in which a new heterogeneous catalyst based on transition metal elements was employed, the new catalyst was named Co-[Bmim]Br/C-700 and then characterized by X-ray photo-electronic spectroscopy, transmission electron microscope and X-ray diffraction. The reaction was carried out by two consecutive dehydrogenations under the catalysis of Co-[Bmim]Br/C-700, which catalytically oxidized the alc. to the aldehyde, and then the aldehyde was subjected to ammoxidation to the nitrile. The catalyst system was suitable for a wide range of substrates and nitriles obtained in high yields, especially, the conversion rate of benzyl alc., 4-methoxybenzyl alc., 4-chlorobenzyl alc. and 4-nitrobenzyl alc. reached 100%. The substitution of ammonia and oxygen for toxic cyanide to participate in the reaction accords with the theory of green chem. And 3-Cyanopyridine (cas: 100-54-9) was used in the research process.

3-Cyanopyridine(cas: 100-54-9) has been shown to have a number of pharmacological effects: it inhibits the production of prostaglandin E2 and nitric oxide in congestive heart failure patients; it prevents the formation of diazonium salt from benzene and nitrogen dioxide; it inhibits the growth of tumor cell lines; and it protects mice from radiation injury by scavenging reactive oxygen species. Category: pyridine-derivatives

Reference:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Xue, Gaijun;Xie, Fukai;Liang, Hongliang;Chen, Guoliang;Dai, Wen published 《Copper-Catalyzed Oxidative C-C Bond Cleavage of Alkyl-(Hetero)arenes Enabling Direct Access to Nitriles》. The research results were published in《Organic Letters》 in 2022.Safety of 3-Cyanopyridine The article conveys some information:

The cleavage and functionalization of C-C bonds has emerged as a powerful tool for discovery of new transformations. Herein, authors report a protocol that enables direct synthesis of nitriles via copper-catalyzed oxidative cleavage and cyanation of C-C bonds in a wide variety of multicarbon alkyl-substituted (hetero)arenes. Detailed mechanistic studies reveal that a tandem oxidative process is involved in this transformation. To complete the study, the researchers used 3-Cyanopyridine (cas: 100-54-9) .

3-Cyanopyridine(cas: 100-54-9) has been shown to have a number of pharmacological effects: it inhibits the production of prostaglandin E2 and nitric oxide in congestive heart failure patients; it prevents the formation of diazonium salt from benzene and nitrogen dioxide; it inhibits the growth of tumor cell lines; and it protects mice from radiation injury by scavenging reactive oxygen species. Safety of 3-Cyanopyridine

Reference:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

de Campos, Victoria M.;Andrade, Mariane A.;Maciel, Edvaldo V. S.;de Toffoli, Ana Lucia;Lancas, Fernando M. published 《Environmentally friendly analysis of sulphonamides in Brazilian honey through automated and miniaturised sample preparation coupled with LC-MS/MS》 in 2022. The article was appeared in 《Food Additives & Contaminants, Part A》. They have made some progress in their research.Formula: C10H9ClN4O2S The article mentions the following:

Increased use of environmentally friendly practices has become a trend in science because of the current awareness regarding climate change and related issues. Similarly for anal. chem., considering the development of greener methods for reducing the use of reagents and samples and also toxic waste generation. To meet such goals, automation, and miniaturization of sample preparation-a well-recognized laborious and time-consuming anal. step-are two promising strategies. This work associates the greener aspects of miniaturization and the performance of automated sample preparation Therefore, we proposed an anal. method using a miniaturized extraction column for pre-concentrating sulphamerazine, sulphamethazine, sulphamethoxazole, sulphadimethoxine, sulphathiazole, and sulphachlorpyridazine from honey and cleaning-up the samples. Several variables were optimized: extractive phase, loading flow, loading phase, and loading time. Under optimized conditions, the method showed adequate linearity between 5.0 and 60 ng g-1 with R > 0.99, and also good selectivity and recovery (114.6-124.1%) which are acceptable according to Brazilian legislation. Intra and inter-day precision were in the range 3.0-5.0%. Although sulfonamides were detected in one of the eight com. honey samples, the value was below the established MRL. The method showed efficiency, while also exhibiting greener characteristics resulting from miniaturization and automation, representing a promising environmentally friendly alternative for conventional sample preparation methods. To complete the study, the researchers used 4-Amino-N-(6-chloropyridazin-3-yl)benzenesulfonamide (cas: 80-32-0) .

4-Amino-N-(6-chloropyridazin-3-yl)benzenesulfonamide(cas: 80-32-0) can be introduced in the drinking water to fabricate aqueous liquid formulations for combating bacterial and protozoal in animals.Formula: C10H9ClN4O2S Besides, sulfachloropyridazine associated to tripelennamine hydrocholoride has been demonstrated to function as an anti-stress agent in poultry after vaccinations.

Reference:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem