Day: October 12, 2022

Maji, Ankur; Gupta, Shivangi; Maji, Milan; Kundu, Sabuj published the artcile< Well-Defined Phosphine-Free Manganese(II)-Complex-Catalyzed Synthesis of Quinolines, Pyrroles, and Pyridines>, Recommanded Product: 1-(Pyridin-3-yl)ethanone, the main research area is quinoline pyrrole pyridine preparation density functional theory; amino alc ketone manganese complex catalyst.

Herein, authors report a simple, phosphine-free, and inexpensive catalytic system based on a manganese(II) complex for synthesizing different important N-heterocycles such as quinolines, pyrroles and pyridines from amino alcs. and ketones. Several control experiments, kinetic studies, and DFT calculations were carried out to support the plausible reaction mechanism. Authors also detected two potential intermediates in the catalytic cycle using ESI-MS anal. Based on these studies, a metal-ligand cooperative mechanism was proposed.

Journal of Organic Chemistry published new progress about Amino alcohols Role: RCT (Reactant), RACT (Reactant or Reagent). 350-03-8 belongs to class pyridine-derivatives, and the molecular formula is C7H7NO, Recommanded Product: 1-(Pyridin-3-yl)ethanone.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Oates, Conor L.; Widegren, Magnus B.; Clarke, Matthew L. published the artcile< Manganese-catalysed transfer hydrogenation of esters>, Application In Synthesis of 93-60-7, the main research area is primary alc preparation manganese catalyst; ester reduction ethanol hydrogen transfer agent.

Manganese catalyzed ester reduction using ethanol as a hydrogen transfer agent in place of dihydrogen is reported. High yields can be achieved for a range of substrates using 1 mol% of a Mn(I) catalyst, with an alkoxide promoter. The catalyst is derived from a tridentate P,N,N ligand.

Chemical Communications (Cambridge, United Kingdom) published new progress about Aliphatic esters Role: RCT (Reactant), RACT (Reactant or Reagent). 93-60-7 belongs to class pyridine-derivatives, and the molecular formula is C7H7NO2, Application In Synthesis of 93-60-7.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Zhu, Guohua; Huang, Yang; Wang, Chun; Lu, Linxia; Sun, Tongming; Wang, Miao; Tang, Yanfeng; Shan, Doudou; Wen, Shuijin; Zhu, Jinli published the artcile< A novel coumarin-based fluorescence chemosensor for Al3+ and its application in cell imaging>, Reference of 93-60-7, the main research area is coumarin fluorescence chemosensor aluminum cell imaging; Al(3+); Chemosensor; Coumarin; Live cells.

As an efficient turn-on fluorescent chemosensor for Al3+, a new coumarin derivative (CND) has been designed and synthesized by the condensation of 8-formyl-7-hydroxycoumarin with niacin hydrazide. The spectroscopic studies revealed that the sensor CND exhibited a remarkable fluorescence enhancement towards Al3+ with high selectivity and sensitivity in EtOH-HEPES (95:5, volume/volume, pH = 7.40), which was attributed to the photoinduced electron transfer (PET) and -C:N isomerization mechanism. Fluorescence titration calculations data showed that the detection limit and the association constants of CND for Al3+ are 2.51 × 10-7 M and 9.64 × 104 M-1, resp. The results of experiments, including Job’s plot, 1H NMR titration and ESI-MS, revealed that the stoichiometric binding between CND and Al3+ was 1:1. The studies of the pH dependency of CND for Al3+ detection, and the cell imaging suggested the sensor CND could be promisingly applied for the recognition of Al3+ in biol. cells.

Spectrochimica Acta, Part A: Molecular and Biomolecular Spectroscopy published new progress about Fluorescence. 93-60-7 belongs to class pyridine-derivatives, and the molecular formula is C7H7NO2, Reference of 93-60-7.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Talik, Tadeusz; Talik, Zofia published the artcile< 2-Fluoronitro-derivatives of pyridine and picolines>, HPLC of Formula: 21901-29-1, the main research area is pyridine fluoro nitro; picoline fluoro nitro; diazotization aminopyridine.

6-Fluoro derivatives from 4-nitro- and 3,5- and 3,4-dinitropyridine, 3- and 5-nitro- and 3,5-dinitro-4-picoline, 3- and 5-nitro- and 3,5-dinitro-2-picoline, and 5-nitro-3-picoline as well as 2-fluoro-5-nitro-3-picoline were prepared in 52.5-85% yields by diazotization of the corresponding amino derivatives in 65% HF.

Roczniki Chemii published new progress about 21901-29-1. 21901-29-1 belongs to class pyridine-derivatives, and the molecular formula is C6H7N3O2, HPLC of Formula: 21901-29-1.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Bedowr, Noha S.; Yahya, Rosiyah B. published the artcile< Synthesis, characterization and thermal stability of binuclear Cu(II) complexes>, Application In Synthesis of 366-18-7, the main research area is copper dodecanoate bipyridine coordination polymer preparation thermal stability.

This research aimed to prepare, characterize and to study thermal properties of the coordination polymers of Cu(II) dodecanoate using ditopic ligands of 2,2′-bipyridine and 4,4′-bipyridine. The freshly prepared Cu(II) complexes were synthesized and characterized by elements composition, functional groups FTIR, UV-visible spectroscopy, magnetic properties, TGA (TGA and DSC) or optical microscopic examination (OPM). Thermally stable Cu(II) dodecanoate complexes were prepared with ditopic ligands of 2,2′-bipyridine and 4,4′-bipyridine for spintronic applications. The exptl. results of the prepared mol. magnets displayed ferromagnetic type of magnetic interactions in the square pyramidal Cu(II) dodecanoate, along with mesomorphic or stable mech. properties.

Journal of Molecular Structure published new progress about Ferromagnetic exchange. 366-18-7 belongs to class pyridine-derivatives, and the molecular formula is C10H8N2, Application In Synthesis of 366-18-7.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Frost, Scott C.; Walker, Paige; Orians, Colin M.; Robbat, Albert Jr. published the artcile< The Chemistry of Green and Roasted Coffee by Selectable 1D/2D Gas Chromatography Mass Spectrometry with Spectral Deconvolution>, Reference of 93-60-7, the main research area is roasted coffee spectral deconvolution gas chromatog mass spectrometry; 2D–GC/MS; GC/MS; coffee; coffee quality; deconvolution; green coffee.

Gas chromatog./mass spectrometry (GC/MS) is a long-standing technique for the anal. of volatile organic compounds (VOCs). When coupled with the Ion Analytics software, GC/MS provides unmatched selectivity in the anal. of complex mixtures and it reduces the reliance on high-resolution chromatog. to obtain clean mass spectra. Here, we present an application of spectral deconvolution, with mass spectral subtraction, to identify a wide array of VOCs in green and roasted coffees. Automated sequential, two-dimensional GC-GC/MS of a roasted coffee sample produced the retention index and spectrum of 750 compounds These initial analytes served as targets for subsequent coffee anal. by GC/MS. The workflow resulted in the quantitation of 511 compounds detected in two different green and roasted coffees. Of these, over 100 compounds serve as candidate differentiators of coffee quality, AAA vs. AA, as designated by the Coopedota cooperative in Costa Rica. Of these, 72 compounds survive the roasting process and can be used to discriminate green coffee quality after roasting.

Molecules published new progress about Gas chromatography. 93-60-7 belongs to class pyridine-derivatives, and the molecular formula is C7H7NO2, Reference of 93-60-7.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Hara, Naofumi; Aso, Koki; Li, Qiao-Zhi; Sakaki, Shigeyoshi; Nakao, Yoshiaki published the artcile< C2-selective alkylation of pyridines by rhodium-aluminum complexes>, Application of C11H16BNO2, the main research area is pyridine alkylation alkene vinylsilane CH activation rhodium aluminum catalyst; alkylpyridine preparation alkylation CH activation vinylsilane alkene bimetallic catalyst.

A C2- and mono-selective alkylation of various pyridines and azines with unactivated alkenes and vinylarenes using a heterobimetallic Rh-Al catalyst is reported. The use of aliphatic alkenes exclusively affords the linear alkylation products, while vinylarenes mainly afford branched alkylation products. The details of the reaction mechanism are revealed by DFT calculations: the reductive elimination of the products is rate-determining, which is consistent with the exptl. results. The origin of the linear/branched selectivity is elucidated based on deformation/interaction anal.

Tetrahedron published new progress about Alkenes Role: RCT (Reactant), RACT (Reactant or Reagent). 329214-79-1 belongs to class pyridine-derivatives, and the molecular formula is C11H16BNO2, Application of C11H16BNO2.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Tsai, Meng-Jung; Luo, Jheng-Hua; Wu, Jing-Yun published the artcile< Two-fold 2D + 2D → 2D interweaved rhombus (4,4) grid: synthesis, structure, and dye removal properties in darkness and in daylight>, Category: pyridine-derivatives, the main research area is pyridinylmethylpyridinyl naphthalimide copper coordination polymer preparation structure rhombus grid.

Compound [Cu(NI-mbpy-44)2(NO3)2]·4H2O (1, NI-mbpy-44 = N-(pyridin-4-ylmethyl)-4-(pyridin-4-yl)-1,8-naphthalimide) adopting a two-dimensional (2D) periodical rhombus (4,4) grid has been synthesized. This grid doubly interweaves in a parallel fashion to result in overall 2D + 2D → 2D networks with approx. 14% sufficient free volumes in which lattice H2O mols. reside. Dye removal studies show that 1 selectively adsorbs anionic methyl orange (MO) and acid orange 7 (AO7) over cationic methylene blue (MB) and malachite green (MG) from aqueous solutions containing single or mixed dyes in darkness at room temperature The exptl. isotherm data were analyzed using linear Langmuir and Freundlich isotherm equations; the results indicated that the Langmuir model showed a better fit for the adsorption of MO and AO7 over 1, with high dark adsorption capacities of 810 and 370 mg g-1, resp., although there could also be other associated mechanisms. The dark adsorption kinetics of MO and AO7 over 1 obeyed the pseudo-second-order kinetic model. Electrostatic attraction appears to be the dominating mechanism for adsorptive removal of MO and AO7 by 1, whereas π-π stacking (MO and AO7) and hydrogen-bonding interactions (AO7) could also be responsible. Exploration of the adsorption performance of MO and AO7, including studying the kinetics in daylight, shows similar results to those obtained in darkness, indicating the negligible influence of daylight on the dye removal. Nevertheless, 1 could liberate NI-mbpy-44 and Cu(II) into water throughout the entire adsorption experiment, which could be a potential environmental hazard, this could cause secondary pollution and mean that 1 is impractical for use as an adsorbent candidate.

Dalton Transactions published new progress about Adsorbents. 3731-53-1 belongs to class pyridine-derivatives, and the molecular formula is C6H8N2, Category: pyridine-derivatives.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Shipe, William D.; Sharik, Steven S.; Barrow, James C.; McGaughey, Georgia B.; Theberge, Cory R.; Uslaner, Jason M.; Yan, Youwei; Renger, John J.; Smith, Sean M.; Coleman, Paul J.; Cox, Christopher D. published the artcile< Discovery and Optimization of a Series of Pyrimidine-Based Phosphodiesterase 10A (PDE10A) Inhibitors through Fragment Screening, Structure-Based Design, and Parallel Synthesis>, Application In Synthesis of 56622-54-9, the main research area is pyrimidine derivative PDE10A inhibitor screening discovery preparation structure.

Screening of a fragment library for PDE10A inhibitors identified a low mol. weight pyrimidine hit with PDE10A Ki of 8700 nM and LE of 0.59. Initial optimization by catalog followed by iterative parallel synthesis guided by X-ray cocrystal structures resulted in rapid potency improvements with minimal loss of ligand efficiency. Compound 15h, with PDE10A Ki of 8.2 pM, LE of 0.49, and >5000-fold selectivity over other PDEs, fully attenuates MK-801-induced hyperlocomotor activity after i.p. dosing.

Journal of Medicinal Chemistry published new progress about Antipsychotics. 56622-54-9 belongs to class pyridine-derivatives, and the molecular formula is C7H10N2, Application In Synthesis of 56622-54-9.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem