Day: October 13, 2022

In 2018,Shu, Bing; Cao, Jiaojiao; Kuang, Guotao; Qiu, Jun; Zhang, Meiling; Zhang, Yan; Wang, Mingxue; Li, Xiaoya; Kang, Shuangshuang; Ou, Tian-Miao; Tan, Jia-Heng; Huang, Zhi-Shu; Li, Ding published 《Syntheses and evaluation of new acridone derivatives for selective binding of oncogene c-myc promoter i-motifs in gene transcriptional regulation》.Chemical Communications (Cambridge, United Kingdom) published the findings.Formula: C7H9NO The information in the text is summarized as follows:

We synthesized a series of acridone derivatives for specific binding ligands of i-motifs. Subsequent evaluations showed that B19 (I) could selectively bind to and stabilize the c-myc promoter i-motif without significant binding to the G-quadruplex and duplex DNA. This caused down-regulation of c-myc transcription and expression, resulting in tumor cell apoptosis. In the part of experimental materials, we found many familiar compounds, such as 2-(2-Hydroxyethyl)pyridine(cas: 103-74-2Formula: C7H9NO)

2-(2-Hydroxyethyl)pyridine(cas: 103-74-2) belongs to pyridine. Pyridine and its simple derivatives are stable and relatively unreactive liquids, with strong penetrating odours that are unpleasant.Formula: C7H9NO

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

In 2018,Indian Journal of Heterocyclic Chemistry included an article by Bhasker, G. Vijaya; Satyanarayana, G. V.; Laxminarayana, E.; Latha, A.; Chary, M. Thirumala. Computed Properties of C5H5BrN2. The article was titled 《Synthesis, antibacterial activity, and docking studies of some new 2-substituted-1,8-naphthyridine derivatives》. The information in the text is summarized as follows:

Two series of novel 2-substituted-1,8-naphthyridine derivatives I (R = quinolin-3-yl, 4-AcC6H4, 2-Br-5-pyridyl, etc.) and II (R = quinolin-3-yl, 4-Cl-2-pyridyl, 2-BrC6H4) were synthesized. These compounds were evaluated for their antibacterial activity. Docking studies for these title compounds are also presented in this communication. In the part of experimental materials, we found many familiar compounds, such as 6-Bromopyridin-3-amine(cas: 13534-97-9Computed Properties of C5H5BrN2)

6-Bromopyridin-3-amine(cas: 13534-97-9) belongs to anime. Large quantities of aliphatic amines are made synthetically. The most widely used industrial method is the reaction of alcohols with ammonia at a high temperature, catalyzed by metals or metal oxide catalysts (e.g., nickel or copper). Mixtures of primary, secondary, and tertiary amines are thereby produced.Computed Properties of C5H5BrN2

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

In 2018,Journal of the American Chemical Society included an article by MacQueen, Preston M.; Tassone, Joseph P.; Diaz, Carlos; Stradiotto, Mark. Synthetic Route of C7H9NO. The article was titled 《Exploiting Ancillary Ligation To Enable Nickel-Catalyzed C-O Cross-Couplings of Aryl Electrophiles with Aliphatic Alcohols》. The information in the text is summarized as follows:

The use of (L)Ni(o-tolyl)Cl precatalysts (L = PAd-DalPhos or CyPAd-DalPhos, I or II, resp.) enables the C(sp2)-O cross-coupling of primary, secondary, or tertiary aliphatic alcs. with (hetero)aryl electrophiles, including unprecedented examples of such nickel-catalyzed transformations employing (hetero)aryl chlorides, sulfonates, and pivalates. In addition to offering a competitive alternative to palladium catalysis, this work establishes the feasibility of utilizing ancillary ligation as a complementary means of promoting challenging nickel-catalyzed C(sp2)-O cross-couplings, without recourse to precious-metal photoredox catalytic methods.2-(2-Hydroxyethyl)pyridine(cas: 103-74-2Synthetic Route of C7H9NO) was used in this study.

2-(2-Hydroxyethyl)pyridine(cas: 103-74-2) belongs to pyridine. When pyridine is adsorbed on oxide surfaces or in porous materials, the following species are commonly observed: (i) pyridine coordinated to Lewis acid sites, (ii) pyridine H-bonded to weakly acidic hydroxyls, and (iii) protonated pyridine. At high coverage, physisorbed pyridine and protonated dimers can also be observed.Synthetic Route of C7H9NO

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

In 2019,Chemical Communications (Cambridge, United Kingdom) included an article by Xu, Rui; Cai, Chun. Synthetic Route of C33H24IrN3. The article was titled 《Three-component difluoroalkylation-thiolation of alkenes by iron-facilitated visible-light photoredox catalysis》. The information in the text is summarized as follows:

An efficient synthesis of(arylthio)difluoroalkanoates R1SCHR2CHR3CF2CO2Et [R1 = 4-MeC6H4, 4-FC6H4, PhCH2, 2-pyridinyl, 2-pyrimidinyl, etc.; R2 = n-hexyl, Ph, 4-MeOC6H4, etc., R3 = H; R2R3 = (CH2)3] has been developed via three-component difluoroalkylation-thiolation of alkenes R2CH:CHR3 with thiols R1SH and Et difluorobromoacetate using iron-facilitated visible light photoredox catalysis. The Csp3-Csp3 and Csp3-S bonds were simultaneously constructed smoothly under mild conditions. The reaction exhibits a broad substrate scope of alkenes and thiols with good to excellent yields. In the experiment, the researchers used fac-Tris(2-phenylpyridine)iridium(cas: 94928-86-6Synthetic Route of C33H24IrN3)

fac-Tris(2-phenylpyridine)iridium(cas: 94928-86-6) belongs to pyridine. In industry and in the lab, pyridine is used as a reaction solvent, particularly when its basicity is useful, and as a starting material for synthesizing some herbicides, fungicides, and antiseptics.Synthetic Route of C33H24IrN3

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

In 2019,International Journal of Molecular Sciences included an article by Marx, Sebastien; Bodart, Laurie; Tumanov, Nikolay; Wouters, Johan. Electric Literature of C6H7Br2N. The article was titled 《Design and synthesis of a new soluble natural β-carboline derivative for preclinical study by intravenous injection》. The information in the text is summarized as follows:

Harmine is a natural β-carboline compound showing several biol. activities, including antiproliferative properties, but this soluble natural mol. lacks selectivity. Harmine derivatives were reported to overcome this problem, but they are usually poorly soluble Here, we designed and synthesized a new 2, 7, 9-trisubstituted mol. (1-methyl-7-(3-methylbutoxy)-9- propyl-2-[(pyridin-2-yl)methyl]-9H-pyrido[3,4-b]indol-2-ium bromide) with a solubility of 1.87 ± 0.07 mg/mL in a simulated injection vehicle. This compound is stable for at least 72 h in acidic and physiol. conditions (pH 1.1 and 7.4) as well as in a simulated injection vehicle (physiol. liquid + 0.1% Tween 80). Solubility in those media is 1.06 ± 0.08 mg/mL and 1.62 ± 0.13 mg/mL at pH 7.4 and 1. The synthesized mol. displays a significant activity on five different cancer cell lines (IC50 range from 0.2 to 2 μM on A549, MDA-MB-231, PANC-1, T98G and Hs683 cell lines). This compound is also more active on cancer cells (MDA-MB-231) than on normal cells (MCF-10a) at IC50 concentrations Due to its high activity at low concentration, such solubility values should be sufficient for further in vivo antitumoral activity evaluation via i.v. injection. The experimental process involved the reaction of 2-(Bromomethyl)pyridine hydrobromide(cas: 31106-82-8Electric Literature of C6H7Br2N)

2-(Bromomethyl)pyridine hydrobromide(cas: 31106-82-8) belongs to pyridine. Pyridine’s structure is isoelectronic with that of benzene, but its properties are quite different. Pyridine is completely miscible with water, whereas benzene is only slightly soluble. Like all hydrocarbons, benzene is neutral (in the acid–base sense), but because of its nitrogen atom, pyridine is a weak base.Electric Literature of C6H7Br2N

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

The author of 《A combined computational/experimental study on HSA binding of two water-soluble Schiff base ligands derived from pyridine derivative and ethylendiamine》 were Molaee, Hajar; Sahihi, Mehdi; Moghadam, Majid; Mirkhani, Valiollah; Tangestaninejad, Shahram; Mohammadpoor-Baltork, Iraj; Amiri Rudbari, Hadi. And the article was published in Journal of Biomolecular Structure and Dynamics in 2019. Name: 4-Acetylpyridine The author mentioned the following in the article:

In this paper, two water-soluble Schiff bases were synthesized by the reaction of 4-pyridinecarbaldehyde or 4-pyridylmethyl ketone with ethylenediamine. Then, the bidentate Schiff base compounds were characterized by 1H NMR spectroscopy and elemental anal. In addition, the mol. structure of one of these compounds was determined by single crystal X-ray diffraction technique. Then, the binding ability of these two Schiff bases with HSA was investigated using UV-vis and fluorescence spectroscopy, mol. docking, and mol. dynamics simulation methods. The experimental part of the paper was very detailed, including the reaction process of 4-Acetylpyridine(cas: 1122-54-9Name: 4-Acetylpyridine)

4-Acetylpyridine(cas: 1122-54-9) belongs to pyridine. Pyridines form stable salts with strong acids. Pyridine itself is often used to neutralize acid formed in a reaction and as a basic solvent. Name: 4-Acetylpyridine

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

The author of 《Generation of N-Centered Radicals via a Photocatalytic Energy Transfer: Remote Double Functionalization of Arenes Facilitated by Singlet Oxygen》 were Soni, Vineet Kumar; Hwang, Ho Seong; Moon, Yu Kyung; Park, Sung-Woo; You, Youngmin; Cho, Eun Jin. And the article was published in Journal of the American Chemical Society in 2019. Safety of fac-Tris(2-phenylpyridine)iridium The author mentioned the following in the article:

An unprecedented approach to the generation of an N-centered radical via a photocatalytic energy-transfer process from readily available heterocyclic precursors is reported, which is distinctive of the previous electron transfer approaches. In combination with singlet oxygen, the in-situ-generated nitrogen radical from the oxadiazoline substrate in the presence of fac-Ir(ppy)3 undergoes a selective ipso addition to arenes to furnish remotely double-functionalized spiro-azalactam products. The mechanistic studies provide compelling evidence that the catalytic cycle selects the energy-transfer pathway. A concurrent activation of mol. oxygen to generate singlet oxygen by energy transfer is also rationalized. Furthermore, the occurrence of the electron transfer phenomenon is excluded on the basis of the neg. driving forces for one-electron transfer between oxadiazoline and the excited state of fac-Ir(ppy)3 with a consideration of their redox potentials. The necessity of singlet oxygen as well as the photoactivated oxadiazoline substrate is clearly supported by a series of controlled experiments D. functional studies have also been carried out to support these observations. The scope of substrates is explored by synthesizing diversely functionalized cyclohexadienone moieties in view of their utility in complex organic syntheses and as potential targets in pharmacol. After reading the article, we found that the author used fac-Tris(2-phenylpyridine)iridium(cas: 94928-86-6Safety of fac-Tris(2-phenylpyridine)iridium)

fac-Tris(2-phenylpyridine)iridium(cas: 94928-86-6) belongs to pyridine. Pyridine derivatives lend themselves to many roles in the spirited field of supramolecular chemistry – whether as the ligand backbone of metal-organic polymers or presiding over the key electronic stations of nanodevices. In biochemistry, pyridine-containing cofactors are necessary nutrients on which our lives depend. Safety of fac-Tris(2-phenylpyridine)iridium

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

The author of 《Polyamine-co-2, 6-diaminopyridine covalently bonded on chitosan for the adsorptive removal of Hg(II) ions from aqueous solution》 were Liang, Wen; Li, Manlin; Jiang, Shuncheng; Ali, Amjad; Zhang, Zengqiang; Li, Ronghua. And the article was published in International Journal of Biological Macromolecules in 2019. Formula: C5H7N3 The author mentioned the following in the article:

In the present study, 2, 6-diaminopyridine (PD) and polyamine compounds (ethylenediamine (EDA), triethylenetetramine (TETA), and tetraethylenepentamine (TEPA)) were used to modify chitosan (CS). The obtained derivatives (PD-CS, PD-EDA-CS, PD-TETA-CS, and PD-TEPA-CS) were identified and employed as adsorbents in batch experiments for the removal of Hg(II) from aqueous solutions The results confirmed that successful modification improves the Hg(II) adsorption significantly compared to pristine CS. The adsorbed amounts of Hg(II) increased gradually and reached maxima at pH values above 4.0 for all derivatives The Hg(II) adsorption equilibrium state was achieved within 12 h, with the process driven by a pseudo-second-order kinetic model. The Langmuir model effectively interpreted the Hg(II) adsorption isotherms; the maximum adsorption capacities for Hg(II) ions at 295 K were 172.7, 303.6, 276.0, and 230.6 mg/g for PD-CS, PD-EDA-CS, PD-TETA-CS, and PD-TEPA-CS, resp. High temperature and low ionic strength favored Hg(II) adsorption. The Hg(II)-loaded CS derivative was easily regenerated and showed acceptable reusability. The further FT-IR and XPS analyses indicate that the Hg(II) adsorption is governed by a process combining electrostatic attraction and a coordination reaction. The CS derivatives produced from polyamine-co-2, 6-diaminopyridine covalently bonded onto CS are promising adsorbents for the adsorptive removal of Hg(II) from an aqueous solution In the part of experimental materials, we found many familiar compounds, such as 2,6-Diaminopyridine(cas: 141-86-6Formula: C5H7N3)

2,6-Diaminopyridine(cas: 141-86-6) belongs to pyridine. Pyridine and its simple derivatives are stable and relatively unreactive liquids, with strong penetrating odours that are unpleasant.Formula: C5H7N3

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

《Carbazole-Based Tetrapodal Anchor Groups for Gold Surfaces: Synthesis and Conductance Properties》 was published in Angewandte Chemie, International Edition in 2020. These research results belong to O’Driscoll, Luke J.; Wang, Xintai; Jay, Michael; Batsanov, Andrei S.; Sadeghi, Hatef; Lambert, Colin J.; Robinson, Benjamin J.; Bryce, Martin R.. Application of 2510-22-7 The article mentions the following:

As the field of mol.-scale electronics matures and the prospect of devices incorporating mol. wires becomes more feasible, it is necessary to progress from the simple anchor groups used in fundamental conductance studies to more elaborate anchors designed with device stability in mind. This study presents oligo(phenylene-ethynylene) wires with one tetrapodal anchor and a Ph or pyridyl head group. The new anchors are designed to bind strongly to Au surfaces without disrupting the conductance pathway of the wires. Conductive probe at. force microscopy (cAFM) was used to determine the conductance of self-assembled monolayers (SAMs) of the wires in Au-SAM-Pt and Au-SAM-graphene junctions, from which the conductance per mol. was derived. For tolane-type wires, mean conductances per mol. of up to 10-4.37 G0 (Pt) and 10-3.78 G0 (graphene) were measured, despite limited electronic coupling to the Au electrode, demonstrating the potential of this approach. Computational studies of the surface binding geometry and transport properties rationalize and support the exptl. results. The experimental process involved the reaction of 4-Ethynylpyridine(cas: 2510-22-7Application of 2510-22-7)

4-Ethynylpyridine(cas: 2510-22-7) belongs to pyridine. Pyridines are often used as catalysts or reagents; particular notice has been paid recently to how pyridine coordinates to metal centers enabling a wide range of valuable reactions. Application of 2510-22-7

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

《In situ formation of nitrogen-doped carbon-wrapped Co3O4 enabling highly efficient and stable catalytic reduction of p-nitrophenol》 was written by Huang, Lu; Zhang, Hang; He, Zhiqiao; Chen, Jianmeng; Song, Shuang. Computed Properties of C5H7N3 And the article was included in Chemical Communications (Cambridge, United Kingdom) in 2020. The article conveys some information:

This study presents a novel nitrogen-doped carbon-wrapped Co3O4 prepared by a facile impregnation-carbonization process using low-cost raw materials. The optimized catalyst exhibits the highest activity reported to date for Co-based catalysts used in the reduction of p-nitrophenol to p-aminophenol with NaBH4 and remains highly stable over seven continuous runs. In the part of experimental materials, we found many familiar compounds, such as 2,6-Diaminopyridine(cas: 141-86-6Computed Properties of C5H7N3)

2,6-Diaminopyridine(cas: 141-86-6) belongs to pyridine. Pyridine and its simple derivatives are stable and relatively unreactive liquids, with strong penetrating odours that are unpleasant.Computed Properties of C5H7N3

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem