Day: October 13, 2022

In 2013,El Abidine Chamas, Zein; Marchi, Enrico; Modelli, Alberto; Fort, Yves; Ceroni, Paola; Mamane, Victor published 《Highly Fluorescent, π-Extended Indenopyrido[2,1-a]isoindolone Derivatives Prepared by a Palladium-Catalysed Cascade Reaction》.European Journal of Organic Chemistry published the findings.Electric Literature of C5H3BrClN The information in the text is summarized as follows:

A new family of heterocyclic pentacyclic compounds were prepared by a cascade reaction involving 2,5-dihalopyridines and (2-formylphenyl)boronic acids. Most of the compounds exhibit high quantum yields of fluorescence in dichloromethane. In some cases, small changes in the substitution pattern caused fluorescence quenching. To rationalize this effect, a detailed photophys. study combined with electrochem. and computational studies was performed on four representative derivatives It appears that the fluorescence quenching is caused by a thermally activated nonradiative deactivation process that can be prevented in a rigid matrix such as ethanol at 77 °K or PMMA. In the experiment, the researchers used many compounds, for example, 5-Bromo-2-chloropyridine(cas: 53939-30-3Electric Literature of C5H3BrClN)

5-Bromo-2-chloropyridine(cas: 53939-30-3) belongs to pyridine. Pyridines form stable salts with strong acids. Pyridine itself is often used to neutralize acid formed in a reaction and as a basic solvent. Electric Literature of C5H3BrClN

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

The author of 《Boronic acid derivatized lanthanide-polyoxometalates with novel B-OH-Ln and B-O-Nb bridges》 were Li, Shujun; Zhao, Yue; Qi, Huihui; Zhou, Yanfang; Liu, Shuxia; Ma, Xiaoming; Zhang, Jie; Chen, Xuenian. And the article was published in Chemical Communications (Cambridge, United Kingdom) in 2019. Application In Synthesis of Pyridin-3-ylboronic acid The author mentioned the following in the article:

Three new boronic acid derivatized lanthanide-polyoxometalates (BA-Ln-POMs) were synthesized, in which boronic acids served as bi- or tri-dentate ligands and exhibited interesting coordination ability towards POMs and LnIII. The pH is crucial in controlling the coordination modes of boronic acid and the formation of B-O-Ln and B-O-Nb bridges. Compared with the boronic acid-free Ln-POM, a longer lifetime was observed for compound 2Eu due to the coordination of boronic acids to the EuIII center. The results came from multiple reactions, including the reaction of Pyridin-3-ylboronic acid(cas: 1692-25-7Application In Synthesis of Pyridin-3-ylboronic acid)

Pyridin-3-ylboronic acid(cas: 1692-25-7) belongs to pyridine. Pyridine is very deactivated towards electrophilic substitution with respect to benzene. For this reason classical formylation, using methods such as the Gattermann or Vilsmeier reactions, are not generally successful. Application In Synthesis of Pyridin-3-ylboronic acid

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

The author of 《A New Schizophrenia Model: Immune Activation is Associated with the Induction of Different Neurotoxic Products which Together Determine Memory Impairments and Schizophrenia Symptom Dimensions》 were Sirivichayakul, Sunee; Kanchanatawan, Buranee; Thika, Supaksorn; Carvalho, Andre F.; Maes, Michael. And the article was published in CNS & Neurological Disorders: Drug Targets in 2019. Computed Properties of C6H5NO2 The author mentioned the following in the article:

Objective: Recently, we reported that stable-phase schizophrenia is characterized by two interrelated symptom dimensions: PHEMN (psychotic, hostility, excitation, mannerism and neg. symptoms); and DAPS (depressive, anxiety and physio-somatic symptoms) and that Major Neuro-Cognitive psychosis (MNP) is the full-blown phenotype of schizophrenia (largely overlapping with deficit schizophrenia). Herein we examined the effects of immune activation in association with tryptophan catabolite (TRYCAT) patterning and memory disorders on PHEMN/DAPS dimensions and MNP. Methods: Serum levels of macrophage inflammatory protein-1 (MIP-1), soluble interleukin (IL)-1 receptor antagonist (sIL-1RA), IL-10, eotaxin, IgA/IgM responses to TRYCATs, and Consortium to Establish a Registry for Alzheimer’s disease (CERAD) tests were assessed in 40 controls and 80 schizophrenia patients. Results: Schizophrenia and MNP were predicted by significantly increased levels of IL-10, eotaxin and TRYCATs. A large part of variance in both PHEMN/DAPS symptom dimensions (42.8%) was explained by cytokine levels and TRYCATs combined. The MIP+sIL-1RA+IL-10 composite score and eotaxin explained each around on the basis of 19% of the variance in symptom dimensions, and approx. 18% of memory deficits. Moreover, MIP+sIL-1RA+IL-10 was significantly associated with elevations in picolinic acid, xanthurenic acid and 3-OH-kynurenine. Partial Least Squares path modeling shows that highly significant effects of MIP+sIL-1RA+IL-10 on symptomatol. are mediated by the effects of noxious TRYCATs on memory deficits. Conclusion: Current findings indicate that in schizophrenia, immune activation may underpin activation of indoleamine-2,3-dioxygenase and kynurenine monooxygenase, while impairments in episodic and semantic memory may be caused by the neurotoxic effects of TRYCATs and eotaxin. The combined effects of immune activation, eotaxin and memory defects determine to a large extent, PHEMN/DAPS symptoms and the MNP phenotype. These findings indicate that schizophrenia phenomenol. is largely mediated by multiple neuro-immune pathways and that immune activation, increased production of eotaxin and neurotoxic TRYCATs (picolinic acid, xanthurenic acid and 3-OH-kynurenine) are new drug targets in schizophrenia and MNP.Picolinic acid(cas: 98-98-6Computed Properties of C6H5NO2) was used in this study.

Picolinic acid(cas: 98-98-6) is used in the preparation of 2-Aminodihydro[1,3]thiazines as BACE 2 inhibitors and their preparation and use in the treatment of diabetes.Computed Properties of C6H5NO2

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

The author of 《Rational Design of Multi-Stimuli-Responsive Scaffolds: Synthesis of Luminescent Oligo(ethynylpyridine)-Containing Alkynylplatinum(II) Polypyridine Foldamers Stabilized by Pt···Pt Interactions》 were Chan, Michael Ho-Yeung; Leung, Sammual Yu-Lut; Yam, Vivian Wing-Wah. And the article was published in Journal of the American Chemical Society in 2019. Name: 2,6-Dibromopyridine The author mentioned the following in the article:

A series of oligo(ethynylpyridine)-containing alkynylplatinum(II) terpyridine/bzimpy (bzimpy = 2,6-bis(N-alkylbenzimidazol-2′-yl)pyridine) metallofoldamers [L3Pt(CC-1,3-Ar)nCCPtL3] (L3 = tpy, bzimpy; Ar = m-phenylene, 2,6-pyridinediyl) has been designed and synthesized to investigate the potential applications of metallofoldamers imparted by the rich spectroscopic responses of Pt···Pt interactions. Apart from the control of the folding/unfolding processes by solvent compositions and temperatures, this class of metallofoldamers has also been found to exhibit reversible folding/unfolding behaviors mediated by the addition of acids/bases due to the incorporation of the acid-sensitive oligo(ethynylpyridine) derivatives More importantly, the intramol. Pt···Pt interaction has been found to play a crucial role in governing the folded state conformation. The conformation of this class of metallofoldamers has been investigated by 2D ROESY NMR, electronic absorption, and emission spectroscopy, which provide further insights into the rational mol. design and multidimensional control of metallofoldamers upon the application of various external stimuli, leading to the preparation of multi-stimuli-responsive materials for potential applications in material sciences. In addition to this study using 2,6-Dibromopyridine, there are many other studies that have used 2,6-Dibromopyridine(cas: 626-05-1Name: 2,6-Dibromopyridine) was used in this study.

2,6-Dibromopyridine(cas: 626-05-1) belongs to pyridine. Pyridine derivatives lend themselves to many roles in the spirited field of supramolecular chemistry – whether as the ligand backbone of metal-organic polymers or presiding over the key electronic stations of nanodevices. In biochemistry, pyridine-containing cofactors are necessary nutrients on which our lives depend. Name: 2,6-Dibromopyridine

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

《Facile Synthesis of Amphiphilic Bottlebrush Block Copolymers Bearing Pyridine Pendants via Click Reaction from Protected Alkyne Side Groups》 was published in Macromolecules (Washington, DC, United States) in 2020. These research results belong to Kim, Myung-Jin; Yu, Yong-Guen; Chae, Chang-Geun; Seo, Ho-Bin; Lee, Jae-Suk. Reference of 2-(Bromomethyl)pyridine hydrobromide The article mentions the following:

We present the facile synthetic platform for the production of amphiphilic bottlebrush block copolymers bearing pyridine pendants through combination of living anionic polymerization (LAP), ring-opening metathesis polymerization (ROMP), and copper-catalyzed azide-alkyne cycloaddition (CuAAC). ω-Norbornenyl poly(4-((trimethylsilyl)ethynyl)styrene) (NBPTMSESt) with controlled mol. weights (Mn = 3-4 kDa) and low dispersity (D = 1.03-1.08) was synthesized by LAP and the subsequent end-capping reaction with exo-N-(n-decyl-10-phenylacrylate)-5-norbornene-2,3-dicarboximide. Well-defined bottlebrush block copolymers (Mn = 134-548 kDa, D = 1.04-1.14) were achieved through sequential ROMP of ω-norbornenyl polystyrene with NBPTMSESt and subsequently deprotected with the clickable alkyne group. Amphiphilic bottlebrush block copolymers were obtained by the click reaction of alkyne and azide functional pyridines in the presence of the organic-soluble catalyst/ligand system of CuBr(PPh3)3 and N,N,N’,N”,N”-pentamethyldiethylenetriamine. These polymers exhibited the three-dimensional ordered porous films through breath-figure self-assembly. The experimental part of the paper was very detailed, including the reaction process of 2-(Bromomethyl)pyridine hydrobromide(cas: 31106-82-8Reference of 2-(Bromomethyl)pyridine hydrobromide)

2-(Bromomethyl)pyridine hydrobromide(cas: 31106-82-8) belongs to pyridine. Pyridine’s structure is isoelectronic with that of benzene, but its properties are quite different. Pyridine is completely miscible with water, whereas benzene is only slightly soluble. Like all hydrocarbons, benzene is neutral (in the acid–base sense), but because of its nitrogen atom, pyridine is a weak base.Reference of 2-(Bromomethyl)pyridine hydrobromide

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

《A low symmetry cluster meets a low symmetry ligand to sharply boost MOF thermal stability》 was published in Chemical Communications (Cambridge, United Kingdom) in 2020. These research results belong to Gao, Yajun; Zhang, Mingxing; Chen, Cong; Zhang, Yong; Gu, Yuming; Wang, Qian; Zhang, Wenwei; Pan, Yi; Ma, Jing; Bai, Junfeng. Recommanded Product: 1692-25-7 The article mentions the following:

A new approach in which a low symmetry cluster meets a low symmetry ligand to sharply boost the thermal stability of a MOF via addnl. inter-linker interactions is presented for the first time, leading to the successful synthesis of a novel binuclear Co-based MOF, {[Co2(L1)2DMF]·1.5DMF·0.75MeOH·1.5H2O}∞ (H2L1 = 5-(pyridin-3-yl)isophthalic acid, NJU-Bai62: NJU-Bai for Nanjing University Bai group), with exceptional thermal stability of up to 450°. This work may open up a new avenue for constructing robust MOFs from abundant, unstable, and low symmetry binuclear clusters, which have usually been ignored by most MOF chemists. In the experimental materials used by the author, we found Pyridin-3-ylboronic acid(cas: 1692-25-7Recommanded Product: 1692-25-7)

Pyridin-3-ylboronic acid(cas: 1692-25-7) belongs to pyridine. Pyridines are often used as catalysts or reagents; particular notice has been paid recently to how pyridine coordinates to metal centers enabling a wide range of valuable reactions. Recommanded Product: 1692-25-7

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

《Simultaneous Fluorescence Imaging Reveals N-Methyl-D-aspartic Acid Receptor Dependent Zn2+/H+ Flux in the Brains of Mice with Depression》 was written by Wang, Xin; Bai, Xiaoyi; Su, Di; Zhang, Yandi; Li, Ping; Lu, Shuyi; Gong, Yulin; Zhang, Wen; Tang, Bo. Category: pyridine-derivatives And the article was included in Analytical Chemistry (Washington, DC, United States) in 2020. The article conveys some information:

Depression is immensely attributed to the overactivation of N-methyl-D-aspartic acid (NMDA) receptor in the brains. As regulatory binding partners of NMDA receptor, both Zn2+ and H+ are intimately interrelated to NMDA receptor’s activity. Therefore, exploring synergistic changes on the levels of Zn2+ and H+ in brains will promote the knowledge and treatment of depression. However, the lack of efficient, appropriate imaging tools limits simultaneously tracking Zn2+ and H+ in living mouse brains. Thus, a well-designed dual-color fluorescent probe (DNP) was fabricated for the simultaneous monitoring of Zn2+ and H+ in the brains of mice with depression. Encountering Zn2+, the probe evoked bright blue fluorescence at 460 nm. Meanwhile, the red fluorescence at 680 nm was decreased with H+ addition With blue/red dual fluorescence signal of DNP, we observed the synchronous increased Zn2+ and H+ in PC12 cells under oxidative stress. Notably, in vivo imaging for the first time revealed the simultaneous reduction of Zn2+ and pH in brains of mice with depression-like behaviors. Further results implied that the NMDA receptor might be responsible for the coinstantaneous fluctuation of Zn2+ and H+ during depression. Altogether, this work is conducive to the knowledge of neural signal transduction mechanisms, advancing our understanding of the pathogenesis in depression. In the part of experimental materials, we found many familiar compounds, such as Bis(pyridin-2-ylmethyl)amine(cas: 1539-42-0Category: pyridine-derivatives)

Bis(pyridin-2-ylmethyl)amine(cas: 1539-42-0) is a secondary amine with two picolyl substituents. As a tridentate ligand this compound provides three nitrogen donors that affords good selectivity for Zn2+ over biologically relevant metals such as Na+, K+, Mg2+ and Ca2+, and leaves coordination sites free for anion binding. Category: pyridine-derivatives

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

《Functionalization of partially reduced graphene oxide by metal complex as electrode material in supercapacitor》 was written by Bakhshandeh, Mohammad Bagher; Kowsari, Elaheh. COA of Formula: C5H7N3 And the article was included in Research on Chemical Intermediates in 2020. The article conveys some information:

High elec. conductivity and high surface area are two main parameters which affect supercapacitor electrode performance. Graphene has gained prominence in electrode of elec. double-layer capacitor due to its high elec. conductivity and high sp. surface area. Functionalization of partially reduced graphene oxide is the state-of-the-art method in synthesis of graphene system which is used in electrode of elec. double-layer capacitors (EDLCs). In this study, graphene system was functionalized by 2,6-diaminopyridine cobalt complex with a simple method in available and engineered porous surface area to eliminate agglomeration of graphene sheets and enhance elec. conductivity of them which is suitable for EDLCs. Curved and porous structure that obtained high and available surface area for supercapacitor electrodes was approved by structural anal. such as X-ray diffraction, Raman spectroscopy, SEM and Brunauer-Emmett-Teller. Furthermore, the XPS and Fourier-transform IR were used for elemental anal. Also, galvanostatic charge/discharge (GCD), cyclic voltammetry and electrochem. impedance spectroscopy were applied to specify electrochem. behavior of the prepared electrode. Accordingly, the elec. resistance obtained was 5.23 Ω. The specific capacitance obtained was 192 F/g by cyclic voltammetry and 107 F/g by GCD methods.2,6-Diaminopyridine(cas: 141-86-6COA of Formula: C5H7N3) was used in this study.

2,6-Diaminopyridine(cas: 141-86-6) belongs to pyridine. Pyridine and its simple derivatives are stable and relatively unreactive liquids, with strong penetrating odours that are unpleasant.COA of Formula: C5H7N3

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

《Transition metal-free B(dan)-installing reaction (dan: naphthalene-1,8-diaminato): H-B(dan) as a B(dan) electrophile》 was written by Li, Jialun; Seki, Michinari; Kamio, Shintaro; Yoshida, Hiroto. Related Products of 3510-66-5 And the article was included in Chemical Communications (Cambridge, United Kingdom) in 2020. The article conveys some information:

H-B(dan) was demonstrated to serve as a B(dan) electrophile, despite its highly diminished boron-Lewis acidity, leading to direct and transition metal-free approach to R-B(dan) of high synthetic utility upon treatment with Grignard reagents. Iterative cross-coupling of 5-bromo-2-pyridyl-B(dan), synthesized by the present method, was also achieved. After reading the article, we found that the author used 2-Bromo-5-methylpyridine(cas: 3510-66-5Related Products of 3510-66-5)

2-Bromo-5-methylpyridine(cas: 3510-66-5) belongs to pyridine. When pyridine is adsorbed on oxide surfaces or in porous materials, the following species are commonly observed: (i) pyridine coordinated to Lewis acid sites, (ii) pyridine H-bonded to weakly acidic hydroxyls, and (iii) protonated pyridine. At high coverage, physisorbed pyridine and protonated dimers can also be observed.Related Products of 3510-66-5

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

《Heteroleptic NiII complexes: Synthesis, structural characterization, computational studies and amoebicidal activity evaluation》 was written by Hernandez-Ayala, Luis Felipe; Toledano-Magana, Yanis; Ortiz-Frade, Luis; Flores-Alamo, Marcos; Galindo-Murillo, Rodrigo; Reina, Miguel; Garcia-Ramos, Juan Carlos; Ruiz-Azuara, Lena. Synthetic Route of C12H12N2 And the article was included in Journal of Inorganic Biochemistry in 2020. The article conveys some information:

In this work, we present the synthesis, characterization, electrochem. studies, DFT calculations, and in vitro amoebicidal effect of seven new heteroleptic NiII coordination compounds The crystal structures of [H2(pdto)](NO3)2 and [Ni(pdto)(NO3)]PF6 are presented, pdto = 2,2′-[1,2-ethanediylbis-(sulfanediyl-2,1-ethanediyl)]dipyridine. The rest of the compounds have general formulas: [Ni(pdto)(N-N)](PF6) where N-N = 2,2′-bipyridine (bpy), 4,4′-dimethyl-2,2′-bipyridine (44dmbpy), 5,5′-dimethyl-2,2′-bipyridine (55dmbpy), 1,10-phenanthroline (phen), 4,7-dimethyl-1,10-phenanthroline (47dmphen) and 5,6-dimethyl-1,10-phenanthroline (56dmphen). The size of N-N ligand and its substituents modulate the compound electronic features and influence their antiproliferative efficiency against Entamoeba histolytica, 56dmphen derivative, shows the biggest molar volume and presents a powerful amoebicidal activity (IC50 = 1.2μM), being seven times more effective than the first-line drug for human amoebiasis metronidazole. Also, increases the reactive oxygen species concentration within the trophozoites. This could be the trigger of the E. histolytica growth inhibition. The antiparasitic effect is described using NiII electron d., molar volume, estimated by DFT, as well as the exptl. redox potential and diffusion coefficients In general, amoebicidal efficiency is directly proportional to the increment of the molar volume and decreases when the redox potential becomes more pos. The experimental part of the paper was very detailed, including the reaction process of 4,4′-Dimethyl-2,2′-bipyridine(cas: 1134-35-6Synthetic Route of C12H12N2)

4,4′-Dimethyl-2,2′-bipyridine(cas: 1134-35-6) is used as a chemical Intermediate. It can be used for the determination of ferrous and cyanide compounds.Synthetic Route of C12H12N2 Furthermore, 4,4′-Dimethyl-2,2′-bipyridine is used in the synthesis of a series of o-phenanthroline-substituted ruthenium(II) complexes.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem