Day: October 13, 2022

Li, Ru-Jin; Marcus, Adam; Fadaei-Tirani, Farzaneh; Severin, Kay published an article in 2021. The article was titled 《Orientational self-sorting: formation of structurally defined Pd4L8 and Pd6L12 cages from low-symmetry dipyridyl ligands》, and you may find the article in Chemical Communications (Cambridge, United Kingdom).Product Details of 1692-25-7 The information in the text is summarized as follows:

Tetra- and hexanuclear coordination cages were obtained in reactions of [Pd(CH3CN)4](BF4)2 with low-symmetry dipyridyl ligands. In both cases, only one structurally defined complex was formed out of a vast pool of potential isomers. After reading the article, we found that the author used Pyridin-3-ylboronic acid(cas: 1692-25-7Product Details of 1692-25-7)

Pyridin-3-ylboronic acid(cas: 1692-25-7) belongs to pyridine. When pyridine is adsorbed on oxide surfaces or in porous materials, the following species are commonly observed: (i) pyridine coordinated to Lewis acid sites, (ii) pyridine H-bonded to weakly acidic hydroxyls, and (iii) protonated pyridine. At high coverage, physisorbed pyridine and protonated dimers can also be observed.Product Details of 1692-25-7

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Zhou, Gui-Juan; Tang, Yi-Yun; Zuo, Jin-Xi; Yi, Tao; Tang, Jun-Peng; Zhang, Ping; Zou, Wei; Tang, Xiao-Qing published an article in 2022. The article was titled 《Itaconate alleviates β2-microglobulin-induced cognitive impairment by enhancing the hippocampal amino-β-carboxymuconate-semialdehyde-decarboxylase/picolinic acid pathway》, and you may find the article in Biochemical Pharmacology (Amsterdam, Netherlands).Synthetic Route of C6H5NO2 The information in the text is summarized as follows:

β2-microglobulin (B2M) has been established to impair cognitive function. However, no treatment is currently available for B2M-induced cognitive dysfunction. Itaconate is a tricarboxylic acid (TCA) cycle intermediate that exerts neuroprotective effects in several neurol. diseases. The amino-β-carboxymuconate-semialdehyde-decarboxylase (ACMSD)/picolinic acid (PIC) pathway is a crucial neuroprotective branch in the kynurenine pathway (KP). The present study sought to investigate whether Itaconate attenuates B2M-induced cognitive impairment and examine the mediatory role of the hippocampal ACMSD/PIC pathway. We demonstrated that 4-Octyl Itaconate (OI, an itaconate derivative) significantly alleviated B2M-induced cognitive dysfunction and hippocampal neurogenesis impairment. OI treatment also increased the expression of ACMSD, elevated the concentration of PIC, and decreased the level of 3-HAA in the hippocampus of B2M-exposed rats. Furthermore, inhibition of ACMSD by TES-991 significantly abolished the protections of Itaconate against B2M-induced cognitive impairment and neurogenesis deficits. Exogenous PIC supplementation in hippocampus also improved cognitive performance and hippocampal neurogenesis in B2M-exposed rats. These findings demonstrated that Itaconate alleviates B2M-induced cognitive impairment by upregulation of the hippocampal ACMSD/PIC pathway. This is the first study to document Itaconate as a promising therapeutic agent to ameliorate cognitive impairment. Moreover, the mechanistic insights into the ACMSD/PIC pathway improve our understanding of it as a potential therapeutic target for neurol. diseases beyond B2M-associated neurocognitive disorders. In the experimental materials used by the author, we found Picolinic acid(cas: 98-98-6Synthetic Route of C6H5NO2)

Picolinic acid(cas: 98-98-6) is used in the preparation of 2-Aminodihydro[1,3]thiazines as BACE 2 inhibitors and their preparation and use in the treatment of diabetes.Synthetic Route of C6H5NO2

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

In 2022,Sutherland, Hamish S.; Lu, Guo-Liang; Tong, Amy S. T.; Conole, Daniel; Franzblau, Scott G.; Upton, Anna M.; Lotlikar, Manisha U.; Cooper, Christopher B.; Palmer, Brian D.; Choi, Peter J.; Denny, William A. published an article in European Journal of Medicinal Chemistry. The title of the article was 《Synthesis and structure-activity relationships for a new class of tetrahydronaphthalene amide inhibitors of Mycobacterium tuberculosis》.Quality Control of Methyl 5-bromopicolinate The author mentioned the following in the article:

Drug resistant tuberculsosis (TB) is global health crisis that demands novel treatment strategies. Bacterial ATP synthase inhibitors such as bedaquiline and next-generation analogs (such as TBAJ-876) have shown promising efficacy in patient populations and preclin. studies, resp., suggesting that selective targeting of this enzyme presents a validated therapeutic strategy for the treatment of TB. In this work, we report tetrahydronaphthalene amides (THNAs) as a new class of ATP synthase inhibitors that are effective in preventing the growth of Mycobacterium tuberculosis (M.tb) in culture. Design, synthesis and comprehensive structure-activity relationship studies for approx. 80 THNA analogs are described, with a small selection of compounds exhibiting potent (in some cases MIC90 <1 μg/mL) in vitro M.tb growth inhibition taken forward to pharmacokinetic and off-target profiling studies. Ultimately, we show that some of these THNAs possess reduced lipophilic properties, decreased hERG liability, faster mouse/human liver microsomal clearance rates and shorter plasma half-lives compared with bedaquiline, potentially addressing of the main concerns of persistence and phospholipidosis associated with bedaquiline. In the part of experimental materials, we found many familiar compounds, such as Methyl 5-bromopicolinate(cas: 29682-15-3Quality Control of Methyl 5-bromopicolinate)

Methyl 5-bromopicolinate(cas: 29682-15-3) belongs to pyridine. When pyridine is adsorbed on oxide surfaces or in porous materials, the following species are commonly observed: (i) pyridine coordinated to Lewis acid sites, (ii) pyridine H-bonded to weakly acidic hydroxyls, and (iii) protonated pyridine. At high coverage, physisorbed pyridine and protonated dimers can also be observed.Quality Control of Methyl 5-bromopicolinate

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Name: 4-EthynylpyridineIn 2022 ,《Discovery of the First Highly Selective Antagonist of the GluK3 Kainate Receptor Subtype》 appeared in International Journal of Molecular Sciences. The author of the article were Chalupnik, Paulina; Vialko, Alina; Pickering, Darryl S.; Hinkkanen, Markus; Donbosco, Stephanie; Moeller, Thor C.; Jensen, Anders A.; Nielsen, Birgitte; Bay, Yasmin; Kristensen, Anders S.; Johansen, Tommy N.; Latka, Kamil; Bajda, Marek; Szymanska, Ewa. The article conveys some information:

In search of selective ligands for the GluK3 kainate receptor subtype, a series of I [R = 3-Me Ph, 4-Me Ph, 4-Et Ph, etc] analogs was synthesized and pharmacol. characterized at selected recombinant ionotropic glutamate receptors. Among them, compound I [R = imidazo[1,2-b]pyridazin-3-ylmethyl] was found to be a competitive GluK3 antagonist with submicromolar affinity and unprecedented high binding selectivity, showing a 400-fold preference for GluK3 over other homomeric receptors GluK1, GluK2, GluK5 and GluA2. Furthermore, in functional assays performed for selected metabotropic glutamate receptor subtypes, I [R = imidazo[1,2-b]pyridazin-3-ylmethyl] did not show agonist or antagonist activity. The mol. determinants underlying the observed affinity profile of I [R = imidazo[1,2-b]pyridazin-3-ylmethyl] were analyzed using mol. docking and mol. dynamics simulations performed for individual GluK1 and GluK3 ligand-binding domains.4-Ethynylpyridine(cas: 2510-22-7Name: 4-Ethynylpyridine) was used in this study.

4-Ethynylpyridine(cas: 2510-22-7) belongs to pyridine. Pyridine and pyridine-derived structures are privileged pharmacophores in medicinal chemistry and an essential functionality for organic chemists. As the prototypical π-deficient heterocycle, pyridine illustrates distinctive chemistry as both substrate and reagent. Name: 4-Ethynylpyridine

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Name: 2,6-DibromopyridineIn 2020 ,《A novel approach for rhodium(III)-catalyzed C-H functionalization of 2,2′-bipyridine derivatives with alkynes: a significant substituent effect》 appeared in Chemical Communications (Cambridge, United Kingdom). The author of the article were Wu, Shaonan; Wang, Zhuo; Bao, Yinwei; Chen, Chen; Liu, Kun; Zhu, Bolin. The article conveys some information:

The authors described a novel approach for the C-H functionalization of 2,2′-bipyridine derivatives with alkynes. DFT calculations and exptl. data showed a significant substituent effect at the 6-position of 2,2′-bipyridine, which weakened the adjacent N-Rh bond and provided the possibility of subsequent rollover cyclometalation, C-H activation, and functionalization.2,6-Dibromopyridine(cas: 626-05-1Name: 2,6-Dibromopyridine) was used in this study.

2,6-Dibromopyridine(cas: 626-05-1) belongs to pyridine. Pyridine and pyridine-derived structures are privileged pharmacophores in medicinal chemistry and an essential functionality for organic chemists. As the prototypical π-deficient heterocycle, pyridine illustrates distinctive chemistry as both substrate and reagent. Name: 2,6-Dibromopyridine

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Formula: C5H7N3In 2020 ,《Synthesis and characterization of nanocollector for removal of nickel ions from synthetic wastewater using ion flotation》 was published in Separation and Purification Technology. The article was written by Hoseinian, Fatemeh Sadat; Rezai, Bahram; Kowsari, Elaheh; Chinnappan, Amutha; Ramakrishna, Seeram. The article contains the following contents:

Amino functionalized graphene oxide was synthesized (AFGO) using a chem. method in order to apply in ion flotation process as a novel nanocollector for nickel ion removal with the aim of reducing collector consumption during the process. The synthesized AFGO was investigated using various anal. anal. To create the neg. charge onto the amino functionalized graphene oxide, 2,6-diaminopyridine was used to improve the properties of amino functionalized graphene oxide for removal of nickel ions with pos. charge from synthetic wastewater using ion flotation. This study introduced a new collector for ion flotation to reduce the required collector concentration during the process which had simple synthesis, economical, high efficiency and stability in a wastewater. The nickel removal percentage of approx. 100% was achieved using the nanocollector. In the part of experimental materials, we found many familiar compounds, such as 2,6-Diaminopyridine(cas: 141-86-6Formula: C5H7N3)

2,6-Diaminopyridine(cas: 141-86-6) belongs to pyridine. Pyridine and its simple derivatives are stable and relatively unreactive liquids, with strong penetrating odours that are unpleasant.Formula: C5H7N3

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Recommanded Product: Bis(pyridin-2-ylmethyl)amineIn 2021 ,《Design of 99mTc-labeled zinc-chelating imaging probe for SPECT imaging of the pancreas》 was published in Bioorganic & Medicinal Chemistry Letters. The article was written by Eeda, Venkateswararao; Hedrick, Andria; Awasthi, Vibhudutta. The article contains the following contents:

Early and sensitive diagnosis of pancreatic diseases is a contemporary clin. challenge. Zinc level in pancreatic tissue and its secretion in pancreatic juice has long been considered a surrogate marker of pancreatic function. The objective of this study was to design a Zn-chelating imaging probe (ZCIP) which could be labeled with 99mTc radionuclide for imaging of pancreas using single photon emission tomog. (SPECT). We synthesized ZCIP as a bifunctional chelate consisting of diethylene triamine pentaacetic acid for 99mTc-chelation at one end and bispicolylethylamine for Zn-complexation at the other end. ZCIP was labeled with 99mTc by standard Sn2+-based reduction method. The 99mTc-labeled ZCIP was studied in normal mice (0.3 mCi) for SPECT imaging. We found that ZCIP consistently labeled with 99mTc radionuclide with over 95% efficiency. Addition of ZCIP altered the spectrum of standard dithizone-Zn complex, indicating its ability to chelate Zn. SPECT data demonstrated the ability of 99mTc-ZCIP to image pancreas with high sensitivity in a non-invasive manner; liver and spleen were the other major organs of 99mTc-ZCIP uptake. Based on these results, we conclude that 99mTc-ZCIP presents as a novel radiotracer for pancreas imaging for diagnosis of diseases such as pancreatitis. After reading the article, we found that the author used Bis(pyridin-2-ylmethyl)amine(cas: 1539-42-0Recommanded Product: Bis(pyridin-2-ylmethyl)amine)

Bis(pyridin-2-ylmethyl)amine(cas: 1539-42-0) is a secondary amine with two picolyl substituents. The compound is a tridentate ligand in coordination chemistry and commonly used to produce Zn-based chemosensors/probes, such as Zinpry.Recommanded Product: Bis(pyridin-2-ylmethyl)amine

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

《A validated UHPLC-MS method for tryptophan metabolites: Application in the diagnosis of multiple sclerosis》 was written by Tomosi, Ferenc; Kecskemeti, Gabor; Cseh, Edina Katalin; Szabo, Elza; Rajda, Cecilia; Kormany, Robert; Szabo, Zoltan; Vecsei, Laszlo; Janaky, Tamas. Application of 98-98-6This research focused onUHPLC mass spectrometry tryptophan metabolite diagnosis multiple sclerosis; Derivatization; DryLab®4; Liquid chromatography-mass spectrometry; Multiple sclerosis; Tryptophan metabolism; Validation. The article conveys some information:

The simultaneous quant. estimation of tryptophan (TRP) and its metabolites represents a great challenge because of their diverse chem. properties, e.g., presence of acidic, basic, and nonpolar functional groups and their immensely different concentrations in biol. matrixes. A short ultra high-performance liquid chromatog. (UHPLC)-tandem mass spectrometry (MS/MS) method was validated for targeted anal. of TRP and its 11 most important metabolites derived via both kynurenine (KYN) and serotonin (SERO) pathways in human serum and cerebrospinal fluid (CSF): SERO, KYN, 3-hydroxyanthranilic acid, 5-hydroxyindoleacetic acid, anthranilic acid, kynurenic acid (KYNA), 3-hydroxykynurenine (3-HK), xanthurenic acid, melatonin, picolinic acid (PICA), and quinolinic acid (QUIN). After selecting the “”best”” reversed-phase column and organic modifier, DryLab4 was used to optimize the gradient time and temperature in chromatog. separation To achieve absolute quantification, deuterium-labeled internal standards were used. Among all compounds, 3 were analyzed in derivatized (Bu ester) forms (3-HK, PICA, and QUIN) and the remaining 9 in underivatized forms. Validation was performed in accordance with the ICH and FDA guidelines to determine the intraday and interday precision, accuracy, sensitivity, and recovery. To demonstrate the applicability of the developed UHPLC-MS/MS method, the aforementioned metabolites were analyzed in serum and CSF samples from patients with multiple sclerosis (multiple sclerosis group) and those with symptomatic or noninflammatory neurol. diseases (control group). The concentration of QUIN dramatically increased, whereas that of KYNA slightly decreased in the multiple sclerosis group, resulting in a significantly increased QUIN/KYNA ratio and significantly decreased PICA/QUIN ratio. In the part of experimental materials, we found many familiar compounds, such as Picolinic acid(cas: 98-98-6Application of 98-98-6)

Picolinic acid(cas: 98-98-6) is used as a chelate for alkaline earth metals. Used to prepare picolinato ligated transition metal complexes. In synthetic organic chemistry, has been used as a substrate in the Mitsunobu reaction and in the Hammick reaction.Application of 98-98-6

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

The author of 《Mitochondria targeted and NADH triggered photodynamic activity of chloromethyl modified Ru(II) complexes under hypoxic conditions》 were Tian, Na; Sun, Weize; Guo, Xusheng; Lu, Jian; Li, Chao; Hou, Yuanjun; Wang, Xuesong; Zhou, Qianxiong. And the article was published in Chemical Communications (Cambridge, United Kingdom) in 2019. COA of Formula: C12H10Cl2N2 The author mentioned the following in the article:

Three chloromethyl-modified Ru(II) complexes were designed and synthesized as mitochondria targeting photosensitizers, which can generate carbon radicals in the presence of NADH under visible light irradiation, cause DNA cleavage and covalent binding in Ar-saturated solutions, and lead to apoptosis of human ovarian carcinoma SKOV-3 cells under hypoxic conditions (3% O2), demonstrating a new mode of type I mechanism to overcome the limitation of hypoxia in photodynamic therapy (PDT). The results came from multiple reactions, including the reaction of 4,4′-Bis(chloromethyl)-2,2′-bipyridine(cas: 138219-98-4COA of Formula: C12H10Cl2N2)

4,4′-Bis(chloromethyl)-2,2′-bipyridine(cas: 138219-98-4) belongs to pyridine derivatives. Several pyridine derivatives play important roles in biological systems. While its biosynthesis is not fully understood, nicotinic acid (vitamin B3) occurs in some bacteria, fungi, and mammals. COA of Formula: C12H10Cl2N2

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

《Heterogeneous photocatalytic degradation of picloram, dicamba, and floumeturon in aqueous suspensions of titanium dioxide》 was published in Journal of Environmental Science and Health in 2005. These research results belong to Rahman, M. Atiqur; Muneer, M.. COA of Formula: C6H2Cl3NO2 The article mentions the following:

Heterogeneous photocatalytic degradation of picloram, dicamba and floumeturon has been investigated in aqueous suspensions of titanium dioxide under a variety of conditions. The degradation was studied by monitoring the change in substrate concentration employing UV spectroscopic technique and decrease in total organic carbon (TOC) content as a function of irradiation time under a variety of conditions. The degradation of the herbicide was studied under different conditions such as pH, catalyst concentration, substrate concentration, different types of TiO2, and in the presence of electron acceptors such as H2O2, KBrO3, and (NH4)2S2O8 besides mol. oxygen. The degradation rates were found to be strongly influenced by all the above parameters. The photocatalyst Degussa P25 was found to be more efficient as compared with other photocatalysts in the case of dicamba and floumeturon, whereas Hombikat UV100 was found to be better for the degradation of picloram. The herbicide picloram was found to degrade faster as compared to dicamba and floumeturon. The degradation products were analyzed by gas chromatog.-mass spectrometry (GC/MS) technique, and plausible mechanisms for the formation of products have been proposed. The experimental part of the paper was very detailed, including the reaction process of 3,5,6-Trichloropicolinic acid(cas: 40360-44-9COA of Formula: C6H2Cl3NO2)

3,5,6-Trichloropicolinic acid(cas: 40360-44-9) belongs to pyridine. Pyridine-based materials are valued for their optical and physical properties as well as their medical potential. Additionally, pyridine-based natural products continue to be discovered and studied for their properties and to understand their biosynthesis.COA of Formula: C6H2Cl3NO2

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem