Day: October 13, 2022

In 2019,Chemical Communications (Cambridge, United Kingdom) included an article by Teng, Kun-Xu; Niu, Li-Ya; Li, Jie; Jia, Lu; Yang, Qing-Zheng. Safety of 4-Ethynylpyridine. The article was titled 《An unexpected coupling-reduction tandem reaction for the synthesis of alkenyl-substituted BODIPYs》. The information in the text is summarized as follows:

We report an unexpected coupling-reduction tandem reaction as a general and efficient one-pot synthesis of alkenyl-substituted boron dipyrromethene (BODIPY) from chlorinated-BODIPY and alkyne. This unique synthesis combined the Sonogashira coupling reaction and reduction reaction without adding an addnl. reagent, which shows higher yields, broader substrate scope and faster reaction rate compared with the conventional methods of the Knoevenagel reaction and Heck coupling reaction. In the experiment, the researchers used 4-Ethynylpyridine(cas: 2510-22-7Safety of 4-Ethynylpyridine)

4-Ethynylpyridine(cas: 2510-22-7) belongs to pyridine. Pyridines are often used as catalysts or reagents; particular notice has been paid recently to how pyridine coordinates to metal centers enabling a wide range of valuable reactions. Safety of 4-Ethynylpyridine

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

In 2019,Chemical Communications (Cambridge, United Kingdom) included an article by Luo, Xuewei; Fan, Zhengning; Zhang, Bo; Chen, Chao; Xi, Chanjuan. Computed Properties of C33H24IrN3. The article was titled 《Visible-light-triggered direct keto-difluoroacetylation of styrenes with (fluorosulfonyl)difluoroacetate and dimethyl sulfoxide leading to α-difluoroacetylated ketones》. The information in the text is summarized as follows:

Photoredox-catalyzed direct keto-difluoroacetylation of styrenes with (fluorosulfonyl)difluoroacetate and DMSO as an oxidant is disclosed. A variety of α-difluoroacetylated ketones bearing functional groups with good yields are obtained using fac-Ir(ppy)3 as a photocatalyst under visible light irradiation In the experiment, the researchers used many compounds, for example, fac-Tris(2-phenylpyridine)iridium(cas: 94928-86-6Computed Properties of C33H24IrN3)

fac-Tris(2-phenylpyridine)iridium(cas: 94928-86-6) belongs to pyridine. Pyridine is very deactivated towards electrophilic substitution with respect to benzene. For this reason classical formylation, using methods such as the Gattermann or Vilsmeier reactions, are not generally successful. Computed Properties of C33H24IrN3

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

《Copper-catalysed three-component carboiodination of arynes: expeditious synthesis of o-alkynyl aryl iodides》 was published in Chemical Communications (Cambridge, United Kingdom) in 2020. These research results belong to Cao, Wenxuan; Niu, Sheng-Li; Shuai, Li; Xiao, Qing. Related Products of 2510-22-7 The article mentions the following:

A copper-catalyzed three-component iodoalkynylation reaction of arynes for the expeditious and versatile synthesis of o-alkynyl aryl iodides was developed. Mechanism research shows that the reaction goes through two steps enabled by copper catalysis: the formation of 1-iodo-2-arylacetylene and the insertion of the aryne into a C(sp)-I bond.4-Ethynylpyridine(cas: 2510-22-7Related Products of 2510-22-7) was used in this study.

4-Ethynylpyridine(cas: 2510-22-7) belongs to pyridine. Pyridines are often used as catalysts or reagents; particular notice has been paid recently to how pyridine coordinates to metal centers enabling a wide range of valuable reactions. Related Products of 2510-22-7

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

《A conjugated microporous polymer as a recyclable heterogeneous ligand for highly efficient regioselective hydrosilylation of allenes》 was written by Jiang, Ya-Nan; Zeng, Jia-Hao; Yang, Ying; Liu, Zhi-Kai; Chen, Jun-Jia; Li, Ding-Chang; Chen, Li; Zhan, Zhuang-Ping. Electric Literature of C5H3Br2N And the article was included in Chemical Communications (Cambridge, United Kingdom) in 2020. The article conveys some information:

Pyridines containing adjacent CC bonds were utilized as ligand units and integrated into the skeleton of conjugated microporous polymers. The resultant Pd-CMP-1 was first applied as a highly efficient heterogeneous catalytic system for Pd-catalyzed allene hydrosilylation towards a wide range of allenes to produce branched allylsilanes with high regioselectivity. The ligand units of the polymer, along with the confinement effect of the porous structure, jointly regulated the regioselectivity. The parts-per-million (ppm) levels of Pd, coordinated with the recyclable heterogeneous ligand, show promise for industrial applications. This work opens a new front of using CMP as an intriguing platform for developing highly efficient catalysts to control the regioselectivities in allene hydrosilylation. The results came from multiple reactions, including the reaction of 2,6-Dibromopyridine(cas: 626-05-1Electric Literature of C5H3Br2N)

2,6-Dibromopyridine(cas: 626-05-1) belongs to pyridine. Pyridines form stable salts with strong acids. Pyridine itself is often used to neutralize acid formed in a reaction and as a basic solvent. Electric Literature of C5H3Br2N

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Lutz, Fabian; Lorenzo-Parodi, Nerea; Schmidt, Torsten C.; Niemeyer, Jochen published an article in 2021. The article was titled 《Heteroternary cucurbit[8]uril complexes as supramolecular scaffolds for self-assembled bifunctional photoredoxcatalysts》, and you may find the article in Chemical Communications (Cambridge, United Kingdom).Synthetic Route of C12H12N2 The information in the text is summarized as follows:

The self-assembly of bifunctional photoredoxcatalysts is reported. A series of photosensitizers and water-reducing catalysts were functionalized with viologen- and naphthol-units, resp. Subsequent formation of the heteroternary cucurbit[8]uril-viologen-naphthol complexes was used for the constitution of bifunctional photoredoxcatalysts for hydrogen generation. In the experiment, the researchers used many compounds, for example, 4,4′-Dimethyl-2,2′-bipyridine(cas: 1134-35-6Synthetic Route of C12H12N2)

4,4′-Dimethyl-2,2′-bipyridine(cas: 1134-35-6) is used as a chemical Intermediate. It can be used for the determination of ferrous and cyanide compounds.Synthetic Route of C12H12N2 Furthermore, 4,4′-Dimethyl-2,2′-bipyridine is used in the synthesis of a series of o-phenanthroline-substituted ruthenium(II) complexes.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Qiao, Liping; Liu, Jiangping; Han, Yunhong; Wei, Fangmian; Liao, Xinxing; Zhang, Cheng; Xie, Lina; Ji, Liangnian; Chao, Hui published an article in 2021. The article was titled 《Rational design of a lysosome-targeting and near-infrared absorbing Ru(II)-BODIPY conjugate for photodynamic therapy》, and you may find the article in Chemical Communications (Cambridge, United Kingdom).Safety of 4,4′-Dimethyl-2,2′-bipyridine The information in the text is summarized as follows:

A Ru(II)-BODIPY conjugate has been rationally designed and exhibits an intense absorption in the NIR region to boost lysosome-targeted PDT in vitro and in vivo. The advantages of Ru(II) and BODIPY were successfully instilled into the conjugate to yield highly effective PDT efficacy against malignant melanoma A375 cells (PI = 3448) and A375 mice xenografts. In the part of experimental materials, we found many familiar compounds, such as 4,4′-Dimethyl-2,2′-bipyridine(cas: 1134-35-6Safety of 4,4′-Dimethyl-2,2′-bipyridine)

4,4′-Dimethyl-2,2′-bipyridine(cas: 1134-35-6) is used as a chemical Intermediate. It can be used for the determination of ferrous and cyanide compounds.Safety of 4,4′-Dimethyl-2,2′-bipyridine Furthermore, 4,4′-Dimethyl-2,2′-bipyridine is used in the synthesis of a series of o-phenanthroline-substituted ruthenium(II) complexes.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

In 2022,Li, Heng-Hui; Li, Shaoyu; Cheng, Jun Kee; Xiang, Shao-Hua; Tan, Bin published an article in Chemical Communications (Cambridge, United Kingdom). The title of the article was 《Direct arylation of N-heterocycles enabled by photoredox catalysis》.Quality Control of 2-Bromo-5-methylpyridine The author mentioned the following in the article:

N-Heterobiaryls are common skeletons found in biol. mols., pharmaceuticals and ligands. Herein, authors document an efficient and redox-neutral photocatalytic system to obtain functionalized N-heterobiaryls under mild conditions. Substrates bearing variegated functional groups are compatible with the developed photocatalytic conditions. This method is translatable to gram-scale synthesis, with a photocatalyst loading as low as 0.1 mol% and minimal variation of the yield. The starting materials are com. available, demonstrating the practicality and accessibility of this methodol. Interestingly, phenols can serve both as coupling partners and proton donors. Arenes without a phenolic hydroxyl group also underwent efficient coupling with HFIP as a solvent. In the experiment, the researchers used 2-Bromo-5-methylpyridine(cas: 3510-66-5Quality Control of 2-Bromo-5-methylpyridine)

2-Bromo-5-methylpyridine(cas: 3510-66-5) belongs to pyridine. In industry and in the lab, pyridine is used as a reaction solvent, particularly when its basicity is useful, and as a starting material for synthesizing some herbicides, fungicides, and antiseptics.Quality Control of 2-Bromo-5-methylpyridine

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

In 2022,Xia, Wu; Ren, Ying-Yi; Liu, Jing; Deng, Bo-Yi; Wang, Feng published an article in Journal of Photochemistry and Photobiology, A: Chemistry. The title of the article was 《Non-synergistic photocatalysis of CO2-to-CO conversion by a binuclear complex of rigidly linking two cobalt catalytic centers》.COA of Formula: C12H13N3 The author mentioned the following in the article:

A novel binuclear cobalt complex C1 of rigidly linking two [Co(TPA)Cl]Cl moieties at meta positions of a benzene was synthesized and characterized as a catalyst for homogeneous photocatalytic CO2 reduction Different from state-of-the-art binuclear catalyst catalyzing CO2 reduction with a synergistic catalysis mechanism, C1 catalyzes CO2-to-CO conversion independently at each cobalt catalytic center. At an optimal condition, system of C1 produced CO with a TON of 721 (based on C1, corrsoponding to TON 360 per cobalt center) and a high selectivity of 91.5%. Electrochem. and steady state spectroscopy studies revealed that a CoICoI species, generated via successive photoinduced electron transfer from excited photosensitizer to C1, is the active species of CO2 conversion. No synergistic effect of two cobalt centers exists for CO2 reduction because of larger Co-Co distance and rigid structure of C1. After reading the article, we found that the author used Bis(pyridin-2-ylmethyl)amine(cas: 1539-42-0COA of Formula: C12H13N3)

Bis(pyridin-2-ylmethyl)amine(cas: 1539-42-0) is a secondary amine with two picolyl substituents. As a tridentate ligand this compound provides three nitrogen donors that affords good selectivity for Zn2+ over biologically relevant metals such as Na+, K+, Mg2+ and Ca2+, and leaves coordination sites free for anion binding. COA of Formula: C12H13N3

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

In 2022,Kullmer, Cesar N. Prieto; Kautzky, Jacob A.; Krska, Shane W.; Nowak, Timothy; Dreher, Spencer D.; MacMillan, David W. C. published an article in Science (Washington, DC, United States). The title of the article was 《Accelerating reaction generality and mechanistic insight through additive mapping》.SDS of cas: 3510-66-5 The author mentioned the following in the article:

Reaction generality is crucial in determining the overall impact and usefulness of synthetic methods. Typical generalization protocols require a priori mechanistic understanding and suffer when applied to complex, less understood systems. An additive mapping approach that rapidly expands the utility of synthetic methods while generating concurrent mechanistic insight was developed. Validation of this approach on the metallaphotoredox decarboxylative arylation resulted in the discovery of a phthalimide ligand additive that overcomes many lingering limitations of this reaction and has important mechanistic implications for nickel-catalyzed cross-couplings. After reading the article, we found that the author used 2-Bromo-5-methylpyridine(cas: 3510-66-5SDS of cas: 3510-66-5)

2-Bromo-5-methylpyridine(cas: 3510-66-5) belongs to pyridine. Pyridine is a relatively complex molecule and exhibits a number of different bands in IR spectra. Among others, the bands characterizing the ν8a and ν19b modes have been found to be sensitive to the coordination or protonation of the molecule. Note that the band that is diagnostic for the PyH+ ion at about 1545 cm− 1 (ν19b mode) does not overlap with any of the other bands.SDS of cas: 3510-66-5

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Recommanded Product: 2-BromonicotinaldehydeIn 2019 ,《Coupling-Isomerization-Cycloisomerization Reaction (CICIR) – An Unexpected and Efficient Domino Approach to Luminescent 2-(Hydroxymethylene)indenones》 appeared in European Journal of Organic Chemistry. The author of the article were Ghazvini, Helya Janatian; Armaghan, Mahsa; Janiak, Christoph; Balalaie, Saeed; Mueller, Thomas J. J.. The article conveys some information:

A Pd/Cu-catalyzed base mediated domino process of ortho-halo (hetero)aryl carboxaldehydes and propargyl alcs. unexpectedly furnish 2-(hydroxymethylene)indenones in good to excellent yield as a result of a coupling-isomerization-cycloisomerization reaction (CICIR). In addition, the title compounds constitute an interesting class of luminophores with tunable emission solvatochromicity.2-Bromonicotinaldehyde(cas: 128071-75-0Recommanded Product: 2-Bromonicotinaldehyde) was used in this study.

2-Bromonicotinaldehyde(cas: 128071-75-0) belongs to pyridine. The basicity and metallophilic high donor number of these π-deficient systems has long favored them as ligands in metal catalysis. The last decade saw pyridine assume a stronger role as functional group for directed C–H oxidation/activation.Recommanded Product: 2-Bromonicotinaldehyde

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem