Day: October 13, 2022

Recommanded Product: 4-CyanopyridineIn 2021 ,《Electron doping of single-walled carbon nanotubes using pyridine-boryl radicals》 appeared in Chemical Communications (Cambridge, United Kingdom). The author of the article were Tanaka, Naoki; Hamasuna, Aoi; Uchida, Takuto; Yamaguchi, Ryohei; Ishii, Taiki; Staylkov, Aleksandar; Fujigaya, Tsuyohiko. The article conveys some information:

Pyridine-boryl (py-boryl) radicals serve as efficient electron-doping reagents for single-walled carbon nanotubes (SWCNTs). The doping mechanism comprises electron transfer from the py-boryl radical to the SWCNT. The formation of a stable py-boryl cation is essential for efficient doping; the captodative effect of the py-boryl cation is important to this process. The experimental process involved the reaction of 4-Cyanopyridine(cas: 100-48-1Recommanded Product: 4-Cyanopyridine)

4-Cyanopyridine(cas: 100-48-1) belongs to pyridine. The basicity and metallophilic high donor number of these π-deficient systems has long favored them as ligands in metal catalysis. The last decade saw pyridine assume a stronger role as functional group for directed C–H oxidation/activation.Recommanded Product: 4-Cyanopyridine

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Category: pyridine-derivativesIn 2021 ,《Synthesis of Novel Pseudocloso Ruthenacarboranes based on an Unsubstituted nido-C2B9H112- Ligand》 was published in European Journal of Inorganic Chemistry. The article was written by Kaltenberg, Alexander A.; Somov, Nikolay V.; Malysheva, Yulia B.; Vorozhtsov, Dmitry L.; Grishin, Ivan D.. The article contains the following contents:

The reaction of the known closo-ruthenacarborane 3-H-3-Cl-3,3-(PPh3)2-closo-3,1,2-RuC2B9H11 with tridentate nitrogen-based bis(pyridylmethyl)amine ligands of the general formula (2-C5H4NCH2)2NR (R = H, Me, Et, iPr, tBu) in benzene solution at 60° allowed us to isolate novel ruthenacarborane clusters 3,3,3-[(2′-NC5H4CH2)2NR]-pseudocloso-3,1,2-RuC2B9H11. According to the performed X-ray study, the obtained compounds are the first examples of pseudocloso-metallacarboranes bearing unsubstituted C2B92-nido-carborane ligand. In spite of the determined pseudocloso structure of the complexes in the solid state, the recorded 11B{1H} NMR spectra indicate that some of them are converted into the closo isomers in solution The conducted quantum-chem. calculations have confirmed the subtle difference between two configurations and possible rearrangement in solution The performed electrochem. investigations show the ability of the formed ruthenacarboranes to undergo reversible oxidation to Ru(III) species. In the experiment, the researchers used Bis(pyridin-2-ylmethyl)amine(cas: 1539-42-0Category: pyridine-derivatives)

Bis(pyridin-2-ylmethyl)amine(cas: 1539-42-0) is a secondary amine with two picolyl substituents. The compound is a tridentate ligand in coordination chemistry and commonly used to produce Zn-based chemosensors/probes, such as Zinpry.Category: pyridine-derivatives

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

《Exploiting the umpolung reactivity of diazo groups: direct access to triazolyl-azaarenes from azaarenes》 was written by Devi, Lalita; Kumar, Prashant; Kant, Ruchir; Rastogi, Namrata. Name: 4-AcetylpyridineThis research focused ontriazolyl isoquinoline pyridine phenanthridine preparation; azaarene diazo iodonium triflate tandem electrophilic substitution dipolar cycloaddition. The article conveys some information:

The present work documents electrophilic substitution of azaarenes, mainly isoquinolines, with hypervalent iodine diazo reagents (HIDR) followed by formal [3+2]-dipolar cycloaddition in a tandem fashion. Other azaarenes viz. pyridines and phenanthridines too could be successfully used in the reaction. The methodol. capitalizes on the umpolung nature of α-aryliodonio diazo compounds for installing a nucleophile, i.e. azaarene, at their α-position. Subsequent ylide formation and intramol. 1,5-cyclization furnished 4,3-fused 1,2,4-triazolyl-azaarenes in good yields. The reaction is notable for its mild conditions, operational simplicity and fairly general scope. In the experiment, the researchers used many compounds, for example, 4-Acetylpyridine(cas: 1122-54-9Name: 4-Acetylpyridine)

4-Acetylpyridine(cas: 1122-54-9) belongs to pyridine. Pyridine-based materials are valued for their optical and physical properties as well as their medical potential. Additionally, pyridine-based natural products continue to be discovered and studied for their properties and to understand their biosynthesis.Name: 4-Acetylpyridine

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

《Fluorine-substituted tetracationic ABAB-phthalocyanines for efficient photodynamic inactivation of Gram-positive and Gram-negative bacteria》 was written by Revuelta-Maza, Miguel A.; Gonzalez-Jimenez, Patricia; Hally, Cormac; Agut, Montserrat; Nonell, Santi; de la Torre, Gema; Torres, Tomas. Recommanded Product: 4-EthynylpyridineThis research focused onzinc fluorine substituted phthalocyanine complex preparation fluorescence; antibacterial activity photodynamic therapy zinc phthalocyanine; Amphiphile; Bacteria; Cationic; Photodynamic inactivation; Phthalocyanine. The article conveys some information:

Herein, the authors report the synthesis and characterization of new amphiphilic phthalocyanines (Pcs), the study of their singlet oxygen generation capabilities, and biol. assays to determine their potential as photosensitizers for photodynamic inactivation of bacteria. In particular, Pcs with an ABAB geometry (A and B refer to differently substituted isoindole constituents) have been synthesized. These mols. are endowed with bulky bis(trifluoromethylphenyl) groups in two facing isoindoles, which hinder aggregation and favor singlet oxygen generation, and pyridinium or alkylammonium moieties in the other two isoindoles. In particular, two water-soluble Pc derivatives (PS-1 and PS-2) proved to be efficient in the photoinactivation of S. aureus and E. coli, selected as models of Gram-pos. and Gram-neg. bacteria. After reading the article, we found that the author used 4-Ethynylpyridine(cas: 2510-22-7Recommanded Product: 4-Ethynylpyridine)

4-Ethynylpyridine(cas: 2510-22-7) belongs to pyridine. Pyridine-based materials are valued for their optical and physical properties as well as their medical potential. Additionally, pyridine-based natural products continue to be discovered and studied for their properties and to understand their biosynthesis.Recommanded Product: 4-Ethynylpyridine

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

SDS of cas: 1158763-55-3On March 31, 2017, Wang, Min; Wu, Chunjiang; Xu, Shan; Zhu, Yan; Li, Wei; Zheng, Pengwu; Zhu, Wufu published an article in Medicinal Chemistry (Sharjah, United Arab Emirates). The article was 《Synthesis, Biological Evaluation and Docking Studies of Sorafenib Derivatives N-(3-fluoro-4-(pyridin-4-yloxy)phenyl)-4(5)-phenylpicolinamides》. The article mentions the following:

Sorafenib is an important VEGFR2/KDR inhibitor which is widely used for the treatment of cancer. In this paper, two series of sorafenib analogs N-(3-fluoro-4-(pyridin-4-yloxy)phenyl)-4- phenylpicolinamides(13a-k) and N-(3-fluoro-4-(pyridin-4-yloxy)phenyl)-5-phenylpicolinamides (14a-k) were designed and synthesized. Their structures were confirmed by various anal. methods, such as 1 H and 13 C NMR, m.p., MS, HRMS. All of them were evaluated for IC50 values against three cancer cell lines (A549, PC-3 and MCF-7). Eleven of the synthesized compounds showed moderate to excellent cytotoxicity activity against different cancer cells, whose potency from single-digit μM to nanomolar range. And five of them were equal to more potent than sorafenib against one or more cell lines. The most promising compound 14c showed excellent antitumor activities against PC-3 and MCF-7 cell lines with IC50 values of 2.62±1.07 μM and 1.14±0.92 μM, which were 1.15 to 2.75-fold more active than sorafenib (3.03±1.01 μM, 3.14±1.65 μM), resp. Structure-activity relationships (SARs) and docking studies indicated that the replacement of diarylurea of sorafenib with phenylpicolinamide moiety benefited to the activity. The position of aryl group and the substituents of aryl group had a great influence on antitumor activity and selectivity. The aryl groups with the substitute of alkyl groups (-CH3), halogen atoms (-F,Cl) were favorable to the cytotoxicity. However, this series of compounds showed moderate activity against VEGFR2/KDR kinase. Mechanism of target compounds was not quite clear and further study will be carried out to identify the possible target.5-(3-Fluorophenyl)picolinic acid(cas: 1158763-55-3SDS of cas: 1158763-55-3) was used in this study.

5-(3-Fluorophenyl)picolinic acid(cas: 1158763-55-3) belongs to pyridine derivatives. The ring atoms in the pyridine molecule are sp2-hybridized. The nitrogen is involved in the π-bonding aromatic system using its unhybridized p orbital. SDS of cas: 1158763-55-3The lone pair is in an sp2 orbital, projecting outward from the ring in the same plane as the σ bonds.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

In 2019,Journal of Biomolecular Structure and Dynamics included an article by Anjomshoa, Marzieh; Torkzadeh-Mahani, Masoud; Sahihi, Mehdi; Rizzoli, Corrado; Ansari, Mehdi; Janczak, Jan; Sherafat Esfahani, Sheila; Ataei, Farangis; Dehkhodaei, Monireh; Amirheidari, Bagher. Synthetic Route of C12H12N2. The article was titled 《Tris-chelated complexes of nickel(II) with bipyridine derivatives: DNA binding and cleavage, BSA binding, molecular docking, and cytotoxicity》. The information in the text is summarized as follows:

Two nickel(II) complexes with substituted bipyridine ligand of the type [Ni(NN)3](ClO4)2, where NN is 4,4′-dimethyl-2,2′-bipyridine (dimethylbpy) () and 4,4′-dimethoxy-2,2′-bipyridine (dimethoxybpy) (), have been synthesized, characterized, and their interaction with DNA and bovine serum albumin (BSA) studied by different phys. methods. X-ray crystal structure of shows a six-coordinate complex in a distorted octahedral geometry. DNA-binding studies of and reveal that both complexes sit in DNA groove and then interact with neighboring nucleotides differently; undergoes a partial intercalation. This is supported by mol.-docking studies, where hydrophobic interactions are apparent between and DNA as compared to hydrogen bonding, hydrophobic, and p-p interactions between and DNA minor groove. Moreover, the two complexes exhibit oxidative cleavage of supercoiled plasmid DNA in the presence of hydrogen peroxide as an activator in the order of >. In terms of interaction with BSA, the results of spectroscopic methods and mol. docking show that binds with BSA only via hydrophobic contacts while interacts through hydrophobic and hydrogen bonding. It has been extensively demonstrated that the nature of the methyl- and methoxy-groups in ligands is a strong determinant of the bioactivity of nickel(II) complexes. This may justify the above differences in biomol. interactions. The experimental process involved the reaction of 4,4′-Dimethyl-2,2′-bipyridine(cas: 1134-35-6Synthetic Route of C12H12N2)

4,4′-Dimethyl-2,2′-bipyridine(cas: 1134-35-6) is used as a chemical Intermediate. It can be used for the determination of ferrous and cyanide compounds.Synthetic Route of C12H12N2 Furthermore, 4,4′-Dimethyl-2,2′-bipyridine is used in the synthesis of a series of o-phenanthroline-substituted ruthenium(II) complexes.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

In 2019,Chemical Communications (Cambridge, United Kingdom) included an article by Xia, Peng-Ju; Ye, Zhi-Peng; Song, Dan; Ren, Ji-Wei; Wu, Han-Wen; Xiao, Jun-An; Xiang, Hao-Yue; Chen, Xiao-Qing; Yang, Hua. Recommanded Product: 94928-86-6. The article was titled 《Photocatalytic reductive radical-radical coupling of N,N’-cyclicazomethine imines with difluorobromo derivatives》. The information in the text is summarized as follows:

A visible-light-induced difluoroalkylation of N,N’-cyclicazomethine imine was successfully realized through a novel photoredox radical-radical cross-coupling reaction. This developed protocol exhibits high functional group tolerance and affords a variety of difluorinated 3-pyrazolidinone scaffolds. Extensive mechanistic investigations have been undertaken, well revealing the involvement of a reductive radical-radical coupling pathway. The experimental process involved the reaction of fac-Tris(2-phenylpyridine)iridium(cas: 94928-86-6Recommanded Product: 94928-86-6)

fac-Tris(2-phenylpyridine)iridium(cas: 94928-86-6) belongs to pyridine. Pyridine is very deactivated towards electrophilic substitution with respect to benzene. For this reason classical formylation, using methods such as the Gattermann or Vilsmeier reactions, are not generally successful. Recommanded Product: 94928-86-6

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

The author of 《Anion-π and H-Bonding Interactions Supporting Encapsulation of [Ln(NO3)6/5]3-/2- (Ln = Nd, Er) with a Triazine-Based Ligand》 were de Bettencourt-Dias, Ana; Beeler, Rose M.; Zimmerman, Joshua R.. And the article was published in Journal of the American Chemical Society in 2019. Related Products of 1539-42-0 The author mentioned the following in the article:

Reaction of NdIII and ErIII nitrate salts with a 1,3,5-tris(dipicolylamine)-triazine (dpat) ligand yielded two unprecedented examples of [Ln(NO3)6/5]3-/2- (Ln = Nd, Er) moieties completely encapsulated by the ligands. They are found in the two new complexes, [(H3dpat)2][(Nd(NO3)6)2]·2CH3CN (1), and the related [(H3dpat)2][(Er(NO3)5)3]·3CH3CN·2H2O (2). The structures of the complexes are similar and they crystallize in the triclinic P-1 space group with a 12.1630(3), b 12.2694(3), c 17.6357(5) Å, and a 14.3372(4), b 17.1271(4), c 25.2207(7) Å, resp. Anion-π interactions, which are reported here for the first time for LnIII ion complexes, hydrogen bonding interactions and π-π stacking support the formation of the encapsulated species. Evidence of the protonated dpat ligand in 1 and 2 was found through isolation of (H2dpat)(NO3)2. Finally, the pH-dependent ability of the ligand to extract LaIII and nitrate ions from aqueous into toluene solution is demonstrated. In the experiment, the researchers used Bis(pyridin-2-ylmethyl)amine(cas: 1539-42-0Related Products of 1539-42-0)

Bis(pyridin-2-ylmethyl)amine(cas: 1539-42-0) is a secondary amine with two picolyl substituents. As a tridentate ligand this compound provides three nitrogen donors that affords good selectivity for Zn2+ over biologically relevant metals such as Na+, K+, Mg2+ and Ca2+, and leaves coordination sites free for anion binding. Related Products of 1539-42-0

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

The author of 《Stress associated protein from Lobularia maritima: Heterologous expression, antioxidant and antimicrobial activities with its preservative effect against Listeria monocytogenes inoculated in beef meat》 were Ben Hsouna, Anis; Ben Saad, Rania; Zouari, Nabil; Ben Romdhane, Walid; Brini, Faical; Ben Salah, Riadh. And the article was published in International Journal of Biological Macromolecules in 2019. Formula: C6H5NO2 The author mentioned the following in the article:

Stress associated Protein from Lobularia maritima (LmSAP) transcripts showed up-regulation in response to wounding, Methyl-jasmonate acid, Picolinic acid, and ethephon treatments. The antioxidant activities of the purified LmSAP protein were evaluated using various in vitro and in vivo assays. LmSAP has an excellent DPPH scavenging ability and exhibits notable reducing power capacity and led to a decrease in TBARS values. The LmSAP showed an important antimicrobial activity against different pathogenic strains tested. In fact, the Inhibition Zone (IZ), Minimal Inhibitory Concentration (MIC) and The Min. Bactericidal Concentration (MCB) recorded were in the range of 14-22 mm, 62-250 μg/mL and 125-250 μg/mL, resp. The LmSAP protein successfully inhibited the growth of L. monocytogenes in minced beef meat. Furthermore, the LmSAP enhanced the sensory acceptability extending the shelf life of minced beef meat. Overall, the finding demonstrates that the application of LmSAP may open new promising opportunities for the prevention of bacterial contamination, particularly L. monocytogenes, during minced beef meat storage. In addition to this study using Picolinic acid, there are many other studies that have used Picolinic acid(cas: 98-98-6Formula: C6H5NO2) was used in this study.

Picolinic acid(cas: 98-98-6) is used in the preparation of 2-Aminodihydro[1,3]thiazines as BACE 2 inhibitors and their preparation and use in the treatment of diabetes.Formula: C6H5NO2

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

《Photocatalytic site-selective C-H difluoroalkylation of aromatic aldehydes》 was published in Chemical Communications (Cambridge, United Kingdom) in 2020. These research results belong to Tang, Wei-Ke; Tang, Fei; Xu, Jun; Zhang, Qi; Dai, Jian-Jun; Feng, Yi-Si; Xu, Hua-Jian. Name: fac-Tris(2-phenylpyridine)iridium The article mentions the following:

The direct photocatalyzed para-selective CAr-H difluoroalkylation of aromatic aldehyde derivatives has been accomplished using a newly explored catalytic system. In addition, when using para-substituted benzaldehydes as substrates, ortho-selective CAr-H difluoroalkylation was also accomplished. It is worth noting that all the above site-selectivity is opposite to traditional Friedel-Crafts reactions of aromatic aldehydes. The preliminary mechanistic investigations indicate that an electrophilic difluoroalkyl radical is involved in the catalytic cycle.fac-Tris(2-phenylpyridine)iridium(cas: 94928-86-6Name: fac-Tris(2-phenylpyridine)iridium) was used in this study.

fac-Tris(2-phenylpyridine)iridium(cas: 94928-86-6) belongs to pyridine. In industry and in the lab, pyridine is used as a reaction solvent, particularly when its basicity is useful, and as a starting material for synthesizing some herbicides, fungicides, and antiseptics.Name: fac-Tris(2-phenylpyridine)iridium

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem