Day: October 13, 2022

Bosch, Eric; Bowling, Nathan P.; Oburn, Shalisa M. published their research in Acta Crystallographica, Section C: Structural Chemistry in 2021. The article was titled 《Conformational control through co-operative nonconventional C-H···N hydrogen bonds》.Safety of 2,6-Dibromopyridine The article contains the following contents:

We report the design, synthesis, and crystal structure of a conjugated aryleneethynyl mol., 2-(2-{4,5-dimethoxy-2-[2-(2,3,4-trifluorophenyl)ethynyl]phenyl}ethynyl)-6-[2-(pyridin-2-yl)ethynyl]pyridine, C30H17F3N2O2, that adopts a planar rhombus conformation in the solid state. The mol. crystallizes in the space group P [inline formula omitted] , with Z = 2, and features two intramol. sp2-C-H···N hydrogen bonds that co-operatively hold the arylethynyl mol. in a rhombus conformation. The H atoms are activated towards hydrogen bonding since they are situated on a trifluorophenyl ring and the H···N distances are 2.470 (16) and 2.646 (16) Å, with C-H···N angles of 161.7 (2) and 164.7 (2)°, resp. Mol. electrostatic potential calculations support the formation of C-H···N hydrogen bonds to the trifluorophenyl moiety. Hirshfeld surface anal. identifies a self-complementary C-H···O dimeric interaction between adjacent 1,2-dimethoxybenzene segments that is shown to be common in structures containing that moiety. After reading the article, we found that the author used 2,6-Dibromopyridine(cas: 626-05-1Safety of 2,6-Dibromopyridine)

2,6-Dibromopyridine(cas: 626-05-1) belongs to pyridine. In industry and in the lab, pyridine is used as a reaction solvent, particularly when its basicity is useful, and as a starting material for synthesizing some herbicides, fungicides, and antiseptics.Safety of 2,6-Dibromopyridine

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Guo, Yuanqiang; Cao, Yunpeng; Song, Hongjian; Liu, Yuxiu; Wang, Qingmin published an article in 2021. The article was titled 《Photoredox relay-catalyzed gem-difluoroallylation of alkyl iodides》, and you may find the article in Chemical Communications (Cambridge, United Kingdom).Reference of Pyridin-3-ylboronic acid The information in the text is summarized as follows:

Herein, a new example of relay catalysis, using a combination of Mn2(CO)10 and an iridium-based photocatalyst, is reported. In this relay catalytic reaction, the Mn catalyst and iridium-based photocatalyst catalyze the reaction at different stages in the desired sequence under the same reaction conditions, and do not inhibit each other. This convenient method transforms a broad scope of alkyl iodides RI (R = iso-Pr, cyclopentyl, 4-methoxyphenethyl, morpholino, etc.) into the corresponding gem-difluoroalkenes R1C(=CF2)CH2R (R1 = Ph, 2-naphthyl, pyridin-3-yl, etc.) via C(sp3)-C(sp3) bond construction. The protocol has good functional group tolerance and is suitable for the late-stage modification of multifunctional complex mols. In the experiment, the researchers used many compounds, for example, Pyridin-3-ylboronic acid(cas: 1692-25-7Reference of Pyridin-3-ylboronic acid)

Pyridin-3-ylboronic acid(cas: 1692-25-7) belongs to pyridine. Pyridine is very deactivated towards electrophilic substitution with respect to benzene. For this reason classical formylation, using methods such as the Gattermann or Vilsmeier reactions, are not generally successful. Reference of Pyridin-3-ylboronic acid

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Dierks, Philipp; Kruse, Ayla; Bokareva, Olga S.; Al-Marri, Mohammed J.; Kalmbach, Jens; Baltrun, Marc; Neuba, Adam; Schoch, Roland; Hohloch, Stephan; Heinze, Katja; Seitz, Michael; Kuehn, Oliver; Lochbrunner, Stefan; Bauer, Matthias published an article in 2021. The article was titled 《Distinct photodynamics of κ-N and κ-C pseudoisomeric iron(II) complexes》, and you may find the article in Chemical Communications (Cambridge, United Kingdom).Quality Control of 2,6-Dibromopyridine The information in the text is summarized as follows:

Two closely related FeII complexes with 2,6-bis(1-ethyl-1H-1,2,3-triazol-4yl)pyridine and 2,6-bis(1,2,3-triazol-5-ylidene)pyridine ligands are presented to gain new insights into the photophysics of bis(tridentate) iron(II) complexes. The [Fe(NN̂N̂)2]2+ pseudoisomer sensitizes singlet oxygen through a MC state with nanosecond lifetime after MLCT excitation, while the bis(tridentate) [Fe(CN̂Ĉ)2]2+ pseudoisomer possesses a similar 3MLCT lifetime as the tris(bidentate) [Fe(CĈ)2(NN̂)]2+ complexes with four mesoionic carbenes. In the experimental materials used by the author, we found 2,6-Dibromopyridine(cas: 626-05-1Quality Control of 2,6-Dibromopyridine)

2,6-Dibromopyridine(cas: 626-05-1) belongs to pyridine. Pyridine derivatives lend themselves to many roles in the spirited field of supramolecular chemistry – whether as the ligand backbone of metal-organic polymers or presiding over the key electronic stations of nanodevices. In biochemistry, pyridine-containing cofactors are necessary nutrients on which our lives depend. Quality Control of 2,6-Dibromopyridine

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Application In Synthesis of 4-CyanopyridineIn 2020 ,《Benzylic C-H heteroarylation of N-(benzyloxy)phthalimides with cyanopyridines enabled by photoredox 1,2-hydrogen atom transfer》 appeared in Chemical Communications (Cambridge, United Kingdom). The author of the article were Zhong, Long-Jin; Wang, Hong-Yu; Ouyang, Xuan-Hui; Li, Jin-Heng; An, De-Lie. The article conveys some information:

A visible light initiated α-C(sp3)-H arylation of N-(benzyloxy)phthalimides with cyanopyridines for the construction of highly valuable pyridinyl-containing diarylmethanols, including bioactive motif-based analogs, is reported. This method enables arylation of the C(sp3)-H bonds adjacent to an oxygen atom through alkoxy radical formation by O-N bond cleavage, 1,2-hydrogen atom transfer (HAT), arylation and C-CN bond cleavage cascades, and offers a means to exploit 1,2-HAT modes to incorporate functional groups for constructing functionalized alcs. In the experimental materials used by the author, we found 4-Cyanopyridine(cas: 100-48-1Application In Synthesis of 4-Cyanopyridine)

4-Cyanopyridine(cas: 100-48-1) belongs to pyridine. The basicity and metallophilic high donor number of these π-deficient systems has long favored them as ligands in metal catalysis. The last decade saw pyridine assume a stronger role as functional group for directed C–H oxidation/activation.Application In Synthesis of 4-Cyanopyridine

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Recommanded Product: 2,6-DibromopyridineIn 2020 ,《Spin transition in a ferrous chloride complex supported by a pentapyridine ligand》 appeared in Chemical Communications (Cambridge, United Kingdom). The author of the article were Boniolo, Manuel; Shylin, Sergii I.; Chernev, Petko; Cheah, Mun Hon; Heizmann, Philipp A.; Huang, Ping; Salhi, Nessima; Hossain, Kamal; Thapper, Anders; Lundberg, Marcus; Messinger, Johannes. The article conveys some information:

Ferrous chloride complexes [FeIILxCl] commonly attain a high-spin state independently of the supporting ligand(s) and temperature Herein, authors present the first report of a complete spin crossover with T1/2 = 80 K in [FeII(Py5OH)Cl]+ (Py5OH = pyridine-2,6-diylbis[di(pyridin-2-yl)methanol]). Both spin forms of the complex are analyzed by x-ray spectroscopy and DFT calculations2,6-Dibromopyridine(cas: 626-05-1Recommanded Product: 2,6-Dibromopyridine) was used in this study.

2,6-Dibromopyridine(cas: 626-05-1) belongs to pyridine. The basicity and metallophilic high donor number of these π-deficient systems has long favored them as ligands in metal catalysis. The last decade saw pyridine assume a stronger role as functional group for directed C–H oxidation/activation.Recommanded Product: 2,6-Dibromopyridine

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Safety of 2-(2-Hydroxyethyl)pyridineIn 2018 ,《Polydentate 4-Pyridyl-terpyridine Containing Discrete Cobalt Phosphonate and Polymeric Cobalt Phosphate as Catalysts for Alcohol Oxidation》 appeared in Zeitschrift fuer Anorganische und Allgemeine Chemie. The author of the article were Bhat, Gulzar A.; Rajendran, Antony; Murugavel, Ramaswamy. The article conveys some information:

Mononuclear discrete cobalt phosphonate [Co(pytpy)(tBuPO3H)2(H2O)]·H2O (1) and 1D zigzag polymeric cobalt phosphate [Co(pytpy)2(dipp)(MeOH)·2MeOH]n (2) were prepared from the reactions of tert-Bu phosphonic acid (tBuPO3H2) and organic-soluble 2,6-diisopropylphenyl phosphate (dippH2) ligands with Co(OAc)2·4H2O in the presence of 4-pyridyl 2,2:6,2-terpyridine in MeOH/CHCl3(1:1 volume/volume) solvent mixture at 25 °C. The new compounds were characterized by anal., thermo-anal., and spectroscopic techniques. Further, the mol. structures were established by single-crystal X-ray diffraction studies. Mass spectrometry anal. reveal that both the compounds exist in the solution phase as dimers. Compound 1 was employed as homogeneous catalysts for alc. oxidation reactions using tert-Bu hydroperoxide (TBHP) as the oxidant. In addition to this study using 2-(2-Hydroxyethyl)pyridine, there are many other studies that have used 2-(2-Hydroxyethyl)pyridine(cas: 103-74-2Safety of 2-(2-Hydroxyethyl)pyridine) was used in this study.

2-(2-Hydroxyethyl)pyridine(cas: 103-74-2) belongs to pyridine. Pyridine and pyridine-derived structures are privileged pharmacophores in medicinal chemistry and an essential functionality for organic chemists. As the prototypical π-deficient heterocycle, pyridine illustrates distinctive chemistry as both substrate and reagent. Safety of 2-(2-Hydroxyethyl)pyridine

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

《Theoretical exploration of 2,2′-bipyridines as electro-active compounds in flow batteries》 was written by Sanchez-Castellanos, Mariano; Flores-Leonar, Martha M.; Mata-Pinzon, Zaahel; Laguna, Humberto G.; Garcia-Ruiz, Karl M.; Rozenel, Sergio S.; Ugalde-Saldivar, Victor M.; Moreno-Esparza, Rafael; Pijpers, Joep J. H.; Amador-Bedolla, Carlos. Formula: C12H10Cl2N2 And the article was included in Physical Chemistry Chemical Physics in 2019. The article conveys some information:

Compounds from the 2,2′-bipyridine mol. family were investigated for use as redox-active materials in organic flow batteries. For 156 2,2′-bipyridine derivatives reported in the academic literature, we calculated the redox potential, the pKa for the second deprotonation reaction, and the solubility in aqueous solutions Using exptl. data on a small subset of derivatives, we were able to calibrate our calculations We find that functionalization with electron-withdrawing groups leads to an increase of the redox potential and to an increase of the mol. acidity (as expressed in a reduction of the pKa value for the second deprotonation step). Furthermore, calculations of solubility in water indicate that some of the studied derivatives have adequate solubility for flow battery applications. Based on an anal. of the physico-chem. properties of the 156 studied compounds, we down-select five mols. with carbonyl- and nitro-based functional groups, whose parameters are especially promising for potential applications as neg. redox-active materials in organic flow batteries. In addition to this study using 4,4′-Bis(chloromethyl)-2,2′-bipyridine, there are many other studies that have used 4,4′-Bis(chloromethyl)-2,2′-bipyridine(cas: 138219-98-4Formula: C12H10Cl2N2) was used in this study.

4,4′-Bis(chloromethyl)-2,2′-bipyridine(cas: 138219-98-4) belongs to pyridine derivatives. The ring atoms in the pyridine molecule are sp2-hybridized. The nitrogen is involved in the π-bonding aromatic system using its unhybridized p orbital. Formula: C12H10Cl2N2 Pyridine has a conjugated system of six π electrons that are delocalized over the ring.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

In 2017,Wang, Xin; Lv, Huichao; Yang, Liguo; Dai, Yuqiang published 《Crystal structure of bis(μ2-azido-κ2N:N)-dichlorido-bis(μ2-2-(pyridin-2-yl)ethan-1-ol-κ2O,N)dicopper(II), C14H18Cl2Cu2N8O2》.Zeitschrift fuer Kristallographie – New Crystal Structures published the findings.Quality Control of 2-(2-Hydroxyethyl)pyridine The information in the text is summarized as follows:

C14H18Cl2Cu2N8O2, monoclinic, P21/n (number 14), a = 6.0166(6) Å, b = 15.2792(14) Å, c = 11.5833(12) Å, β = 100.295(1)°, V = 1047.70(18) Å3, Z = 2, Rgt(F) = 0.0412, wRref(F2) = 0.0884, T = 298 K. In the experiment, the researchers used 2-(2-Hydroxyethyl)pyridine(cas: 103-74-2Quality Control of 2-(2-Hydroxyethyl)pyridine)

2-(2-Hydroxyethyl)pyridine(cas: 103-74-2) belongs to pyridine. Pyridine is very deactivated towards electrophilic substitution with respect to benzene. For this reason classical formylation, using methods such as the Gattermann or Vilsmeier reactions, are not generally successful. Quality Control of 2-(2-Hydroxyethyl)pyridine

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

In 2018,Chemical Communications (Cambridge, United Kingdom) included an article by Fieser, Megan E.; Schimler, Sydonie D.; Mitchell, Lauren A.; Wilborn, Emily G.; John, Alex; Hogan, Levi T.; Benson, Brooke; LaPointe, Anne M.; Tolman, William B.. Application In Synthesis of 2-(2-Hydroxyethyl)pyridine. The article was titled 《Dual-catalytic decarbonylation of fatty acid methyl esters to form olefins》. The information in the text is summarized as follows:

The homogeneous dehydrative decarbonylation of fatty acid Me esters (FAMEs) to form olefins was reported. In order to facilitate cleavage of the unactivated acyl C-O bond of the alkyl ester, a one pot dual-catalytic directing group strategy was developed through optimization of the individual transesterification and decarbonylation reaction steps. The experimental part of the paper was very detailed, including the reaction process of 2-(2-Hydroxyethyl)pyridine(cas: 103-74-2Application In Synthesis of 2-(2-Hydroxyethyl)pyridine)

2-(2-Hydroxyethyl)pyridine(cas: 103-74-2) belongs to pyridine. Pyridine derivatives lend themselves to many roles in the spirited field of supramolecular chemistry – whether as the ligand backbone of metal-organic polymers or presiding over the key electronic stations of nanodevices. In biochemistry, pyridine-containing cofactors are necessary nutrients on which our lives depend. Application In Synthesis of 2-(2-Hydroxyethyl)pyridine

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

The author of 《Synthesis of ethyl 4-(4-nitrophenoxy) picolinate》 were Xiong, Hehua; Gao, Yanli; Yang, Qi; Tang, Qidong; Zheng, Pengwu. And the article was published in IOP Conference Series: Materials Science and Engineering in 2019. Category: pyridine-derivatives The author mentioned the following in the article:

Et 4-(4-nitrophenoxy) picolinate 4 is an important intermediate for the synthesis of many biol. active compounds The compound Et 4-(4- nitrophenoxy) picolinate was obtained by three simple steps to synthesis from 2- picoliniacid. In this paper, three novel chloropicolinoyl chloride derivatives were prepared The structure was confirmed by MS and 1H NMR. Furthermore, the synthetic method was optimized. The total yield of the target product was 78.57%. The experimental part of the paper was very detailed, including the reaction process of Picolinic acid(cas: 98-98-6Category: pyridine-derivatives)

Picolinic acid(cas: 98-98-6) is used in the preparation of 2-Aminodihydro[1,3]thiazines as BACE 2 inhibitors and their preparation and use in the treatment of diabetes.Category: pyridine-derivatives

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem