Day: October 13, 2022

《Crystal structure of 5-((bis(pyridin-2-ylmethyl)amino)methyl)quinolin-8-ol, C22H20N4O》 was published in Zeitschrift fuer Kristallographie – New Crystal Structures in 2020. These research results belong to Liu, Jia; Nie, Xu-Liang; Yin, Zhong-Ping; Peng, Da-Yong; Shi, Xu-Gen. Synthetic Route of C12H13N3 The article mentions the following:

C22H20N4O, monoclinic, P21/n (number 14), a = 11.1861(14) Å, b = 8.1418(10) Å, c = 20.461(3) Å, β = 97.433(1)°, V = 1847.8(4) Å3, Z = 4, Rgt(F) = 0.0357, wRref(F2) = 0.1002, T = 296(2) K. CCDC number: 1967398. To a mixture of 8-hydroxyquinoline-5-carbaldehyde (1.04 g, 6 mmol) and bis(pyridin-2-ylmethyl)amine (1.22 g, 6 mmol) in CH2Cl2 (50 mL) was added sodium triacetoxyborohydride (1.4 g, 6.6 mmol) at 0 °C. The mixture was stirred for 24 h at room temperature Dichloromethane was removed by evaporation and the residue was purified by chromatog. on silica gel (eluent: Et acetate) to give the yellow solid [5, 6]. m.p. 102 °C-106 0C; 1H NMR (400 MHz, CDCl3) δ [ppm] 8.78-8.73 (m, 1H), 8.65-8.57 (m, 1H), 8.56-8.51 (m, 2H), 7.67- 7.60 (m, 2H), 7.55-7.49 (m, 1H), 7.48-7.42 (m, 1H), 7.41-7.35 (m, 2H), 7.21-7.13 (m, 2H), 7.06 (d, j = 7.8 Hz, 1H), 4.25-4.14 (m, 2H), 4.06-3.95 (m, 4H); 13C NMR (100 MHz, CDCl3) δ [ppm] 158.07, 152.08, 148.51, 147.48, 138.48, 136.81, 133.99, 129.86, 127.77,124.02,123.65,122.31,121.53,108.94, 59.681, 56.29. After reading the article, we found that the author used Bis(pyridin-2-ylmethyl)amine(cas: 1539-42-0Synthetic Route of C12H13N3)

Bis(pyridin-2-ylmethyl)amine(cas: 1539-42-0) is a secondary amine with two picolyl substituents. As a tridentate ligand this compound provides three nitrogen donors that affords good selectivity for Zn2+ over biologically relevant metals such as Na+, K+, Mg2+ and Ca2+, and leaves coordination sites free for anion binding. Synthetic Route of C12H13N3

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

《Structures and photophysical properties of two luminescent bipyridine compounds: 2′,6′-difluoro-6-[3-(pyridin-2-yloxy)phenyl]-2,3′-bipyridine and 2′,6′-dimethoxy-6-[3-(pyridin-2-yloxy)phenyl]-2,3′-bipyridine》 was published in Acta Crystallographica, Section C: Structural Chemistry in 2020. These research results belong to Park, Ki-Min; Yang, Kiyull; Moon, Suk-Hee; Kang, Youngjin. Related Products of 626-05-1 The article mentions the following:

The title compounds, C21H13F2N3O (1) and C23H19N3O3 (2), have been synthesized by typical cross-coupling reactions. Both compounds have been characterized by single-crystal X-ray diffraction. Bipyridine 1 exhibits a fully extended structure in which the terminal pyridine rings are oriented away from each other, while bipyridine 2 displays a bent structure in which terminal pyridine rings are oriented in the same direction. Several intermol. interactions lead to the formation of two- and three-dimensional supramol. networks in the crystal structures of 1 and 2, resp. Compound 1 bears fluorine substituents and emits a strong fluorescence with λmax = 325 nm, while methoxy-substituted compound 2 displays red-shifted emissions with λmax = 366 nm. The emissions observed in both compounds originate from phenyl- and 2,3′-bipyridine-based π-π* transitions, according to theor. calculations Both compounds have high triplet energies (T1) ranging from 2.64 to 2.65 eV, which makes them potential host materials in organic light-emitting diodes (OLEDs). In the experimental materials used by the author, we found 2,6-Dibromopyridine(cas: 626-05-1Related Products of 626-05-1)

2,6-Dibromopyridine(cas: 626-05-1) belongs to pyridine. Pyridine is very deactivated towards electrophilic substitution with respect to benzene. For this reason classical formylation, using methods such as the Gattermann or Vilsmeier reactions, are not generally successful. Related Products of 626-05-1

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

In 2022,Peng, Sasa; Wang, Huaxin; Ding, Haichang; Fan, Congbin; Liu, Gang; Pu, Shouzhi published an article in Journal of Photochemistry and Photobiology, A: Chemistry. The title of the article was 《A high selective chemosensor for detection of Al3+ based on diarylethene with a hydrazide unit》.Recommanded Product: 2510-22-7 The author mentioned the following in the article:

Al3+ plays an indispensable role in different physiol. processes. However, excess Al3+ is destructive to health. Here, a diarylethene-based fluorescent sensor (1O) was synthesized by attaching a hydrazide group to diarylethene moiety through Schiff base structure. In acetonitrile, 1O displayed excellent selectivity and sensitivity to Al3+. The fluorescence intensity increased by 70-fold and accompanied by the color of the solution changed from dark to blue with the addition of Al3+. Further, the potential response mechanism of 1O toward Al3+ was proposed and verified by 1H NMR titrations and mass spectrometry anal., the stoichiometric ratios of the sensor with Al3+ appeared to be 1:1 with the detection limit of 0.073 μM. In addition, 1O has been successfully applied to the detection of Al3+ in real water samples, and it also has successfully designed as mol. logic circuit and test strips. In the experiment, the researchers used many compounds, for example, 4-Ethynylpyridine(cas: 2510-22-7Recommanded Product: 2510-22-7)

4-Ethynylpyridine(cas: 2510-22-7) belongs to pyridine. Pyridine is very deactivated towards electrophilic substitution with respect to benzene. For this reason classical formylation, using methods such as the Gattermann or Vilsmeier reactions, are not generally successful. Recommanded Product: 2510-22-7

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

SDS of cas: 1134-35-6In 2020 ,《Unexpected disruption of the dimensionality-driven two-photon absorption enhancement within a multipolar polypyridyl ruthenium complex series》 was published in Chemical Communications (Cambridge, United Kingdom). The article was written by Durand, Nicolas; Mhanna, Rana; Savel, Paul; Akdas-Kilic, Huriye; Malval, Jean-Pierre; Soppera, Olivier; Fillaut, Jean-Luc. The article contains the following contents:

The dimensionality-driven 2-photon absorption (2PA) enhancement effect is studied in functionalized bipyridyl Ru complexes. The design strategy leads to very high 2PA responses up to ~1500 GM. The 2PA performance vs. dimensionality correlation reaches an unexpected limit stemming from anti-cooperative interchromophoric couplings. The experimental process involved the reaction of 4,4′-Dimethyl-2,2′-bipyridine(cas: 1134-35-6SDS of cas: 1134-35-6)

4,4′-Dimethyl-2,2′-bipyridine(cas: 1134-35-6) is used in the synthesis of a series of o-phenanthroline-substituted ruthenium(II) complexes.SDS of cas: 1134-35-6 Furthermore, 4,4′-Dimethyl-2,2′-bipyridine is used as a chemical Intermediate. It can be used for the determination of ferrous and cyanide compounds.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Name: 2-(2-Hydroxyethyl)pyridineIn 2020 ,《Synthesis and antimicrobial activities of Schiff base from nitrogen containing heterocycles》 was published in Journal of Applicable Chemistry (Lumami, India). The article was written by Maisuriya, Pratik K.; Soni, Hetal I.; Patel, Jaydeep A.; Patel, Navin B.. The article contains the following contents:

This article dealt with microwave assisted synthesis of Schiff bases N-(aryl)(((pyridinyl)ethoxy)phenyl)methanimines I [R = Ph, 4-MeC6H4, 4-ClC6H4, etc.] from (2-(pyridinyl)ethoxy)benzaldehyde using catalytically amount of concentrateH2SO4 at room temperature MW stimulated synthetic route provided diverse advantages such as reaction rate acceleration, less byproduct, higher yield and reproducibility of final product. The structure of final compounds was established by elemental anal. such as IR, 1H NMR, 13C NMR, mass spectroscopy and also evaluated for their antibacterial, antifungal potency. The biol. potent Schiff base I [R = benzothiazol-2-yl] was found most active against S. aureus (MIC=25μg mL-1) with subjected to reference drug chloramphenicol and ciprofloxacin. The final compounds I [R = 3-ClC6H4, 4-ClC6H4, benzothiazol-2-yl] displayed good antibacterial activity (MIC=50μg mL-1) with reference drug. In the experiment, the researchers used many compounds, for example, 2-(2-Hydroxyethyl)pyridine(cas: 103-74-2Name: 2-(2-Hydroxyethyl)pyridine)

2-(2-Hydroxyethyl)pyridine(cas: 103-74-2) belongs to pyridine. Pyridine and pyridine-derived structures are privileged pharmacophores in medicinal chemistry and an essential functionality for organic chemists. As the prototypical π-deficient heterocycle, pyridine illustrates distinctive chemistry as both substrate and reagent. Name: 2-(2-Hydroxyethyl)pyridine

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Application In Synthesis of 4-CyanopyridineIn 2019 ,《Three AgI, CuI and CdII coordination polymers based on the new asymmetrical ligand 2-{4-[(1H-imidazol-1-yl)methyl]phenyl}-5-(pyridin-4-yl)-1,3,4-oxadiazole: syntheses, characterization and emission properties》 was published in Acta Crystallographica, Section C: Structural Chemistry. The article was written by Jin, Guo-Xia; You, Tian-Chao; Ma, Jian-Ping. The article contains the following contents:

The new asym. organic ligand 2-{4-[(1H-imidazol-1-yl)methyl]phenyl}-5-(pyridin-4-yl)-1,3,4-oxadiazole (L, C17H13N5O), containing pyridine and imidazole terminal groups, as well as potential oxdiazole coordination sites, was designed and synthesized. The coordination chem. of L with soft AgI, CuI and CdII metal ions was investigated and three new coordination polymers (CPs), namely, catena-poly[[silver(I)-μ-2-{4-[(1H-imidazol-1-yl)methyl]phenyl}-5-(pyridin-4-yl)-1,3,4-oxadiazole] hexafluoridophosphate], {[Ag(L)]PF6}n, catena-poly[[copper(I)-di-μ-iodido-copper(I)-bis(μ-2-{4-[(1H-imidazol-1-yl)methyl]phenyl}-5-(pyridin-4-yl)-1,3,4-oxadiazole)] 1,4-dioxane monosolvate], {[Cu2I2(L)2]·C4H8O2}n, and catena-poly[[[dinitratocopper(II)]-bis(μ-2-{4-[(1H-imidazol-1-yl)methyl]phenyl}-5-(pyridin-4-yl)-1,3,4-oxadiazole)]-methanol-water (1/1/0.65)], {[Cd(L)2(NO3)2]·2CH4O·0.65H2O}n, were obtained. The exptl. results show that ligand L coordinates easily with linear AgI, tetrahedral CuI and octahedral CdII metal atoms to form one-dimensional polymeric structures. The intermediate oxadiazole ring does not participate in the coordination interactions with the metal ions. In all three CPs, weak π-π interactions between the nearly coplanar pyridine, oxadiazole and benzene rings play an important role in the packing of the polymeric chains. In the experiment, the researchers used many compounds, for example, 4-Cyanopyridine(cas: 100-48-1Application In Synthesis of 4-Cyanopyridine)

4-Cyanopyridine(cas: 100-48-1) belongs to pyridine. Pyridine and pyridine-derived structures are privileged pharmacophores in medicinal chemistry and an essential functionality for organic chemists. As the prototypical π-deficient heterocycle, pyridine illustrates distinctive chemistry as both substrate and reagent. Application In Synthesis of 4-Cyanopyridine

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

SDS of cas: 2510-22-7In 2019 ,《Copper-catalyzed aminothiolation of terminal alkynes with tunable regioselectivity》 was published in Chemical Communications (Cambridge, United Kingdom). The article was written by Kuang, Jinqiang; Xia, Yuanzhi; Yang, An; Zhang, Heng; Su, Chenliang; Lee, Daesung. The article contains the following contents:

A simple, mild, and efficient copper(I)-catalyzed aminothiolation of terminal alkynes R1CCH (R1 = HOCH2CH2, Me3Si, cyclohexen-1-yl, Ph, pyridin-2-yl, etc.) with 5-R2-substituted 2-mercaptobenzimidazoles (R2 = H, Me, MeO, O2N) gave both 2- and 3-substituted thiazolo[3,2-a]benzimidazoles I, where complementary regioselectivities could be achieved by using sterically different phenanthroline-based ligands, such as 1,10-phenanthroline and 2,9-diisopropyl-1,10-phenanthroline. In addition to this study using 4-Ethynylpyridine, there are many other studies that have used 4-Ethynylpyridine(cas: 2510-22-7SDS of cas: 2510-22-7) was used in this study.

4-Ethynylpyridine(cas: 2510-22-7) belongs to pyridine. Pyridines, quinolines, and isoquinolines have found a function in almost all aspects of organic chemistry. Pyridine has found use as a solvent, base, ligand, functional group, and molecular scaffold. As structural elements, these moieties are potent electron-deficient groups, metal-directing functionalities, fluorophores, and medicinally important pharmacophores. SDS of cas: 2510-22-7

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

《Activity and electrochemical properties: iron complexes of the anticancer drug triapine and its analogs》 was written by Plamthottam, Sheba; Sun, Daniel; Van Valkenburgh, Juno; Valenzuela, Jeffrey; Ruehle, Bastian; Steele, Dalton; Poddar, Soumya; Marshalik, Maxim; Hernandez, Selena; Radu, Caius Gabriel; Zink, Jeffrey I.. HPLC of Formula: 39856-58-1 And the article was included in JBIC, Journal of Biological Inorganic Chemistry on August 31 ,2019. The article conveys some information:

Abstract: Triapine (3-AP), is an iron-binding ligand and anticancer drug that is an inhibitor of human ribonucleotide reductase (RNR). Inhibition of RNR by 3-AP results in the depletion of dNTP precursors of DNA, thereby selectively starving fast-replicating cancer cells of nucleotides for survival. The redox-active form of 3-AP directly responsible for inhibition of RNR is the Fe(II)(3-AP)2 complex. In this work, we synthesize 12 analogs of 3-AP, test their inhibition of RNR in vitro, and study the electronic properties of their iron complexes. The reduction and oxidation events of 3-AP iron complexes that are crucial for the inhibition of RNR are modeled with solution studies. We monitor the pH necessary to induce reduction in iron complexes of 3-AP analogs in a reducing environment, as well as the kinetics of oxidation in an oxidizing environment. The oxidation state of the complex is monitored using UV-Vis spectroscopy. Isoquinoline analogs of 3-AP favor the maintenance of the biol. active reduced complex and possess oxidation kinetics that allow redox cycling, consistent with their effective inhibition of RNR seen in our in vitro experiments In contrast, methylation on the thiosemicarbazone secondary amine moiety of 3-AP produces analogs that form iron complexes with much higher redox potentials, that do not redox cycle, and are inactive against RNR in vitro. Graphic abstract: The catalytic subunit of human Ribonucleotide Reductase (RNR), contains a tyrosyl radical in the enzyme active site. Fe(II) complexes of 3-AP and its analogs can quench the radical and, subsequently, inactivate RNR. The potency of RNR inhibitors is highly dependent on the redox properties of the iron complexes, which can be tuned by ligand modifications. Complexes are found to be active within a narrow redox window imposed by the cellular environment.[Figure not available: see fulltext.]. In the experimental materials used by the author, we found 2-Bromopyridin-3-amine(cas: 39856-58-1HPLC of Formula: 39856-58-1)

2-Bromopyridin-3-amine(cas: 39856-58-1) belongs to anime. Reduction of nitro compounds, RNO2, by hydrogen or other reducing agents produces primary amines cleanly (i.e., without a mixture of products), but the method is mostly used for aromatic amines because of the limited availability of aliphatic nitro compounds. Reduction of nitriles and oximes (R2C=NOH) also yields primary amines.HPLC of Formula: 39856-58-1

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

《An activity-based two-photon fluorescent probe for real-time and reversible imaging of oxidative stress in the rat brain》 was written by Liang, Chunjing; Chen, Xianghan; Tang, Qiao; Ji, Wenliang; Jiang, Ying; Mao, Lanqun; Wang, Ming. Computed Properties of C7H7NOThis research focused ontwo photon fluorescent probe imaging oxidative stress brain. The article conveys some information:

The real-time and reversible detection of cellular glutathione and oxidative stress challenges the study of the redox homeostasis of biol. systems. The authors report herein a modular approach to design the Michael addition between glutathione and coumarin derivatives for fluorescence imaging of the reversible and dynamic change of oxidative stress in living cells and the rat brain. The results came from multiple reactions, including the reaction of 4-Acetylpyridine(cas: 1122-54-9Computed Properties of C7H7NO)

4-Acetylpyridine(cas: 1122-54-9) belongs to pyridine. Pyridine-based materials are valued for their optical and physical properties as well as their medical potential. Additionally, pyridine-based natural products continue to be discovered and studied for their properties and to understand their biosynthesis.Computed Properties of C7H7NO

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

In 2016,Popowski, Yanay; Goldberg, Israel; Kol, Moshe published 《The stereoselectivity of bipyrrolidine-based sequential polydentate ligands around Ru(II)》.Chemical Communications (Cambridge, United Kingdom) published the findings.Product Details of 31106-82-8 The information in the text is summarized as follows:

The Ru(II) coordination chem. of the sequential hexadentate, tetradentate and the novel hybrid pentadentate ligands assembled around the chiral bipyrrolidine core and including bipyridyl and pyridyl periphery units is described. The bipyridine group exhibited priority in binding over the bipyrrolidine group, which led to a diastereomer mixture in the case of the hexadentate ligand (R,R)-bis(bipyridinylmethyl)-2,2′-bipyrrolidine (1). Employing only monopyridyl or a combination of monopyridyl (3) and bipyridyl (4) peripheral groups restored the chiral induction ability to the bipyrrolidine core resulting in predetermined chiral-at-metal complexes. In addition to this study using 2-(Bromomethyl)pyridine hydrobromide, there are many other studies that have used 2-(Bromomethyl)pyridine hydrobromide(cas: 31106-82-8Product Details of 31106-82-8) was used in this study.

2-(Bromomethyl)pyridine hydrobromide(cas: 31106-82-8) belongs to pyridine. Pyridine is very deactivated towards electrophilic substitution with respect to benzene. For this reason classical formylation, using methods such as the Gattermann or Vilsmeier reactions, are not generally successful. Product Details of 31106-82-8

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem