Day: October 14, 2022

Wang, Hai; Wang, Liang; Wang, Sai; Dong, Xue; Zhang, Jian; Xiao, Feng-Shou published the artcile< Aerobic Activation of C-H Bond in Amines Over a Nanorod Manganese Oxide Catalyst>, Application of C6H8N2, the main research area is aerobic activation amine nanorod manganese oxide catalyst; amide preparation green chem.

The development of heterogeneous catalysts for the synthesis of pharmaceutically relevant compounds is always important for chem. research. Here, we report a selective aerobic oxidation of aromatic and aliphatic amines to corresponding amides over a nanorod manganese oxide (NR-MnOx) catalyst. The kinetic studies reveal that the NR-MnOx catalyzed amine-to-amide reaction proceeds the oxidative dehydrogenation of the amines into nitriles, followed by hydrolysis of nitrile into amides. The NR-MnOx exhibits fast kinetics and high selectivities in these steps, as well as hinders the byproduct formation. More importantly, the NR-MnOx catalyst is stable and reusable in the continuous recycle tests with water as a sole byproduct, exhibiting superior sustainability and significant advancement to outperform the traditional amide production route in acidic or basic media with toxic byproducts.

ChemCatChem published new progress about Amides Role: SPN (Synthetic Preparation), PREP (Preparation). 3731-53-1 belongs to class pyridine-derivatives, and the molecular formula is C6H8N2, Application of C6H8N2.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Voisin, Anne Sophie; Bouillon, Alexandre; Lancelot, Jean-Charles; Rault, Sylvain published the artcile< Efficient synthesis of halohydroxypyridines by hydroxydeboronation>, SDS of cas: 96630-88-5, the main research area is halohydroxypyridine preparation regioselective hydroxydeboronation halopyridinylboronic acid ester.

This paper describes a general method for the synthesis of halohydroxypyridines from novel halopyridinylboronic acids and esters recently described by some of us. Halopyridinylboronic acids and esters have been efficiently hydroxydeboronated under mild conditions by employing hydrogen peroxide or meta-chloroperbenzoic acid. These hydroxylations take place regioselectively without other oxidation (N-oxide formation).

Tetrahedron published new progress about Aromatic nitrogen heterocycles Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 96630-88-5 belongs to class pyridine-derivatives, and the molecular formula is C5H4ClNO, SDS of cas: 96630-88-5.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Thuery, Pierre; Harrowfield, Jack published the artcile< Contrasting Structure-Directing Effects in the Uranyl-Phthalate/Isophthalate Isomer Systems>, Category: pyridine-derivatives, the main research area is crystal growth mol structure directing uranyl phthalate isophthalate isomer.

Reaction of uranyl cations with phthalic (H2pht) or isophthalic (H2ipht) acids under solvohydrothermal conditions was performed in the presence of 3d-block metal cations associated with chelating nitrogen donors to give nine zero-, mono-, and diperiodic complexes. [UO2(pht)2Zn(phen)2]2·4H2O (1), where phen is 1,10-phenanthroline, is a heterometallic, tetranuclear complex, while the counterion separation in [Ni(bipy)3][UO2(pht)(NO3)]2 (2), where bipy is 2,2′-bipyridine, yields a monoperiodic, helical uranyl ion complex crystallizing in a pure enantiomeric form. The diperiodic network in [Ni(phen)3][(UO2)3(O)(pht)3]·6H2O (3) displays pseudotrigonal, cuplike cavities containing part of the bulky counterions. [(UO2)2(O)(pht)2Ni(cyclam)(H2O)]2·H2O (4), where cyclam is 1,4,8,11-tetraazacyclotetradecane, is a discrete, bis(μ3-oxo)-bridged tetranuclear uranyl complex of common geometry, to which two Ni(cyclam)2+ moieties are attached through oxo bonding to uranyl. Separation of the 3d-block metal ion complex in [Ni(cyclam)]2[(UO2)7(pht)8(NO3)2] (5) and [Cu(R,S-Me6cyclam)][(UO2)5(O)2(pht)4(H2O)2]·4H2O (6), where R,S-Me6cyclam is 7(R),14(S)-5,5,7,12,12,14-hexamethylcyclam, results in the formation of quasi-planar diperiodic networks hydrogen bonded to the counterions. The three isophthalate complexes [(UO2)2(ipht)3Cu(bipy)2]·H2O (7), [(UO2)2(ipht)2(HCOO)2Ni(cyclam)] (8), and [(UO2)2(ipht)2(HCOO)2Cu(R,S-Me6cyclam)] (9) crystallize as heterometallic diperiodic species with Cu(bipy)22+ being only decorating in 7, while Ni2+ and Cu2+ in 8 and 9 bridge uranyl-containing chains into a network with a V2O5 topol.

Crystal Growth & Design published new progress about Crystal growth. 366-18-7 belongs to class pyridine-derivatives, and the molecular formula is C10H8N2, Category: pyridine-derivatives.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Hu, Yongke; Xia, Jiawei; Li, Jin; Li, Huaju; Li, Yanxing; Li, Shaozhong; Duanmu, Chuansong; Li, Bindong; Wang, Xin published the artcile< Direct oxidative esterification of alcohols catalyzed by a nitrogen-doped carbon black-supported PdBi bimetallic catalyst under ambient conditions>, Electric Literature of 93-60-7, the main research area is PdBi bimetallic catalyzed oxidative esterification alc; aryl ester preparation PdBi bimetallic catalyzed oxidative esterification.

A highly efficient nitrogen-doped carbon black (NCB)-supported PdBi alloy nanocatalyst has been fabricated via a facile coredn. wet chem. approach. The optimal PdBi/NCB shows outstanding catalytic performance with broad substrate scope, good functional group tolerance towards direct oxidative esterification of alcs. under mild conditions in a heterogeneous catalytic system with air as the sole oxidant. A variety of benzylic and allylic alcs. were smoothly reacted with methanol and even with long-chain aliphatic alcs., providing desired esters in good to excellent yields. Moreover, the as-prepared catalyst is easily recycled and can be reused at least five times without a significant loss of catalytic activity. Superior catalytic activity is mainly attributable to the unique structure of the catalyst, including synergetic electronic effect between Pd and Bi, as well as modulated surface character by acidification and N doping for better active components’ anchoring and dispersion, as well as reactants’ adsorption. This study provides a facial, practical, eco-friendly and efficient catalytic system for oxidative esterification of alcs. and shows promising prospect in industrial production

Journal of Materials Science published new progress about Alcohols Role: RCT (Reactant), RACT (Reactant or Reagent). 93-60-7 belongs to class pyridine-derivatives, and the molecular formula is C7H7NO2, Electric Literature of 93-60-7.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Brendel, Matthias; Sakhare, Priyanka R.; Dahiya, Gaurav; Subramanian, Parthasarathi; Kaliappan, Krishna P. published the artcile< Serendipitous Synthesis of Pyridoquinazolinones via an Oxidative C-C Bond Cleavage>, Application In Synthesis of 188577-68-6, the main research area is serendipitous synthesis pyridoquinazolinone oxidative carbon carbon bond cleavage.

A direct one-pot copper-catalyzed oxidative C-C bond cleavage route to the synthesis of pyridoquinazolinones is described. This one-pot strategy involves a copper-catalyzed C-N coupling followed by concomitant C(sp3)-H oxidation and amidation via oxidative C-C bond cleavage under an O2 atmosphere to deliver the target mols. in high yields.

Journal of Organic Chemistry published new progress about Acetophenones Role: RCT (Reactant), RACT (Reactant or Reagent). 188577-68-6 belongs to class pyridine-derivatives, and the molecular formula is C5H4Cl2N2, Application In Synthesis of 188577-68-6.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Li, Longjia; Liu, Zibo; Tang, Shanyu; Li, Jiao; Ren, Xuanhe; Yang, Guanyu; Li, Heng; Yuan, Bingxin published the artcile< Amphiphilic ligands for Cu-catalyzed aerobic oxidation to synthesize 9-fluorenones in water>, Product Details of C10H6Cl2N2, the main research area is fluorenone preparation; fluorene aerobic oxidation copper catalyst.

A series of amphiphilic PEG-functionalized nitrogen ligands were developed for the highly efficient copper-catalyzed aerobic oxidation of 9-fluorenes, with mol. oxygen as the sole oxidant in neat water to afford 9-fluorenones I [R = H, 2-NH2, 2-I, etc.]. A broad range of functional groups were well tolerated and thus offered the opportunity for further functionalization.

Catalysis Communications published new progress about Fluorenes Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 1762-41-0 belongs to class pyridine-derivatives, and the molecular formula is C10H6Cl2N2, Product Details of C10H6Cl2N2.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Xiao, Xuan; Wang, Kewei; Zong, Qingyu; Tu, Yalan; Dong, Yansong; Yuan, Youyong published the artcile< Polyprodrug with glutathione depletion and cascade drug activation for multi-drug resistance reversal>, HPLC of Formula: 2127-03-9, the main research area is polydisulfide prodrug glutathione depletion multidrug resistance reversal; Glutathione response; Multidrug resistance; poly(disulfide).

High intracellular glutathione (GSH) levels play an important role in multidrug resistance (MDR) in cancer cells. It remains challenging to develop a drug delivery system that is simultaneously capable of GSH depletion and drug activation for multidrug resistance reversal. Herein, we designed a polyprodrug (denoted as PSSD) based on poly(disulfide) conjugated with doxorubicin (DOX) on the polymer side chains that exhibits GSH depletion and cascade DOX activation for drug resistance reversal. The poly(disulfide) backbone with a high disulfide d. depletes intracellular antioxidant GSH via the disulfide-thiol exchange reaction to disrupt intracellular redox homeostasis in cells. Simultaneously, DOX can be activated through a cascade reaction, and degradation of the poly(disulfide) backbone further facilitates its drug release. Therefore, poly(disulfide) can be used as a GSH scavenger to reverse MDR as well as a prodrug backbone to target high intracellular GSH levels in cancer cells, providing a general strategy for drug resistance reversal.

Biomaterials published new progress about Antitumor agent resistance. 2127-03-9 belongs to class pyridine-derivatives, and the molecular formula is C10H8N2S2, HPLC of Formula: 2127-03-9.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Allen, Sonia A.; Datta, Sandipan; Sandoval, Jose; Tomilov, Alexey; Sears, Thomas; Woolard, Kevin; Angelastro, James M.; Cortopassi, Gino A. published the artcile< Cetylpyridinium chloride is a potent AMP-activated kinase (AMPK) inducer and has therapeutic potential in cancer>, Name: 1-Hexadecylpyridin-1-ium chloride, the main research area is cancer cetylpyridinium chloride AMP activated kinase therapeutics; AMP-activated protein kinase; AMPK; Cancer; Cetylpyridinium chloride; Mitochondrial inhibitor; Quaternary ammonium salt.

AMP-activated protein kinase (AMPK) is a eukaryotic energy sensor and protector from mitochondrial/energetic stress that is also a therapeutic target for cancer and metabolic disease. Metformin is an AMPK inducer that has been used in cancer therapeutic trials. Through screening we isolated cetylpyridinium chloride (CPC), a drug known to dose-dependently inhibit mitochondrial complex 1, as a potent and dose-dependent AMPK stimulator. Mitochondrial biogenesis and bioenergetics changes have also been implicated in glioblastoma, which is the most aggressive form of brain tumors. Cetylpyridinium chloride has been administered in humans as a safe drug-disinfectant for several decades, and we report here that under in vitro conditions, cetylpyridinium chloride kills glioblastoma cells in a dose dependent manner at a higher efficacy compared to current standard of care drug, temozolomide.

Mitochondrion published new progress about Brain neoplasm Role: BSU (Biological Study, Unclassified), BIOL (Biological Study). 123-03-5 belongs to class pyridine-derivatives, and the molecular formula is C21H38ClN, Name: 1-Hexadecylpyridin-1-ium chloride.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Zhou, Sen; Hou, Xiaoya; Yang, Kai; Guo, Minjie; Zhao, Wentao; Tang, Xiangyang; Wang, Guangwei published the artcile< Direct Synthesis of N-Difluoromethyl-2-pyridones from Pyridines>, Name: 1,2-Di(pyridin-2-yl)disulfane, the main research area is difluoromethylpyridone difluoromethylquinolinone preparation.

A novel method for the synthesis of N-difluoromethyl-2-pyridones was described. This protocol enables the synthesis of N-difluoromethyl-2-pyridones from readily available pyridines using mild reaction conditions that are compatible with a wide range of functional groups. The preliminary mechanistic study revealed that N-difluoromethylpyridinium salts were the key intermediates to complete this conversion.

Journal of Organic Chemistry published new progress about One-pot synthesis. 2127-03-9 belongs to class pyridine-derivatives, and the molecular formula is C10H8N2S2, Name: 1,2-Di(pyridin-2-yl)disulfane.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Shokurov, Alexander V.; Meshkov, Ivan N.; Bulach, Veronique; Gorbunova, Yulia G.; Hosseini, Mir Wais; Tsivadze, Aslan Yu.; Arslanov, Vladimir V.; Selektor, Sofia L. published the artcile< Restriction of the rotational relaxation of a butadiyne-bridged porphyrin dimer in ultrathin films>, Application In Synthesis of 3731-53-1, the main research area is porphyrin dimer diazabicyclooctane aminomethylpyridine film preparation dynamic behavior UV.

The dynamic behavior of a porphyrin dimer, based on the covalent linkage of two macrocyclic moieties with a butadiyne connector, was studied in thin films by UV-visible and emission spectroscopies. The degree of π-conjugation through control of intramol. motion was studied without employing extreme conditions such as cryogenic temperatures or high viscosity. By exploiting the propensity of the dimer to bind axial ligands through Zn-N bonds, the coplanar and orthogonal conformations of the dimer may be stabilized in ultrathin films at the air/water interface. Also, using the Langmuir-Blodgett technique, monolayer-thick matrix-free films on solid substrates containing the porphyrin dimer were obtained. In the latter case, the dimer exists in either an exclusively coplanar state or a mixture of conformational states depending on the nature of the axial ligand: 1,4-diazabicyclo[2.2.2]-octane (DABCO) or 4-aminomethylpyridine (AMP).

New Journal of Chemistry published new progress about Lattice dynamics. 3731-53-1 belongs to class pyridine-derivatives, and the molecular formula is C6H8N2, Application In Synthesis of 3731-53-1.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem