Day: October 14, 2022

Qin, Lei; Zhou, Guo-Jun; Yu, You-Zhu; Nojiri, Hiroyuki; Schroder, Christian; Winpenny, Richard E. P.; Zheng, Yan-Zhen published the artcile< Topological Self-Assembly of Highly Symmetric Lanthanide Clusters: A Magnetic Study of Exchange-Coupling ""Fingerprints"" in Giant Gadolinium(III) Cages>, Computed Properties of 73018-09-4, the main research area is gadolinium cage self assembly magnetization exchange interaction crystal structure.

The creation of a perfect hollow nanoscopic sphere of metal centers is clearly an unrealizable synthetic challenge. It is, however, an inspirational challenge from the viewpoint of chem. architecture and also as finite mol. species may provide unique microscopic insight into the origin and onset of phenomena such as topol. spin-frustration effects found in infinite 2D and 3D systems. Herein, we report a series of high-symmetry gadolinium(III) (S = 7/2) polyhedra, Gd20, Gd32, Gd50, and Gd60, to test an approach based on assembling polymetallic fragments that contain different polygons. Structural anal. reveals that the Gd20 cage resembles a dodecahedron; the vertices of the Gd32 polyhedron exactly reveal symmetry Oh; Gd50 displays an unprecedented polyhedron in which an icosidodecahedron Gd30 core is encapsulated by an outer Gd20 dodecahedral shell with approx. Ih symmetry; and the Gd60 shows a truncated octahedron geometry. Exptl. and theor. magnetic studies show that this series produces the expected antiferromagnetic interaction that can be modeled based on classical spins at the Gd sites. From the magnetization analyses, we can roughly correlate the derivative bands to the Gd-O-Gd angles. Such a magneto-structural correlation may be used as “”fingerprints”” to identify these cages.

Journal of the American Chemical Society published new progress about Antiferromagnetic exchange. 73018-09-4 belongs to class pyridine-derivatives, and the molecular formula is C5H4ClNO, Computed Properties of 73018-09-4.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Babaev, Eugene V.; Rybakov, Victor B. published the artcile< Phenacylation of 6-methyl-beta-nitropyridin-2-ones and further heterocyclization of products>, Product Details of C6H7N3O2, the main research area is betanitropyridinone phenacylation; phenacylpyridone heterocyclization; 8-nitro-5-RO-indolizines; Phenacylation of beta-nitropyridin-2-ones; oxazole-pyrrole ring transformation.

Reaction between the derivatives of 6-methyl-beta-nitropyridin-2-one and phenacyl bromides was studied, and the yields observed were extremely low. The pyridones were converted via chloropyridines to methoxyderivatives, which were N-phenacylated. N-Phenacyl derivatives of 4,6-dimethyl-5-nitropyridin-2-one under the action of base gave 5-hydroxy-8-nitroindolizine and under acidic conditions gave 5-methyl-6-nitrooxazole[3,2-a]pyridinium salt, which underwent recyclization with MeONa to 5-methoxy-8-nitroindolizine.

Molecules published new progress about Acylation. 21901-29-1 belongs to class pyridine-derivatives, and the molecular formula is C6H7N3O2, Product Details of C6H7N3O2.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Niroobakhsh, Zahra; LaNasa, Jacob A.; Belmonte, Andrew; Hickey, Robert J. published the artcile< Rapid Stabilization of Immiscible Fluids using Nanostructured Interfaces via Surfactant Association>, Safety of 1-Hexadecylpyridin-1-ium chloride, the main research area is nanostructured interface immiscible fluid rapid stabilization.

Surfactant mols. have been extensively used as emulsifying agents to stabilize immiscible fluids. Droplet stability has been shown to be increased when ordered nanoscale phases form at the interface of the two fluids due to surfactant association Here, we report on using mixtures of a cationic surfactant and long chained alkenes with polar head groups [e.g., cetylpyridinium chloride (CPCl) and oleic acid] to create an ordered nanoscale lamellar morphol. at aqueous-oil interfaces. The self-assembled nanostructure at the liquid-liquid interface was characterized using small-angle x-ray scattering, and the mech. properties were measured using interfacial rheol. We hypothesize that the resulting lamellar morphol. at the liquid-liquid interface is driven by the change in critical packing parameter when the CPCl mols. are diluted by the presence of the long chain alkenes with polar head groups, which leads to a spherical micelle-to-lamellar phase transition. The work presented here has larger implications for using nanostructured interfacial material to sep. different fluids in flowing conditions for biosystems and in 3D printing technol.

Physical Review Letters published new progress about Encapsulation Role: PEP (Physical, Engineering or Chemical Process), PROC (Process). 123-03-5 belongs to class pyridine-derivatives, and the molecular formula is C21H38ClN, Safety of 1-Hexadecylpyridin-1-ium chloride.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Zhao, Changgui; Ye, Zhengqing; Ma, Zhi-xiong; Wildman, Scott A.; Blaszczyk, Stephanie A.; Hu, Lihong; Guizei, Ilia A.; Tang, Weiping published the artcile< A general strategy for diversifying complex natural products to polycyclic scaffolds with medium-sized rings>, HPLC of Formula: 3731-53-1, the main research area is polycyclic steroid preparation oxidation ring expastion natural product.

The interrogation of complex biol. pathways demands diverse small mol. tool compounds, which can often lead to important therapeutics for the treatment of human diseases. Since natural products are the most valuable source for the discovery of therapeutics, the derivatization of natural products has been extensively investigated to generate mols. for biol. screenings. However, most previous approaches only modified a limited number of functional groups, which resulted in a limited number of skeleta. Here, a general strategy for the preparation of a library of complex small mols. by combining state-of-the-art chem. – the site-selective oxidation of C-H bonds – with reactions that expand rigid, small rings in polycyclic steroids to medium-sized rings is described. This library occupies a unique chem. space compared to selected diverse reference compounds The diversification strategy developed herein for steroids can also be expanded to other types of natural products.

Nature Communications published new progress about Alkylation. 3731-53-1 belongs to class pyridine-derivatives, and the molecular formula is C6H8N2, HPLC of Formula: 3731-53-1.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Luo, Yuncong; Jiang, Shengjie; Xu, Xin published the artcile< Yttrium-Catalyzed ortho-Selective C-H Borylation of Pyridines with Pinacolborane>, Related Products of 581-47-5, the main research area is yttrium catalyzed carbon hydrogen borylation pyridine pinacolborane; crystal mol structure pyridyl boronate; pentamethylcyclopentadienyl yttrium pyridyl boronate intermediate preparation crystal mol structure; Borylation; C−H Activation; Pyridines; Regioselectivity; Yttrium.

This work reports a site-selective C-H borylation of pyridines at the ortho-position with pinacolborane enabled by an yttrocene catalyst. The reaction provides a new family of 2-pyridyl boronates with a broad substrate scope and high atom efficiency. The resultant boronates were able to undergo a variety of transformations, e.g., oxidation, Suzuki-Miyaura coupling, Chan-Lam amination and etherification. Catalytic intermediates, including ortho-C-H metalated and borylated complexes, were isolated from stoichiometric experiments and confirmed by single-crystal x-ray diffraction.

Angewandte Chemie, International Edition published new progress about Amination. 581-47-5 belongs to class pyridine-derivatives, and the molecular formula is C10H8N2, Related Products of 581-47-5.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Zhu, Hongmei; Wu, Shaohang; Yao, Jiaxu; Chen, Rui; Pan, Ming; Chen, Weitao; Zhou, Jing; Zhang, Wenjun; Wang, Tao; Chen, Wei published the artcile< An effective surface modification strategy with high reproducibility for simultaneously improving efficiency and stability of inverted MA-free perovskite solar cells>, Computed Properties of 350-03-8, the main research area is perovskite solar cell surface modification high reproducibility efficiency stability.

Perovskite solar cells (PSCs) have become the front-running photovoltaic technol. and have triggered enormous research interest worldwide owing to their ultra-high solar-to-elec. power conversion efficiency and low fabrication costs, but their poor intrinsic stability issues still constitute the main obstacles that hinder their rapid commercialization. Herein, we demonstrate that, by carefully designing the modifier’s mol. structure, a facile, highly reproducible and scalable surface modification strategy can effectively enhance both the stability and efficiency of inverted PSCs. The most efficient modifier (2-acetylpyridine) can not only passivate the surface traps of the perovskite film but also enhance its stability against moisture by forming a hydrophobic capping layer on top. Accordingly, the efficiency of the inverted PSC has been improved from 16.75% to 20.05% for the best-performing one, which is, to our knowledge, among the highest values for inverted MA-free PSCs. More encouragingly, the stability of the modified devices can also be largely enhanced: the devices retained 95%, 90%, and 91% of their initial efficiencies after storage in the dark in ambient air for 2000 h, 85°C thermal aging for 500 h in the dark, and light soaking at 45°C for 500 h, resp.

Journal of Materials Chemistry A: Materials for Energy and Sustainability published new progress about Electric current-potential relationship. 350-03-8 belongs to class pyridine-derivatives, and the molecular formula is C7H7NO, Computed Properties of 350-03-8.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Zheng, Dongxiao; Li, Anze; Zhang, Man; Wang, Xiuli; Wu, Bin; Zhao, Pei; Jia, Xiaoyong; Ding, Jiandong; Zou, Qi; Zhu, Liangliang published the artcile< An excitation-dependent ratiometric dual-emission strategy for the large-scale enhancement of fluorescent tint control>, Application In Synthesis of 123-03-5, the main research area is carbon quantum dot surface state zeta potential photoexcitation fluorescence.

An alternative and convenient strategy for preparing carbon dots (CDs) with multicolor and dual-emission fluorescence is described. For this dual-emission characteristic, the short-wavelength emission reveals unique excitation-dependent fluorescence behavior, during which the long-wavelength emission remains unshifted regardless of the excitation. Consequently, such excitation-dependent ratiometric dual emission can be applied into a fluorescent tint control of this material between the cold and warm white-light regions. This unique property allows the CDs to be further translated into film sheets for visual detection of the irradiation source, and to also be conjugated with calf thymus DNA for multichannel bioimaging. These results offer new insights for the development of easy-to-handle techniques for material luminescent color tuning.

Nanoscale published new progress about Cytotoxicity. 123-03-5 belongs to class pyridine-derivatives, and the molecular formula is C21H38ClN, Application In Synthesis of 123-03-5.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Zhang, Jing; Han, Fu-She published the artcile< Pd-Catalyzed Aerobic Oxidative Heck Cross-Coupling for the Straightforward Construction of Indole δ-Lactams>, Related Products of 93-60-7, the main research area is indolyl amide palladium catalyst oxidative Heck coupling regioselective hetereocyclization; fused indolyl lactam preparation; Catalysis; Chemistry; Organic Chemistry.

A co-ligand-prompted Pd-catalyzed 6-exo-trig intramol. cyclization of indolyl amides via the aerobic oxidative Heck cross-coupling. The method provided a general and efficient way for the construction of [6.5.6]-tricyclic indole δ-lactams. A mechanistic study suggests that a Pd(I)/Pd(III) catalytic cycle should be responsible for effective coupling, which represents a mechanistically alternative pathway when compared with the Pd(0)/Pd(II) cycle proposed for other related coupling reactions.

iScience published new progress about Alkenes Role: PRP (Properties), RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 93-60-7 belongs to class pyridine-derivatives, and the molecular formula is C7H7NO2, Related Products of 93-60-7.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Darwish, Shaban; Sadeghiani, Neda; Fong, Shirley; Mozaffari, Saghar; Hamidi, Parinaz; Withana, Thimanthi; Yang, Sun; Tiwari, Rakesh Kumar; Parang, Keykavous published the artcile< Synthesis and antiproliferative activities of doxorubicin thiol conjugates and doxorubicin-SS-cyclic peptide>, Safety of 1,2-Di(pyridin-2-yl)disulfane, the main research area is human embryonic kidney ovarian fibrosarcoma leukemia; cyclopeptide preparation antitumor doxorubicin fluorescence cellular uptake chemotherapy antiproliferative; Anticancer; Cardiotoxicity; Cellular uptake; Cyclic peptide; Disulfide; Doxorubicin; Thiol.

Myocardial toxicity and drug resistance caused by drug efflux are major limitations of doxorubicin (Dox)-based chemotherapy. Dox structure modification could be used to develop conjugates with an improved biol. profile, such as antiproliferative activity and higher cellular retention. Thus, Dox thiol conjugates, Dox thiol (Dox-SH), thiol-reactive Dox-SS-pyridine (SS = disulfide), and a Dox-SS-cell-penetrating cyclic peptide, Dox-SS-[C(WR)4K], were synthesized. Dox was reacted with Traut’s reagent to generate Dox-SH. Cytotoxicity of the compounds was examined in human embryonic kidney (HEK-293), human ovarian cancer (SKOV-3), human fibrosarcoma (HT-1080), and human leukemia (CCRF-CEM) cells. These data indicate that Dox-SH, Dox-SS-Pyr, and Dox-SS-[C(WR)4K] have the potential to be further examined as Dox alternatives and anticancer agents.

European Journal of Medicinal Chemistry published new progress about Antiproliferative agents. 2127-03-9 belongs to class pyridine-derivatives, and the molecular formula is C10H8N2S2, Safety of 1,2-Di(pyridin-2-yl)disulfane.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Rani, S. Mahil; Brindha, J.; Reji, T. F. Abbs Fen published the artcile< Synthesis, computational studies and antioxidant activity of some 3-(2-alkylamino-4-aminothiazole-5-oyl)pyridines>, Name: 1-(Pyridin-3-yl)ethanone, the main research area is alkylamino aminothiazoloyl pyridine preparation antioxidant DFT HOMO LUMO.

A series of thiazoloylpyridine derivatives I (R = Et, n-Pr, i-Pr, n-Bu, allyl) has been synthesized and analyzed to confirm the structure of the product using IR, 1H and 13C NMR, mass spectra and anal. data. Optimized structural and electronic parameters of all the compounds I have been calculated by using B3LYP/ 6-31G basis set. The Mulliken charges of all atoms have been evaluated. All the synthesized compounds I have been examined for antioxidant activities. The antioxidant activity of 3-(2-alkylamino-4-aminothiazol -5-oyl)pyridines I have been analyzed using DPPH radical scavenging assay. The compounds I (R = Et, n-Pr) possess higher radical scavenging activity.

Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry published new progress about Antioxidants. 350-03-8 belongs to class pyridine-derivatives, and the molecular formula is C7H7NO, Name: 1-(Pyridin-3-yl)ethanone.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem