Day: October 14, 2022

Hawash, Mohammed; Kahraman, Deniz Cansen; Ergun, Sezen Guntekin; Cetin-Atalay, Rengul; Baytas, Sultan Nacak published the artcile< Synthesis of novel indole-isoxazole hybrids and evaluation of their cytotoxic activities on hepatocellular carcinoma cell lines>, Quality Control of 3731-53-1, the main research area is indole isoxazole carboxamide preparation antitumor activity physicochem property; Apoptosis; CDK4; Cell cycle arrest; Hepatocellular carcinoma; Indole; Isoxazole.

In this study, a series of indole-3-isoxazole-5-carboxamide derivatives I (R = n-butylamine, 3,4,5-(trimethoxyphenyl)aminyl, morpholin-4-yl, etc.) was designed, synthesized, and evaluated for their anticancer activities. The cytotoxic activity was performed against Huh7, MCF7 and HCT116 cancer cell lines using sulforhodamine B assay. Some compounds I showed potent anticancer activities and three of them were chosen for further evaluation on liver cancer cell lines based on SRB assay and real-time cell growth tracking anal. Compounds I were shown to cause arrest in the G0/G1 phase in Huh7 cells and caused a significant decrease in CDK4 levels. A good correlation was obtained between the theor. predictions of bioavailability using Molinspiration calculation, Lipinski’s rule of five, and exptl. verification. These investigations reveal that indole-isoxazole hybrid system have the potential for the development of novel anticancer agents.

BMC Chemistry published new progress about Amides Role: PAC (Pharmacological Activity), PRP (Properties), SPN (Synthetic Preparation), THU (Therapeutic Use), BIOL (Biological Study), PREP (Preparation), USES (Uses). 3731-53-1 belongs to class pyridine-derivatives, and the molecular formula is C6H8N2, Quality Control of 3731-53-1.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Sun, Bin; Dong, Yue; Lei, Kang; Wang, Jian; Zhao, Liyu; Liu, Min published the artcile< Design, synthesis and biological evaluation of amide-pyridine derivatives as novel dual-target (SE, CYP51) antifungal inhibitors>, COA of Formula: C6H8N2, the main research area is amide pyridine derivative preparation squalene cyclooxygenase CYP51 inhibitor antifungal; 3D QSAR model; Amide-pyridine compounds; Antifungal activity; Dual-target; Molecular docking.

Based on the anal. of the squalene cyclooxygenase (SE) and 14α-demethylase (CYP51) inhibitors pharmacophore feature and the dual-target active sites, a series of compounds with amide-pyridine scaffolds have been designed and synthesized to treat the increasing incidence of drug-resistant fungal infections. In vitro evaluation showed that these compounds have a certain degree of antifungal activity. The most potent compounds 11a, 11b with MIC values in the range of 0.125-2 μg/mL had a broad-spectrum antifungal activity and exhibited excellent inhibitory activity against drug-resistant pathogenic fungi. Preliminary mechanism studies revealed that the compound 11b might play an antifungal role by inhibiting the activity of SE and CYP51. Notably compounds did not show the genotoxicity through plasmid binding assay. Finally, this study of mol. docking, ADME/T prediction and the construction of 3D QSAR model were performed. These results can point out the direction for further optimization of the lead compound

Bioorganic & Medicinal Chemistry published new progress about Drug resistance. 3731-53-1 belongs to class pyridine-derivatives, and the molecular formula is C6H8N2, COA of Formula: C6H8N2.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Liu, Zhong; He, Jia-Hao; Zhang, Ming; Shi, Zhu-Jun; Tang, Han; Zhou, Xin-Yue; Tian, Jun-Jie; Wang, Xiao-Chen published the artcile< Borane-Catalyzed C3-Alkylation of Pyridines with Imines, Aldehydes, or Ketones as Electrophiles>, Category: pyridine-derivatives, the main research area is C3 selective pyridine preparation regioselective; pyridine imine aldehyde ketone alkylation borane catalyst.

Achieving C3-selective pyridine functionalization is a longstanding challenge in organic chem. The existing methods, including electrophilic aromatic substitution and C-H activation, often require harsh reaction conditions and excess pyridine and generate multiple regioisomers. Herein, authors report a method for borane-catalyzed tandem reactions that result in exclusively C3-selective alkylation of pyridines. These tandem reactions consist of pyridine hydroboration, nucleophilic addition of the resulting dihydropyridine to an imine, an aldehyde, or a ketone, and subsequent oxidative aromatization. Because the pyridine is the limiting reactant and the reaction conditions are mild, this method constitutes a practical tool for late-stage functionalization of structurally complex pharmaceuticals bearing a pyridine moiety.

Journal of the American Chemical Society published new progress about Aldehydes Role: RCT (Reactant), RACT (Reactant or Reagent). 3796-23-4 belongs to class pyridine-derivatives, and the molecular formula is C6H4F3N, Category: pyridine-derivatives.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Garcia-Cuellar, Claudia Maria; Hernandez-Delgadillo, Rene; Solis-Soto, Juan Manuel; Meester, Irene; Sanchez-Perez, Yesennia; Nakagoshi-Cepeda, Sergio Eduardo; Nakagoshi-Cepeda, Maria Argelia Akemi; Chellam, Shankararaman; Cabral-Romero, Claudio published the artcile< Cetylpyridinium chloride inhibits human breast tumor cells growth in a no-selective way>, Synthetic Route of 123-03-5, the main research area is breast tumor cell growth cetylpyridinium chloride anticancer; Antitumor activity; LD50 assay; cetylpyridinium chloride; chemotherapy; human breast cancer; quaternary ammonium salts.

Objective: Analyze the antitumor capacity of cetylpyridinium chloride (CPC) on human breast tumor cells, and the possible action mechanism. Material and methods: The human breast tumor cells MCF-7 and no-tumor breast cells MCF-10A were exposed to CPC under various condition (concentration and duration). Cell viability was measured with MTT assay, the LIVE/DEAD assay, and fluorescence microscopy. Membrane permeability after CPC exposure was evaluated by Calcein AM assay, mitochondrial morphol. with a MitoView staining, and genotoxicity with the comet assay and fluorescence microscopy. Results: CPC was cytotoxic to both MCF-7 and MCF-10A as of a 24-h exposure to 0.1μM. Cytotoxicity was dosedependent and reached 91for MCF-7 and 78for MCF-10A after a 24-h exposure to 100μM CPC, which outperformed the pos. control doxorubicin in effectiveness and selectivity. The LD50 of CPC on was 6μM for MCF-7 and 8μM for MCF-10A, yielding a selectivity index of 1.41. With respect to the action mechanisms, the comet assay did not reveal genome fragmentation. On the other hand, membrane damage was dose-dependent and may also affect mitochondrial morphol. Conclusion: Cetylpyridinium chloride inhibits MCF-7 cell growing in a non-selective way as of 5min of exposure. The action mechanism of CPC on tumor cells involves cell membrane damage without change neither mitochondrial morphol. nor genotoxicity.

Journal of Applied Biomaterials & Functional Materials published new progress about Antitumor agents. 123-03-5 belongs to class pyridine-derivatives, and the molecular formula is C21H38ClN, Synthetic Route of 123-03-5.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Xiong, Yun; Zhang, Pangzhen; Luo, Jiaqian; Johnson, Stuart; Fang, Zhongxiang published the artcile< Effect of processing on the phenolic contents, antioxidant activity and volatile compounds of sorghum grain tea>, Application of C7H7NO2, the main research area is Sorghum tea phenol antioxidant volatile compound.

Sorghum grain is rich in phenolic compounds and may be used to develop functional tea beverages. This work investigated the effect of processing techniques on the phenolic contents, antioxidant activity, and volatile compounds of a white color sorghum (Liberty) grain tea. Significant (P ≤ 0.05) increase of total phenolic content, total flavonoid content and condensed tannin content were observed during the processing, whereas the antioxidant activity was not statistically enhanced. A total of 63 volatile compounds were detected including 5 alcs., 13 alkanes, 2 aldehydes, 2 carboxylic acids, 15 esters, 4 ketones, 3 pyrazines and 1 phenylenediamine, which were affected by the processing techniques. The sorghum tea made from powder form infusion had more abundant volatile compounds compared to whole grain form infusion. The findings of this research have potential to expand human consumption of sorghum grain in the new form of grain tea.

Journal of Cereal Science published new progress about Alcohols Role: BSU (Biological Study, Unclassified), BIOL (Biological Study). 93-60-7 belongs to class pyridine-derivatives, and the molecular formula is C7H7NO2, Application of C7H7NO2.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Hou, Shaohua; Yang, Xiping; Yang, Yuejing; Tong, Yu; Chen, Quanwei; Wan, Boheng; Wei, Ran; Lu, Tao; Chen, Yadong; Hu, Qinghua published the artcile< Design, synthesis and biological evaluation of 1H-indazole derivatives as novel ASK1 inhibitors>, COA of Formula: C11H16BNO2, the main research area is aryl indazole preparation ASK inhibition mol docking SAR; 1H-indazole derivatives; ASK1 inhibitor; Inflammatory bowel disease.

A series of novel ASK1 inhibitors, e.g., I and II with 1H-indazole scaffold were designed, synthesized and evaluated for their ASK1 kinase activity and AP1-HEK293 cell inhibitory effect. Systematic structure-activity relationship (SAR) efforts led to the discovery of promising compound II, which showed excellent in vitro ASK1 kinase activity and potent inhibitory effects on ASK1 in AP1-HEK293 cells. In a tumor necrosis factor-α (TNF-α)-induced HT-29 intestinal epithelial cell model, compound II exhibited a significantly protective effect on cell viability comparable to that of GS-4997; moreover, compound II exhibited no obvious cytotoxicity against HT-29 cells at concentrations up to 25μM. Mechanistic research demonstrated that compound II suppressed phosphorylation in the ASK1-p38/JNK signaling pathway in HT-29 cells and regulated the expression levels of apoptosis-related proteins. Altogether, these results showed that compound II may serve as a potential candidate compound for the treatment of inflammatory bowel disease (IBD).

European Journal of Medicinal Chemistry published new progress about Amides Role: PAC (Pharmacological Activity), RCT (Reactant), SPN (Synthetic Preparation), THU (Therapeutic Use), BIOL (Biological Study), RACT (Reactant or Reagent), PREP (Preparation), USES (Uses). 329214-79-1 belongs to class pyridine-derivatives, and the molecular formula is C11H16BNO2, COA of Formula: C11H16BNO2.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Chakraborty, Gargi; Sikari, Rina; Das, Siuli; Mondal, Rakesh; Sinha, Suman; Banerjee, Seemika; Paul, Nanda D. published the artcile< Dehydrogenative Synthesis of Quinolines, 2-Aminoquinolines, and Quinazolines Using Singlet Diradical Ni(II)-Catalysts>, Formula: C7H7NO, the main research area is quinoline biomimetic synthesis; aminoquinoline biomimetic synthesis; quinazoline biomimetic synthesis; nickel complex diamine singlet diradical oxidative condensation coupling catalyst.

Simple, straightforward, and atom economic methods for the synthesis of quinolines, 2-aminoquinolines, and quinazolines via biomimetic dehydrogenative condensation/coupling reactions, catalyzed by well-defined inexpensive and easy to prepare singlet diradical Ni(II)-catalysts featuring two antiferromagnetically coupled singlet diradical diamine type ligands are described. Various polysubstituted quinolines, 2-aminoquinolines, and quinazolines were synthesized in moderate to good yields from different low-cost and readily accessible starting materials. Several control experiments were carried out to get insight into the reaction mechanism which shows that the nickel and the coordinated diamine ligands participate in a synergistic way during the dehydrogenation of alcs.

Journal of Organic Chemistry published new progress about Acetonitriles Role: RCT (Reactant), RACT (Reactant or Reagent) (phenylacetonitriles). 350-03-8 belongs to class pyridine-derivatives, and the molecular formula is C7H7NO, Formula: C7H7NO.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Mori, Kisho; Hirase, Mitsuhiro; Morishige, Takahiro; Takano, Eri; Sunayama, Hirobumi; Kitayama, Yukiya; Inubushi, Sachiko; Sasaki, Ryohei; Yashiro, Masakazu; Takeuchi, Toshifumi published the artcile< A Pretreatment-Free, Polymer-Based Platform Prepared by Molecular Imprinting and Post-Imprinting Modifications for Sensing Intact Exosomes>, Recommanded Product: 1,2-Di(pyridin-2-yl)disulfane, the main research area is exosome detection fluorescence polymer sensing platform antibody cancer; exosomes; fluorescence; membrane proteins; molecular imprinting; post-imprinting modifications.

Exosomes are small (30-100 nm) membrane vesicles that serve as regulatory agents for intercellular communication in cancers. Currently, exosomes are detected by immuno-based assays with appropriate pretreatments like ultracentrifugation and are time consuming (>12 h). We present a novel pretreatment-free fluorescence-based sensing platform for intact exosomes, wherein exchangeable antibodies and fluorescent reporter mols. were aligned inside exosome-binding cavities. Such antibody-containing fluorescent reporter-grafted nanocavities were prepared on a substrate by well-designed mol. imprinting and post-imprinting modifications to introduce antibodies and fluorescent reporter mols. only inside the binding nanocavities, enabling sufficiently high sensitivity to detect intact exosomes without pretreatment. The effectiveness of the system was demonstrated by using it to discriminate between normal exosomes and those originating from prostate cancer and analyze exosomes in tear drops.

Angewandte Chemie, International Edition published new progress about Antibodies and Immunoglobulins Role: ARU (Analytical Role, Unclassified), TEM (Technical or Engineered Material Use), ANST (Analytical Study), USES (Uses) (anti-CD9). 2127-03-9 belongs to class pyridine-derivatives, and the molecular formula is C10H8N2S2, Recommanded Product: 1,2-Di(pyridin-2-yl)disulfane.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Zhang, Kena; Li, Hui; Li, Jingya; Zou, Dapeng; Wu, Yangjie; Wu, Yusheng published the artcile< An efficient palladium-catalyzed synthesis of 1-heteroaryl-4-aminopiperidine derivatives from heteroaryl chlorides>, Recommanded Product: 3-Chloro-2-methoxypyridine, the main research area is aminopiperidine heteroaryl preparation Buchwald Hartwig amination palladium.

An efficient protocol for the synthesis of 1-heteroaryl-4-(N-methyl)aminopiperidines starting from heteroaryl chloride derivatives is described. A broad range of 1-heteroaryl-4-(N-Boc-N-methyl)aminopiperidine derivatives, e.g., I and II, were obtained in good to excellent yields using DavePhos as optimal ligand for Pd-catalyzed Buchwald-Hartwig amination reaction. After a mild and efficient acidolysis the amination products could be obtained successfully.

Tetrahedron Letters published new progress about Buchwald-Hartwig reaction. 13472-84-9 belongs to class pyridine-derivatives, and the molecular formula is C6H6ClNO, Recommanded Product: 3-Chloro-2-methoxypyridine.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Talik, Tadeusz; Talik, Zofia published the artcile< Synthesis of some sulfo derivatives of pyridine>, Recommanded Product: 2-Fluoro-6-methyl-3-nitropyridine, the main research area is pyridine nitro sulfo; fluoropyridine sulfurization; sulfide pyridyl oxidation.

Fluoropyridine I (R = F, NO2 in 3 or 6 positions, Me in 3,4,5,6-position) were treated with MeSH and EtSH to give I (R = MeS, EtS), which were oxidized to give I (R = MeSO2, EtSO2).

Polish Journal of Chemistry published new progress about 19346-45-3. 19346-45-3 belongs to class pyridine-derivatives, and the molecular formula is C6H5FN2O2, Recommanded Product: 2-Fluoro-6-methyl-3-nitropyridine.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem