Day: October 14, 2022

Yakovlev, Ivan A.; Mikhailov, Artem A.; Eremina, Julia A.; Klyushova, Lyubov S.; Nadolinny, Vladimir A.; Kostin, Gennadiy A. published the artcile< Nitric oxide release and related light-induced cytotoxicity of ruthenium nitrosyls with coordinated nicotinate derivatives>, Application In Synthesis of 93-60-7, the main research area is synthesis ruthenium nitrosyl nicotinate complex nitric oxide release; ruthenium nitrosyl nicotinate complex photoinduced cytotoxicity.

The synthetic approaches for the preparation of trans(NO,OH)-cis(NO2,NO2)-[RuNO(L)2(NO2)2OH], where L = Et nicotinate (1) and Me nicotinate (2), are reported. The structures of the complexes were characterized by x-ray diffraction and analyzed by Hirshfeld surface anal. Both compounds show a nitric oxide release reaction under 445 or 532 nm irradiation of DMSO solutions, which was studied by combined UV-visible- (UV-visible), IR- (IR), and EPR spectroscopy and d. functional theory (DFT) calculations The charge transfer from the OH-Ru-NO chain and nitrite ligands to the antibonding orbitals of Ru-NO is responsible for the photo-cleavage of the ruthenium-nitrosyl bond. The elimination of NO leads to a side reaction, the protonation of the parent hydroxyl compound The cytotoxicity and photo-induced cytotoxicity investigations of both compounds on the breast adenocarcinoma cell line MCF-7 reveal that (1) and (2) are cytotoxic with IC50 values of 27.5 ± 2.8μM and 23.3 ± 0.3μM, resp. Also, (1) shows an increase of the toxicity after light irradiation by 7 times (IC50 = 4.1 ± 0.1), which makes it a prominent target for deeper biol. investigations.

Dalton Transactions published new progress about Antitumor agents. 93-60-7 belongs to class pyridine-derivatives, and the molecular formula is C7H7NO2, Application In Synthesis of 93-60-7.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Dan, Krishna; Veetil, Aneesh T.; Chakraborty, Kasturi; Krishnan, Yamuna published the artcile< DNA nanodevices map enzymatic activity in organelles>, Safety of 1,2-Di(pyridin-2-yl)disulfane, the main research area is DNA nanodevice endosomal fluorescent imaging.

Cellular reporters of enzyme activity are based on either fluorescent proteins or small mols. Such reporters provide information corresponding to wherever inside cells the enzyme is maximally active and preclude minor populations present in subcellular compartments. Here the authors describe a chem. imaging strategy to selectively interrogate minor, subcellular pools of enzymic activity. This new technol. confines the detection chem. to a designated organelle, enabling imaging of enzymic cleavage exclusively within the organelle. The authors have thus quant. mapped disulfide reduction exclusively in endosomes in Caenorhabditis elegans and identified that exchange is mediated by minor populations of the enzymes PDI-3 and TRX-1 resident in endosomes. Impeding intraendosomal disulfide reduction by knocking down TRX-1 protects nematodes from infection by Corynebacterium diphtheriae, revealing the importance of this minor pool of endosomal TRX-1. TRX-1 also mediates endosomal disulfide reduction in human cells. A range of enzymic cleavage reactions in organelles are amenable to anal. by this new reporter strategy.

Nature Nanotechnology published new progress about Caenorhabditis elegans. 2127-03-9 belongs to class pyridine-derivatives, and the molecular formula is C10H8N2S2, Safety of 1,2-Di(pyridin-2-yl)disulfane.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Zeng, L.; Sirbu, D.; Waddell, P. G.; Tkachenko, N. V.; Probert, M. R.; Benniston, A. C. published the artcile< Hydrogen peroxide assisted photorelease of an anthraquinone-based ligand from [Ru(2,2'-bipyridine)2(9,10-dioxo-9,10-dihydroanthracen-1-olate)]Cl in aqueous solution>, Application In Synthesis of 366-18-7, the main research area is ruthenium hydroxyanthraquinone bipy complex preparation redox potential antitumor CD; crystal structure ruthenium hydroxyanthraquinone bipy complex.

A new class of light-activated ruthenium(II) complex was designed as a potential blocker of biol. functioning, especially for targeting redox reactions within mitochondria under light activation. Based on our concepts the complex [Ru(bipy)2(1-hydroxyanthra-9,10-quinone)]Cl (RU1) was prepared and studied to understand the preliminary reaction mechanisms and its excited state behavior through a series of stability tests, electrochem., UV-Visible kinetics and femtosecond transient absorption spectroscopy experiments Under white light in the presence of H2O2 two different reactions (fast and slow) appear to take place. The complex loses the quinone-based ligand and a resulting Ru(III) or Ru(V) species is produced. The complex RU1 shows potential to consume H2O2 from the one carbon metabolism in mitochondria, and hence may cut the energy cycle pathway of tumor cells.

Dalton Transactions published new progress about Antitumor agents. 366-18-7 belongs to class pyridine-derivatives, and the molecular formula is C10H8N2, Application In Synthesis of 366-18-7.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Zheng, Meng; Jiang, Tong; Yang, Wen; Zou, Yan; Wu, Haigang; Liu, Xiuhua; Zhu, Fengping; Qian, Rongjun; Ling, Daishun; McDonald, Kerrie; Shi, Jinjun; Shi, Bingyang published the artcile< The siRNAsome: A Cation-Free and Versatile Nanostructure for siRNA and Drug Co-delivery>, Application of C10H8N2S2, the main research area is siRNAsome nanostructure siRNA drug codelivery; co-delivery; nanostructures; siRNA; synergistic therapy; vesicles.

Nanoparticles show great potential for drug delivery. However, suitable nanostructures capable of loading a range of drugs together with the co-delivery of siRNAs, which avoid the problem of cation-associated cytotoxicity, are lacking. Herein, we report an small interfering RNA (siRNA)-based vesicle (siRNAsome), which consists of a hydrophilic siRNA shell, a thermal- and intracellular-reduction-sensitive hydrophobic median layer, and an empty aqueous interior that meets this need. The siRNAsome can serve as a versatile nanostructure to load drug agents with divergent chem. properties, therapeutic proteins as well as co-delivering immobilized siRNAs without transfection agents. Importantly, the inherent thermal/reduction-responsiveness enables controlled drug loading and release. When siRNAsomes are loaded with the hydrophilic drug doxorubicin hydrochloride and anti-P-glycoprotein siRNA, synergistic therapeutic activity is achieved in multidrug resistant cancer cells and a tumor model.

Angewandte Chemie, International Edition published new progress about Antitumor agents. 2127-03-9 belongs to class pyridine-derivatives, and the molecular formula is C10H8N2S2, Application of C10H8N2S2.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Kumar, Manoj; Pandey, Sushil K.; Chaudhary, Neha; Mishra, Anand; Gupta, Deepshikha published the artcile< Highly efficient method for the synthesis of substituted benzimidazoles using sodium metabisulfite adsorbed on silica gel>, Application In Synthesis of 212268-13-8, the main research area is benzimidazole preparation green chem; benzaldehyde heterocyclization phenylenediamine sodium metabisulfite silica.

A simple efficient and economical method is established to synthesize N-(un)substituted benzimidazoles from the corresponding benzaldehydes and N-(un)substituted o-phenylenediamines in moderate to excellent yields using sodium metabisulfite adsorbed on silica gel in ethanol. Most of the reactions are completed at ambient temperature with easy product isolation.

Results in Chemistry published new progress about Aldehydes Role: RCT (Reactant), RACT (Reactant or Reagent). 212268-13-8 belongs to class pyridine-derivatives, and the molecular formula is C5H6FN3, Application In Synthesis of 212268-13-8.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Wei, Xiao-Jing; Abdiaj, Irini; Sambiagio, Carlo; Li, Chenfei; Zysman-Colman, Eli; Alcazar, Jesus; Noel, Timothy published the artcile< Visible-Light-Promoted Iron-Catalyzed C(sp2)-C(sp3) Kumada Cross-Coupling in Flow>, Related Products of 13472-84-9, the main research area is Kumada cross coupling aryl chloride Grignard reagent iron catalyst; visible light Kumada cross coupling iron catalyst mechanism flow; Kumada coupling; cross-coupling; flow chemistry; iron catalysis; photocatalysis.

A continuous-flow, visible-light-promoted method has been developed to overcome the limitations of iron-catalyzed Kumada-Corriu cross-coupling reactions. A variety of strongly electron rich aryl chlorides, previously hardly reactive, could be efficiently coupled with aliphatic Grignard reagents at room temperature in high yields and within a few minutes’ residence time, considerably enhancing the applicability of this iron-catalyzed reaction. The robustness of this protocol was demonstrated on a multigram scale, thus providing the potential for future pharmaceutical application. The mechanism was studied using radical clock experiments, kinetic measurements, DFT and other techniques.

Angewandte Chemie, International Edition published new progress about Aryl chlorides Role: RCT (Reactant), RACT (Reactant or Reagent). 13472-84-9 belongs to class pyridine-derivatives, and the molecular formula is C6H6ClNO, Related Products of 13472-84-9.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Chowdhury, Suman; Rakshit, Atanu; Acharjee, Animesh; Ghosh, Aniruddha; Mahali, Kalachand; Saha, Bidyut published the artcile< Ru(III) catalysed oxidation of 2-propanol by Cr(VI) in micellar media>, Safety of 1-Hexadecylpyridin-1-ium chloride, the main research area is propanol ruthenium catalyst oxidation kinetics mechanism UV spectra.

Acetone, the simplest ketone of abundant useful is produced from 2-propanol by oxidation with hexavalent Cr(VI) sluggishly under pseudo 1st order reaction condition. The rate is enhanced considerably using Ru(III) metal salt solution at ppm level as a catalyst. Addnl. rate enhancement, is obtained in SDS micellar media, is reflected in rapid reduction of peak height of absorbance curve of the oxidant Cr(VI) at λmax = 440 nm. The product, acetone is confirmed by IR spectrum of 2, 4- DNP derivative and 1H NMR study of acetone.

Journal of Molecular Liquids published new progress about NMR (nuclear magnetic resonance), chemical shift. 123-03-5 belongs to class pyridine-derivatives, and the molecular formula is C21H38ClN, Safety of 1-Hexadecylpyridin-1-ium chloride.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Yang, Gongming; Li, Zhipeng; Liu, Yuhan; Guo, Donghui; Sheng, Xijun; Wang, Jian published the artcile< Organocatalytic Higher-Order [8+2] Cycloaddition for the Assembly of Atropoenantiomeric 3-Arylindolizines>, Application of C6H4F3N, the main research area is arylindolizine preparation enantioselective; ylide ynal cycloaddition organocatalyst.

An unprecedented atroposelective [8+2] cycloaddition reaction between pyridinium/isoquinolinium ylides and ynals was presented. It was worth noting that this protocol represented a new example of the organocatalyzed atropoenantioselective higher-order cycloaddition reaction, providing various axial chiral 3-arylindolizines, e.g., I in good yields and high enantioselectivities. In addition, the obtained axially chiral 3-aryldolizines also provided many opportunities for structural transformations and potential drug discovery.

Organic Letters published new progress about Alkynes, internal Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 3796-23-4 belongs to class pyridine-derivatives, and the molecular formula is C6H4F3N, Application of C6H4F3N.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Hasanzadeh Esfahani, Maryam; Iranmanesh, Hasti; Beves, Jonathon E.; Kaur, Manpreet; Jasinski, Jerry P.; Behzad, Mahdi published the artcile< Crystal structures and antibacterial properties of Cu(II) complexes containing an unsymmetrical N2O Schiff base ligand and bidentate N-donor heterocyclic co-ligands>, Safety of 2,2′-Bipyridine, the main research area is copper Schiff propanediamine salicylaldehyde complex preparation; crystal structure copper Schiff propanediamine salicylaldehyde complex.

Three new Cu(II) Schiff base complexes with bidentate N-donor heterocyclic co-ligands, 2,2′-bipyridine (1), 1,10-phenanthroline (2), and 2,9-dimethyl-1,10-phenanthroline (3), were synthesized and characterized by FTIR and UV-visible spectroscopy. Mol. structures of [C20H21CuN4O](ClO4) (1) and [C24H25CuN4O](ClO4) (3) were characterized by single-crystal x-ray crystallog. The Schiff base ligand is an N2O-type ligand, which is the mono-condensed form of the reaction between 1,3-propanediamine and salicylaldehyde. The antibacterial activities of these complexes were studied against one gram pos. and four gram neg. bacteria. Considerable antibacterial activity was obtained against both gram type bacteria. Complexes 2 and 3 with 1,10-phenanthroline and 2,9-dimethyl-1,10-phenanthroline, resp., showed better antibacterial activity compared to which has the 2,2′-bipyridine co-ligand.

Journal of Coordination Chemistry published new progress about Antibacterial agents. 366-18-7 belongs to class pyridine-derivatives, and the molecular formula is C10H8N2, Safety of 2,2′-Bipyridine.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Manteau, Baptiste; Genix, Pierre; Brelot, Lydia; Vors, Jean-Pierre; Pazenok, Sergiy; Giornal, Florence; Leuenberger, Charlotte; Leroux, Frederic R. published the artcile< A General Approach to (Trifluoromethoxy)pyridines: first X-ray Structure Determinations and Quantum Chemistry Studies>, Reference of 73018-09-4, the main research area is general approach synthesis Trifluoromethoxy pyridines crystal structure; ab initio energy profiles rotation trifluoromethoxy methoxy pyridines.

The previously unknown 2-, 3-, and 4-(trifluoromethoxy)pyridines have now become readily accessible by means of an efficient and straightforward large-scale synthesis. Their regioselective functionalization by organometallic methods has been studied and has afforded new and highly important building blocks for life-sciences-oriented research. In addition, the first X-ray crystallog. structure determinations of (trifluoromethoxy)pyridines have been performed. Lowest-energy conformations of (trifluoromethoxy)pyridines and (trifluoromethoxy)pyridinium cations were determined by in silico studies.

European Journal of Organic Chemistry published new progress about Anomeric effect. 73018-09-4 belongs to class pyridine-derivatives, and the molecular formula is C5H4ClNO, Reference of 73018-09-4.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem