Day: October 14, 2022

Schirrmacher, Ralf; Wangler, Bjorn; Schirrmacher, Esther; August, Thorsten; Rosch, Frank published the artcile< Dimethylpyridin-4-ylamine-catalysed alcoholysis of 2-amino-N,N,N-trimethyl-9H-purine-6-ylammonium chloride: An effective route to O6-substituted guanine derivatives from alcohols with poor nucleophilicity>, Name: 2-Fluoro-3-(hydroxymethyl)pyridine, the main research area is dimethylpyridinylamine catalyzed alcoholysis nucleophilicity aminotrimethylpurinylammonium chloride; guanine alc derivative preparation.

Dimethylpyridin-4-ylamine (DMAP)-catalyzed reactions of 2-amino-N,N,N-trimethyl-9H-purine-6-ylammonium chloride with fluoropyridine methoxides and various other alkoxides in DMSO at 60 °C gave the corresponding coupling products in moderate to good yields between 20-87%. Under these reaction conditions, fluorinated O6-substituted Guanine derivatives have been synthesized which could not be obtained via known analogous literature procedures. The resp. yields of known O6-substituted guanine derivatives could be significantly improved by using this method. The efficient use of DMAP as an excellent nucleophilic catalyst in the syntheses of O6-substituted Guanine derivatives has thus been demonstrated.

Synthesis published new progress about Alcohols Role: RCT (Reactant), RACT (Reactant or Reagent). 131747-55-2 belongs to class pyridine-derivatives, and the molecular formula is C6H6FNO, Name: 2-Fluoro-3-(hydroxymethyl)pyridine.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Chen, Zhi-Min; Liu, Jianbo; Guo, Jing-Yao; Loch, Maximillan; DeLuca, Ryan J.; Sigman, Matthew S. published the artcile< Palladium-catalyzed enantioselective alkenylation of alkenylbenzene derivatives>, Application of C13H15F3N2O, the main research area is alkenylarene alkenyl triflate palladium catalyst regioselective enantioselective Heck reaction.

A regioselective and enantioselective palladium-catalyzed relay Heck alkenylation of alkenylbenzene derivatives to construct remote stereocenters was disclosed. Various β-substituted styrenes were readily obtained in moderate yields with good to excellent levels of enantioselectivity. This strategy provided rapid access to enantioenriched δ, ε, ζ and η-alkenyl aryl compounds from simple starting materials. Mechanistic studies suggested that termination of the relay reaction was controlled by affinity of the arene for the Pd complex during migration.

Chemical Science published new progress about Alkenyl alcohols Role: RCT (Reactant), RACT (Reactant or Reagent). 1416819-91-4 belongs to class pyridine-derivatives, and the molecular formula is C13H15F3N2O, Application of C13H15F3N2O.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Chakroun, Rami W.; Wang, Feihu; Lin, Ran; Wang, Yin; Su, Hao; Pompa, Danielle; Cui, Honggang published the artcile< Fine-Tuning the Linear Release Rate of Paclitaxel-Bearing Supramolecular Filament Hydrogels through Molecular Engineering>, Name: 1,2-Di(pyridin-2-yl)disulfane, the main research area is paclitaxel prodrug peptide hydrogel; chemotherapy; controlled release; drug delivery; hydrogels; molecular assembly; prodrug.

One key design feature in the development of any local drug delivery system is the controlled release of therapeutic agents over a certain period of time. In this context, we report the characteristic feature of a supramol. filament hydrogel system that enables a linear and sustainable drug release over the period of several months. Through covalent linkage with a short peptide sequence, we are able to convert an anticancer drug, paclitaxel (PTX), to a class of prodrug hydrogelators with varying critical gelation concentrations These self-assembling PTX prodrugs associate into filamentous nanostructures in aqueous conditions and consequently percolate into a supramol. filament network in the presence of appropriate counterions. The intriguing linear drug release profile is rooted in the supramol. nature of the self-assembling filaments which maintain a constant monomer concentration at the gelation conditions. We found that mol. engineering of the prodrug design, such as varying the number of oppositely charged amino acids or through the incorporation of hydrophobic segments, allows for the fine-tuning of the PTX linear release rate. In cell studies, these PTX prodrugs can exert effective cytotoxicity against glioblastoma cell lines and also primary brain cancer cells derived from patients and show enhanced tumor penetration in a cancer spheroid model. We believe this drug-bearing hydrogel platform offers an exciting opportunity for the local treatment of human diseases.

ACS Nano published new progress about Amphiphiles. 2127-03-9 belongs to class pyridine-derivatives, and the molecular formula is C10H8N2S2, Name: 1,2-Di(pyridin-2-yl)disulfane.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Vitali, Valerio; Nava, Giovanni; Zanchetta, Giuliano; Bragheri, Francesca; Crespi, Andrea; Osellame, Roberto; Bellini, Tommaso; Cristiani, Ilaria; Minzioni, Paolo published the artcile< Integrated Optofluidic Chip for Oscillatory Microrheology>, Recommanded Product: 1-Hexadecylpyridin-1-ium chloride, the main research area is integrated optofluidic chip oscillatory microrheol interferometer waveguide.

Abstract: We propose and demonstrate an on-chip optofluidic device allowing active oscillatory microrheol. measurements with sub-μL sample volume, low cost and high flexibility. Thanks to the use of this optofluidic microrheometer it is possible to measure the viscoelastic properties of complex fluids in the frequency range 0.01-10 Hz at different temperatures The system is based on the optical forces exerted on a microbead by two counterpropagating IR laser beams. The core elements of the optical part, integrated waveguides and an optical modulator, are fabricated by fs-laser writing on a glass substrate. The system performance is validated by measuring viscoelastic solutions of aqueous worm-like micelles composed by Cetylpyridinium Chloride (CPyCl) and Sodium Salicylate (NaSal).

Scientific Reports published new progress about Electric potential. 123-03-5 belongs to class pyridine-derivatives, and the molecular formula is C21H38ClN, Recommanded Product: 1-Hexadecylpyridin-1-ium chloride.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Rawat, Manish; Rawat, Diwan S. published the artcile< Cu2O-Decorated Marigold Hollow Alumina Microsphere Nanoparticles as a Robust and Efficient Catalyst for the Synthesis of Isoquinolones>, Electric Literature of 350-03-8, the main research area is copper oxide decorated marigold hollow alumina microsphere catalyst preparation; isoquinolone green preparation.

A novel Cu2O-decorated marigold hollow alumina microsphere nanocatalytic system for the synthesis of isoquinolones I [R1 = H, 7-Me, 6-F; R2 = Ph, 4-ClC6H4, 2-thienyl, etc.] using 2-bromobenzonitriles and ketones under neat condition was reported. The prepared nanocatalyst was well characterized by SEM, high-resolution transmission electron microscopy, powder X-ray diffraction, energy-dispersive X-ray anal., XPS and Brunauer-Emmett-Teller techniques. The present method was facile and showed better green chem. metrics such as low E-factor, high reaction mass efficiency, and high turnover number and could be reused for five cycles without any loss in its catalytic activity.

ACS Sustainable Chemistry & Engineering published new progress about Aromatic nitriles Role: RCT (Reactant), RACT (Reactant or Reagent). 350-03-8 belongs to class pyridine-derivatives, and the molecular formula is C7H7NO, Electric Literature of 350-03-8.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Mandal, Rajorshi; Garai, Abhijit; Peli, Simone; Datta, Prasanta K.; Biradha, Kumar published the artcile< Photoinduced bending of single crystals of a linear bis-olefin via water-templated solid-state [2+2] photopolymerization reaction>, Recommanded Product: Pyridin-4-ylmethanamine, the main research area is photocycloaddition photopolymerization crystal bending; photoactuators; photochemistry; photoinduced bending; solid-state [2+2] photopolymerization.

The single crystals of two structural isomers of bis-olefinic mols. were shown to have contrasting properties in terms of their photoreactivity: one exhibits an excellent ability to form polymers, accompanied with bending of crystals upon irradiation, while the other is photostable. The photoreactive crystal is a first example in which [2+2] polymerization leads to bending of the crystals, with implications for the design of photoactuators. The hydrate formation ability of one of these mol. isomers promotes the solid-state reactivity in its crystal, as the H2O mols. act as a template to bring the olefin mols. into the required arrangement for [2+2] polymerization Further, the crystals of the polymer exhibited better flexibility and smoothed surfaces compared to those of the monomers. In addition, under UV-light the diene emits bluish violet light while the polymer emits green light, indicating that the luminescence property can be tuned through photoirradiation

Chemistry – A European Journal published new progress about [2+2] Photocycloaddition reaction. 3731-53-1 belongs to class pyridine-derivatives, and the molecular formula is C6H8N2, Recommanded Product: Pyridin-4-ylmethanamine.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Kassem, Salma; Lee, Alan T. L.; Leigh, David A.; Markevicius, Augustinas; Tetlow, Daniel J.; Toriumi, Naoyuki published the artcile< Site-to-site peptide transport on a molecular platform using a small-molecule robotic arm>, Application of C10H8N2S2, the main research area is small mol robotic arm peptide transport.

Peptides attached to a cysteine hydrazide ‘transporter module’ are transported selectively in either direction between two chem. similar sites on a mol. platform, enabled by the discovery of new operating methods for a mol. transporter that functions through ratcheting. Substrate repositioning is achieved using a small-mol. robotic arm controlled by a protonation-mediated rotary switch and attachment/release dynamic covalent chem. A polar solvent mixtures were found to favor Z to E isomerization of the doubly-protonated switch, transporting cargo in one direction (arbitrarily defined as ‘forward’) in up to 85% yield, while polar solvent mixtures were unexpectedly found to favor E to Z isomerization enabling transport in the reverse (‘backward’) direction in >98% yield. Transport of the substrates proceeded in a matter of hours (compared to 6 days even for simple cargoes with the original system) without the peptides at any time dissociating from the machine nor exchanging with others in the bulk. Under the new operating conditions, key intermediates of the switch are sufficiently stabilized within the macrocycle formed between switch, arm, substrate and platform that they can be identified and structurally characterized by 1H NMR. The size of the peptide cargo has no significant effect on the rate or efficiency of transport in either direction. The new operating conditions allow detailed phys. organic chem. of the ratcheted transport mechanism to be uncovered, improve efficiency, and enable the transport of more complex cargoes than was previously possible.

Chemical Science published new progress about Peptides Role: BSU (Biological Study, Unclassified), BIOL (Biological Study). 2127-03-9 belongs to class pyridine-derivatives, and the molecular formula is C10H8N2S2, Application of C10H8N2S2.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Troschuetz, Reinhard; Karger, Alexander published the artcile< Versatile synthesis of 6-substituted 8-deazapteridine-2,4-diamines. Formal total synthesis of 8,10-dideazaminopterin>, HPLC of Formula: 21901-29-1, the main research area is deazapteridinediamine preparation; dideazaaminopterin formal total synthesis.

A new synthesis of 4-amino-4-deoxy-8,10-dideazapteroic acid (I, R =CH2CH2C6H4CO2H-4, R1 = H) and 6-substituted and 5,6-anelated 8-deazapteridine-2,4-diamines I [R = Me, CH2CH2C6H4CO2Me-4, R1 = H; RR1 = (CH2)4] is described. Starting from (H2N)2C:CHNO2 or (H2N)2C:CHCO2Et and RCOCR1:CHNMe2, I can be prepared via functional group transformation of 2-aminopyridines yielding 3-amino-α-picolinonitriles which are cyclocondensed with guanidine.

Journal of Heterocyclic Chemistry published new progress about 21901-29-1. 21901-29-1 belongs to class pyridine-derivatives, and the molecular formula is C6H7N3O2, HPLC of Formula: 21901-29-1.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Mohan, Midhun; Essalhi, Mohamed; Zaye, Sarah; Rana, Love Karan; Maris, Thierry; Duong, Adam published the artcile< Hydrogen Bond Patterns of Dipyridone and Bis(Hydroxypyridinium) Cations>, Recommanded Product: 2-(Benzyloxy)-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine, the main research area is hydrogen bonding synthon Pyridone group; crystal structure Hydroxypyridinium Cation.

Dipyridonyl-substituted derivatives I,II,III ( 2,3,4, resp.) of benzene, pyridine, and pyrazine, resp., were synthesized to examine the ability of 2-pyridone and its protonated species to direct the self-assembly by hydrogen bonding. Structural anal. by single-crystal X-ray diffraction (SCXRD) of 2 and 4 in trifluoroacetic acid demonstrated that salts are formed as a result of the transfer of protons from the acid to the base (organic species) to generate a bis(hydroxypyridinium) dication. However, if no proton transfer takes place like in the case of crystals of 3 grown from DMSO/H2O, the self-assembly is mainly directed by the typical R22(8) hydrogen bond motif of 2-pyridone. These results indicate that the process of converting a neutral 2-pyridonyl group into a hydroxypyridinium cation makes structure prediction difficult. Consequently, examination of proton transfer and assembly of dipyridone and its protonated species are of interest. In combination with SCXRD, Hirshfeld surface anal. (HSA) was also used to have a better understanding on the nature of intermol. interactions within crystal structures of 2-4. The large number of F···H/H···F, H···O/O···H, H···H, and H···C/C···H contacts revealed by HSA indicates that hydrogen bonding and van der Waals interactions mainly contribute to crystal packing.

ACS Omega published new progress about Crystal engineering. 832735-54-3 belongs to class pyridine-derivatives, and the molecular formula is C18H22BNO3, Recommanded Product: 2-(Benzyloxy)-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Das, Jagadish; Vellakkaran, Mari; Banerjee, Debasis published the artcile< Nickel-Catalyzed Alkylation of Ketone Enolates: Synthesis of Monoselective Linear Ketones>, Product Details of C7H7NO, the main research area is ketone alc nickel monoselective alkylation catalyst; linear ketone preparation green chem.

Herein we have developed a Ni-catalyzed protocol for the synthesis of linear ketones. Aryl, alkyl, and heteroaryl ketones as well as alcs. yielded the monoselective ketones in up to 90% yield. The catalytic protocol was successfully applied in to a gram-scale synthesis. For a practical utility, applications of a steroid derivative, oleyl alc., and naproxen alc. were employed. Preliminary catalytic investigations involving the isolation of a Ni intermediate and defined Ni-H species as well as a series of deuterium-labeling experiments were performed.

Journal of Organic Chemistry published new progress about Alcohols Role: RCT (Reactant), RACT (Reactant or Reagent). 350-03-8 belongs to class pyridine-derivatives, and the molecular formula is C7H7NO, Product Details of C7H7NO.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem