Day: October 14, 2022

Mack, Arthur G.; Suschitzky, Hans; Wakefield, Basil J. published the artcile< Polyhaloaromatic compounds. Part 39. Synthesis of the bromo- and iodo-tetrachloropyridines>, Recommanded Product: 2,3,4,6-Tetrachloropyridine, the main research area is bromotetrachloropyridine; iodotetrachloropyridine; pyridine bromo tetrachloro.

The title compounds I (R = Br, iodo, R1 = R2 = Cl; R = R2 = Cl, R1 = Br, iodo; R = R1 = Cl, R2 = Br, iodo) were prepared via the corresponding pyridylhydrazines or pyridyllithium or -magnesium derivatives Thus, reaction of pentachloropyridine N-oxide with N2H4 in EtOH (reflux 2 h) gave 2,3,4,5-tetrachloro-6-hydrazinopyridine which with Br-HBr gave 60% I (R = Br, R1 = R2 = Cl). Metalation of 2,3,4,6-tetrachloropyridine with BuLi followed by reaction with Br and iodine gave 58% I (R = R2 = Cl, R1 = Br) and 60% I (R = R2 = Cl, R1 = iodo), resp. Reaction of pentachloropyridine in THF with Mg at -10° gave 2,3,5,6-tetrachloro-4-pyridylmagnesium chloride which reacted with Br (-75°) to give 61% I (R = R1 = Cl, R2 = Br).

Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999) published new progress about 14121-36-9. 14121-36-9 belongs to class pyridine-derivatives, and the molecular formula is C5HCl4N, Recommanded Product: 2,3,4,6-Tetrachloropyridine.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Leer, Katharina; Cinar, Gizem; Solomun, Jana I.; Martin, Liam; Nischang, Ivo; Traeger, Anja published the artcile< Core-crosslinked, temperature- and pH-responsive micelles: design, physicochemical characterization, and gene delivery application>, Synthetic Route of 2127-03-9, the main research area is block copolymer micelles temperature pH gene delivery cytotoxicity.

Stimuli-responsive block copolymer micelles can provide tailored properties for the efficient delivery of genetic material. In particular, temperature- and pH-responsive materials are of interest, since their physicochem. properties can be easily tailored to meet the requirements for successful gene delivery. Within this study, a stimuli-responsive micelle system for gene delivery was designed based on a diblock copolymer consisting of poly(N,N-diethylacrylamide) (PDEAm) as a temperature-responsive segment combined with poly(aminoethyl acrylamide) (PAEAm) as a pH-responsive, cationic segment. Upon temperature increase, the PDEAm block becomes hydrophobic due to its lower critical solution temperature (LCST), leading to micelle formation. Furthermore, the monomer 2-(pyridin-2-yldisulfanyl)ethyl acrylate (PDSAc) was incorporated into the temperature-responsive PDEAm building block enabling disulfide crosslinking of the formed micelle core to stabilize its structure regardless of temperature and dilution The cloud points of the PDEAm block and the diblock copolymer were investigated by turbidimetry and fluorescence spectroscopy. The temperature-dependent formation of micelles was analyzed by dynamic light scattering (DLS) and elucidated in detail by an anal. ultracentrifuge (AUC), which provided detailed insights into the solution dynamics between polymers and assembled micelles as a function of temperature Finally, the micelles were investigated for their applicability as gene delivery vectors by evaluation of cytotoxicity, pDNA binding, and transfection efficiency using HEK293T cells. The investigations showed that core-crosslinking resulted in a 13-fold increase in observed transfection efficiency. Our study presents a comprehensive investigation from polymer synthesis to an in-depth physicochem. characterization and biol. application of a crosslinked micelle system including stimuli-responsive behavior.

Nanoscale published new progress about Cell viability. 2127-03-9 belongs to class pyridine-derivatives, and the molecular formula is C10H8N2S2, Synthetic Route of 2127-03-9.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Ma, Yulu; Tang, Huaijun; Dong, Xueyan; Wang, Kaimin; Liu, Manhong; Wang, Yuna published the artcile< A dual-functional 3D coordination polymer as a luminescent sensor for acetone in an aqueous medium and detecting the temperature>, Safety of 3-(Methoxycarbonyl)pyridine, the main research area is cadmium carboxybenzylcarboxypyridinium pyridinylethane preparation luminescent sensor acetone; crystal structure cadmium carboxybenzylcarboxypyridinium pyridinylethane coordination polymer.

A novel coordination polymer, {[Cd4(Ccbp)3(dpe)4·4H2O]·(ClO4)5·4H2O} (1) (Ccbp = 3-carboxy-1-(3-carboxybenzyl)pyridin-1-ium, dpe = 1,2-di(pyridin-4-yl)ethane), was synthesized under hydrothermal conditions by a zwitterionic organic ligand and dipyridine ligand, and was fully characterized. Coordination polymer 1 with a pyridine cation basic skeleton can be used as the 1st potential dual-function luminescence sensing material for the selective, sensitive and recyclable sensing of acetone mols. in aqueous phase and for the quant. detection of ultra-low temperatures of 10 to 70 K.

Inorganic Chemistry Communications published new progress about Crystal structure. 93-60-7 belongs to class pyridine-derivatives, and the molecular formula is C7H7NO2, Safety of 3-(Methoxycarbonyl)pyridine.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Hamon, J. J.; Tabor, Rico F.; Striolo, Alberto; Grady, Brian P. published the artcile< Directly probing surfactant adsorption on nanoscopic trenches and pillars>, SDS of cas: 123-03-5, the main research area is surfactant adsorption silica nanostructure; Adsorption; Atomic force microscopy; Cationic surfactant; Cetylpyridinium chloride; Force curves; Silica; Surfactant; Tetradecyltrimethylammonium bromide.

Confinement causes a change in the amount of surfactant adsorbed and in the adsorption morphol. Two cationic surfactants, tetradecyltrimethylammonium bromide (TTAB) and cetylpyridinium chloride (CPC) were adsorbed at the silica-water interface. Atomic force microscopy (AFM) force curves were measured on 50 nm and 80 nm wide trenches. Force curves were also measured on silica pillars, and the results were quantified based on distance from the edge. Trenches: Adsorbed surfactants films in 50 nm and 80 nm trenches showed the same break-through values. However, compared to unconfined values, TTAB in trenches had decreased break-through and adhesion forces while CPC in trenches had increased break-through and adhesion forces, indicating that surfactant identity varies the confinement effect. Pillars: Near the edge, few surfactants adsorb, and those that do extend in the direction normal to the surface. While the exptl. data agree qual. with previous coarse-grained mol. dynamic simulations, the length scales at which the phenomena are detected differ by ∼ half-order of magnitude. Specifically, exptl. data show measurable effects on adsorbed surfactant morphol. at a distance from the edge 10-20 times the length of a surfactant mol. after accounting for the ∼8 nm size of the probe.

Journal of Colloid and Interface Science published new progress about Electron beam lithography. 123-03-5 belongs to class pyridine-derivatives, and the molecular formula is C21H38ClN, SDS of cas: 123-03-5.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Ferreira, Joana T.; Pina, Joao; Ribeiro, Carlos A. F.; Fernandes, Rosa; Tome, Joao P. C.; Torres, Tomas; Rodriguez-Morgade, M. Salome published the artcile< A ruthenium phthalocyanine functionalized with a folic acid unit as a photosensitizer for photodynamic therapy: Synthesis, characterization and in vitro evaluation>, Category: pyridine-derivatives, the main research area is ruthenium phthalocyanine functionalization folic acid photosensitizer photodynamic therapy.

A folate-targeted ruthenium(II) phthalocyanine (Ru(FA-Py)(DMSO)(PEG)8Pc), endowed with a pyridyl ligand functionalized with one folic acid unit (FA-Py) at one of the two axial coordination sites, and a dimethylsulfoxide (DMSO) ligand coordinated to the other axial position, resp., is described. In order to enhance its biocompatibility, the RuPc is donated with eight PEG chains attached at the peripheral positions. The observed singlet oxygen quantum yields of the PS measured in DMSO and in water are of 0.74 and 0.36, resp., in line with those observed for other RuPcs bearing comparable axial and peripheral substitution. In vitro PDT activity of the compound has been evaluated in HT-1376 human bladder cancer cell line. Ru(FA-Py)(DMSO)(PEG)8Pc revealed a slightly higher cellular uptake than those observed for the corresponding carbohydrate-substituted PSs and a better photodynamic activity compared to the glucose-functionalized RuPc.

Journal of Porphyrins and Phthalocyanines published new progress about Biocompatibility. 3731-53-1 belongs to class pyridine-derivatives, and the molecular formula is C6H8N2, Category: pyridine-derivatives.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Dubovoy, Viktor; Nawrocki, Shiri; Verma, Gaurav; Wojtas, Lukasz; Desai, Primit; Al-Tameemi, Hassan; Brinzari, Tatiana V.; Stranick, Michael; Chen, Dailin; Xu, Shaopeng; Ma, Shengqian; Boyd, Jeffrey M.; Asefa, Tewodros; Pan, Long published the artcile< Synthesis, Characterization, and Investigation of the Antimicrobial Activity of Cetylpyridinium Tetrachlorozincate>, Synthetic Route of 123-03-5, the main research area is zinc chloro complex preparation bactericide; silica amorphous preparation gas adsorption; crystal structure zinc chloro complex.

Cetylpyridinium tetrachlorozincate (referred to herein as (CP)2ZnCl4) was synthesized and its solid-state structure was elucidated via single-crystal X-ray diffraction (SC-XRD), revealing a stoichiometry of C42H76Cl4N2Zn with two cetylpyridinium (CP) cations per [ZnCl4]2- tetrahedra. Crystal structures at 100 and 298 K exhibited a zig-zag pattern with alternating alkyl chains and zinc units. The material showed potential for application as a broad-spectrum antimicrobial agent, to reduce volatile sulfur compounds (VSCs) generated by bacteria, and in the fabrication of advanced functional materials. Min. inhibitory concentration (MIC) of (CP)2ZnCl4 was 60, 6, and 6μg mL-1 for Salmonella enterica, Staphylococcus aureus, and Streptococcus mutans, resp. The MIC values of (CP)2ZnCl4 were comparable to that of pure cetylpyridinium chloride (CPC), despite the fact that approx. 16% of the bactericidal CPC is replaced with bacteriostatic ZnCl2 in the structure. A modified layer-by-layer deposition technique was implemented to synthesize mesoporous silica (i.e., SBA-15) loaded with approx. 9.0 weight % CPC and 8.9 weight % Zn.

ACS Omega published new progress about Antibacterial agents. 123-03-5 belongs to class pyridine-derivatives, and the molecular formula is C21H38ClN, Synthetic Route of 123-03-5.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Li, Xiaotong; He, Yihui; Kepenekian, Mikael; Guo, Peijun; Ke, Weijun; Even, Jacky; Katan, Claudine; Stoumpos, Constantinos C.; Schaller, Richard D.; Kanatzidis, Mercouri G. published the artcile< Three-Dimensional Lead Iodide Perovskitoid Hybrids with High X-ray Photoresponse>, Formula: C6H8N2, the main research area is lead iodide perovskitoid hybrid 3D high X ray photoresponse; X ray detector lead iodide perovskitoid hybrid; crystal structure lead iodide perovskitoid hybrid.

Large organic A cations cannot stabilize the 3D perovskite AMX3 structure because they cannot be accommodated in the cubo-octahedral cage (do not follow the Goldschmidt tolerance factor rule), and they generally template low-dimensional structures. Here we report that the large dication aminomethylpyridinium (AMPY) can template novel 3D structures which resemble conventional perovskites. They have the formula (xAMPY)M2I6 (x = 3 or 4, M = Sn2+ or Pb2+) which is double of the AMX3 formula. However, because of the steric requirement of the Goldschmidt tolerance factor rule, it is impossible for (xAMPY)M2I6 to form proper perovskite structures. Instead, a combination of corner-sharing and edge-sharing connectivity is adopted in these compounds leading to the new 3D structures. DFT calculations reveal that the compounds are indirect band gap semiconductors with direct band gaps presenting at slightly higher energies and dispersive electronic bands. The indirect band gaps of the Sn and Pb compounds are ~1.7 and 2.0 eV, resp., which is slightly higher than the corresponding AMI3 3D perovskites. The Raman spectra for the compounds are diffuse, with a broad rising central peak at very low frequencies around 0 cm-1, a feature that is characteristic of dynamical lattices, high anharmonicity, and dissipative vibrations very similar to the 3D AMX3 perovskites. Devices of (3AMPY)Pb2I6 crystals exhibit clear photoresponse under ambient light without applied bias, reflecting a high carrier mobility (μ) and long carrier lifetime (τ). The devices also exhibit sizable X-ray generated photocurrent with a high μτ product of ~1.2 x 10-4 cm2 /V and an X-ray sensitivity of 207 μC·Gy-1·cm-2.

Journal of the American Chemical Society published new progress about Band structure. 3731-53-1 belongs to class pyridine-derivatives, and the molecular formula is C6H8N2, Formula: C6H8N2.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Mack, Arthur G.; Suschitzky, Hans; Wakefield, Basil J. published the artcile< Polyhaloaromatic compounds. Part 43. Inter- and intramolecular reactions of polychloroaromatic compounds with copper>, Name: 2,3,4,6-Tetrachloropyridine, the main research area is Ullmann reaction polychlorohalopyridine copper; chlorohalopyridine Ullmann intermol reaction; pyridine polychloro halo Ullmann reaction.

The Ullmann reaction of 4-bromotetrachloropyridine with Cu in DMF gave products arising from halogen exchange and reduction reaction in addition to the expected coupled products whereas pentachloropyridines gave tetrachloropyridines only. The Ullmann reaction of 4-(o-halophenoxy)- and 4-(o-halothiophenoxy)tetrahalopyridines gave products arising from cyclization, reduction, and halogen transfer. Some Cu reacts initially with the pyridyl rather than the o-haloaryl group. The results suggest the Ullmann reaction proceeds by a mechanism involving a pyridylcopper intermediate. Nucleophilic substitution products of pentahalopyridines with phenols, thiophenols, and aniline, were obtained.

Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999) published new progress about Aromatic hydrocarbons Role: RCT (Reactant), RACT (Reactant or Reagent). 14121-36-9 belongs to class pyridine-derivatives, and the molecular formula is C5HCl4N, Name: 2,3,4,6-Tetrachloropyridine.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Leibler, Isabelle Nathalie-Marie; Tekle-Smith, Makeda A.; Doyle, Abigail G. published the artcile< A general strategy for C(sp3)-H functionalization with nucleophiles using methyl radical as a hydrogen atom abstractor>, Recommanded Product: Ir(p-F-ppy)3, the main research area is hydrocarbon triethylamine hydrogen fluoride iridium catalyst photochem fluorination reaction; hydrofluorocarbon preparation; difluorodiphenylmethane nucleophile iridium catalyst photochem carbon hydrogen functionalization; carbon functionalized difluorodiphenylmethane preparation.

A strategy that transforms C(sp3)-H bonds into carbocations via sequential hydrogen atom transfer (HAT) and oxidative radical-polar crossover were discussed. The resulting carbocation was functionalized by a variety of nucleophiles-including halides, water, alcs., thiols, an electron-rich arene and an azide-to effect diverse bond formations. Mechanistic studies indicated that HAT was mediated by Me radical-a previously unexplored HAT agent with differing polarity to many of those used in photoredox catalysis-enabling new site-selectivity for late-stage C(sp3)-H functionalization.

Nature Communications published new progress about Bond activation catalysts. 370878-69-6 belongs to class pyridine-derivatives, and the molecular formula is C33H21F3IrN3, Recommanded Product: Ir(p-F-ppy)3.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Ju, Zhao-Yang; Song, Li-Na; Chong, Ming-Ben; Cheng, Dang-Guo; Hou, Yang; Zhang, Xi-Ming; Zhang, Qing-Hua; Ren, Lan-Hui published the artcile< Selective Aerobic Oxidation of Csp3-H Bonds Catalyzed by Yeast-Derived Nitrogen, Phosphorus, and Oxygen Codoped Carbon Materials>, HPLC of Formula: 350-03-8, the main research area is ketone ester preparation green chem regioselective; carbon hydrogen bond activation aerobic oxidation; yeast nitrogen phosphorus oxygen codoped carbon material catalyst.

Nitrogen, phosphorus and oxygen codoped carbon catalysts were successfully synthesized using dried yeast powder as pyrolysis precursor. The yeast-derived heteroatom-doped carbon (yeast@C) catalysts exhibited outstanding performance in the oxidation of Csp3-H bonds to ketones and esters giving excellent products yields (up to 98% yield) without organic solvents at low O2 pressure (0.1 MPa). The catalytic oxidation protocol exhibited broad range of substrates (38 examples) with good functional group tolerance, excellent regioselectivity and synthetic utility. The yeast-derived heteroatom-doped carbon catalysts showed good reusability and stability after recycle six times without any significant loss of activity. Exptl. results and DFT calculations proved the important role of N-oxide (N+-O-) on the surface of yeast@C and a reasonable carbon radical mechanism.

Journal of Organic Chemistry published new progress about C-H bond activation. 350-03-8 belongs to class pyridine-derivatives, and the molecular formula is C7H7NO, HPLC of Formula: 350-03-8.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem