Day: October 14, 2022

Saidalimu, Ibrayim; Liang, Yumeng; Niina, Kiyoteru; Tanagawa, Kazuhiro; Saito, Norimichi; Shibata, Norio published the artcile< Synthesis of aryl and heteroaryl tetrafluoro-λ6-sulfanyl chlorides from diaryl disulfides using trichloroisocyanuric acid and potassium fluoride>, Synthetic Route of 2127-03-9, the main research area is aryl heteroaryl tetrafluoro sulfanyl chloride preparation; diaryl disulfide trichloroisocyanuric acid potassium fluoride oxidative chlorotetrafluorination.

A catalyst-free method for the synthesis of aryl and heteroaryl tetrafluoro-λ6-sulfanyl chlorides (Ar-SF4Cl) by using trichloroisocyanuric acid and potassium fluoride in acetonitrile was presented. The method has wide substrate generality and proceeded well with high yields even in the absence of acid catalysts. The preparation of meta- and para-SF4Cl-substituted pyridines using TCCA was achieved for the first time.

Organic Chemistry Frontiers published new progress about Aromatic compounds, disulfides Role: RCT (Reactant), RACT (Reactant or Reagent). 2127-03-9 belongs to class pyridine-derivatives, and the molecular formula is C10H8N2S2, Synthetic Route of 2127-03-9.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Wang, Song; Tian, Chengcheng published the artcile< Polyvinylpolypyrrolidone supported Bronsted acidic catalyst for esterification>, Electric Literature of 21876-43-7, the main research area is polyvinylpolypyrrolidone support Bronsted acidic catalyst esterification.

A polyvinylpolypyrrolidone (PVPP) supported Bronsted acidic catalyst ([PVPP-BS]HSO4) was prepared by coupling SO3H functionalized polyvinylpolypyrrolidone with H2SO4 in this work. After the characterization through FT-IR, FESEM, TG, BET, and elemental anal., it was found that 1,4-butane sultone (BS) and sulfuric acid reacted with PVPP and were immobilized on PVPP surface. The prepared [PVPP-BS]HSO4 catalyst shows high catalytic activity for a series of esterification reactions and could be separated from the reacted mixture easily. Moreover, this catalyst could be recycled and reused for six times without significant loss of catalytic performance.

International Journal of Polymer Science published new progress about Esterification. 21876-43-7 belongs to class pyridine-derivatives, and the molecular formula is C9H13NO3S, Electric Literature of 21876-43-7.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Tierno, Anthony F.; Walters, Jennifer C.; Vazquez-Lopez, Andres; Xiao, Xiao; Wengryniuk, Sarah E. published the artcile< Heterocyclic group transfer reactions with I(III) N-HVI reagents: access to N-alkyl(heteroaryl)onium salts via olefin aminolactonization>, Formula: C11H16BNO2, the main research area is alkylheteroarylonium salt preparation; alkenoic acid heterocycle aminolactonization.

Herein, leverage (bis)cationic nitrogen-ligated I(III) hypervalent iodine reagents, or N-HVIs, as “”heterocyclic group transfer reagents”” to provide access to a broad scope of N-alkyl(heteroaryl)onium salts e.g., I via the aminolactonization of alkenoic acids e.g., 2,2-diphenylpent-4-enoic acid, the first example of engaging an olefin to directly generate these salts. The reactions proceed in excellent yields, under mild conditions, and are capable of incorporating a broad scope of sterically and electronically diverse aromatic heterocycles such as pyridine, 4-piperidinylpyridine, 1-methylimidazole, etc.. The N-HVI reagents can be generated in situ, the products are isolated via simple trituration, and subsequent derivatizations demonstrate the power of this platform for diversity-oriented synthesis of 6-membered nitrogen heterocycles e.g., I.

Chemical Science published new progress about Amination. 329214-79-1 belongs to class pyridine-derivatives, and the molecular formula is C11H16BNO2, Formula: C11H16BNO2.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Xu, Linan; Feng, Lili; Li, Xin; An, Qi published the artcile< Stable polymer/inorganic composite multilayers using covalent cross-linking assisted by a magnetic field>, HPLC of Formula: 123-03-5, the main research area is polymer composite multilayer covalent crosslinking magnetic field.

In this study, stable composite multilayers incorporating magnetic montmorillonite (MMT) and weak polyelectrolyte were prepared under the assistance of a magnetic field. We reported a facile method for fabrication of covalently crosslinked Layer-by-Layer (LbL) multilayers using a photosensitive crosslinking agent 4,4′-diazostilbene-2,2′-disulfonic acid disodium salt that carried double azido groups. The multilayers after crosslinking presented improved stability against extreme solution conditions (basic solution pH = 14), and over 78.15% of magnetic MMT remained on the substrate, in clear contrast with the non-crosslinked multilayers, for which less than 8% of the magnetic MMT remained. The results of UV-Vis spectroscopy and SEM measurements supported the improvement in the stability of the multilayers. Moreover, the assistance of the external magnetic field improved the LbL assembly efficiency and the crosslinking step achieved the mol. retarded release. When gauze was used as the substrate, the mass loading under the magnetic field was approx. 0.976 mg/cm2, which was 4.2 times the amount deposited on gauze without an external magnetic field. After interfacial modification of gauze using LbL multilayers, the static contact angle transformed from hydrophobic (111.25°) to perfect hydrophilic. When we employed aspirin as the target drug, it took 23 h for the crosslinked multilayers to achieve saturated release, as opposed to 9 h for the non-crosslinked multilayers.

Journal of Materials Science published new progress about Crosslinking. 123-03-5 belongs to class pyridine-derivatives, and the molecular formula is C21H38ClN, HPLC of Formula: 123-03-5.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Li, Jun-Xia; Du, Zhong-Xiang; Zhang, Lu-Lu; Liu, Duo-Li; Pan, Qiu-Yue published the artcile< Doubly mononuclear co-crystal and oxalato-bridged binuclear copper compounds containing flexible 2-((3,5,6-trichloropyridin-2-yl)oxy)acetate tectons: Synthesis, crystal analysis and magnetic properties>, Quality Control of 366-18-7, the main research area is copper trichloropyridinyloxyacetate oxalato bipyridine preparation crystal structure.

Two new Cu compounds, [Cu(3,5,6-tcpa)2(H2O)4]·[Cu(3,5,6-tcpa)2(H2O)2] (1) and [Cu2(3,5,6-tcpa)2(2,2′-bipy)2(oxa)]·2EtOH (2) (3,5,6-Htcpa = 2-((3,5,6-trichloro pyridin-2-yl)oxy)acetic acid, 2,2′-bipy = 2,2′-bipyridine, oxa = oxalate dianion), were synthesized by solvothermal method and systematically characterized. Single-crystal x-ray diffraction anal. show that 1 is an interesting double mononuclear co-crystal and consists of two discrete and stereochem. different complexes: one octahedral, the other tetrahedral about the Cu centers. While for 2, two equivalent Cu ions are in square pyramidal geometry and linked by oxalate anion forming a novel binuclear cluster. The O-H···O H bonds, Cl···Cl halogen bonds and/or π···π stacking interactions play an important part in construction of the 3-dimensional networks for 1 and 2. The magnetic measurements indicate that there is weak antiferromagnetic coupling between two Cu ions in 1 and 2. Notably, compound 2 also can be obtained in a higher yield with 1 as one of the starting material and the driving force for this transition process was carefully discussed.

Inorganica Chimica Acta published new progress about Antiferromagnetic exchange. 366-18-7 belongs to class pyridine-derivatives, and the molecular formula is C10H8N2, Quality Control of 366-18-7.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Ngcephe, Ayanda M.; Sinha, Manish Kumar; Purcell, Walter published the artcile< Solvent extraction and separation of palladium from platinum group elements: Synthesis and characterization of 2-mercaptopyridine N-oxide-palladium (II) complex>, COA of Formula: C5H4NNaOS, the main research area is palladium solvent extraction mercaptopyridine oxide sodium salt crystal structure.

Platinum group elements (PGEs) are known for their similar chem. properties, which complicates their isolation and separation from mineral ores and recycled products such as autocatalysts. Therefore, this study investigated the separation of PGEs (except Os) in a synthetic autocatalyst mixture using 2-mercaptopyridine N-oxide sodium salt (NaPT) as an extractant. Solvent extraction was performed with an aqueous mixture containing Pt, Pd, Rh, Ir and Ru and NaPT in the presence of toluene, which produced a pink organic layer. An ICP anal. indicated a complete absence of Pd in the orange aqueous layer. The extractions were repeated with different [HCl] and [PT-] and the anal. results confirmed the complete extraction of Pd from the mixture The formation of a Pd(PT)2 complex in the pink product was confirmed with IR, 1H and 13C NMR. Pd(OAc)2 reacted with NaPT in DMF to form pink crystals, which were suitable for crystallog. The pink crystals were also characterized with IR, 1H and 13C and identical to the product isolated after solvent extraction The crystal structure indicated the isolation of the square planar Pd(PT)2·DMF complex, which crystalized in the monoclinic P21/n space group with four mols. per unit cell. The two PT- ligands in the complex bonded with the sulfur atoms (and also the oxygen atoms) cis with respect to each other, with the S-Pd-S and O-Pd-O bond angles at 96.27(5) and 91.08(14)° resp. The two Pd-S bonds distances were 2.2443(13) and 2.2416(15) Å. The selective and complete isolation of Pd from a mixture of PGE using NaPT can be extremely useful in the recovery of Pd from autoctalaysts and other mixed PGE waste materials.

Journal of Molecular Structure published new progress about Crystal structure (of Pd(PT)2 complex). 3811-73-2 belongs to class pyridine-derivatives, and the molecular formula is C5H4NNaOS, COA of Formula: C5H4NNaOS.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Chowdhury, Budhadeb; Mondal, Monohar Hossain; Barman, Milan Krishna; Saha, Bidyut published the artcile< A study on the synthesis of alkaline copper(III)-periodate (DPC) complex with an overview of its redox behavior in aqueous micellar media>, Category: pyridine-derivatives, the main research area is copper periodate preparation stability redox behavior micellar media.

The Cu(III)-periodate (DPC) was synthesized in an alk. medium. The stability of this complex is significantly dependent on the pH of the medium; studies reported its stability in alk. media. The stability of DPC was studied in different surfactant media for the 1st time. The + 3 oxidation state of Cu is very useful for its high potential value and thus a representative electron transfer reaction between long chain alc. (1-pentanol) and Cu(III) complex was monitored.

Research on Chemical Intermediates published new progress about Oxidation. 123-03-5 belongs to class pyridine-derivatives, and the molecular formula is C21H38ClN, Category: pyridine-derivatives.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Sun, Suqun; He, Min; Dai, Yuanwei; Li, Xin; Liu, Zhijun; Yao, Li published the artcile< Catalytic acetalization: an efficient strategy for high-value utilization of biodiesel-derived glycerol>, Formula: C9H13NO3S, the main research area is biodiesel derived glycerol acetalization ester sulfatefunctionalized ionic liquid catalyst.

In this study, an efficient process for high value utilization of biodiesel-derived glycerol was proposed via a simple reaction of acetalization catalyzed by novel catalysts of ester sulfatefunctionalized ionic liquids (ILs). The relationship between the IL structure and its catalytic activity was investigated. The effects of reaction conditions, and the substrate adaptability, were also carefully studied. The results demonstrate that ester sulfate-functionalized IL shows excellent catalytic activity on the acetalization of glycerol with aldehyde (ketone).Under the optimized condition, 87% glycerol conversion was obtained with 99% acetal selectivity when glycerol was condensed with cyclohexanone. In particular, 29% of product consists of six-membered compound, an important fine chem. and an excellent precursor in organic chem., because of the significant steric-hindrance effect of IL catalyst. Furthermore, the IL catalyst shows good recyclability where insignificant activity loss was exhibited even after six runs.

Catalysts published new progress about Acetalization. 21876-43-7 belongs to class pyridine-derivatives, and the molecular formula is C9H13NO3S, Formula: C9H13NO3S.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Nunez Alonso, David; Perez-Torralba, Marta; Claramunt, Rosa M.; Torralba, M. Carmen; Delgado-Martinez, Patricia; Alkorta, Ibon; Elguero, Jose; Roussel, Christian published the artcile< Regiospecific Synthesis and Structural Studies of 3,5-Dihydro-4H-pyrido[2,3-b][1,4]diazepin-4-ones and Comparison with 1,3-Dihydro-2H-benzo[b][1,4]diazepin-2-ones>, Application of C5H6FN3, the main research area is regioselective preparation pyridodiazepinone; diaminopyridine Et aroylacetate cyclocondensation mol modeling.

Nine 3,5-dihydro-4H-pyrido[2,3-b][1,4]diazepin-4-ones, some of which contain fluoro-substituents, have been regiospecifically prepared by reaction of 2,3-diaminopyridines with Et aroylacetates. In two cases, open intermediates have been isolated and these are related to the reaction pathway. The X-ray crystal structure of 1-methyl-4-phenyl-3,5-dihydro-4H-pyrido[2,3-b][1,4]diazepin-4-one has been solved (formula, C15H13N3O; crystal system, monoclinic; space group, C2/c). This is an asym. unit constituted by a single nonplanar mol. and its conformational enantiomer due to the presence of the seven-membered diazepin-2-one moiety, which introduces a certain degree of torsion in the adjacent pyridine ring. The 1H, 13C, 15N, and 19F NMR spectra were obtained and the chem. shifts, together with those of the previously published 1,3-dihydro-2H-benzo[b][1,4]diazepin-2-ones, i.e., a total of 544 values, were successfully compared with the chem. shifts calculated at the gauge invariant AO (GIAO)/Becke, three-parameter, Lee-Yang-Parr (B3LYP)/6-311++G(d,p) level. The seven-membered ring inversion barrier in 5-benzyl-2-phenyl-3,5-dihydro-4H-pyrido[2,3-b][1,4]diazepin-4-one was determined and, in conjunction with the data from the literature, compared with the B3LYP/6-311++G(d,p) computed values. This allowed the determination of several structural effects. The rotation about the exocyclic N1-CR bond was also calculated and its dynamic properties were discussed.

ACS Omega published new progress about Crystal structure. 212268-13-8 belongs to class pyridine-derivatives, and the molecular formula is C5H6FN3, Application of C5H6FN3.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Xia, Chunnian; Yao, Zhengguang; Xu, Lijuan; Zhang, Wannian; Chen, Haihu; Zhuang, Chunlin published the artcile< Structure-based bioisosterism design of thio-benzoxazepinones as novel necroptosis inhibitors>, Reference of 19346-45-3, the main research area is necroptosis bioisosterism design thiobenzoxazepinones; Bioisosterism; Chirality; Necroptosis; Thio-benzoxazepinone.

Necroptosis is reported to play a critical role in contributing to a variety of human pathologies. The benzoxazepinone GSK′772 is a potent necroptosis inhibitor optimized using a hit from a DNA-encoded library, which is currently in phase II clin. trials for psoriasis, rheumatoid arthritis, and ulcerative colitis. In the present study, the bioisosterism strategy was applied to replace the amide and benzene ring of GSK′772 based on the co-crystal structure of GSK′772 with its binding target RIPK1. As a result, the novel thio-benzoxazepinones exhibited higher anti-necroptosis activity in a human HT-29 cell necroptosis model. The effect on anti-necroptosis activity by the chirality was significantly reduced in the thio-benzoxazepinones, which was explained by the ligand conformation calculation Among these analogs, compound 11 (S) and 12 (R) specifically inhibited necroptosis rather than apoptosis with EC50 values of 2.8 and 22.6 nM. They blocked necrosome formation by inhibiting the phosphorylation of RIPK1, RIPK3 and MLKL in necroptotic cells. Collectively, the highly potent thio-benzoxazepinones represent promising lead structures for further development of necroptosis-related diseases.

European Journal of Medicinal Chemistry published new progress about Cell survival. 19346-45-3 belongs to class pyridine-derivatives, and the molecular formula is C6H5FN2O2, Reference of 19346-45-3.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem