Day: October 14, 2022

Estabrook, Daniel A.; Day, Rachael A.; Sletten, Ellen M. published the artcile< Redox-Responsive Gene Delivery from Perfluorocarbon Nanoemulsions through Cleavable Poly(2-oxazoline) Surfactants>, Safety of 1,2-Di(pyridin-2-yl)disulfane, the main research area is polyoxazoline surfactant perfluorocarbon nanoemulsion redox responsive gene delivery; emulsions; gene delivery; interfacial chemistry; poly(2-oxazoline); stimuli-responsive carriers.

The clin. utility of emulsions as delivery vehicles is hindered by a dependence on passive release. Stimuli-responsive emulsions overcome this limitation but rely on external triggers or are composed of nanoparticle-stabilized droplets that preclude sizes necessary for biomedical applications. Here, we employ cleavable poly(2-oxazoline) diblock copolymer surfactants to form perfluorocarbon (PFC) nanoemulsions that release cargo upon exposure to glutathione. These surfactants allow for the first example of redox-responsive nanoemulsions in cellulo. A noncovalent fluorous tagging strategy is leveraged to solubilize a GFP plasmid inside the PFC nanoemulsions, whereupon protein expression is achieved selectively when employing a stimuli-responsive surfactant. This work contributes a methodol. for non-viral gene delivery and represents a general approach to nanoemulsions that respond to endogenous stimuli.

Angewandte Chemie, International Edition published new progress about Drug delivery systems. 2127-03-9 belongs to class pyridine-derivatives, and the molecular formula is C10H8N2S2, Safety of 1,2-Di(pyridin-2-yl)disulfane.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Singh, A.; Fennell, C. J.; Weaver, J. D. published the artcile< Photocatalyst size controls electron and energy transfer: selectable E/Z isomer synthesis via C-F alkenylation>, Quality Control of 370878-69-6, the main research area is alkyne fluoroarene iridium photocatalyst selective alkenylation; alkene preparation isomerization.

A model was developed en route to a photocatalytic Caryl-F alkenylation reaction of alkynes and highly-fluorinated arenes as partners. By judicious choice of photocatalyst, access to E- or Z-olefins was accomplished, even in the case of synthetically challenging trisubstituted alkenes. The generality and transferability of this model was tested by evaluating established photocatalytic reactions, resulting in shortened reaction times and access to complimentary Z-cinnamylamines in the photocatalytic [2+2] and C-H vinylation of amines, resp. These results showed that, taking into account the size of the photocatalyst provides predictive ability and control in photochem. quenching events.

Chemical Science published new progress about Alkenes Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 370878-69-6 belongs to class pyridine-derivatives, and the molecular formula is C33H21F3IrN3, Quality Control of 370878-69-6.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Sepehri, Nima; Khoshneviszadeh, Mehdi; Farid, Sara Moghadam; Moayedi, Seyedeh Sara; Asgari, Mohammad Sadegh; Moazzam, Ali; Hosseini, Samanesadat; Adibi, Hossein; Larijani, Bagher; Pirhadi, Somayeh; Attarroshan, Mahshid; Sakhteman, AmirHossein; Kabiri, Maryam; Hamedifar, Haleh; Iraji, Aida; Mahdavi, Mohammad published the artcile< Design, synthesis, biological evaluation, and molecular docking study of thioxo-2,3-dihydroquinazolinone derivative as tyrosinase inhibitors>, Related Products of 3731-53-1, the main research area is thioxo dihydroquinazolinone preparation antioxidant docking tyrosinase inhibitor.

In this study, a series of thioxo-dihydroquinazolinone compounds I (R1 = i-Pr, Ph, pyridin-3-ylmethyl, cyclopentyl, etc.) were designed and synthesized as tyrosinase inhibitors. Among the investigated compounds, I (R1 = i-Pr (III)) demonstrated the best inhibitory activity with an IC50 value of 15.48μM compared to kojic acid as a pos. control with IC50 value of 9.30μM. In kinetic evaluation against tyrosinase, (III) depicted a mixed inhibition pattern. Addnl., antioxidant evaluations exhibited moderate to weak potency in 2,2-diphenyl-1-picrylhydrazyl (DPPH) assay. The detailed interactions and binding mode toward tyrosinase of the most potent derivative were explicated by mol. docking study. Moreover, the computer-aided drug-likeness and pharmacokinetic studies were also carried out.

Journal of Molecular Structure published new progress about Amines Role: RCT (Reactant), RACT (Reactant or Reagent). 3731-53-1 belongs to class pyridine-derivatives, and the molecular formula is C6H8N2, Related Products of 3731-53-1.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Epsztajn, J.; Plotka, M. W.; Grabowska, A. published the artcile< Application of organolithium compounds in organic synthesis. Part 19. Synthetic strategies based on aromatic metalation. A concise regiospecific synthesis of 3-halogenated picolinic and isonicotinic acids>, Reference of 53636-56-9, the main research area is picolinic acid halogenated preparation; isonicotinic acid halogenated preparation; halogenated picolinic isonicotinic acid preparation.

The synthesis of the halogenated picolin- and isonicotinanilides I (R = Cl, Br, iodo, X = N, Y = CH; X = CH, Y = N) (II) via metalation (n-BuLi) of the anilides I (R = H) and then the reaction of the generated bis-lithiated anilides with halogenating agents (CCl3-CCl3, CH2Br-CH2Br, I2) followed by subsequent acidic hydrolysis of II, as a way of regiospecific transformation of picolinic and isonicotinic acids into their C3-halogenated derivatives, is described.

Synthetic Communications published new progress about Regiochemistry. 53636-56-9 belongs to class pyridine-derivatives, and the molecular formula is C7H6BrNO2, Reference of 53636-56-9.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Podeschwa, Michael A. L.; Rossen, Kai published the artcile< Efficient Access to Methyl-1-hydroxy-2-naphthoates and Heterocyclic Analogues>, HPLC of Formula: 53636-56-9, the main research area is naphthoate hydroxy heterocyclic analog preparation; Heck coupling halobenzoate butenoate Dieckmann cyclization.

We report the synthesis of Me 1-hydroxy-2-naphthoate derivatives and heterocyclic analogs using a two-step approach. This short route employs a Heck coupling of a 2-halobenzoate with Me 3-butenoate followed by a Dieckmann cyclization, yielding the 1-hydroxynaphthalene-2-carboxylic acid derivatives in the multigram scale.

Organic Process Research & Development published new progress about Dieckmann condensation. 53636-56-9 belongs to class pyridine-derivatives, and the molecular formula is C7H6BrNO2, HPLC of Formula: 53636-56-9.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Beak, Peter; Covington, Johnny B.; White, J. Matthew published the artcile< Quantitative model of solvent effects on hydroxypyridine-pyridone and mercaptopyridine-thiopyridone equilibriums: correlation with reaction-field and hydrogen-bonding effects>, Quality Control of 73018-09-4, the main research area is tautomerism pyridone hydroxypyridine; mercaptopyridone thiopyridone tautomerism; solvent effect tautomerization.

A model for the effect of reaction field and H bonding on the relative energies of protomers is applied to the equilibrium between 6-chloro-2-hydroxypyridine and 6-chloro-2-pyridone, 2-mercaptopyridine and 2-thiopyridone, 6-chloro-2-mercaptopyridine and 6-chloro-2-thiopyridone, and 4-mercaptopyridine and 4-thiopyridone in a wide range of solvents. Quant. correlation is obtained by a multivariable anal. In addition to satisfactory statistical tests of the correlation, estimates of the difference in free energies between the isomers in the vapor phase and of the dipole moment component of the reaction-field term are obtained which compare well with the available independent values. These criteria are shown to signal an unacceptable correlation for the case of 2-chloro-4-hydroxypyridine and 2-chloro-4-pyridone. The advantage of this model, which provides an understanding of the effect of mol. environment on protomeric equilibrium in terms of reasonable phys. interactions, over empirical approaches is noted.

Journal of Organic Chemistry published new progress about Free energy. 73018-09-4 belongs to class pyridine-derivatives, and the molecular formula is C5H4ClNO, Quality Control of 73018-09-4.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Mowat, Jeffrey; Ehrmann, Alexander H. M.; Christian, Sven; Sperl, Carolyn; Menz, Stephan; Guenther, Judith; Hillig, Roman C.; Bauser, Marcus; Schwede, Wolfgang published the artcile< Identification of the Highly Active, Species Cross-Reactive Complex I Inhibitor BAY-179>, Recommanded Product: 5-Fluoropyridine-2,3-diamine, the main research area is BAY179 complex I inhibitor anticancer amide isostere.

Mitochondria are key regulators of energy supply and cell death. Generation of ATP within mitochondria occurs through oxidative phosphorylation (OXPHOS), a process which utilizes the four complexes (complex I-IV) of the electron transport chain and ATP synthase. Certain oncogenic mutations (e.g., LKB1 or mIDH) can further enhance the reliance of cancer cells on OXPHOS for their energetic requirements, rendering cells sensitive to complex I inhibition and highlighting the potential value of complex I as a therapeutic target. Herein, we describe the discovery of a potent, selective, and species cross-reactive complex I inhibitor. A high-throughput screen of the Bayer compound library followed by hit triaging and initial hit-to-lead activities led to a lead structure which was further optimized in a comprehensive lead optimization campaign. Focusing on balancing potency and metabolic stability, this program resulted in the identification of BAY-179, an excellent in vivo suitable tool with which to probe the biol. relevance of complex I inhibition in cancer indications.

ACS Medicinal Chemistry Letters published new progress about Antitumor agents. 212268-13-8 belongs to class pyridine-derivatives, and the molecular formula is C5H6FN3, Recommanded Product: 5-Fluoropyridine-2,3-diamine.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Kumar, Manish; Kumar, Gyanendra; Mogha, Navin Kumar; Jain, Ritu; Hussain, Firasat; Masram, Dhanraj T. published the artcile< Structure, DNA/proteins binding, docking and cytotoxicity studies of copper(II) complexes with the first quinolone drug nalidixic acid and 2,2'-dipyridylamine>, Quality Control of 366-18-7, the main research area is crystal structure copper nalidixate dipyridylamine; copper nalidixate dipyridylamine preparation DNA HSA BSA binding cytotoxicity; Copper complexes; Crystal structure; Cytotoxicity; DFT calculations; DNA and proteins binding studies; Molecular docking studies.

This work presents the synthesis, structural characterization and biol. affinity of the newly synthesized Cu(II) complexes with the 1st antibacterial quinolone drug nalidixic acid (nal) [Cu(nal)2(H2O)], (1) or N-donor ligand 2,2′-dipyridylamine (bipyam). [Cu(II)(nal)(bipyam)Cl], (2) reveals a distorted square pyramidal based geometry in Cu(II) atom confirmed by x-ray crystallog. technique. The theor. stabilities and optimized structures of the complex were obtained from DFT calculations The ability of the complexes to bind with calf thymus DNA (CT DNA) were studied by electronic absorption, fluorescence, CD, and viscosity measurements techniques. The complexes strongly interact with CT DNA via intercalative mode but complex 2 exhibits the highest affinity giving Kb = 3.91 ± 0.13 × 106, M-1. The fluorescence spectroscopy measurements show that both complexes have the superior ability to the replacement of EtBr from DNA-bound EtBr solution and bind to DNA through intercalative mode. Both complex also shows the superior affinity towards proteins with comparatively high binding constant values which were further revealed by fluorescence spectroscopy measurements. Mol. docking anal. indicates that the interaction of the complexes and proteins are stabilized by H bonding and hydrophobic interaction. Also, the results of in vitro cytotoxicity reveal that the complex 2 has excellent cytotoxicity than 1 against human breast cancer cell lines (MCF-7).

Spectrochimica Acta, Part A: Molecular and Biomolecular Spectroscopy published new progress about Antitumor agents. 366-18-7 belongs to class pyridine-derivatives, and the molecular formula is C10H8N2, Quality Control of 366-18-7.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Heusler, Arne; Fliege, Julian; Wagener, Tobias; Glorius, Frank published the artcile< Substituted Dihydropyridine Synthesis by Dearomatization of Pyridines>, Synthetic Route of 93-60-7, the main research area is dihydropyridine preparation regioselective; pyridine triflic anhydride dearomatization trimethylamine borane; phenyl chloroformate pyridine dearomatization trimethylamine borane; boranes; chemoselectivity; nitrogen heterocycles; reduction; synthetic methods.

The synthesis of a broad variety of N-substituted 1,4-dihydropyridines I [R = H, 3-Me, 3,5-di-Br, etc.; R1 = Tf, CO2Ph] and 1,2-dihydropyridines II [R2 = F, Cl, CF3, Ph, SPh; R3 = H, F, trimethylsilyl] by very mild and selective reduction with amine borane was reported for the first time.

Angewandte Chemie, International Edition published new progress about Dearomatization. 93-60-7 belongs to class pyridine-derivatives, and the molecular formula is C7H7NO2, Synthetic Route of 93-60-7.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Zhang, Chun; Tutkowski, Brandon; DeLuca, Ryan J.; Joyce, Leo A.; Wiest, Olaf; Sigman, Matthew S. published the artcile< Palladium-catalyzed enantioselective Heck alkenylation of trisubstituted allylic alkenols: a redox-relay strategy to construct vicinal stereocenters>, Safety of (R)-4-(tert-Butyl)-2-(5-(trifluoromethyl)pyridin-2-yl)-4,5-dihydrooxazole, the main research area is alkenyl aldehyde ketone preparation enantioselective diastereoselective; allylic alkenol alkenyl triflate redox relay Heck palladium catalyst.

An enantioselective, redox-relay Heck alkenylation of trisubstituted allylic alkenol substrates with alkenyl triflates was developed to afford alkenyl aldehydes/ketones e.g., I. This process enabled the construction of vicinal stereocenters in high diastereo- and enantioselectivity and allowed the formation of enolizable α-carbonyl methyl-substituted stereocenters with no observed epimerization under the reported reaction conditions.

Chemical Science published new progress about Alkenals Role: SPN (Synthetic Preparation), PREP (Preparation). 1428537-19-2 belongs to class pyridine-derivatives, and the molecular formula is C13H15F3N2O, Safety of (R)-4-(tert-Butyl)-2-(5-(trifluoromethyl)pyridin-2-yl)-4,5-dihydrooxazole.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem