Day: October 14, 2022

Allen, Jamie R.; Bahamonde, Ana; Furukawa, Yukino; Sigman, Matthew S. published the artcile< Enantioselective N-Alkylation of Indoles via an Intermolecular Aza-Wacker-Type Reaction>, SDS of cas: 1416819-91-4, the main research area is indolylalkanal chemoselective enantioselective preparation; chemoselective enantioselective aza Wacker reaction allylic homoallylic alc indole; enantioselective alkylation indole allylic homoallylic alc palladium catalyst; stereochem mechanism aza Wacker reaction deuterated allylic alc indole.

In the presence of Pd(MeCN)2(OTs)2 and a nonracemic pyridinyloxazoline, 3-substituted indoles such as 3-phenylindole underwent intermol., chemoselective, and enantioselective alkylation/aza-Wacker reactions with cis-allylic and cis-homoallylic alcs. such as (Z)-EtCH:CHCH2OH mediated by p-benzoquinone in 1,2-dichloroethane to yield nonracemic β- and γ-(1-indolyl)alkanals such as I; enamines generated under other conditions were not formed. The mechanism was studied using the reaction of a deuterium-labeled allylic alc.; the stereochem. of the product supported a syn amino-palladation mechanism for the reaction.

Journal of the American Chemical Society published new progress about Alcohols, homoallylic Role: RCT (Reactant), RACT (Reactant or Reagent). 1416819-91-4 belongs to class pyridine-derivatives, and the molecular formula is C13H15F3N2O, SDS of cas: 1416819-91-4.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Slepukhin, P. A.; Boltacheva, N. S.; Filyakova, V. I.; Charushin, V. N. published the artcile< Synthesis and structure of lithium 3-trifluoromethyl-1,3-diketonates containing pyridyl substituents>, Electric Literature of 350-03-8, the main research area is lithium fluoromethyldiketonate preparation crystal structure.

Lithium 3-trifluoromethyl-1,3-diketonates containing pyridyl substituents were synthesized. The specific features of the crystal structures of Li (Z)-1,1,1-trifluoro-4-oxo-4-(pyridin-3-yl)- and (Z)-1,1,1-trifluoro-4-oxo-4-(pyridin-4-yl)but-2-en-2-olates were revealed by x-ray diffraction. These compounds have a polymeric structure with Li cations in different coordination modes. The 1,3-diketonate group is involved in chelation and formation of O bridges, thereby linking two types of Li atoms.

Russian Chemical Bulletin published new progress about Crystal structure. 350-03-8 belongs to class pyridine-derivatives, and the molecular formula is C7H7NO, Electric Literature of 350-03-8.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Chen, Dong-Mei; Wu, Xiao-Fan; Liu, Yong-Jie; Huang, Chao; Zhu, Bi-Xue published the artcile< Synthesis, crystal structures and vapor adsorption properties of Hg(II) and Cd(II) coordination polymers derived from two hydrazone Schiff base ligands>, Electric Literature of 350-03-8, the main research area is cadmium mercury Schiff aminobenzoylhydrazide acetylpyridine complex preparation gas adsorption; crystal structure cadmium mercury Schiff aminobenzoylhydrazide acetylpyridine complex.

Four coordination polymers, [HgL1Br2]n (1), {[Cd(L1)2Cl2]·2CH3OH}n (2), [HgL2Cl2]n (3) and [Cd(L2)2Cl2]n (4), were synthesized and characterized from two hydrazone Schiff base ligands (L1 and L2) with mercury(II) or cadmium(II) halide, resp. In complexes 1 and 3, each mercury(II) center is five-coordinated with distorted square pyramidal geometry in 1-dimensional coordination polymers. In complexes 2 and 4, each cadmium(II) center is six-coordinated with slightly distorted octahedral geometry in 1-dimensional looped-chain structures. The ligands show different coordination sites in the formation of coordination polymers. In complexes 2, 3 and 4, the ligands coordinate to the metal centers by pyridine nitrogen atoms and amino nitrogen atoms, whereas in complex 1 it coordinates by pyridine nitrogen atoms and carbonyl oxygen atoms instead of amino nitrogen atoms.

Inorganica Chimica Acta published new progress about Crystal structure. 350-03-8 belongs to class pyridine-derivatives, and the molecular formula is C7H7NO, Electric Literature of 350-03-8.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Bird, Clive W. published the artcile< Heteroaromaticity. 7. Some quantitative aspects of the tauomerism of hydroxy and mercapto azines>, Synthetic Route of 73018-09-4, the main research area is aromaticity hydroxy azine tautomer crystallog; resonance energy change tautomerization; mercapto azine tautomerism.

Aromaticity indexes have been calculated from crystallog. data for a range of oxo tautomers of hydroxy azines. The differences between these indexes and those for the hydroxy azines lead to values for changes in resonance energies accompanying tautomerization. These values are closely parallel to those previously measured for the same process in aqueous solution

Tetrahedron published new progress about Aromatic nitrogen heterocycles Role: PRP (Properties). 73018-09-4 belongs to class pyridine-derivatives, and the molecular formula is C5H4ClNO, Synthetic Route of 73018-09-4.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Reusch, Engelbert; Holzmeier, Fabian; Gerlach, Marius; Fischer, Ingo; Hemberger, Patrick published the artcile< Decomposition of Picolyl Radicals at High Temperature: A Mass Selective Threshold Photoelectron Spectroscopy Study>, HPLC of Formula: 3731-53-1, the main research area is picolyl radical decomposition mechanism potential energy surface; ionization energy; photoelectron spectroscopy; pyrolysis; radicals; synchrotron radiation.

The reaction products of the picolyl radicals at high temperature were characterized by mass-selective threshold photoelectron spectroscopy in the gas phase. Aminomethylpyridines were pyrolyzed to initially produce picolyl radicals (m/z=92). At higher temperatures further thermal reaction products are generated in the pyrolysis reactor. All compounds were identified by mass-selected threshold photoelectron spectroscopy and several hitherto unexplored reactive mols. were characterized. The mechanism for several dissociation pathways was outlined in computations. The spectrum of m/z=91, resulting from hydrogen loss of picolyl, shows four isomers, two ethynyl pyrroles with adiabatic ionization energies (IEad) of 7.99 eV (2-ethynyl-1H-pyrrole) and 8.12 eV (3-ethynyl-1H-pyrrole), and two cyclopentadiene carbonitriles with IE’s of 9.14 eV (cyclopenta-1,3-diene-1-carbonitrile) and 9.25 eV (cyclopenta-1,4-diene-1-carbonitrile). A second consecutive hydrogen loss forms the cyanocyclopentadienyl radical with IE’s of 9.07 eV (T0) and 9.21 eV (S1). This compound dissociates further to acetylene and the cyanopropynyl radical (IE=9.35 eV). Furthermore, the cyclopentadienyl radical, penta-1,3-diyne, cyclopentadiene and propargyl were identified in the spectra. Computations indicate that dissociation of picolyl proceeds initially via a resonance-stabilized seven-membered ring.

Chemistry – A European Journal published new progress about Adiabatic ionization potential. 3731-53-1 belongs to class pyridine-derivatives, and the molecular formula is C6H8N2, HPLC of Formula: 3731-53-1.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Knight, Brian J.; Tolchin, Zachary A.; Smith, Joel M. published the artcile< A predictive model for additions to N-alkyl pyridiniums>, Recommanded Product: 3-(Methoxycarbonyl)pyridine, the main research area is pyridine Grignard methyl triflate regioselective dearomative addition; dihydropyridine preparation.

Disclosed in this communication is a thorough study on the dearomative addition of organomagnesium nucleophiles to N-alkyl pyridinium electrophiles. The regiochem. outcomes have observable and predictable trends associated with the substituent patterns on the pyridinium electrophile. Often, the substituent effects can be either additive, giving high selectivities, or ablative, giving competing outcomes. Addnl., the nature of the organometallic nucleophilic component was also investigated for its role in the regioselective outcome. The effects of either reactive component are important to both the overall reactivity and site of nucleophilic addition The utility of these observed trends is demonstrated in a concise, dearomative synthesis of a tricyclic compound shown to have insecticidal activity.

Chemical Communications (Cambridge, United Kingdom) published new progress about Dearomatization. 93-60-7 belongs to class pyridine-derivatives, and the molecular formula is C7H7NO2, Recommanded Product: 3-(Methoxycarbonyl)pyridine.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Kanno, Sanae; Hirano, Seishiro; Kato, Hideaki; Fukuta, Mamiko; Mukai, Toshiji; Aoki, Yasuhiro published the artcile< Benzalkonium chloride and cetylpyridinium chloride induce apoptosis in human lung epithelial cells and alter surface activity of pulmonary surfactant monolayers.>, SDS of cas: 123-03-5, the main research area is lung epithelial cell benzalkonium cetylpyridinium chloride apoptosis; A549 alveolar epithelial cell; Apoptosis; Langmuir-blodgett monolayer; Pulmonary surfactant; Quaternary ammonium disinfectant; Surface pressure/trough area isotherm.

To examine whether BAC and CPC aerosols deposited in the alveolar region alter pulmonary function, we studied the effects on pulmonary surfactant using two-step in vitro models; cytotoxicity using A549 alveolar epithelial cell and changes in surface activity of the pulmonary surfactant monolayer using both Surfacten and 1,2-dipalmitoyl-sn-glycero-3-phosphocholine (DPPC). Cell viability was decreased with BAC and CPC dose-dependently. A comparison of cytotoxicity among BAC homologues with different length of alkyl chain showed that C16-BAC, which has the longest alkyl chain, was more cytotoxic than C12- or C14-BAC. Caspase-3/7 activity and cleaved form of caspase-3 and PARP were increased in BAC- and CPC-exposed cells. The elevated caspase-3/7 activity and their cleaved active forms were abolished by caspase-3-inhibitor. The collapse pressure diminished with increasing concentration of CPC. Topog. images indicated that BAC and CPC resulted in smaller condensed lipid domains compared to the control. Conversely, PC without hydrocarbon tail group, showed no cytotoxicity and did not change the isotherms and AFM images. These results indicate that BAC and CPC cause cell death via caspase-3-dependent apoptotic pathway in A549 cells and alter the alveolar surfactant activity. These effects can be attributed to the long alkyl chain of BAC and CPC.

Chemico-Biological Interactions published new progress about Apoptosis. 123-03-5 belongs to class pyridine-derivatives, and the molecular formula is C21H38ClN, SDS of cas: 123-03-5.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Kang, Ji-Hoon; Park, Jun-Beom; Song, Kyung Bin published the artcile< Inhibitory activities of quaternary ammonium surfactants against Escherichia coli O157:H7, Salmonella Typhimurium, and Listeria monocytogenes inoculated on spinach leaves>, Application of C21H38ClN, the main research area is Escherichia Salmonella Listeria quaternary ammonium surfactant disinfection food safety.

Antimicrobial activities of quaternary ammonium surfactants (QAS) have been reported, but the effects of various QAS on the disinfection of foodborne pathogens on fresh produce have not been compared. Thus, the objective of this study was to determine the most effective QAS to be used as a disinfectant for fresh produce to replace chlorine-based sanitizers through comparison of inhibitory activities of the various QAS (benzalkonium chloride, benzethonium chloride, cetylpyridinium chloride, cetyltrimethylammonium bromide, tetraethylammonium bromide) against Escherichia coli O157:H7, Salmonella Typhimurium, and Listeria monocytogenes inoculated on spinach leaves. Among the QAS used in this study, cetylpyridinium chloride (CPC) exhibited maximum inhibitory activity because of its high pos. ζ-potential value (67.23 mV), resulting in 3.33, 3.28, and 4.54 log-reductions against E. coli O157:H7, S. Typhimurium, and L. monocytogenes, resp. The microbial count reductions by CPC were higher than those obtained by NaOCl treatment at 80 mg/L. The CPC treatment produced fewer injured cells than NaOCl treatment. In addition, CPC treatment did not alter the surface color and weight loss of spinach samples during storage. Thus, these results suggest that CPC could be used as an effective sanitizer to improve the microbial safety of spinach leaves.

LWT–Food Science and Technology published new progress about Escherichia coli. 123-03-5 belongs to class pyridine-derivatives, and the molecular formula is C21H38ClN, Application of C21H38ClN.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Kowalkowska-Zedler, D.; Dolega, A.; Nedelko, N.; Lyszczek, R.; Aleshkevych, P.; Demchenko, I.; Luczak, J.; Slawska-Waniewska, A.; Pladzyk, A. published the artcile< Structural, magnetic and spectral properties of tetrahedral cobalt(II) silanethiolates: a variety of structures and manifestation of field-induced slow magnetic relaxation>, Name: Pyridin-4-ylmethanamine, the main research area is cobalt silanethiolate aminopyridine aminomethylpyridine complex preparation magnetic property; thermal stability cobalt silanethiolate aminopyridine aminomethylpyridine; crystal structure cobalt silanethiolate aminopyridine aminomethylpyridine.

Blue crystals of five heteroleptic cobalt(II) silanethiolates 1-5 have been obtained by the reaction of [Co{SSi(tBuO)3}2(NH3)]2 with aminopyridines and aminomethylpyridines at an appropriate molar ratio and their structural, spectral, thermal and magnetic properties have been established and described. All complexes 1-5 contain Co(II) ions in a tetrahedral CoN2S2 environment formed by (tBuO)3SiS- residues and pyridines and present variable structures. Complexes 1-3 are mononuclear [Co{SSi(tBuO)3}2(L1)2] (L1 = 2-aminopyridine 2AP, 3-aminopyridine 3AP, and 4-aminopyridine 4AP). The application of 3AMP and 4AMP (3-aminomethylpyridine and 4-aminomethylpyridine) allows either dinuclear complex 4 [Co{SSi(tBuO)3}2(μ-3AMP)]2 or 1D coordination polymer 5 with the formula of [Co{SSi(tBuO)3}2(μ-4AMP)]n to be obtained. The mol. structures of 1-5 were determined by single-crystal X-ray and powder diffraction, UV-vis and FTIR spectrocopy for solid samples and their thermal properties were characterized by TG-DSC and TG-FTIR methods. The dc and ac magnetic and EPR studies of polycrystalline samples have been performed. For all complexes, the obtained data show a behavior typical of paramagnetic high-spin Co(II) ions in a tetrahedral geometry, with a considerable contribution of the ZFS effect in a low temperature range. All complexes were also probed for SIM behavior. The modeling of the magnetic and EPR data was done for samples 1, 3, 4 and 5 to estimate ZFS parameters. The obtained results imply a neg. value of the axial parameter D in complex 4 and pos. D values for the rest of the compounds A comparative magneto-structural anal. of complexes 4 and 5 points to the high sensitivity of the single-ion magnetic anisotropy of tetrahedral Co(II) complexes to subtle changes in the first and second coordination spheres of Co(II) ions.

Dalton Transactions published new progress about Aminopyridines Role: PEP (Physical, Engineering or Chemical Process), PRP (Properties), SPN (Synthetic Preparation), PROC (Process), PREP (Preparation) (cobalt complexes). 3731-53-1 belongs to class pyridine-derivatives, and the molecular formula is C6H8N2, Name: Pyridin-4-ylmethanamine.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Dong, Zhen; Liu, Junzi; Wen, Di; Zhai, Maolin; Zhao, Long published the artcile< Aminomethylpyridine isomers functionalized cellulose microspheres for TcO-4/ReO-4 uptake: Structure-properties relationship and their application in different aquatic systems>, Safety of Pyridin-4-ylmethanamine, the main research area is cellulose aminomethylpyridine isomer technetium rhenium oxide adsorption; (99)Tc; Adsorption mechanism; ReO(4)(-); Removal; Structure-properties relationship.

Technetium-99 (99Tc) is a long-lived radioactive nuclide that poses great threat to environment, hence selective removal of 99Tc from aquatic system is always an issue. Aminomethylpyridine (AMP) equipped with pyridine and amino, is a promising receptor for TcO4- and its surrogate ReO4-, thus it is of interest to explore and understand the structure-properties relationship of ReO4- adsorption related to n-AMP structure that differ in amino Me position. In this work, three n-AMP functionalized cellulose microspheres (n-AMPR, n = 2, 3, 4) were synthesized and employed for TcO4-/ReO4- uptake. The effect of aminomethyl position on adsorption properties of n-AMPR for ReO4- were investigated and compared. Adsorption kinetics and adsorption isotherm showed that adsorption speed and adsorption capacity were in order of 3-AMPR > 2-AMPR > 4-AMPR. DFT calculation verified that the adsorption of ReO4- by n-AMPR was attributed to electrostatic interaction and hydrogen bonding interaction, the order of adsorption abilities of n-AMPR was due to that steric effect and hydrogen bond collaborated in stabilizing n-AMPR-ReO4- complexes. The column experiments demonstrated that 3-AMPR can be selectively remove ReO4- from simulated groundwater. More importantly, 99Tc column experiments showed that 3-AMPR had a better ability for actual radioactive TcO4-.

Journal of Hazardous Materials published new progress about Adsorption. 3731-53-1 belongs to class pyridine-derivatives, and the molecular formula is C6H8N2, Safety of Pyridin-4-ylmethanamine.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem