Day: October 14, 2022

In 2015,Mou, Jianfeng; Park, Ann; Cai, Yu; Yuan, Junying; Yuan, Chengye published 《Structure-activity relationship study of E6 as a novel necroptosis inducer》.Bioorganic & Medicinal Chemistry Letters published the findings.Reference of 6-Bromopyridin-3-amine The information in the text is summarized as follows:

Necroptosis inducers represent a promising potential treatment for drug-resistant cancer. We herein describe the structure modification of E6, which was identified recently as a potent and selective necroptosis inducer. The studies described herein demonstrate for the first time that functionalized biphenyl derivatives possess necroptosis inducer activity. Furthermore, these studies have led to the identification of two promising compounds (I; R = 4-OMe, R = 4-OEt) that can be used for further optimization studies as well as mechanism of action investigations. The experimental process involved the reaction of 6-Bromopyridin-3-amine(cas: 13534-97-9Reference of 6-Bromopyridin-3-amine)

6-Bromopyridin-3-amine(cas: 13534-97-9) belongs to anime. The reaction of alkyl halides, R―X, where X is a halogen, or analogous reagents with ammonia (or amines) is useful with certain compounds. Not all alkyl halides are effective reagents; the reaction is sluggish with secondary alkyl groups and fails with tertiary ones. Its usefulness is largely confined to primary alkyl halides (those having two hydrogen atoms on the reacting site).Reference of 6-Bromopyridin-3-amine

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

In 2017,Garcia-Carceles, Javier; Decara, Juan M.; Vazquez-Villa, Henar; Rodriguez, Ramon; Codesido, Eva; Cruces, Jacobo; Brea, Jose; Loza, Maria I.; Alen, Francisco; Botta, Joaquin; McCormick, Peter J.; Ballesteros, Juan A.; Benhamu, Bellinda; Rodriguez de Fonseca, Fernando; Lopez-Rodriguez, Maria L. published 《A Positive Allosteric Modulator of the Serotonin 5-HT2C Receptor for Obesity》.Journal of Medicinal Chemistry published the findings.Formula: C6H7Br2N The information in the text is summarized as follows:

The 5-HT2CR agonist lorcaserin, clin. approved for the treatment of obesity, causes important side effects mainly related to subtype selectivity. In the search for 5-HT2CR allosteric modulators as safer antiobesity drugs, a chem. library from Vivia Biotech was screened using ExviTech platform. Structural modifications of identified hit VA240 in synthesized analogs 6-41 afforded compound 11 (N-[(1-benzyl-1H-indol-3-yl)methyl]pyridin-3-amine, VA012), which exhibited dose-dependent enhancement of serotonin efficacy, no significant off-target activities, and low binding competition with serotonin or other orthosteric ligands. PAM 11 was very active in feeding inhibition in rodents, an effect that was not related to the activation of 5-HT2AR. A combination of 11 with the SSRI sertraline increased the anorectic effect. Subchronic administration of 11 reduced food intake and body weight gain without causing CNS-related malaise. The behavior of compound 11 identified in this work supports the interest of a serotonin 5-HT2CR PAM as a promising therapeutic approach for obesity. In the experiment, the researchers used many compounds, for example, 2-(Bromomethyl)pyridine hydrobromide(cas: 31106-82-8Formula: C6H7Br2N)

2-(Bromomethyl)pyridine hydrobromide(cas: 31106-82-8) belongs to pyridine. Pyridine is widely used in the precursor to agrochemicals and pharmaceuticals. Also, it is used as an important reagent and organic solvent.Formula: C6H7Br2N

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

In 2017,Silvi, Mattia; Sandford, Christopher; Aggarwal, Varinder K. published 《Merging Photoredox with 1,2-Metallate Rearrangements: The Photochemical Alkylation of Vinyl Boronate Complexes》.Journal of the American Chemical Society published the findings.Electric Literature of C5H3BrClN The information in the text is summarized as follows:

Vinyl boronates react with electron-deficient alkyl iodides in the presence of visible light to give boronic esters in which two new C-C bonds were created. The reaction occurs by radical addition of an electron-deficient alkyl radical to the vinyl boronate followed by electron transfer with another mol. of alkyl iodide, continuing the chain, and triggering a 1,2-metalate rearrangement. In a number of cases, the use of a photoredox catalyst enhances yields significantly. The scope of the radical precursor includes α-iodo ketones, esters, nitriles, primary amides, α-fluorinated halo-acetates and perfluoroalkyl iodides. In the experiment, the researchers used 5-Bromo-2-chloropyridine(cas: 53939-30-3Electric Literature of C5H3BrClN)

5-Bromo-2-chloropyridine(cas: 53939-30-3) belongs to pyridine. Pyridine derivatives lend themselves to many roles in the spirited field of supramolecular chemistry – whether as the ligand backbone of metal-organic polymers or presiding over the key electronic stations of nanodevices. In biochemistry, pyridine-containing cofactors are necessary nutrients on which our lives depend. Electric Literature of C5H3BrClN

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

In 2019,Journal of the American Chemical Society included an article by Tanaka, Keita; Ewing, William R.; Yu, Jin-Quan. Synthetic Route of C6H7Br2N. The article was titled 《Hemilabile Benzyl Ether Enables γ-C(sp3)-H Carbonylation and Olefination of Alcohols》. The information in the text is summarized as follows:

Pd-catalyzed C(sp3)-H activation of alc. typically shows β-selectivity due to the required distance between the chelating atom in the attached directing group and the targeted C-H bonds. Herein the authors report the design of a hemilabile directing group which exploits the chelation of a readily removable benzyl ether moiety to direct γ- or δ-C-H carbonylation and olefination of alcs. The utility of this approach is also demonstrated in the late-stage C-H functionalization of β-estradiol to rapidly prepare desired analogs that required multi-step syntheses with classical methods. In addition to this study using 2-(Bromomethyl)pyridine hydrobromide, there are many other studies that have used 2-(Bromomethyl)pyridine hydrobromide(cas: 31106-82-8Synthetic Route of C6H7Br2N) was used in this study.

2-(Bromomethyl)pyridine hydrobromide(cas: 31106-82-8) belongs to pyridine. Pyridine’s structure is isoelectronic with that of benzene, but its properties are quite different. Pyridine is completely miscible with water, whereas benzene is only slightly soluble. Like all hydrocarbons, benzene is neutral (in the acid–base sense), but because of its nitrogen atom, pyridine is a weak base.Synthetic Route of C6H7Br2N

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

In 2019,Photochemical & Photobiological Sciences included an article by Kumar, Girijesh; Guda, Ramu; Husain, Ahmad; Patra, Ranjan; Kirandeep; Kasula, Mamatha. Reference of 4-Cyanopyridine. The article was titled 《Synthesis and photophysical properties of pyridyl conjugated triazole appended naphthalenediimide derivatives》. The information in the text is summarized as follows:

A series of three substituted triazole appended naphthalenediimide (NDI)-derivatives, 2,7-bis(3,5-di(pyridin-X-yl)-4H-1,2,4-triazol-4-yl)benzo[lmn][3,8]phenanthroline-1,3,6,8(2H,7H)-tetraones (where X = 2, NDI-PyTz-1; 3, NDI-PyTz-2; and 4, NDI-PyTz-3), were designed, synthesized and well characterized using various anal. and spectroscopic techniques. All the three NDI-PyTz derivatives exhibited decent electronic properties as suggested by DFT, cyclic voltammetry and fluorescence studies. In particular, NDI-PyTz-1 demonstrated the generation of a stable anion radical [NDI-PyTz-1].-. In the part of experimental materials, we found many familiar compounds, such as 4-Cyanopyridine(cas: 100-48-1Reference of 4-Cyanopyridine)

4-Cyanopyridine(cas: 100-48-1) belongs to pyridine. Pyridine’s structure is isoelectronic with that of benzene, but its properties are quite different. Pyridine is completely miscible with water, whereas benzene is only slightly soluble. Like all hydrocarbons, benzene is neutral (in the acid–base sense), but because of its nitrogen atom, pyridine is a weak base.Reference of 4-Cyanopyridine

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

In 2019,European Journal of Medicinal Chemistry included an article by Moir, Michael; Lane, Samuel; Lai, Felcia; Connor, Mark; Hibbs, David E.; Kassiou, Michael. Related Products of 128071-75-0. The article was titled 《Strategies to develop selective CB2 receptor agonists from indole carboxamide synthetic cannabinoids》. The information in the text is summarized as follows:

Activation of the CB2 receptor is an attractive therapeutic strategy for the treatment of a wide range of inflammatory diseases. However, receptor subtype selectivity is necessary in order to circumvent the psychoactive effects associated with activation of the CB1 receptor. We aimed to use potent, non-selective synthetic cannabinoids designer drugs to develop selective CB2 receptor agonists. Simple structural modifications such as moving the amide substituent of 3-amidoalkylindole synthetic cannabinoids to the 2-position and bioisosteric replacement of the indole core to the 7-azaindole scaffold are shown to be effective and general strategies to impart receptor subtype selectivity. 2-Amidoalkylindole 16 (EC50 CB1 > 10 μM, EC50 CB2 = 189 nM) and 3-amidoalkyl-7-azaindole 21 (EC50 CB1 > 10 μM, EC50 = 49 nM) were found to be potent and selective agonists with favorable physicochem. properties. Docking studies were used to elucidate the mol. basis for the observed receptor subtype selectivity for these compounds The experimental part of the paper was very detailed, including the reaction process of 2-Bromonicotinaldehyde(cas: 128071-75-0Related Products of 128071-75-0)

2-Bromonicotinaldehyde(cas: 128071-75-0) belongs to pyridine. Pyridines are often used as catalysts or reagents; particular notice has been paid recently to how pyridine coordinates to metal centers enabling a wide range of valuable reactions. Related Products of 128071-75-0

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

In 2019,Angewandte Chemie, International Edition included an article by Yang, Zhongming; Zhao, Weijia; Liu, Wei; Wei, Xing; Chen, Meng; Zhang, Xiao; Zhang, Xiaolei; Liang, Yong; Lu, Changsheng; Yan, Hong. Computed Properties of C7H9NO. The article was titled 《Metal-Free Oxidative B-N Coupling of nido-Carborane with N-Heterocycles》. The information in the text is summarized as follows:

A general method for the oxidative substitution of nido-carborane (7,8-C2B9H12-) with N-heterocycles has been developed by using 2,3-dichloro-5,6-dicyanobenzoquinone (DDQ) as an oxidant, producing 9-Het-7,8-R2-7,8-dicarbaundecaboranes(11) [Het = pyridine, (iso)quinoline, (benz)imidazole, (benzo)thiazole, oxazole, pyrazole, pyrimidine 6-azaindole; R = Ph, H, Me, tBu, RR = CH2CH:CHCH2]. This metal-free B-N coupling strategy, in both inter- and intramol. fashions, gave rise to a wide array of charge-compensated, boron-substituted nido-carboranes in high yields (up to 97%) with excellent functional-group tolerance under mild reaction conditions. The reaction mechanism was investigated by d.-functional theory (DFT) calculations A successive single-electron transfer (SET), B-H hydrogen-atom transfer (HAT), and nucleophilic attack pathway is proposed. This method provides a new approach to nitrogen-containing carboranes with potential applications in medicine and materials. In the part of experimental materials, we found many familiar compounds, such as 2-(2-Hydroxyethyl)pyridine(cas: 103-74-2Computed Properties of C7H9NO)

2-(2-Hydroxyethyl)pyridine(cas: 103-74-2) belongs to pyridine. Pyridines are often used as catalysts or reagents; particular notice has been paid recently to how pyridine coordinates to metal centers enabling a wide range of valuable reactions. Computed Properties of C7H9NO

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

In 2019,Organic & Biomolecular Chemistry included an article by Satpathi, Bishnupada; Dutta, Lona; Ramasastry, S. S. V.. Recommanded Product: 2-Bromonicotinaldehyde. The article was titled 《Phosphine- and water-promoted pentannulative aldol reaction》. The information in the text is summarized as follows:

An efficient metal-free intramol. aldol reaction for the synthesis of an unusual class of cyclopentanoids was described. The reaction of α-substituted dienones tethered with ketones in the presence of tributylphosphine and water provided aldols. The role of water was realized to be crucial for this transformation. Furthermore, isotopic labeling experiments provided vital information about the reaction mechanism. In the experiment, the researchers used 2-Bromonicotinaldehyde(cas: 128071-75-0Recommanded Product: 2-Bromonicotinaldehyde)

2-Bromonicotinaldehyde(cas: 128071-75-0) belongs to pyridine. Pyridine is very deactivated towards electrophilic substitution with respect to benzene. For this reason classical formylation, using methods such as the Gattermann or Vilsmeier reactions, are not generally successful. Recommanded Product: 2-Bromonicotinaldehyde

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

The author of 《Ultrafast photodynamics of an azopyridine-functionalized iron(II) complex: implications for the concept of ligand-driven light-induced spin change》 were Megow, Sebastian; Fitschen, Henrike-Leonie; Tuczek, Felix; Temps, Friedrich. And the article was published in Journal of Physical Chemistry Letters in 2019. Synthetic Route of C6H7Br2N The author mentioned the following in the article:

We report on the ultrafast photodynamics of an iron(II) complex with a photoisomerizable pentadentate azo-tetrapyridylamino ligand after irradiation with UV light. The results of femtosecond transient electronic absorption spectroscopy performed on the low-spin (LS) form of the title complex show that initial excitation of the ππ* state of the azopyridine unit in the ligand at λpump = 312 nm is followed by an ultrafast intersystem crossing (ISC) that leads to the formation of a metal-centered (MC) 5T state, in competition with the intended photoswitching of the azopyridine unit. Addnl. measurements carried out upon excitation of the singlet metal-to-ligand charge-transfer (1MLCT) transition at λpump = 455 nm suggest that this energy transfer occurs via an MLCT state. The resulting high-spin (HS) 5T state of the complex is metastable and recovers to the LS ground state with a time constant of ∼3 ns. The implications of these observations on the ligand-driven light-induced spin change concept are discussed. After reading the article, we found that the author used 2-(Bromomethyl)pyridine hydrobromide(cas: 31106-82-8Synthetic Route of C6H7Br2N)

2-(Bromomethyl)pyridine hydrobromide(cas: 31106-82-8) belongs to pyridine. Pyridines form stable salts with strong acids. Pyridine itself is often used to neutralize acid formed in a reaction and as a basic solvent. Synthetic Route of C6H7Br2N

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

The author of 《Visible-Light-Induced Atom Transfer Radical Addition and Cyclization of Perfluoroalkyl Halides with 1,n-Enynes》 were Wang, Shuo-Wen; Yu, Jian; Zhou, Qin-Yi; Chen, Si-Yu; Xu, Zhen-Hua; Tang, Shi. And the article was published in ACS Sustainable Chemistry & Engineering in 2019. Application of 94928-86-6 The author mentioned the following in the article:

A mild and efficient visible-light-induced atom transfer radical addition and cyclization of 1,n-enynes (n = 6, 7) with perfluoroalkyl halides, leading to halo-perfluorinated N-heterocycles, was developed. This protocol offers a mild, completely atom-economic, and general access to perfluorinated 2,4-dihydronquinolin-2(1H)-ones and pyrrolidines from corresponding benzene and N-tethered 1,n-enynes (n = 6, 7) via 5-6-exo-dig cyclization, allowing for the expedient incorporation of a wide variety of perfluorinated groups, such as CF3, i/n-C3F7, n-C4F9, n-C6F13, n-C8F17, n-C10F21, CF2Br, CF2CO2Et, etc. In addition, the reactions using 1,7-enynes (n = 6, 7) bearing a tert-butyl-linked alkynyl moiety enable a divergent cyclization involving a hydrogen atom transfer (HAT) process, thereby leading to novel α,α-halo-perfluorinated 2,4-dihydronquinolin-2(1H)-ones. The experimental process involved the reaction of fac-Tris(2-phenylpyridine)iridium(cas: 94928-86-6Application of 94928-86-6)

fac-Tris(2-phenylpyridine)iridium(cas: 94928-86-6) belongs to pyridine. Pyridine is a relatively complex molecule and exhibits a number of different bands in IR spectra. Among others, the bands characterizing the ν8a and ν19b modes have been found to be sensitive to the coordination or protonation of the molecule. Note that the band that is diagnostic for the PyH+ ion at about 1545 cm− 1 (ν19b mode) does not overlap with any of the other bands.Application of 94928-86-6

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem