Day: October 17, 2022

Liu, Yan-Hua; Xie, Pei-Pei; Liu, Lei; Fan, Jun; Zhang, Zhuo-Zhuo; Hong, Xin; Shi, Bing-Feng published their research in Journal of the American Chemical Society in 2021. The article was titled 《Cp*Co(III)-Catalyzed Enantioselective Hydroarylation of Unactivated Terminal Alkenes via C-H Activation》.Application of 3510-66-5 The article contains the following contents:

Enantioselective hydroarylation of unactivated terminal alkenes RCH=CH2 (R = n-hexyl, benzyl, cyclohexylmethyl, etc.) constitutes a prominent challenge in organic chem. Synthesis of Cp*Co(III)-catalyzed asym. hydroarylation of unactivated aliphatic terminal alkenes assisted by a new type of tailor-made amino acid ligands. Critical to the chiral induction was the engaging of a novel noncovalent interaction (NCI), which has seldomly been disclosed in C-H activation area, arising from the mol. recognition among the organocobalt(III) intermediate, the coordinated alkene and the well-designed chiral ligand. A broad range of C2 alkylated indoles were obtained in high yields and excellent enantioselectivities. DFT calculations revealed the reaction mechanism and elucidated the origins of chiral induction in the stereodetermining alkene insertion step. The results came from multiple reactions, including the reaction of 2-Bromo-5-methylpyridine(cas: 3510-66-5Application of 3510-66-5)

2-Bromo-5-methylpyridine(cas: 3510-66-5) belongs to pyridine. Pyridine is widely used in the precursor to agrochemicals and pharmaceuticals. Also, it is used as an important reagent and organic solvent.Application of 3510-66-5

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Lu, Fu-Dong; Lu, Liang-Qiu; He, Gui-Feng; Bai, Jun-Chuan; Xiao, Wen-Jing published their research in Journal of the American Chemical Society in 2021. The article was titled 《Enantioselective Radical Carbocyanation of 1,3-Dienes via Photocatalytic Generation of Allylcopper Complexes》.COA of Formula: C33H24IrN3 The article contains the following contents:

1,3-Dienes are readily available feedstocks that are widely used in the laboratory and industry. However, the potential of converting 1,3-dienes into value-added products, especially chiral products, has not yet been fully exploited. By synergetic photoredox/copper catalysis, we achieve the first visible-light-induced, enantioselective carbocyanation of 1,3-dienes by using carboxylic acid derivatives and trimethylsilyl cyanide. Under mild and neutral conditions, a diverse range of chiral allyl cyanides are produced in generally good efficiency and with high enantioselectivity from bench-stable and user-safe chems. Moreover, preliminary results also confirm that this success can be expanded to 1,3-enynes and the four-component carbonylative carbocyanation of 1,3-dienes and 1,3-enynes. In the experiment, the researchers used many compounds, for example, fac-Tris(2-phenylpyridine)iridium(cas: 94928-86-6COA of Formula: C33H24IrN3)

fac-Tris(2-phenylpyridine)iridium(cas: 94928-86-6) belongs to pyridine. Pyridine is widely used in the precursor to agrochemicals and pharmaceuticals. Also, it is used as an important reagent and organic solvent.COA of Formula: C33H24IrN3

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Afsharnadery, Fatemeh; Khosravi, Kaveh; Zolfigol, Mohammad Ali published their research in Applied Organometallic Chemistry in 2021. The article was titled 《A novel magnetically recyclable semi-dendrimer catalyst-based ethanolpyridole supported on ferrite nanoparticles (HNPs@Py) for the synthesis of biscoumarin and dihydropyrano[3,2-c]chromene derivatives》.Synthetic Route of C7H9NO The article contains the following contents:

The novel organic-inorganic nanohybrid magnetic nanoparticles (HNPs@Py) were prepared by a simple method and characterized by FT-IR, XRD, FE-SEM, TGA, VSM, EDX, and MAP. The catalytic activity of this new (HNPs@Py) was studied for green synthesis of biscoumarins I (R = 4-Br, 3-NO2, 2-OH, etc.) and 3,4-dihydropyrano[c]chromene derivatives II (Ar = 2,4-dichlorophenyl, naphthalen-2-yl, 3-hydroxyphenyl). The short reaction time, high yields, simple workup, and easy separation of catalyst from the reaction mixture by an external magnetic field are the main advantages of the present protocol. In the experiment, the researchers used 2-(2-Hydroxyethyl)pyridine(cas: 103-74-2Synthetic Route of C7H9NO)

2-(2-Hydroxyethyl)pyridine(cas: 103-74-2) belongs to pyridine. Pyridine’s structure is isoelectronic with that of benzene, but its properties are quite different. Pyridine is completely miscible with water, whereas benzene is only slightly soluble. Like all hydrocarbons, benzene is neutral (in the acid–base sense), but because of its nitrogen atom, pyridine is a weak base.Synthetic Route of C7H9NO

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Jia, Pei-Pei; Xu, Lin; Hu, Yi-Xiong; Li, Wei-Jian; Wang, Xu-Qing; Ling, Qing-Hui; Shi, Xueliang; Yin, Guang-Qiang; Li, Xiaopeng; Sun, Haitao; Jiang, Yanrong; Yang, Hai-Bo published an article in 2021. The article was titled 《Orthogonal Self-Assembly of a Two-Step Fluorescence-Resonance Energy Transfer System with Improved Photosensitization Efficiency and Photooxidation Activity》, and you may find the article in Journal of the American Chemical Society.Recommanded Product: 4-Ethynylpyridine The information in the text is summarized as follows:

During the past few decades, fabrication of multistep fluorescence-resonance energy transfer (FRET) systems has become one of the most attractive topics within supramol. chem., chem. biol., and materials science. However, it is challenging to efficiently prepare multistep FRET systems with precise control of the distances between locations and the numbers of fluorophores. Herein we present the successful fabrication of a two-step FRET system bearing specific numbers of anthracene, coumarin, and BODIPY moieties at precise distances and locations through an efficient and controllable orthogonal self-assembly approach based on metal-ligand coordination and host-guest interactions. Notably, the photosensitization efficiency and photooxidation activity of the two-step FRET system gradually increased with the number of energy transfer steps. For example, the two-step FRET system exhibited 1.5-fold higher 1O2 generation efficiency and 1.2-fold higher photooxidation activity than that of its corresponding one-step FRET system. This research not only provides the first successful example of the efficient preparation of multistep FRET systems through orthogonal self-assembly involving coordination and host-guest interactions but also pushes multistep FRET systems toward the application of photosensitized oxidation of a sulfur mustard simulant. The experimental process involved the reaction of 4-Ethynylpyridine(cas: 2510-22-7Recommanded Product: 4-Ethynylpyridine)

4-Ethynylpyridine(cas: 2510-22-7) belongs to pyridine. Pyridine is very deactivated towards electrophilic substitution with respect to benzene. For this reason classical formylation, using methods such as the Gattermann or Vilsmeier reactions, are not generally successful. Recommanded Product: 4-Ethynylpyridine

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Ghosh, Pradip; Jacobi von Wangelin, Axel published an article in 2021. The article was titled 《Manganese-Catalyzed Hydroborations with Broad Scope》, and you may find the article in Angewandte Chemie, International Edition.Reference of 4-Cyanopyridine The information in the text is summarized as follows:

Reductive transformations of easily available oxidized matter are at the heart of synthetic manipulation and chem. valorization. The applications of catalytic hydrofunctionalization benefit from the use of liquid reducing agents and operationally facile setups. Metal-catalyzed hydroborations provide a highly prolific platform for reductive valorizations of stable C:X electrophiles. Here, the authors report an especially facile, broad-scope reduction of various functions including carbonyls, carboxylates, pyridines, carbodiimides, and carbonates under very mild conditions with the inexpensive pre-catalyst Mn(hmds)2. The reaction could be successfully applied to depolymerizations In the experiment, the researchers used 4-Cyanopyridine(cas: 100-48-1Reference of 4-Cyanopyridine)

4-Cyanopyridine(cas: 100-48-1) belongs to pyridine. Pyridine is a relatively complex molecule and exhibits a number of different bands in IR spectra. Among others, the bands characterizing the ν8a and ν19b modes have been found to be sensitive to the coordination or protonation of the molecule. Note that the band that is diagnostic for the PyH+ ion at about 1545 cm− 1 (ν19b mode) does not overlap with any of the other bands.Reference of 4-Cyanopyridine

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Upadhyay, Rahul; Singh, Deepak; Maurya, Sushil K. published an article in 2021. The article was titled 《Highly efficient heterogeneous V2O5@TiO2 catalyzed the rapid transformation of boronic acids to phenols》, and you may find the article in European Journal of Organic Chemistry.Quality Control of Pyridin-3-ylboronic acid The information in the text is summarized as follows:

A V2O5@TiO2 catalyzed green and efficient protocol for hydroxylation of boronic acid into phenol was developed utilizing environmentally benign oxidant hydrogen peroxide. A wide range of electron-donating and electron-withdrawing group-containing (hetero)aryl boronic acids were transformed into their corresponding phenol. The methodol. was also applied successfully to transform various natural and bioactive mols. like tocopherol, amino acids, cinchonidine, vasicinone, menthol and pharmaceuticals such as ciprofloxacin, ibuprofen and paracetamol. The other feature of methodol. included gram-scale synthetic applicability, recyclability and short reaction time. The experimental process involved the reaction of Pyridin-3-ylboronic acid(cas: 1692-25-7Quality Control of Pyridin-3-ylboronic acid)

Pyridin-3-ylboronic acid(cas: 1692-25-7) belongs to pyridine. Pyridine derivatives lend themselves to many roles in the spirited field of supramolecular chemistry – whether as the ligand backbone of metal-organic polymers or presiding over the key electronic stations of nanodevices. In biochemistry, pyridine-containing cofactors are necessary nutrients on which our lives depend. Quality Control of Pyridin-3-ylboronic acid

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Bodedla, Govardhana Babu; Tritton, Daniel Nnaemaka; Chen, Xi; Zhao, Jianzhang; Guo, Zeling; Leung, Ken Cham-Fai; Wong, Wai-Yeung; Zhu, Xunjin published an article in 2021. The article was titled 《Cocatalyst-free Photocatalytic Hydrogen Evolution with Simple Heteroleptic Iridium(III) Complexes》, and you may find the article in ACS Applied Energy Materials.Computed Properties of C12H12N2 The information in the text is summarized as follows:

A simple heteroleptic iridium(III) photosensitizer, Ir-1, containing two ligands 5-(trifluoromethyl)-2-phenylpyridine (ĈN-CF3) and bipyridine (N̂N) has for the first time been studied for cocatalyst-free photocatalytic hydrogen evolution (PHE). The complex Ir-1 produces a hydrogen production rate (ηH2) of 3.2 mmol g-1 h-1, which is over 3.6-fold higher than that of the control complex Ir-2 (0.9 mmol g-1 h-1) containing bipyridine and 2-phenylpyridine ligands without CF3 groups. The higher ηH2 of Ir-1 could be ascribed to the high light-harvesting property, longer triplet electron lifetime, and more appropriate driving force for accepting electrons from the sacrificial donor, which enable efficient charge separation and transfer of electrons for hydrogen evolution. Addnl., the photostability issues of Ir-1 and Ir-2 are addressed by the selection of suitable organic solvent/water photocatalytic systems. In the experiment, the researchers used 4,4′-Dimethyl-2,2′-bipyridine(cas: 1134-35-6Computed Properties of C12H12N2)

4,4′-Dimethyl-2,2′-bipyridine(cas: 1134-35-6) is used in the synthesis of a series of o-phenanthroline-substituted ruthenium(II) complexes.Computed Properties of C12H12N2 Furthermore, 4,4′-Dimethyl-2,2′-bipyridine is used as a chemical Intermediate. It can be used for the determination of ferrous and cyanide compounds.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

In 2022,Abednatanzi, Sara; Gohari Derakhshandeh, Parviz; Dalapati, Sasanka; Veerapandian, Savita K. P.; Froissart, Anne-Claire; Epping, Jan Dirk; Morent, Rino; De Geyter, Nathalie; Van Der Voort, Pascal published an article in ACS Applied Materials & Interfaces. The title of the article was 《Metal-Free Chemoselective Reduction of Nitroarenes Catalyzed by Covalent Triazine Frameworks: The Role of Embedded Heteroatoms》.Formula: C5H5BrN2 The author mentioned the following in the article:

Development of robust nanoporous covalent triazine frameworks (CTFs) as metal-free catalysts for the green chemoselective reduction of nitroarenes. The turnover frequency was found to be 43.03 h-1, exceeding activities of the heteroatom-doped carbon nanomaterials by a factor of 30. The XPS and control experiments provided further insights into the nature of active species for prompt catalysis. This report confirmed the importance of quaternary ‘N’ and ‘F’ atom functionalities to create active hydrogen species via charge delocalization as a critical step in improving the catalytic activity. In the part of experimental materials, we found many familiar compounds, such as 6-Bromopyridin-3-amine(cas: 13534-97-9Formula: C5H5BrN2)

6-Bromopyridin-3-amine(cas: 13534-97-9) belongs to anime. In organic chemistry, amines are compounds and functional groups that contain a basic nitrogen atom with a lone pair. Amines are formally derivatives of ammonia (NH3), wherein one or more hydrogen atoms have been replaced by a substituent such as an alkyl or aryl group (these may respectively be called alkylamines and arylamines; amines in which both types of substituent are attached to one nitrogen atom may be called alkylarylamines).Formula: C5H5BrN2

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

In 2022,Cheng, Heyong; Yang, Tingyuan; Edwards, Madison; Tang, Shuli; Xu, Shiqing; Yan, Xin published an article in Journal of the American Chemical Society. The title of the article was 《Picomole-Scale Transition Metal Electrocatalysis Screening Platform for Discovery of Mild C-C Coupling and C-H Arylation through in Situ Anodically Generated Cationic Pd》.Recommanded Product: 626-05-1 The author mentioned the following in the article:

Development of new transition metal-catalyzed electrochem. promises to improve overall synthetic efficiency. Here the authors describe the 1st integrated platform for online screening of electrochem. transition-metal catalysis. It uses the intrinsic electrochem. capabilities of nanoelectrospray ionization mass spectrometry (nano-ESI-MS) and picomole-scale anodic corrosion of a Pd electrode to generate and evaluate highly efficient cationic catalysts for mild electrocatalysis. The authors demonstrate the power of the novel electrocatalysis platform by (1) identifying electrolytic Pd-catalyzed Suzuki coupling at room temperature, (2) discovering Pd-catalyzed electrochem. C-H arylation in the absence of external oxidant or additive, (3) developing electrolyzed Suzuki coupling/C-H arylation cascades, and (4) achieving late-stage functionalization of two drug mols. by the newly developed mild electrocatalytic C-H arylation. More importantly, the scale-up reactions confirm that new electrochem. pathways discovered by nano-ESI can be implemented under the conventional electrolytic reaction conditions. This approach enables in situ mechanistic studies by capturing various intermediates including transient transition metal species by MS, and thus uncovering the critical role of anodically generated cationic Pd catalyst in promoting otherwise sluggish transmetalation in C-H arylation. The anodically generated cationic Pd with superior catalytic efficiency and novel online electrochem. screening platform hold great potentials for discovering mild transition-metal-catalyzed reactions. In the experiment, the researchers used many compounds, for example, 2,6-Dibromopyridine(cas: 626-05-1Recommanded Product: 626-05-1)

2,6-Dibromopyridine(cas: 626-05-1) belongs to pyridine. Pyridine is a relatively complex molecule and exhibits a number of different bands in IR spectra. Among others, the bands characterizing the ν8a and ν19b modes have been found to be sensitive to the coordination or protonation of the molecule. Note that the band that is diagnostic for the PyH+ ion at about 1545 cm− 1 (ν19b mode) does not overlap with any of the other bands.Recommanded Product: 626-05-1

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Application In Synthesis of 2,6-DibromopyridineIn 2021 ,《Electronic Properties of Rhenium(I) Carbonyl Complexes Bearing Strongly Donating Hexahydro-Pyrimidopyrimidine Based Ligands》 appeared in European Journal of Inorganic Chemistry. The author of the article were Auvray, Thomas; Pal, Amlan K.; Hanan, Garry S.. The article conveys some information:

Re(I) tricarbonyl complexes were synthesized using bi- and tridentate ligands equipped with one or two hexahydro-pyrimidopyrimidine (hpp) units attached to either a pyridine or a pyrazine ring. These complexes were characterized by NMR, ESI-MS, vibrational and optical spectroscopies as well as electrochem. Their structures were determined via single-crystal x-ray crystallog. and modelled using both DFT and TD-DFT methods. The complexes are non-emissive in solution at room temperature but display emission with mixed intra ligand (major) and metal-ligand (minor) charge transfer characters at 77 K. Addnl., both pyrazine-based complexes appear to be emissive in the solid state, presumably due to the presence of intermol. interactions, as observed in the crystal structure. In the experiment, the researchers used many compounds, for example, 2,6-Dibromopyridine(cas: 626-05-1Application In Synthesis of 2,6-Dibromopyridine)

2,6-Dibromopyridine(cas: 626-05-1) belongs to pyridine. The basicity and metallophilic high donor number of these π-deficient systems has long favored them as ligands in metal catalysis. The last decade saw pyridine assume a stronger role as functional group for directed C–H oxidation/activation.Application In Synthesis of 2,6-Dibromopyridine

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem