Day: October 17, 2022

Iddon, Brian; Mack, Arthur G.; Suschitzky, Hans; Taylor, Jack A.; Wakefield, Basil J. published the artcile< Polyhaloaromatic compounds. Part 42. Carbon-13 NMR spectra of polyhalopyridines and 2-pyrimidines>, Synthetic Route of 14121-36-9, the main research area is carbon NMR polyhalo pyridine pyrimidine; substituent effect NMR halopyridine.

13C NMR spectra are reported for 103 polyhalopyridines and 8 polyhalopyrimidines. Substituent effects were calculated and the results used to assign structures.

Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999) published new progress about NMR (nuclear magnetic resonance). 14121-36-9 belongs to class pyridine-derivatives, and the molecular formula is C5HCl4N, Synthetic Route of 14121-36-9.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Vijeta, Arjun; Reisner, Erwin published the artcile< Carbon nitride as a heterogeneous visible-light photocatalyst for the Minisci reaction and coupling to H2 production>, Computed Properties of 93-60-7, the main research area is heterogeneous Minisci hydrogen evolution reaction photocatalyst.

Cyanamide functionalized carbon nitride powder is reported as a photocatalyst for direct Minisci-type coupling of heteroarenes with ethers, alcs., and amides using atm. oxygen as the oxidant at room temperature This mild protocol displays broad substrate scope, good functional group tolerance and the catalyst can be easily isolated and reused for several cycles. It thereby addresses the two major limitations of previously reported photoredox-mediated Minisci reactions: (i) use of expensive and potentially harmful non-recyclable photocatalysts, and (ii) requirement of a stoichiometric amount of strong chem. oxidant. Finally, using platinum as a co-catalyst with the carbon nitride allows this light-mediated reaction to generate two value-added products under an anaerobic atm. – functionalized heteroarenes and H2 fuel.

Chemical Communications (Cambridge, United Kingdom) published new progress about Hydrogen evolution reaction catalysts. 93-60-7 belongs to class pyridine-derivatives, and the molecular formula is C7H7NO2, Computed Properties of 93-60-7.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Blache, Yves; Gueiffier, Alain; Chavignon, Olivier; Viols, Henry; Teulade, Jean Claude; Chapat, Jean Pierre published the artcile< Compared reactivity of 3-, 5-, 6-, and 8-aminoimidazo[1,2-α]pyridines in Combes reaction: access to imidazonaphthyridines and dipyrido[1,2-a:3',2'-d]imidazole>, Application of C6H7N3O2, the main research area is aminoimidazopyridine Combes reaction; imidazonaphthyridine; dipyridoimidazole.

The synthesis of imidazo[1,2-a][1,8]naphthyridines and dipyrido[1,2-a:3′,2′-d]imidazole by treatment of aminoimidazo[1,2-a]pyridines following the Combes procedure is described.

Heterocycles published new progress about 22280-62-2. 22280-62-2 belongs to class pyridine-derivatives, and the molecular formula is C6H7N3O2, Application of C6H7N3O2.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Zheng, Yan-Long; Newman, Stephen G. published the artcile< Methyl Esters as Cross-Coupling Electrophiles: Direct Synthesis of Amide Bonds>, Application In Synthesis of 93-60-7, the main research area is methyl ester amine nickel catalyzed cross coupling amide preparation.

Amide bond formation and transition metal-catalyzed cross-coupling are two of the most frequently used chem. reactions in organic synthesis. Recently, an overlap between these two reaction families was identified when Pd and Ni catalysts were demonstrated to cleave the strong C-O bond present in esters via oxidative addition When simple Me and Et esters are used, this transformation provides a powerful alternative to classical amide bond formations, which commonly feature stoichiometric activating agents. Thus far, few redox-active catalysts have been demonstrated to activate the C(acyl)-O bond of alkyl esters, which makes it difficult to perform informed screening when a challenging reaction needs optimization. We demonstrate that Ni catalysts bearing diverse NHC, phosphine, and nitrogen-containing ligands can all be used to activate Me esters and enable their use in direct amide bond formation.

ACS Catalysis published new progress about Aliphatic esters Role: RCT (Reactant), RACT (Reactant or Reagent). 93-60-7 belongs to class pyridine-derivatives, and the molecular formula is C7H7NO2, Application In Synthesis of 93-60-7.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Cai, Yuxing; Chen, Jiean; Huang, Yong published the artcile< N-Heterocyclic Carbene-Catalyzed 1,4-Alkylacylation of 1,3-Enynes>, Computed Properties of 350-03-8, the main research area is allenone preparation; enyne aldehyde radical precursor alkylacylation heterocyclic carbene catalyst.

The radical relay coupling reaction recently emerged as a powerful synthetic strategy for producing tetrasubstituted allenes R(R1CHR2)C=C=C(R3)C(O)R4 (R = H, Me; R1 = trifluoromethyl, 1,1-difluoro-2-methoxy-2-oxoethyl, 3-cyanopropyl, etc.; R2 = Me, Ph, thiophen-3-yl, pyridin-3-yl, etc.; R3 = hexyl, cyclopropyl, Ph, 4-(1,3-dioxo-2,3-dihydro-1H-isoindol-2-yl)butyl, etc.; R4 = Ph, furan-2-yl, pyridin-3-yl, etc.). However, bond-forming processes involving the allenyl radical intermediate are mostly limited to those promoted by transition metals. In this report, a ketyl radical generated from single-electron oxidation of the Breslow intermediate, which is an excellent coupling partner of allenyl radicals is described. An organocatalytic 1,4-alkylacylation of 1,3-enynes RCH=C(R2)CCR3 occurred smoothly in the presence of an aldehyde R4CHO, a radical precursor, and an N-heterocyclic carbene catalyst. This transformation showed remarkable tolerance to both aromatic and aliphatic aldehydes, enyne substitution, and diversified radical precursors.

Organic Letters published new progress about Acylation. 350-03-8 belongs to class pyridine-derivatives, and the molecular formula is C7H7NO, Computed Properties of 350-03-8.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Trobe, Melanie; Vareka, Martin; Schreiner, Till; Dobrounig, Patrick; Doler, Carina; Holzinger, Ella B.; Steinegger, Andreas; Breinbauer, Rolf published the artcile< A Modular synthesis of teraryl-based α-helix mimetics, part 3: Iodophenyltriflate core fragments featuring side chains of proteinogenic amino acids>, Recommanded Product: 3-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine, the main research area is peptidomimetic helix teraryl amino acid synthesis protein interaction inhibitor; Suzuki Miyaura coupling Wittig reaction iodo salicylic aldehyde amination; Inhibitors; Peptide mimetics; Protein–protein interactions; Suzuki coupling; Triflate.

Teraryl-based α-helix mimetics have proven to be useful compounds for the inhibition of protein-protein interactions (PPI). We have developed a modular and flexible approach for the synthesis of teraryl-based α-helix mimetics using a benzene core unit featuring two leaving groups of differentiated reactivity in the Pd-catalyzed cross-coupling used for teraryl assembly. In previous publications we have introduced the methodol. of 4-iodophenyltriflates decorated with the side chains of some of the proteinogenic amino acids. We herein report the core fragments corresponding to the previously missing amino acids Arg, Asn, Asp, Met, Trp and Tyr. Therefore, our set now encompasses all relevant amino acid analogs with the exception of His. In order to be compatible with the triflate moiety, some of the nucleophilic side chains had to be provided in a protected form to serve as stable building blocks. Addnl., cross-coupling procedures for the assembly of teraryls were investigated.

European Journal of Organic Chemistry published new progress about Amination. 329214-79-1 belongs to class pyridine-derivatives, and the molecular formula is C11H16BNO2, Recommanded Product: 3-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Wang, Amu; Liu, Ya-Zhou; Shen, Zhongke; Qiao, Zeen; Ma, Xiaofeng published the artcile< Regioselective Synthesis of Pyrazolo[1,5-a]pyridine via TEMPO-Mediated [3 + 2] Annulation-Aromatization of N-Aminopyridines and α,β-Unsaturated Compounds>, Safety of 3-(Trifluoromethyl)pyridine, the main research area is pyridiniumamine trimethylbenzenesulfonate alkene TEMPO catalyst regioselective annulation aromatization; pyrazolopyridine preparation.

A TEMPO-mediated [3 + 2] annulation-aromatization protocol for the preparation of pyrazolo[1,5-a]pyridines from N-aminopyridines and α,β-unsaturated compounds were developed. The procedure offered multisubstituted pyrazolo[1,5-a]pyridines in good to excellent yield with high and predictable regioselectivity. The modification of marketed drugs including Loratadine, Abiraterone and Metochalcone, a one-pot three-step gram scale synthesis of key intermediate for the preparation of Selpercatinib were demonstrated. Mechanism studies showed that TEMPO served both as a Lewis acid and as an oxidant.

Organic Letters published new progress about [3+2] Cycloaddition reaction (regioselective). 3796-23-4 belongs to class pyridine-derivatives, and the molecular formula is C6H4F3N, Safety of 3-(Trifluoromethyl)pyridine.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Zheng, Ke; Iqbal, Sarah; Hernandez, Pamela; Park, HaJeung; LoGrasso, Philip V.; Feng, Yangbo published the artcile< Correction to Design and Synthesis of Highly Potent and Isoform Selective JNK3 Inhibitors: SAR Studies on Aminopyrazole Derivatives [Erratum to document cited in CA162:029776]>, Product Details of C7H10N2, the main research area is aminopyrazole JNK3 enzyme inhibitor preparation structure neurodegeneration erratum.

On page S4, Section 2.1, Line 1 of the supporting Inforamtion is incorrect; The correct information is given.

Journal of Medicinal Chemistry published new progress about Drug metabolism. 56622-54-9 belongs to class pyridine-derivatives, and the molecular formula is C7H10N2, Product Details of C7H10N2.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Constable, Edwin C.; Housecroft, Catherine E. published the artcile< The early years of 2,2'-bipyridine-a ligand in its own lifetime>, Electric Literature of 366-18-7, the main research area is 2,2’-bipyridine; coordination chemistry; history; supramolecular chemistry; synthesis.

The first fifty years of the chem. of 2,2′-bipyridine are reviewed from its first discovery in 1888 to the outbreak of the second global conflict in 1939. The coordination chem. and anal. applications are described and placed in the context of the increasingly sophisticated methods of characterization which became available to the chemist in this time period. Many of the “”simple”” complexes of 2,2′-bipyridine reported in the early literature have been subsequently shown to have more complex structures.

Molecules published new progress about 366-18-7. 366-18-7 belongs to class pyridine-derivatives, and the molecular formula is C10H8N2, Electric Literature of 366-18-7.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Hikawa, Hidemasa; Nakayama, Taku; Nakamura, Shunki; Kikkawa, Shoko; Azumaya, Isao published the artcile< Dehydrative amination of benzhydrols with electron-withdrawing group-substituted 2-aminopyridines utilizing Au(III)/TPPMS catalyst system in water>, Synthetic Route of 22280-62-2, the main research area is benzyl aminopyridine preparation; benzhydrol aminopyridine dehydrative amination gold sodium diphenylphosphinobenzene sulfonate water.

Authors report a method for gold(III)/sodium diphenylphosphinobenzene-3-sulfonate (TPPMS)-catalyzed direct amination of benzhydrols using 2-aminopyridines with poor nucleophilic character in water. Various functional groups such as electron-withdrawing nitro, cyano and halogen groups were tolerated well to form the desired N-benzylated 2-aminopyridine compounds On the basis of mechanistic studies including kinetic profiles, Hammett study and isotope effects, authors propose a pathway in which a Lewis acidic gold cation species activates the sp3 C-O bond of the alc. in the rate-determining step.

Organic & Biomolecular Chemistry published new progress about Amination (dehydrative). 22280-62-2 belongs to class pyridine-derivatives, and the molecular formula is C6H7N3O2, Synthetic Route of 22280-62-2.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem