Day: October 17, 2022

Lamb, Claire J. C.; Vilela, Filipe; Lee, Ai-Lan published the artcile< Pd(II)-Catalyzed Enantioselective Desymmetrization of Polycyclic Cyclohexenediones: Conjugate Addition versus Oxidative Heck>, Product Details of C13H15F3N2O, the main research area is polycyclic cyclohexenedione arylboronic acid stereoselective palladium desymmetrization Heck reaction.

Pd(II)-catalyzed desymmetrization of polycyclic cyclohexenediones has been achieved with high enantio- and diastereoselectivities. Up to five contiguous stereocenters are desymmetrized, while simultaneously, an addnl. stereocenter is created by the enantioselective conjugate addition Surprisingly, the conjugate addition products dominate even under typical oxidative Heck conditions, and these observations may provide some insight into the competition between the two related reactions.

Organic Letters published new progress about Arylboronic acids Role: RCT (Reactant), RACT (Reactant or Reagent). 1416819-91-4 belongs to class pyridine-derivatives, and the molecular formula is C13H15F3N2O, Product Details of C13H15F3N2O.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Patel, Paresh N.; Desai, Dipen H.; Patel, Nilam C.; Deshmukh, Amar G. published the artcile< Efficient multicomponent processes for synthesis of novel poly-nuclear hetero aryl substituted terpyridine scaffolds: Single crystal XRD study>, Category: pyridine-derivatives, the main research area is naphthalenyl terpyridine preparation uv vis spectra fluorescence; benzothiophenyl terpyridine preparation; acetyl pyridine naphthaldehyde benzothiophene aldehyde multicomponent condensation reaction.

Authors studied the synthesis of novel terpyridine scaffolds from poly-nuclear and hetero-aryl aldehydes by the multicomponent condensation reactions with various acetyl pyridine derivatives in the presence of ammonium hydroxide. Comparative studies of two different processes catalyzed by potassium hydroxide and pyrrolidine have been performed and presented in this report. The structures of all the newly prepared terpyridine mols. have been well established by preforming various spectral anal. and single crystal XRD studies for selected mols. This approach addressed some structural miscellany concerns currently facing in photo-luminescent chem., and the derived hybrid pyridines could be used as suitable precursors for the synthesis of related photo-luminescent systems. The prepared scaffolds as such and their d-block or f-block metal complexes and coordination polymers may provide an efficient candidate for photo-luminescent chem.

Journal of Molecular Structure published new progress about Aryl aldehydes Role: RCT (Reactant), RACT (Reactant or Reagent). 350-03-8 belongs to class pyridine-derivatives, and the molecular formula is C7H7NO, Category: pyridine-derivatives.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Gajeles, Ghellyn; Kim, Se Mi; Yoo, Jong-Cheol; Lee, Kyung-Koo; Lee, Sang Hee published the artcile< Recyclable anhydride catalyst for H2O2 oxidation: N-oxidation of pyridine derivatives>, Category: pyridine-derivatives, the main research area is pyridine oxide green preparation; oxidation pyridine poly maleic anhydride alt octadecene catalyst.

The catalytic efficiency and recyclability of poly(maleic anhydride-alt-1-octadecene) (Od-MA) and poly(maleic anhydride-alt-1-isobutylene) (Bu-MA) were evaluated for use in the development of a metal-free, reusable catalyst for the oxidation of pyridines to pyridine N-oxides, such as I [R = 2-Cl, 3-Br, 2-CO2H, etc.] in the presence of H2O2. The Od-MA catalyst was easily recovered via filtration with recovery yields exceeding 99.8%. The catalyst retained its activity after multiple uses and did not require any treatment for reuse. The Od-MA and H2O2 catalytic system described herein was eco-friendly, operationally simple, and cost-effective; thus, it was industrially applicable. Od-MA and H2O2 could potentially be used in place of percarboxylic acid as an oxidant in a wide range of oxidation reactions.

RSC Advances published new progress about Green chemistry. 3811-73-2 belongs to class pyridine-derivatives, and the molecular formula is C5H4NNaOS, Category: pyridine-derivatives.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Liu, Shengrong; Chen, Ming; Cao, Xiaoqiang; Li, Guang; Zhang, Di; Li, Mingzhen; Meng, Na; Yin, Jieji; Yan, Bingqi published the artcile< Chromium (VI) removal from water using cetylpyridinium chloride (CPC)-modified montmorillonite>, Reference of 123-03-5, the main research area is chromium removal water cetylpyridinium chloride modified montmorillonite.

Montmorillonite (Mt) has been used widely for metal removal from water and wastewater due to its various advantages including low cost, large surface area, high structure stability, and high ion exchange capacity. However, the removal of anionic hexavalent chromium (Cr) using Mt is inhibited by the neg. charges on the adsorbent. To enhance Cr (VI) adsorption on Mt, a cationic surfactant – cetylpyridinium chloride (CPC) – was utilized to modify the interlayer surface of Mt. Fourier-transform IR spectroscopy and X-ray diffraction were performed to characterize the CPC modified Mt (CPC-Mt) and the structure change of Mt. Studies have shown that CPC intercalated into Mt interlayers via electrostatic interaction between Mt and CPC, as well as the hydrophobic interaction among CPC mols. After modification, the CPC-Mt showed a pos. zeta potential at pH 2-11; while the sp. surface area decreased, CPC effectively increased the interlayer distance of Ca-Mt, with a maximum d001 value of 4.37 nm, and provided more exchange sites for Cr (VI) adsorption. Cr (VI) was efficiently removed using CPC-Mt at low pH values, but the removal was influenced adversely by the increase of pH and ionic strength. The adsorption process was described by a Langmuir isotherm model with the constant of 0.342 L/mg and the maximum adsorption capacity of 43.84 mg/g at 298 K, and by a pseudo-second order kinetic model with a kinetic coefficient of 6.62 g/(mg·min). The adsorption mechanism anal. has shown that electrostatic attraction is the main mechanism for Cr (VI) removal; at the same time, the reduction of Cr (VI) to Cr (III) by Fe (II) in Mt cannot be neglected at low pH values, which increased Cr removal and was confirmed by the X-ray photoelectron spectroscopic anal.

Separation and Purification Technology published new progress about Adsorbents. 123-03-5 belongs to class pyridine-derivatives, and the molecular formula is C21H38ClN, Reference of 123-03-5.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Hsu, Day-Shin; Wang, Meng-Yu; Huang, Jiun-Yi published the artcile< Asymmetric Total Syntheses of (+)-5-epi-Schisansphenin B and the Proposed Structure of (+)-15-Hydroxyacora-4(14),8-diene>, Reference of 1416819-91-4, the main research area is Heck alkenylation Stetter Tiffeneau Demjanov enantioselective diastereoselective regioselective; epi schisansphenin B total synthesis; hydroxyacoradiene total synthesis.

The asym. total syntheses of (+)-5-epi-schisansphenin B and the proposed structure of (+)-15-hydroxyacora-4(14),8-diene have been accomplished from 1,3-cyclopentadione in eight synthetic steps. The enantioselective palladium-catalyzed redox-relay Heck alkenylation, the intramol. Stetter reaction, and the regioselective Tiffeneau-Demjanov-type ring expansion were the pivotal steps in these syntheses.

Journal of Organic Chemistry published new progress about Alkenylation, stereoselective (redox-relay Heck). 1416819-91-4 belongs to class pyridine-derivatives, and the molecular formula is C13H15F3N2O, Reference of 1416819-91-4.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Mihajlovic-Lalic, Ljiljana E.; Stankovic, Dalibor; Novakovic, Irena; Grguric-Sipka, Sanja published the artcile< (Electro)chemical and antimicrobial characterization of novel Ru(II) bipyridine complexes with acetylpyridine analogs>, Related Products of 350-03-8, the main research area is ruthenium bipyridine acetylpyridine complex preparation antibacterial antifungal antioxidant; DNA intercalation ruthenium bipyridine acetylpyridine complex.

Three ruthenium-bipyridine complexes (1-3) carrying acetylpyridine ligand unit were synthesized in methanol via the reaction of [RuCl2(bpy)2] with corresponding acetylpyridine (2-, 3-, and 4-acpy). Obtained complexes were characterized by (1H and 13C) NMR and IR spectroscopy, MS spectrometry, UV-visible spectrophotometry, and cyclic voltammetry. Their structural characterization revealed bidentate coordination mode for 2-acpy while 3- and 4-acpy acted as monodentate ligands. The electrochem. profile of newly synthesized compounds was studied by cyclic voltammetry which confirmed their electrochem. activity. Voltammetric responses within the -1.20 < Ep < 1.50 v range of potentials were summarized in two major events: Ru(II)→Ru(III) oxidation spotted at apparatus ΔEp = 0.65 v and successive reductions of bpy units located from -0.79 v to 0.47 v (vs. Ag/AgCl (3 M) electrode). The DNA-binding activity of the complexes was evaluated by both UV-visible spectrophotometry and cyclic voltammetry indicating DNA-intercalation with a slight contribution of electrostatic interactions. Furthermore, antimicrobial activity was tested against bacterial and fungal strains, for which moderate activity was observed Assessment of in vitro toxicity against freshly hatched nauplii of Artemia salina as well as radical scavenging capacity was evaluated. The test compounds showed neither toxicity nor antioxidant activity. Journal of Coordination Chemistry published new progress about Antibacterial agents. 350-03-8 belongs to class pyridine-derivatives, and the molecular formula is C7H7NO, Related Products of 350-03-8.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Testaferri, Lorenzo; Tiecco, Marcello; Tingoli, Marco; Bartoli, Donatella; Massoli, Alberto published the artcile< The reactions of some halogenated pyridines with methoxide and methanethiolate ions in dimethylformamide>, Application of C6H6ClNO, the main research area is pyridine dihalo substitution methoxide alkanethiolate; halopyridine substitution methoxide alkanethiolate; substitution dihalopyridine methoxide alkanethiolate; mercaptopyridine; alkylthiopyridine.

Dihalopyridines I (R = 2-Br, R1 = 5-, 6-Br; R = 2-, 5-Cl, R1 = 3-Cl) reacted with NaSR2 (R2 = Me, CHMe2) in DMF to give 73-96% mono- or bis-substitution products I (R = SR2) or I (R = R1 = SR2), depending upon reaction conditions. The dihalo compounds reacted with NaOMe to give 72-93% I (R = OMe), but bis-substitution occurred easily only for I (R = 2-Br, R1 = 6-Br; R = 5-Cl, R1 = 3-Cl). Some I [R(R1) = OMe, R1(R) = SMe] were prepared by further reaction of monosubstitution products. I (R = R1 = SCHMe2 were fragmented by Na-HMPA to give I (R = R1 = SH), which were isolated as I (R = R1 = SMe) in 63-80% yield.

Tetrahedron published new progress about Nucleophilic aromatic substitution reaction. 13472-84-9 belongs to class pyridine-derivatives, and the molecular formula is C6H6ClNO, Application of C6H6ClNO.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Liang, Apeng; Li, Xinjian; Liu, Dongfeng; Li, Jingya; Zou, Dapeng; Wu, Yangjie; Wu, Yusheng published the artcile< The palladium-catalyzed cross-coupling reactions of trifluoroethyl iodide with aryl and heteroaryl boronic acid esters>, Name: 2-(Benzyloxy)-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine, the main research area is aryl boronic acid ester trifluoroethyl iodide cross coupling palladium; heteroaryl boronic acid ester trifluoroethyl iodide cross coupling palladium; trifluoroethyl arene preparation; palladium cross coupling catalyst.

The cross-coupling reactions of 1,1,1-trifluoro-2-iodoethane with aryl and heteroaryl boronic acid esters have been successfully achieved. The new protocol allows for a convenient introduction of trifluoroethyl groups into a variety of aryl and heteroaryl moieties under mild conditions.

Chemical Communications (Cambridge, United Kingdom) published new progress about Boronic acids, esters Role: RCT (Reactant), RACT (Reactant or Reagent) (aryl/heteroaryl). 832735-54-3 belongs to class pyridine-derivatives, and the molecular formula is C18H22BNO3, Name: 2-(Benzyloxy)-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Koovits, Paul J.; Dessoy, Marco A.; Matheeussen, An; Maes, Louis; Caljon, Guy; Mowbray, Charles E.; Kratz, Jadel M.; Dias, Luiz C. published the artcile< Structure-activity relationship of 4-azaindole-2-piperidine derivatives as agents against Trypanosoma cruzi>, Synthetic Route of 1050501-88-6, the main research area is azaindole piperidine structure activity relationship trypanosoma cruzi chagas disease; Azaindole; Chagas disease; Drug discovery; Neglected diseases.

The structure-activity relationship of a 4-Azaindole-2-piperidine compound selected from GlaxoSmithKline’s recently disclosed open-resource “”Chagas box”” and possessing moderate activity against Trypanosoma cruzi, the parasite responsible for Chagas disease, is presented. Despite considerable medicinal chem. efforts, a suitably potent and metabolically stable compound could not be identified to advance the series into in vivo studies. This research should be of interest to those in the area of neglected diseases and in particular anti-kinetoplastid drug discovery.

Bioorganic & Medicinal Chemistry Letters published new progress about Chagas disease. 1050501-88-6 belongs to class pyridine-derivatives, and the molecular formula is C5H4BrClN2, Synthetic Route of 1050501-88-6.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Gao, Kaige; Liu, Chunlin; Zhang, Wei; Wang, Kangni; Liu, Wenlong published the artcile< Pyroelectricity and fieldinduced spin-flop in 4-(aminomethyl)pyridinium manganese chloride dihydrate>, Quality Control of 3731-53-1, the main research area is aminomethyl pyridinium manganese chloride dihydrate pyroelectricity spinflop; ferroelectric; pyroelectric; single crystal; spin-flop.

Large single crystals of (4-(Aminomethyl)pyridinium)2 MnCl4 • 2H2O (1) were grown by slow evaporation of solution The crystal structure was solved to be Pi, which belongs to the ̅central sym. space group. But small pyroelec. current was detected, as well as a ferroelec. hysteresis loop. The pyroelec. and the ferroelec. properties were attributed to the strain caused by defects. Temperature-dependent magnetic curves and the M-H curve show that 1 is antiferromagnetic ordering below 2.5 K. A field-induced spin-flop is observed in the antiferromagnetic ordering state.

Royal Society Open Science published new progress about Antiferromagnetic films. 3731-53-1 belongs to class pyridine-derivatives, and the molecular formula is C6H8N2, Quality Control of 3731-53-1.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem