Day: October 17, 2022

McConnell, Danielle L.; Blades, Alisha M.; Rodrigues, Danielle Gomes; Keyes, Phoebe V.; Sonberg, Justin C.; Anthony, Caitlin E.; Rachad, Sofia; Simone, Olivia M.; Sullivan, Caroline F.; Shapiro, Jonathan D.; Williams, Christopher C.; Schafer, Benjamin C.; Glanzer, Amy M.; Hutchinson, Holly L.; Thayaparan, Ashley B.; Krevlin, Zoe A.; Bote, Isabella C.; Haffary, Yasin A.; Bhandari, Sambat; Goodman, Jack A.; Majireck, Max M. published an article in 2021. The article was titled 《Synthesis of Bench-Stable N-Quaternized Ketene N,O-Acetals and Preliminary Evaluation as Reagents in Organic Synthesis》, and you may find the article in Journal of Organic Chemistry.Category: pyridine-derivatives The information in the text is summarized as follows:

In this report, a general synthetic approach to a variety of bench-stable N-quaternized ketene N,O-acetals I (R = H, 2-Ph, 4-Me, 2,6-Cl2, etc.; X = OTf, NTf2) via treatment of pyridine II or aniline bases with acetylenic ethers R1CC (R1 = OEt, 4-methoxyphenyl) and an appropriate Bronsted or Lewis acid (triflic acid, triflimide, or scandium(III) triflate) have been described. The resulting pyridinium I and anilinium salts C6H5N+((CH3)CH2)C(=CH2)R1 X- can be used as reagents or synthetic intermediates in multiple reaction types. For example, N-(1-ethoxyvinyl)pyridinium or anilinium salts can thermally release highly reactive O-Et ketenium ions for use in acid catalyst-free electrophilic aromatic substitutions. N-(1-ethoxyvinyl)-2-halopyridinium salts I (R = 2-Cl, 2-Br) can be employed in peptide couplings as a derivative of Mukaiyama reagent (2-chloro-1-methylpyridinium iodide) or react with phenylmethanamine in nucleophilic aromatic substitutions under mild conditions. These preliminary reactions illustrate the broad potential of these currently understudied compounds in organic synthesis. In the experiment, the researchers used many compounds, for example, 2,6-Dibromopyridine(cas: 626-05-1Category: pyridine-derivatives)

2,6-Dibromopyridine(cas: 626-05-1) belongs to pyridine. Pyridine is very deactivated towards electrophilic substitution with respect to benzene. For this reason classical formylation, using methods such as the Gattermann or Vilsmeier reactions, are not generally successful. Category: pyridine-derivatives

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Liu, Wenwu; Liu, Xin; Tian, Liting; Gao, Yaping; Liu, Wenjie; Chen, Huanhua; Jiang, Xiaowen; Xu, Zihua; Ding, Huaiwei; Zhao, Qingchun published an article in 2021. The article was titled 《Design, synthesis and biological evaluation of harmine derivatives as potent GSK-3β/DYRK1A dual inhibitors for the treatment of Alzheimer’s disease》, and you may find the article in European Journal of Medicinal Chemistry.HPLC of Formula: 1692-25-7 The information in the text is summarized as follows:

Alzheimer’s disease (AD) is a chronic and progressive neurodegenerative disease, characterized by irreversible cognitive impairment, memory loss and behavioral disturbances, ultimately leading to death. Glycogen synthase kinase 3β (GSK-3β) and dual-specificity tyrosine phosphorylation regulated kinase1A (DYRK1A) have gained a lot of attention for its role in tau pathol. To search for potential dual GSK-3β/DYRK1A inhibitors, we focused on harmine, a natural β-carboline alkaloid, which has been extensively studied for its various biol. effects on the prevention of AD. In this study, a new series of harmine derivatives were designed, synthesized and evaluated as dual GSK-3β/DYRK1A inhibitors for their multiple biol. activities. The in vitro results indicated that most of them displayed promising activity against GSK-3β and DYRK1A. Among them, compound ZDWX-25 (I) showed potent inhibitory effects on GSK-3β and DYRK1A with IC50 values of 71 and 103 nM, resp. Mol. modeling and kinetic studies verified that ZDWX-25 could interact with the ATP binding pocket of GSK-3β and DYRK1A. Western blot anal. revealed that ZDWX-25 inhibited hyperphosphorylation of tau protein in okadaic acid (OKA)-induced SH-SY5Y cells. In addition, ZDWX-25 showed good blood-brain barrier penetrability in vitro. More importantly, ZDWX-25 could ameliorate the impaired learning and memory in APP/PS1/Tau transgenic mice. These results indicated that the harmine-based compounds could be served as promising dual-targeted candidates for AD. In the experiment, the researchers used Pyridin-3-ylboronic acid(cas: 1692-25-7HPLC of Formula: 1692-25-7)

Pyridin-3-ylboronic acid(cas: 1692-25-7) belongs to pyridine. Pyridines form stable salts with strong acids. Pyridine itself is often used to neutralize acid formed in a reaction and as a basic solvent. HPLC of Formula: 1692-25-7

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Xu, Mizhi; Paul, McKinley K.; Bullard, Krista K.; DuPre, Christopher; Gutekunst, Will R. published an article in 2021. The article was titled 《Modulating Twisted Amide Geometry and Reactivity Through Remote Substituent Effects》, and you may find the article in Journal of the American Chemical Society.SDS of cas: 1692-25-7 The information in the text is summarized as follows:

The unusual reactivity of twisted amides has long been associated with the degree of amide distortion, though classical bridged bicyclic amides offer limited methods to further modify these parameters. Here, we report that the geometry and reactivity of a single twisted amide scaffold can be significantly modulated through remote substituent effects. Guided by calculated ground state geometries, a library of twisted amide derivatives was efficiently prepared through a divergent synthetic strategy. Kinetic and mechanistic investigations of these amides in the alkylation/halide-rebound ring-opening reaction with alkyl halides show a strong pos. correlation between the electron donating ability of the substituent and distortion of the amide bond, leading to rates of nucleophilic substitution spanning nearly 2 orders of magnitude. The rate limiting step of the cascade sequence is found to be dependent on the nature of the substituent, and addnl. studies highlight the role of solvent polarity and halide ion on reaction pathway and efficiency. The experimental part of the paper was very detailed, including the reaction process of Pyridin-3-ylboronic acid(cas: 1692-25-7SDS of cas: 1692-25-7)

Pyridin-3-ylboronic acid(cas: 1692-25-7) belongs to pyridine. When pyridine is adsorbed on oxide surfaces or in porous materials, the following species are commonly observed: (i) pyridine coordinated to Lewis acid sites, (ii) pyridine H-bonded to weakly acidic hydroxyls, and (iii) protonated pyridine. At high coverage, physisorbed pyridine and protonated dimers can also be observed.SDS of cas: 1692-25-7

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Lu, Fangjie; Xu, Dong; Lu, Yusheng; Dai, Bin; Zhu, Mingyuan published an article in 2021. The article was titled 《High nitrogen carbon material with rich defects as highly efficient metal-free catalyst for excellent catalytic performance of acetylene hydrochlorination》, and you may find the article in Chinese Journal of Chemical Engineering.Product Details of 141-86-6 The information in the text is summarized as follows:

In this work, we developed a simple strategy to synthesize a carbon material with high nitrogen and rich carbon defects. Our approach polymerized diaminopyridine (DAP) and ammonium persulfate (APS). Following a range of different temperature pyrolysis approaches, the resulting rough surface was shown to exhibit edge defects due to N-doping on graphite carbon. A series of catalysts were evaluated using a variety of characterization techniques and tested for catalytic performance. The catalytic performance of the N-doped carbon material enhanced alongside an increment in carbon defects. The NC-800 catalyst exhibited outstanding catalytic activity and stability in acetylene hydrochlorination (C2H2 GHSV = 30 h-1, at 220 °C, the acetylene conversion rate was 98%), with its stability reaching up to 450 h. Due to NC-800 having a nitrogen content of up to 13.46%, it had the largest sp. surface area and a high defect amount, as well as strong C2H2 and HCl adsorption. NC-800 has excellent catalytic activity and stability to reflect its unlimited potential as a carbon material. In addition to this study using 2,6-Diaminopyridine, there are many other studies that have used 2,6-Diaminopyridine(cas: 141-86-6Product Details of 141-86-6) was used in this study.

2,6-Diaminopyridine(cas: 141-86-6) belongs to pyridine. Pyridine and its simple derivatives are stable and relatively unreactive liquids, with strong penetrating odours that are unpleasant.Product Details of 141-86-6

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Stahlberger, M.; Steinlein, O.; Adam, C. R.; Rotter, M.; Hohmann, J.; Nieger, M.; Koeberle, B.; Braese, S. published an article in 2022. The article was titled 《Fluorescent annulated imidazo[4,5-c]isoquinolines via a GBB-3CR/imidoylation sequence – DNA-interactions in pUC-19 gel electrophoresis mobility shift assay》, and you may find the article in Organic & Biomolecular Chemistry.Electric Literature of C6H4BrNO The information in the text is summarized as follows:

The development of a sequential synthesis route towards annulated imidazo[4,5-c]isoquinolines comprising a GBB-3CR, followed by an intramol. imidoylative cyclization was reported. X-Ray crystallog. revealed a flat 3D structure of the obtained polyheterocycles. Thus, their interactions with double-stranded DNA was evaluated by establishing a pUC-19 plasmid-based gel electrophoresis mobility shift assay, revealing a stabilizing effect on ds-DNA against strand-break inducing conditions.2-Bromonicotinaldehyde(cas: 128071-75-0Electric Literature of C6H4BrNO) was used in this study.

2-Bromonicotinaldehyde(cas: 128071-75-0) belongs to pyridine. Pyridine is widely used in the precursor to agrochemicals and pharmaceuticals. Also, it is used as an important reagent and organic solvent.Electric Literature of C6H4BrNO

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Zhang, Lei; Pfund, Bjorn; Wenger, Oliver S.; Hu, Xile published an article in 2022. The article was titled 《Oxidase-Type C-H/C-H Coupling Using an Isoquinoline-Derived Organic Photocatalyst》, and you may find the article in Angewandte Chemie, International Edition.Name: 4-Cyanopyridine The information in the text is summarized as follows:

Herein, an isoquinoline-derived diaryl ketone-type photocatalyst I, which has much enhanced absorption of blue and visible light compared to conventional diaryl ketones was reported. This photocatalyst enables dehydrogenative cross-coupling of heteroarenes e.g., II with inactivated and activated alkanes viz. cyclohexane, THF, adamantane, etc. as well as aldehydes viz. propanal, pentanal, 3-methylbutanal, cyclopropanecarbaldehyde, cyclopentanecarbaldehyde using air as the oxidant. A wide range of heterocycles with various functional groups are suitable substrates. Transient absorption and excited-state quenching experiments point to an unconventional mechanism that involves an excited state ”self-quenching” process to generate the N-radical cation form of the sensitizer, which subsequently abstracts a hydrogen atom from the alkane substrate to yield a reactive alkyl radical. After reading the article, we found that the author used 4-Cyanopyridine(cas: 100-48-1Name: 4-Cyanopyridine)

4-Cyanopyridine(cas: 100-48-1) belongs to pyridine. Pyridine is widely used in the precursor to agrochemicals and pharmaceuticals. Also, it is used as an important reagent and organic solvent.Name: 4-Cyanopyridine

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Nau, Jennifer; Bruening, Vincent; Biesen, Lukas; Knedel, Tim-Oliver; Janiak, Christoph; Mueller, Thomas J. J. published an article in 2022. The article was titled 《Synthesis and Electronic Properties of Conjugated syn,syn-Dithienothiazine Donor-Acceptor-Donor Dumbbells》, and you may find the article in European Journal of Organic Chemistry.Category: pyridine-derivatives The information in the text is summarized as follows:

A series of conjugated syn,syn-dithienothiazine donor-acceptor-donor dumbbells was readily synthesized by Suzuki coupling or a one-pot α-lithiation-zincation-Negishi coupling sequence in moderate to good yield. The title compounds were all electron-rich reversible oxidizable redox systems with a relatively narrow range of oxidation potentials according to cyclic voltammetry. UV/Vis and fluorescence spectroscopy however showed a significant effect of the electronic nature of the conjugated bridging system on absorption and emission characteristics. Furthermore, a highly polar excited state was corroborated by Lippert-Mataga anal. of the emission solvatochromicity as well as by TD-DFT calculation of absorption and emission maxima, which classified these dumbbell systems as redox active, luminescent low band gap chromophores with exptl. determined optical band gaps between 2.20 and 2.50 eV. In the part of experimental materials, we found many familiar compounds, such as 2,5-Dibromopyridine(cas: 624-28-2Category: pyridine-derivatives)

2,5-Dibromopyridine(cas: 624-28-2) belongs to pyridine. In industry and in the lab, pyridine is used as a reaction solvent, particularly when its basicity is useful, and as a starting material for synthesizing some herbicides, fungicides, and antiseptics.Category: pyridine-derivatives

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

In 2022,Yang, Dongxu; Chen, Xiangyi; He, Dongsheng; Frommhold, Andreas; Shi, Xiaoqing; Boden, Stuart A.; Lebedeva, Maria A.; Ershova, Olga V.; Palmer, Richard E.; Li, Ziyou; Shi, Haofei; Gao, Jianzhi; Pan, Minghu; Khlobystov, Andrei N.; Chamberlain, Thomas W.; Robinson, Alex P. G. published an article in Journal of Physical Chemistry Letters. The title of the article was 《A Fullerene-Platinum Complex for Direct Functional Patterning of Single Metal Atom-Embedded Carbon Nanostructures》.Name: 4,4′-Dimethyl-2,2′-bipyridine The author mentioned the following in the article:

The development of patterning materials (“”resists””) at the nanoscale involves two distinct trends-one is toward high sensitivity and resolution for miniaturization, the other aims at functionalization of the resists to realize bottom-up construction of distinct nanoarchitectures. Patterning of carbon nanostructures, a seemingly ideal application for organic functional resists, has been highly reliant on complicated pattern transfer processes due to a lack of patternable precursors. Here we present a fullerene-metal coordination complex as a fabrication material for direct functional patterning of sub-10 nm metal-containing carbon structures. The attachment of one platinum atom per fullerene mol. not only leads to significant improvement of sensitivity and resolution, but also enables stable at. dispersion of the platinum ions within the carbon matrix, which may gain fundamentally new interest in functional patterning of hierarchical carbon nanostructures. In the part of experimental materials, we found many familiar compounds, such as 4,4′-Dimethyl-2,2′-bipyridine(cas: 1134-35-6Name: 4,4′-Dimethyl-2,2′-bipyridine)

4,4′-Dimethyl-2,2′-bipyridine(cas: 1134-35-6) is used as a chemical Intermediate. It can be used for the determination of ferrous and cyanide compounds.Name: 4,4′-Dimethyl-2,2′-bipyridine Furthermore, 4,4′-Dimethyl-2,2′-bipyridine is used in the synthesis of a series of o-phenanthroline-substituted ruthenium(II) complexes.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

COA of Formula: C5H3BrClNIn 2015 ,《Iridium-Catalyzed Asymmetric Hydrogenation of 2-Pyridyl Cyclic Imines: A Highly Enantioselective Approach to Nicotine Derivatives》 appeared in Journal of the American Chemical Society. The author of the article were Guo, Cui; Sun, Dong-Wei; Yang, Shuang; Mao, Shen-Jie; Xu, Xiao-Hua; Zhu, Shou-Fei; Zhou, Qi-Lin. The article conveys some information:

A highly efficient asym. hydrogenation of cyclic imines containing a pyridyl moiety was established by using iridium catalysts with chiral spiro phosphine-oxazoline ligands. This process will facilitate the development of new nicotine-related pharmaceuticals I [R = 6-F, 6-Cl, 6-Me, etc; n = 1, 2, 3]. The introduction of a substituent at the ortho position of the pyridyl ring to reduce its coordinating ability ensures the success of the hydrogenation and excellent enantioselectivity. After reading the article, we found that the author used 5-Bromo-2-chloropyridine(cas: 53939-30-3COA of Formula: C5H3BrClN)

5-Bromo-2-chloropyridine(cas: 53939-30-3) belongs to pyridine. Pyridine and pyridine-derived structures are privileged pharmacophores in medicinal chemistry and an essential functionality for organic chemists. As the prototypical π-deficient heterocycle, pyridine illustrates distinctive chemistry as both substrate and reagent. COA of Formula: C5H3BrClN

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Recommanded Product: 2-BromonicotinaldehydeIn 2018 ,《Synthesis of Pyrimidine Fused Quinolines by Ligand-Free Copper-Catalyzed Domino Reactions》 appeared in Journal of Organic Chemistry. The author of the article were Panday, Anoop Kumar; Mishra, Richa; Jana, Asim; Parvin, Tasneem; Choudhury, Lokman H.. The article conveys some information:

Herein we report two novel methods for the synthesis of pyrimidine fused quinolines using one-pot C-C and C-N bond forming strategy from the reaction of 6-amino uracils with 2-bromo benzaldehydes or 2-bromobenzyl bromide derivatives in the presence of 10-mol% CuCl2 without using any ligand. The reaction of 2-bromobenzaldehyde or its derivatives with 6-amino-uracils in the presence K2CO3 as base and catalytic amount of CuCl2 in DMF medium under microwave heating conditions provide corresponding pyrimidine-fused quinoline derivatives in good yields within 30 min. Alternatively, pyrimidine fused quinoline derivatives have been synthesized from the reaction of 2-bromobenzyl bromides with 6-amino-uracil derivatives in the presence of mol. oxygen, CuCl2 (10-mol%) and K2CO3 as base in DMF under reflux conditions. Structures of all the products were unambiguously confirmed by spectroscopic techniques and by recording single crystal XRD of I. In addition to this study using 2-Bromonicotinaldehyde, there are many other studies that have used 2-Bromonicotinaldehyde(cas: 128071-75-0Recommanded Product: 2-Bromonicotinaldehyde) was used in this study.

2-Bromonicotinaldehyde(cas: 128071-75-0) belongs to pyridine. Pyridine and pyridine-derived structures are privileged pharmacophores in medicinal chemistry and an essential functionality for organic chemists. As the prototypical π-deficient heterocycle, pyridine illustrates distinctive chemistry as both substrate and reagent. Recommanded Product: 2-Bromonicotinaldehyde

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem