Day: October 17, 2022

Related Products of 141-86-6In 2019 ,《A new ratiometric, colorimetric and ”turn-on” fluorescent chemosensor for the detection of cyanide ions based on a phenol-bisthiazolopyridine hybrid》 appeared in New Journal of Chemistry. The author of the article were Assadollahnejad, Nazafarin; Kargar, Maryam; Darabi, Hossein Reza; Abouali, Negar; Jamshidi, Shadi; Sharifi, Ali; Aghapoor, Kioumars; Sayahi, Hani. The article conveys some information:

A novel C2-sym. ratiometric fluorescence and colorimetric cyanide (CN-) sensor 1 (I) based on a phenol-bisthiazolopyridine hybrid was synthesized and characterized. Among the various screened anions, this chromogenic receptor 1 showed only a distinct visible color change from colorless to yellow and blue to green fluorescence toward CN- in both pure methanol and aqueous methanol. The ”turn-on” ratiometric fluorescence (emission shift = 95 nm) and colorimetric (absorbance shift = 45 nm) detection of CN- can be attributed to the deprotonation of the OH groups of 1, as evidenced by OH- and 1H NMR experiments The binding mode of 1 with CN- was determined to be a 1 : 1 stoichiometry through a Job plot. Probe 1 was also highly sensitive (LOD = 75 nM) as measured by ratiometric fluorescence (I420/I515 nm) methods. Moreover, the reversibility of the deprotonated 1 by HCl in both solution and the solid state (TLC paper test strips) was successful. In general, probe 1 is a promising CN- indicator in terms of its ease-of-use, selectivity, sensitivity, rapid response (<1 s), reversibility and test kit application. In the experiment, the researchers used many compounds, for example, 2,6-Diaminopyridine(cas: 141-86-6Related Products of 141-86-6)

2,6-Diaminopyridine(cas: 141-86-6) belongs to pyridine. Pyridine and its simple derivatives are stable and relatively unreactive liquids, with strong penetrating odours that are unpleasant.Related Products of 141-86-6

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

COA of Formula: C6H4BrNOIn 2018 ,《Synthetic Access to Functionalized Dipolarophiles of Lewis Basic Complexant Scaffolds through Sonogashira Cross-Coupling》 was published in Journal of Organic Chemistry. The article was written by Chaudhuri, Sauradip; Carrick, Jesse D.. The article contains the following contents:

Soft Lewis basic complexants that facilitate selective removal of discrete ions resident in spent nuclear fuel can decrease repository volume and radiotoxicity and are of significant interest. Optimization of chelation efficacy is predicated on modular access to synthons to rapidly evaluate structure-activity relationships. The following work highlights efficient access to functionalized synthons for use as potential dipolarophiles in subsequent cycloaddition processes via Sonogashira coupling of 3-(6-bromo-pyridin-2-yl)-[1,2,4]triazine scaffolds. The 41 examples explored during method development evaluated electrophile and nucleophile diversity affording the desired coupled products in 31-96% isolated yield. Method optimization, substrate scope, a scale-up reaction, and downstream product functionalization are reported herein. After reading the article, we found that the author used 2-Bromonicotinaldehyde(cas: 128071-75-0COA of Formula: C6H4BrNO)

2-Bromonicotinaldehyde(cas: 128071-75-0) belongs to pyridine. Pyridines, quinolines, and isoquinolines have found a function in almost all aspects of organic chemistry. Pyridine has found use as a solvent, base, ligand, functional group, and molecular scaffold. As structural elements, these moieties are potent electron-deficient groups, metal-directing functionalities, fluorophores, and medicinally important pharmacophores. COA of Formula: C6H4BrNO

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Recommanded Product: 1539-42-0In 2021 ,《Going the dHis-tance: Site-Directed Cu2+ Labeling of Proteins and Nucleic Acids》 was published in Accounts of Chemical Research. The article was written by Gamble Jarvi, Austin; Bogetti, Xiaowei; Singewald, Kevin; Ghosh, Shreya; Saxena, Sunil. The article contains the following contents:

Conspectus: In this Account, we showcase site-directed Cu2+ labeling in proteins and DNA, which has opened new avenues for the measurement of the structure and dynamics of biomols. using ESR (EPR) spectroscopy. In proteins, the spin label is assembled in situ from natural amino acid residues and a metal complex and requires no post-expression synthetic modification or purification procedures. The labeling scheme exploits a double histidine (dHis) motif, which utilizes endogenous or site-specifically mutated histidine residues to coordinate a Cu2+ complex. Pulsed EPR measurements on such Cu2+-labeled proteins potentially yield distance distributions that are up to 5 times narrower than the common protein spin label-the approach, thus, overcomes the inherent limitation of the current technol., which relies on a spin label with a highly flexible side chain. This labeling scheme provides a straightforward method that elucidates biophys. information that is costly, complicated, or simply inaccessible by traditional EPR labels. Examples include the direct measurement of protein backbone dynamics at β-sheet sites, which are largely inaccessible through traditional spin labels, and rigid Cu2+-Cu2+ distance measurements that enable higher precision in the anal. of protein conformations, conformational changes, interactions with other biomols., and the relative orientations of two labeled protein subunits. Likewise, a Cu2+ label has been developed for use in DNA, which is small, is nucleotide independent, and is positioned within the DNA helix. The placement of the Cu2+ label directly reports on the biol. relevant backbone distance. Addnl., for both of these labeling techniques, we have developed models for interpretation of the EPR distance information, primarily utilizing mol. dynamics (MD) simulations. Initial results using force fields developed for both protein and DNA labels have agreed with exptl. results, which has been a major bottleneck for traditional spin labels. Looking ahead, we anticipate new combinations of MD and EPR to further our understanding of protein and DNA conformational changes, as well as working synergistically to investigate protein-DNA interactions. In addition to this study using Bis(pyridin-2-ylmethyl)amine, there are many other studies that have used Bis(pyridin-2-ylmethyl)amine(cas: 1539-42-0Recommanded Product: 1539-42-0) was used in this study.

Bis(pyridin-2-ylmethyl)amine(cas: 1539-42-0) is a secondary amine with two picolyl substituents. The compound is a tridentate ligand in coordination chemistry and commonly used to produce Zn-based chemosensors/probes, such as Zinpry.Recommanded Product: 1539-42-0

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Product Details of 3510-66-5In 2020 ,《Sulfur(IV)-Mediated Unsymmetrical Heterocycle Cross-Couplings》 was published in Angewandte Chemie, International Edition. The article was written by Zhou, Min; Tsien, Jet; Qin, Tian. The article contains the following contents:

Despite the tremendous utilities of metal-mediated cross-couplings in modern organic chem., coupling reactions involving nitrogenous heteroarenes remain a challenging undertaking – coordination of Lewis basic atoms into metal centers often necessitate elevated temperature, high catalyst loading, etc. Herein, the authors report a sulfur (IV) mediated cross-coupling amendable for the efficient synthesis of heteroaromatic substrates. Addition of heteroaryl nucleophiles to a simple, readily-accessible alkyl sulfinyl (IV) chloride gave a trigonal bipyramidal sulfurane intermediate. Reductive elimination therefrom provides bis-heteroaryl products in a practical and efficient fashion. The experimental process involved the reaction of 2-Bromo-5-methylpyridine(cas: 3510-66-5Product Details of 3510-66-5)

2-Bromo-5-methylpyridine(cas: 3510-66-5) belongs to pyridine. Pyridines, quinolines, and isoquinolines have found a function in almost all aspects of organic chemistry. Pyridine has found use as a solvent, base, ligand, functional group, and molecular scaffold. As structural elements, these moieties are potent electron-deficient groups, metal-directing functionalities, fluorophores, and medicinally important pharmacophores. Product Details of 3510-66-5

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Quality Control of 4-CyanopyridineIn 2019 ,《Direct Arylation of α-Amino C(sp3)-H Bonds by Convergent Paired Electrolysis》 was published in Angewandte Chemie, International Edition. The article was written by Ma, Yueyue; Yao, Xiantong; Zhang, Lei; Ni, Pufan; Cheng, Ruihua; Ye, Jinxing. The article contains the following contents:

A metal-free convergent paired electrolysis strategy to synthesize benzylic amines through direct arylation of tertiary amines and benzonitrile derivatives at room temperature was developed. This TEMPO-mediated electrocatalytic reaction made full use of both anodic oxidation and cathodic reduction without metals or stoichiometric oxidants, thus showing great potential and advantages for practical synthesis. This convergent paired electrolysis method provided a straightforward and powerful means to activate C-H bonds and realize cross-coupling with cathodically generated species. The experimental process involved the reaction of 4-Cyanopyridine(cas: 100-48-1Quality Control of 4-Cyanopyridine)

4-Cyanopyridine(cas: 100-48-1) belongs to pyridine. Pyridines, quinolines, and isoquinolines have found a function in almost all aspects of organic chemistry. Pyridine has found use as a solvent, base, ligand, functional group, and molecular scaffold. As structural elements, these moieties are potent electron-deficient groups, metal-directing functionalities, fluorophores, and medicinally important pharmacophores. Quality Control of 4-Cyanopyridine

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Application In Synthesis of 2-BromonicotinaldehydeIn 2020 ,《Elemental Sulfur-Promoted [2+3+1] Annulation for Synthesis of Functionalized Thiochromeno[2,3-b]indoles from Indole Derivatives》 was published in Asian Journal of Organic Chemistry. The article was written by Liu, Jianming; Wang, Zhixian; Wang, Ke; Liu, Dong; Yang, Yan; Fan, Junjun; Zhuo, Kelei; Yue, Yuanyuan. The article contains the following contents:

An intermol. [2+3+1] annulation between indoles I (R1 = H, Me, OMe, Cl, Br; R2 = H, Me, F, OMe, Cl, Br; R3 = H, Me, Cl, F; R4 = H, OMe, Br, Cl) and aromatic aldehyde derivatives 2-Br-3-R5-4-R6-5-R7C6HCHO (R5 = H; R6 = H, Me; R7 = H, F, CF3; R5R6 = -CH=CH-CH=CH-) and 2-bromonicotinaldehyde was successfully achieved by utilizing elemental sulfur as the promoter and coupling partner. This direct and operationally simple procedure provided a rapid and reliable approach to synthesize functionalized thiochromeno[2,3-b]indoles II and pyrido[3′, 2′:5,6]thiopyrano[2, 3-b]indoles III. Preliminary mechanistic studies indicated that elemental sulfur enhanced the nucleophilicity of the 3-position of indole to attack an aldehyde group, and C-H cleavage of indole was not involved in the rate-determining step. The results came from multiple reactions, including the reaction of 2-Bromonicotinaldehyde(cas: 128071-75-0Application In Synthesis of 2-Bromonicotinaldehyde)

2-Bromonicotinaldehyde(cas: 128071-75-0) belongs to pyridine. Pyridines, quinolines, and isoquinolines have found a function in almost all aspects of organic chemistry. Pyridine has found use as a solvent, base, ligand, functional group, and molecular scaffold. As structural elements, these moieties are potent electron-deficient groups, metal-directing functionalities, fluorophores, and medicinally important pharmacophores. Application In Synthesis of 2-Bromonicotinaldehyde

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

《Copper-Catalyzed Enantioselective Three-Component Synthesis of Optically Active Propargylamines from Aldehydes, Amines, and Aliphatic Alkynes》 was published in Chemistry – A European Journal in 2010. These research results belong to Nakamura, Shuichi; Ohara, Mutsuyo; Nakamura, Yuko; Shibata, Norio; Toru, Takeshi. COA of Formula: C35H27N3O2 The article mentions the following:

An enantioselective three-component reaction of aldehydes, amines, and aliphatic alkynes catalyzed by C2-sym. pybim Cu1 catalysts to give propargylamines, e.g., I in good yields and with high enantioselectivity has been developed. This process has many advantages, such as simplified operation and mild reaction conditions. These results open a novel way to synthesize optically active propargylamines. In the experiment, the researchers used many compounds, for example, 2,6-Bis((4S,5S)-4,5-diphenyl-4,5-dihydrooxazol-2-yl)pyridine(cas: 410092-98-7COA of Formula: C35H27N3O2)

2,6-Bis((4S,5S)-4,5-diphenyl-4,5-dihydrooxazol-2-yl)pyridine(cas: 410092-98-7) belongs to pyridine derivatives. The ring atoms in the pyridine molecule are sp2-hybridized. The nitrogen is involved in the π-bonding aromatic system using its unhybridized p orbital. COA of Formula: C35H27N3O2The lone pair is in an sp2 orbital, projecting outward from the ring in the same plane as the σ bonds.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

《Dynamics of Closure of a Zinc Bis-Porphyrin Molecular Tweezers with Copper(II) Ions and Electron Transfer》 was written by Habermeyer, Benoit; Takai, Atsuro; Gros, Claude P.; El Ojaimi, Maya; Barbe, Jean-Michel; Fukuzumi, Shun-Ichi. Electric Literature of C7H6BrNO2This research focused onzinc bisporphyrin mol tweezer copper amine imine spacer preparation; mol tweezer zinc bisporphyrin copper complexation electron transfer; redox potential zinc bisporphyrin mol tweezer copper coordination closure; electrochem redox zinc bisporphyrin mol tweezer copper coordination. The article conveys some information:

Zinc bis-porphyrin mol. tweezers composed of a N4 spacer bound through pyridyl units to the meso position of porphyrins were synthesized, and the tweezers are closed by the coordination of a Cu(II) ion inside the spacer ligand. The effect of the π-π interaction between the porphyrin rings in the closed conformation on the absorption spectra of multi-electron oxidized species and the reduction potentials were clarified by chem. and electrochem. oxidation of the closed form of the zinc bis-porphyrin mol. tweezers in comparison with the open form without Cu(II) ion and the corresponding porphyrin monomer. The shifts in redox potentials and absorption spectrum of the porphyrin dication indicate a strong electronic interaction between the two oxidized porphyrins in the closed form, whereas there is little interaction between them in the neutral form. The dynamics of Cu(II) ion coordination and subsequent electron transfer was examined by using a stopped-flow UV/visible spectroscopic technique. Coordination of Cu(II) occurs prior to electron-transfer oxidation of the closed form of the zinc bis-porphyrin mol. tweezers. In the experimental materials used by the author, we found Methyl 5-bromopicolinate(cas: 29682-15-3Electric Literature of C7H6BrNO2)

Methyl 5-bromopicolinate(cas: 29682-15-3) belongs to pyridine. Pyridine-based materials are valued for their optical and physical properties as well as their medical potential. Additionally, pyridine-based natural products continue to be discovered and studied for their properties and to understand their biosynthesis.Electric Literature of C7H6BrNO2

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

《Near-Infrared Fluorescent Theranostic Cisplatin Prodrug with Transcatheter Intra-Arterial Therapy: Application to Rabbit Hepatocellular Carcinoma》 was written by Li, Qiang; Wang, Qi; Wang, Saibo; Zhu, Shiqin; Yuan, Tianwen; Guo, Zhiqian; Cao, Jun; Tian, He; Zhu, Wei-Hong. HPLC of Formula: 103-74-2This research focused ontranscatheter intra arterial therapy cisplatin prodrug hepatocellular carcinoma. The article conveys some information:

Transcatheter intra-arterial therapy (TIT) has become valuable in the battle against primary and secondary hepatic malignancies. However, the lack of a mechanism to visualize real-time drug release and avoid fast metabolic clearance of chemotherapeutic agents is the primary barrier to TIT for hepatocellular carcinoma. Here, a specific near-IR (NIR) fluorescent prodrug platform, i.e., DSPE-mPEG/DCM-S-Pt micelles (DCM-S-Pt@PEG), to assist TIT in direct administration to large mammals like rabbits, is presented. DCM-S-Pt@PEG consists of a NIR fluorophore for tracing drug release, a nonspecific antitumor drug cisplatin for hepatocellular carcinoma treatment, a glutathione-activatable disulfide linker, and a DSPE-mPEG nano-micelle carrier for controllable drug release. DCM-S-Pt@PEGcan make the drug accumulation in tumor tissues enhance the therapeutic effect by: (i) specific delivery of prodrug to hepatic tumor tissues through the femoral artery by TIT, (ii) sustained drug-release from the biodegradable lipid DSPE-mPEG micelle to minimize metabolic clearance, and (iii) cancer biomarker-activated drug release. It provides a promising strategy to assist TIT in treating unresectable devastating hepatocellular carcinoma administration in the rabbit model, rather than common mouse model. In the experiment, the researchers used 2-(2-Hydroxyethyl)pyridine(cas: 103-74-2HPLC of Formula: 103-74-2)

2-(2-Hydroxyethyl)pyridine(cas: 103-74-2) belongs to pyridine. Pyridine-based materials are valued for their optical and physical properties as well as their medical potential. Additionally, pyridine-based natural products continue to be discovered and studied for their properties and to understand their biosynthesis.HPLC of Formula: 103-74-2

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

《Structure-Guided Discovery of Potent and Selective Inhibitors of ERK1/2 from a Modestly Active and Promiscuous Chemical Start Point》 was written by Ward, Richard A.; Bethel, Paul; Cook, Calum; Davies, Emma; Debreczeni, Judit E.; Fairley, Gary; Feron, Lyman; Flemington, Vikki; Graham, Mark A.; Greenwood, Ryan; Griffin, Nicola; Hanson, Lyndsey; Hopcroft, Philip; Howard, Tina D.; Hudson, Julian; James, Michael; Jones, Clifford D.; Jones, Christopher R.; Lamont, Scott; Lewis, Richard; Lindsay, Nicola; Roberts, Karen; Simpson, Iain; St-Gallay, Steve; Swallow, Steve; Tang, Jia; Tonge, Michael; Wang, Zhenhua; Zhai, Baochang. Related Products of 1365836-53-8 And the article was included in Journal of Medicinal Chemistry on April 27 ,2017. The article conveys some information:

There are a number of small-mol. inhibitors targeting the RAS/RAF/MEK/ERK signaling pathway that have either been approved or are in clin. development for oncol. across a range of disease indications. The inhibition of ERK1/2 is of significant current interest, as cell lines with acquired resistance to BRAF and MEK inhibitors have been shown to maintain sensitivity to ERK1/2 inhibition in preclin. models. This article reports on authors’ recent work to identify novel, potent, and selective reversible ERK1/2 inhibitors from a low-mol.-weight, modestly active, and highly promiscuous chem. start point, compound I. To guide and inform the evolution of this series, inhibitor binding mode information from X-ray crystal structures was critical in the rapid exploration of this template to compound II, which was active when tested in in vivo antitumor efficacy experiments After reading the article, we found that the author used (6-Methylpyridin-2-yl)methanamine hydrochloride(cas: 1365836-53-8Related Products of 1365836-53-8)

(6-Methylpyridin-2-yl)methanamine hydrochloride(cas: 1365836-53-8) belongs to anime. The methylamines occur in small amounts in some plants. Many polyfunctional amines (i.e., those having other functional groups in the molecule) occur as alkaloids in plants—for example, mescaline, 2-(3,4,5-trimethoxyphenyl)ethylamine; the cyclic amines nicotine, atropine, morphine, and cocaine; and the quaternary salt choline, N-(2-hydroxyethyl)trimethylammonium chloride, which is present in nerve synapses and in plant and animal cells.Related Products of 1365836-53-8

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem